For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Full Length
MAP4K5 (KHS1) is a serine/threonine kinase that belongs to the GCK family of kinases and has been implicated as an upstream regulator of MAP kinase signaling pathways. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for MAP4K5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: germinal center kinase-related; KHS; Kinase homologous to SPS1/STE20; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5; Mitogen-activated protein kinase kinase kinase kinase 5
Gene Aliases: GCKR; KHS; KHS1; MAP4K5; MAPKKKK5
UniProt ID: (Human) Q9Y4K4
Entrez Gene ID: (Human) 11183
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