Invitrogen

MRE11 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

View all (32) MRE11 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-31262

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Immunoprecipitation (IP)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein fragment corresponding to a region within amino acids 132 and 572 of Human Mre11
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2548736

Product Specific Information

Recommended positive controls: HeLa, A431, C8D30, NIH-3T3, PC-12.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex. This complex plays a central role in double-strand break repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3'-5' exonuclease activity which are provided by MRE11. RAD50 is required to bind DNA ends and hold them in close proximity. Mutations in the gene could result in ataxia-telangiectasia-like disorder 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: AT-like disease; DNA recombination and repair protein; Double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; endo/exonuclease Mre11; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; mmMRE11A; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11-like protein A

View more View less

Gene Aliases: ATLD; HNGS1; MRE11; MRE11A; MRE11B

View more View less

UniProt ID: (Human) P49959, (Rat) Q9JIM0, (Mouse) Q61216

View more View less

Entrez Gene ID: (Human) 4361, (Rat) 64046, (Mouse) 17535

View more View less

Function(s)
single-stranded DNA endodeoxyribonuclease activity DNA binding double-stranded DNA binding ATP-dependent DNA helicase activity nuclease activity endodeoxyribonuclease activity protein binding protein C-terminus binding 3'-5' exonuclease activity manganese ion binding cadherin binding involved in cell-cell adhesion endonuclease activity exonuclease activity hydrolase activity
Process(es)
regulation of mitotic recombination double-strand break repair via homologous recombination DNA double-strand break processing DNA synthesis involved in DNA repair strand displacement DNA replication DNA repair double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination cellular response to DNA damage stimulus telomere maintenance via telomerase sister chromatid cohesion mitotic G2 DNA damage checkpoint synapsis reciprocal meiotic recombination heart development cell proliferation viral process intra-S DNA damage checkpoint telomeric 3' overhang formation positive regulation of protein autophosphorylation positive regulation of telomere maintenance positive regulation of type I interferon production DNA duplex unwinding negative regulation of DNA endoreduplication positive regulation of kinase activity negative regulation of apoptotic process negative regulation of viral entry into host cell nucleic acid phosphodiester bond hydrolysis cell-cell adhesion regulation of signal transduction by p53 class mediator telomere maintenance base-excision repair nucleotide-excision repair chromosome organization meiotic cell cycle DNA metabolic process
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support