Product References
Oncogenic BRAFV600E induces microglial proliferation through extracellular signal-regulated kinase and neuronal death through c-Jun N-terminal kinase.
Neural regeneration research
Ye Q,Srivastava P,Al-Kuwari N,Chen X
PA5-17646 was used in Immunocytochemistry-immunofluorescence to identify distinct consequences mediated by distinct downstream effectors in dividing glial cells and in neurons following the same BRAF mutational activation and a causal link between BRAF-activated microglia and neuronal cell death that does not require physical proximity.
Sat Jul 01 00:00:00 EDT 2023
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.
Cell reports
Sun C,Seranova E,Cohen MA,Chipara M,Roberts J,Astuti D,Palhegyi AM,Acharjee A,Sedlackova L,Kataura T,Otten EG,Panda PK,Lara-Reyna S,Korsgen ME,Kauffman KJ,Huerta-Uribe A,Zatyka M,Silva LFSE,Torresi J,Zhang S,Hughes GW,Ward C,Kuechler ER,Cartwright D,Trushin S,Trushina E,Sahay G,Buganim Y,Lavery GG,Gsponer J,Anderson DG,Frickel EM,Rosenstock TR,Barrett T,Maddocks ODK,Tennant DA,Wang H,Jaenisch R,Korolchuk VI,Sarkar S
PA5-17646 was used in Immunocytochemistry to elucidate a mechanistic link between autophagy deficiency and neuronal cell death that can be targeted for therapeutic interventions in neurodegenerative and lysosomal storage diseases associated with autophagic defect.
Tue May 30 00:00:00 EDT 2023
A Gelatin Methacrylate-Based Hydrogel as a Potential Bioink for 3D Bioprinting and Neuronal Differentiation.
Pharmaceutics
Cruz EM,Machado LS,Zamproni LN,Bim LV,Ferreira PS,Pinto LA,Pessan LA,Backes EH,Porcionatto MA
PA5-17646 was used in Immunocytochemistry-immunofluorescence to indicate that bioinks, 2.5/2.5G/GMA_Gx and 4GMA_Gx, can support neural cell survival and modulate neural differentiation.
Mon Feb 13 00:00:00 EST 2023
Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells.
Aging cell
You Y,Hersh SW,Aslebagh R,Shaffer SA,Ikezu S,Mez J,Lunetta KL,Logue MW,Farrer LA,Ikezu T
PA5-17646 was used in Immunocytochemistry to demonstrate specific effects of rs14462445 on mis-processing of tau and suggest a potential role of AKAP9 in AD pathogenesis.
Wed Jun 01 00:00:00 EDT 2022
Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells.
Aging cell
You Y,Hersh SW,Aslebagh R,Shaffer SA,Ikezu S,Mez J,Lunetta KL,Logue MW,Farrer LA,Ikezu T
PA5-17646 was used in Immunocytochemistry to demonstrate specific effects of rs14462445 on mis-processing of tau and suggest a potential role of AKAP9 in AD pathogenesis.
Wed Jun 01 00:00:00 EDT 2022
SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways.
Pathogens (Basel, Switzerland)
Rothan HA,Kumari P,Stone S,Natekar JP,Arora K,Auroni TT,Kumar M
PA5-17646 was used in Immunocytochemistry to investigate the effects of a SARS-CoV-2 infection by generating primary neuronal cultures from K18-hACE2 mice.
Thu Feb 17 00:00:00 EST 2022
SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways.
Pathogens (Basel, Switzerland)
Rothan HA,Kumari P,Stone S,Natekar JP,Arora K,Auroni TT,Kumar M
PA5-17646 was used in Immunocytochemistry to investigate the effects of a SARS-CoV-2 infection by generating primary neuronal cultures from K18-hACE2 mice.
Thu Feb 17 00:00:00 EST 2022
Mitochondrial oxidative stress contributes to the pathological aggregation and accumulation of tau oligomers in Alzheimer's disease.
Human molecular genetics
Du F,Yu Q,Kanaan NM,Yan SS
PA5-17646 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to provide substantial evidence that mitochondria-mediated oxidative stress contributes to tau oligomer formation and accumulation.
Wed Aug 17 00:00:00 EDT 2022
Nanoscale Patterning of In Vitro Neuronal Circuits.
ACS nano
Mateus JC,Weaver S,van Swaay D,Renz AF,Hengsteler J,Aguiar P,Vörös J
PA5-17646 was used in Immunocytochemistry-immunofluorescence to create polydimethylsiloxane (PDMS) structures with features ranging from 150 nm to a few millimeters using a combination of electron beam lithography and photolithography.
Tue Apr 26 00:00:00 EDT 2022
Low dose lead exposure induces alterations on heterochromatin hallmarks persisting through SH-SY5Y cell differentiation.
Chemosphere
Lin LF,Xie J,Sánchez OF,Bryan C,Freeman JL,Yuan C
PA5-17646 was used in Immunocytochemistry to suggest that exposure to low dose of Pb prior to differentiation can result in persistent epigenome alterations that can potentially be responsible for the observed phenotypic changes.
Mon Feb 01 00:00:00 EST 2021
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.
Nature aging
Dehkordi SK,Walker J,Sah E,Bennett E,Atrian F,Frost B,Woost B,Bennett RE,Orr TC,Zhou Y,Andhey PS,Colonna M,Sudmant PH,Xu P,Wang M,Zhang B,Zare H,Orr ME
PA5-17646 was used in Immunohistochemistry-immunofluorescence to show that CDKN2D/p19-expressing neurons with NFTs represent a unique cellular population in human AD with a senescence phenotype.
Wed Dec 01 00:00:00 EST 2021
Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
Molecular cell
Young-Baird SK,Lourenço MB,Elder MK,Klann E,Liebau S,Dever TE
PA5-17646 was used in Immunocytochemistry-immunoflourescence to show that a mutation at the C terminus of eIF2γ impairs CDC123 promotion of eIF2 complex formation and decreases the level of eIF2-GTP-Met-tRNAiMet ternary complexes, using patient-derived induced pluripotent stem cells.
Thu Feb 20 00:00:00 EST 2020
Microfluidic Multielectrode Arrays for Spatially Localized Drug Delivery and Electrical Recordings of Primary Neuronal Cultures.
Frontiers in bioengineering and biotechnology
Bruno G,Colistra N,Melle G,Cerea A,Hubarevich A,Deleye L,De Angelis F,Dipalo M
PA5-17646 was used in Immunocytochemistry-Immunofluorescence to develop a microfluidic multielectrode array platform for performing electrical recordings of primary neurons and targeted drug delivery.
Mon Sep 28 00:00:00 EDT 2020
Microfluidic Multielectrode Arrays for Spatially Localized Drug Delivery and Electrical Recordings of Primary Neuronal Cultures.
Frontiers in bioengineering and biotechnology
Bruno G,Colistra N,Melle G,Cerea A,Hubarevich A,Deleye L,De Angelis F,Dipalo M
PA5-17646 was used in Immunocytochemistry-Immunofluorescence to develop a microfluidic multielectrode array platform for performing electrical recordings of primary neurons and targeted drug delivery.
Mon Sep 28 00:00:00 EDT 2020
The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons.
Frontiers in aging neuroscience
Machiela E,Jeloka R,Caron NS,Mehta S,Schmidt ME,Baddeley HJE,Tom CM,Polturi N,Xie Y,Mattis VB,Hayden MR,Southwell AL
PA5-17646 was used in Immunocytochemistry to suggest a role for aging in HD pathogenesis and an interaction between the biological age of HD neurons and sensitivity to exogenous stress.
Sat Nov 04 00:00:00 EDT 2023
Progesterone through Progesterone Receptor B Isoform Promotes Rodent Embryonic Oligodendrogenesis.
Cells
González-Orozco JC,Moral-Morales AD,Camacho-Arroyo I
PA5-17646 was used in Immunocytochemistry-immunoflourescence to suggest that the expression and regulation of progesterone receptor (PR) isoforms should determine the oligodendrogenic and promyelinating actions of progesterone in a tissue and developmentally dependent manner.
Tue Apr 14 00:00:00 EDT 2020
Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells.
bioRxiv : the preprint server for biology
Tristan CA,Ormanoglu P,Slamecka J,Malley C,Chu PH,Jovanovic VM,Gedik Y,Bonney C,Barnaeva E,Braisted J,Mallanna SK,Dorjsuren D,Iannotti MJ,Voss TC,Michael S,Simeonov A,Singeç I
PA5-17646 was used in Immunocytochemistry to conclude that combining stem cell-based models and non-stop robotic cell culture may become a powerful strategy to increase scientific rigor and productivity, which are particularly important during public health emergencies (e.g. opioid crisis, COVID-19 pandemic).
Mon Aug 03 00:00:00 EDT 2020
Scaling Principles of Distributed Circuits.
Current biology : CB
Srinivasan S,Stevens CF
PA5-17646 was used in Immunohistochemistry to study the scalability of neuronal distributed circuits in the olfactory bulb and piriform cortex in six mammals.
Mon Aug 05 00:00:00 EDT 2019
Determinants of Zika virus host tropism uncovered by deep mutational scanning.
Nature microbiology
Setoh YX,Amarilla AA,Peng NYG,Griffiths RE,Carrera J,Freney ME,Nakayama E,Ogawa S,Watterson D,Modhiran N,Nanyonga FE,Torres FJ,Slonchak A,Periasamy P,Prow NA,Tang B,Harrison J,Hobson-Peters J,Cuddihy T,Cooper-White J,Hall RA,Young PR,Mackenzie JM,Wolvetang E,Bloom JD,Suhrbier A,Khromykh AA
Published figure using MAP2 polyclonal antibody (Product # PA5-17646) in Immunohistochemistry
Wed May 01 00:00:00 EDT 2019
Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity.
Acta neuropathologica communications
Duan T,Smith AJ,Verkman AS
PA5-17646 was used in Immunohistochemistry-immunofluorescence to establish a novel cellular pathogenesis mechanism in AQP4-IgG seropositive NMO and provide evidence that inflammatory mechanisms can cause widespread tissue damage in NMO independently of the secondary effects from astrocyte loss.
Thu Jul 11 00:00:00 EDT 2019
An RGD small-molecule integrin antagonist induces detachment-mediated anoikis in glioma cancer stem cells.
International journal of oncology
Paolillo M,Galiazzo MC,Daga A,Ciusani E,Serra M,Colombo L,Schinelli S
PA5-17646 was used in Immunocytochemistry to indicate that small-molecule integrin antagonists have potential as a therapeutic tool for decreasing glioma cancer stem cells dissemination.
Sat Dec 01 00:00:00 EST 2018
