Product References
An ultrasensitive planar array p24 Gag ELISA to detect HIV-1 in diverse biological matrixes.
Scientific reports
Levinger C,Howard JN,Cheng J,Tang P,Joshi A,Catalfamo M,Bosque A
Published figure using CD4 monoclonal antibody (Product # MHCD0405) in Flow Cytometry
Wed Dec 08 00:00:00 EST 2021
Broadly active zinc finger protein-guided transcriptional activation of HIV-1.
Molecular therapy. Methods & clinical development
Scott TA,O'Meally D,Grepo NA,Soemardy C,Lazar DC,Zheng Y,Weinberg MS,Planelles V,Morris KV
MHCD0405 was used in Flow cytometry/Cell sorting to provide proof of concept for the application of a novel, therapeutically relevant, protein transactivator to purge cellular reservoirs of HIV-1.
Fri Mar 12 00:00:00 EST 2021
Broadly active zinc finger protein-guided transcriptional activation of HIV-1.
Molecular therapy. Methods & clinical development
Scott TA,O'Meally D,Grepo NA,Soemardy C,Lazar DC,Zheng Y,Weinberg MS,Planelles V,Morris KV
MHCD0405 was used in Flow cytometry/Cell sorting to provide proof of concept for the application of a novel, therapeutically relevant, protein transactivator to purge cellular reservoirs of HIV-1.
Fri Mar 12 00:00:00 EST 2021
High-Throughput Generation of Bipod (Fab × scFv) Bispecific Antibodies Exploits Differential Chain Expression and Affinity Capture.
Scientific reports
Nesspor TC,Kinealy K,Mazzanti N,Diem MD,Boye K,Hoffman H,Springer C,Sprenkle J,Powers G,Jiang H,La Porte SL,Ganesan R,Singh S,Zwolak A
MHCD0405 was used in Functional assays to describe a high-throughput method for generation of Bipods based on protein A and CH1 domain affinity capture.
Tue May 05 00:00:00 EDT 2020
High-Throughput Generation of Bipod (Fab × scFv) Bispecific Antibodies Exploits Differential Chain Expression and Affinity Capture.
Scientific reports
Nesspor TC,Kinealy K,Mazzanti N,Diem MD,Boye K,Hoffman H,Springer C,Sprenkle J,Powers G,Jiang H,La Porte SL,Ganesan R,Singh S,Zwolak A
MHCD0405 was used in Functional assays to describe a high-throughput method for generation of Bipods based on protein A and CH1 domain affinity capture.
Tue May 05 00:00:00 EDT 2020
MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment.
Nature
Calvanese V,Nguyen AT,Bolan TJ,Vavilina A,Su T,Lee LK,Wang Y,Lay FD,Magnusson M,Crooks GM,Kurdistani SK,Mikkola HKA
MHCD0405 was used in Flow cytometry/Cell sorting to identify MLLT3 (also known as AF9) as a crucial regulator of HSCs that is highly enriched in human fetal, neonatal and adult HSCs, but downregulated in culture.
Sun Dec 01 00:00:00 EST 2019
MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment.
Nature
Calvanese V,Nguyen AT,Bolan TJ,Vavilina A,Su T,Lee LK,Wang Y,Lay FD,Magnusson M,Crooks GM,Kurdistani SK,Mikkola HKA
MHCD0405 was used in Flow cytometry/Cell sorting to identify MLLT3 (also known as AF9) as a crucial regulator of HSCs that is highly enriched in human fetal, neonatal and adult HSCs, but downregulated in culture.
Sun Dec 01 00:00:00 EST 2019
Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission.
Cell host & microbe
Buffalo CZ,Stürzel CM,Heusinger E,Kmiec D,Kirchhoff F,Hurley JH,Ren X
MHCD0405 was used in Flow cytometry/Cell sorting to determine the molecular basis for tetherin counteraction and the structure of AP-2 complex with a simian tetherin and simian immunodeficiency virus Nef by cryoelectron microscopy.
Wed Sep 11 00:00:00 EDT 2019
Transcriptional Circuit Fragility Influences HIV Proviral Fate.
Cell reports
Morton EL,Forst CV,Zheng Y,DePaula-Silva AB,Ramirez NP,Planelles V,D'Orso I
MHCD0405 was used in Flow cytometry/Cell sorting to study the effect of transcriptional fragility on HIV viral fate and cure efforts.
Tue Apr 02 00:00:00 EDT 2019
Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo.
Cell host & microbe
Yamada E,Nakaoka S,Klein L,Reith E,Langer S,Hopfensperger K,Iwami S,Schreiber G,Kirchhoff F,Koyanagi Y,Sauter D,Sato K
MHCD0405 was used in Flow cytometry/Cell sorting to demonstrate that the anti-tetherin activity of Vpu is a prerequisite for efficient viral spread during the early phase of infection.
Wed Jan 10 00:00:00 EST 2018
Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2.
Journal of virology
Heusinger E,Deppe K,Sette P,Krapp C,Kmiec D,Kluge SF,Marx PA,Apetrei C,Kirchhoff F,Sauter D
MHCD0405 was used in Flow cytometry/Cell sorting to investigate whether or how different groups of HIV-2 antagonise human tetherin.
Sat Sep 15 00:00:00 EDT 2018
Interleukin-1 receptor-associated kinase 3 downregulation in peripheral blood mononuclear cells attenuates immunosuppression in sepsis.
Experimental and therapeutic medicine
Xia Q,Zhou Y,Wang X,Fu S
MHCD0405 was used in Flow cytometry/Cell sorting to evaluate the expression and function of IL-1 receptor-associated kinase 3 in blood mononuclear cells from a model of sepsis-induced immunosuppression.
Thu Feb 01 00:00:00 EST 2018
Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity.
Nature communications
Joas S,Parrish EH,Gnanadurai CW,Lump E,Stürzel CM,Parrish NF,Learn GH,Sauermann U,Neumann B,Rensing KM,Fuchs D,Billingsley JM,Bosinger SE,Silvestri G,Apetrei C,Huot N,Garcia-Tellez T,Müller-Trutwin M,Hotter D,Sauter D,Stahl-Hennig C,Hahn BH,Kirchhoff F
MHCD0405 was used in Flow cytometry/Cell sorting to incorporate two putative HIV-1 virulence determinants, Vpu and Nef, into a non-pathogenic simian immunodeficiency virus (SIV)agm strain and test their impact in African green monkeys.
Tue Apr 10 00:00:00 EDT 2018
Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.
Nature communications
Manrique S,Sauter D,Horenkamp FA,Lülf S,Yu H,Hotter D,Anand K,Kirchhoff F,Geyer M
Published figure using CD4 monoclonal antibody (Product # MHCD0405) in Flow Cytometry
Tue Sep 05 00:00:00 EDT 2017
TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia.
Oncoimmunology
Catakovic K,Gassner FJ,Ratswohl C,Zaborsky N,Rebhandl S,Schubert M,Steiner M,Gutjahr JC,Pleyer L,Egle A,Hartmann TN,Greil R,Geisberger R
MHCD0405 was used in Flow cytometry/Cell sorting to reveal that TIGIT+CD4+T cells provide a supportive microenvironment for CLL cells.
Sat Jan 29 00:00:00 EST 2022
Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells.
Nature communications
Vazquez-Lombardi R,Loetsch C,Zinkl D,Jackson J,Schofield P,Deenick EK,King C,Phan TG,Webster KE,Sprent J,Christ D
MHCD0405 was used in Flow cytometry/Cell sorting to underpin an unexpected mechanism of action and provide important guidance for the development of next generation IL-2 therapeutics.
Fri May 12 00:00:00 EDT 2017
Medial HOXA genes demarcate haematopoietic stem cell fate during human development.
Nature cell biology
Dou DR,Calvanese V,Sierra MI,Nguyen AT,Minasian A,Saarikoski P,Sasidharan R,Ramirez CM,Zack JA,Crooks GM,Galic Z,Mikkola HK
MHCD0405 was used in flow cytometry to study how retinoic acid-induced HOXA gene expression controls hematopoietic stem/progenitor cells fate, identify, and function
Wed Jun 01 00:00:00 EDT 2016
Modeling HIV-1 Latency in Primary T Cells Using a Replication-Competent Virus.
AIDS research and human retroviruses
Martins LJ,Bonczkowski P,Spivak AM,De Spiegelaere W,Novis CL,DePaula-Silva AB,Malatinkova E,Trypsteen W,Bosque A,Vanderkerckhove L,Planelles V
MHCD0405 was used in flow cytometry to develop a model that uses cultured central memory CD4 positive T cells and replication-competent HIV-1
Mon Feb 01 00:00:00 EST 2016
Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance.
mBio
Kmiec D,Iyer SS,Stürzel CM,Sauter D,Hahn BH,Kirchhoff F
MHCD0405 was used in flow cytometry elucidate the impact of Vpu-mediated tetherin antagonism on HIV infection
Tue Aug 16 00:00:00 EDT 2016
A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1.
PloS one
Langer SM,Hopfensperger K,Iyer SS,Kreider EF,Learn GH,Lee LH,Hahn BH,Sauter D
Published figure using CD4 monoclonal antibody (Product # MHCD0405) in Flow Cytometry
Tue Jun 14 00:00:00 EDT 2016
PEITC treatment suppresses myeloid derived tumor suppressor cells to inhibit breast tumor growth.
Oncoimmunology
Gupta P,Wright SE,Srivastava SK
Published figure using CD4 monoclonal antibody (Product # MHCD0405) in Flow Cytometry
Sun Feb 01 00:00:00 EST 2015
HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells.
eLife
Reeder JE,Kwak YT,McNamara RP,Forst CV,D'Orso I
Published figure using CD4 monoclonal antibody (Product # MHCD0405) in Flow Cytometry
Wed Oct 21 00:00:00 EDT 2015
An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription.
Molecular therapy : the journal of the American Society of Gene Therapy
Saayman S,Ackley A,Turner AW,Famiglietti M,Bosque A,Clemson M,Planelles V,Morris KV
MHCD0405 was used in flow cytometry to characterize the effects of human immunodeficiency virus lncRNA expression
Sun Jun 01 00:00:00 EDT 2014
Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.
PloS one
de Carvalho JV,de Castro RO,da Silva EZ,Silveira PP,da Silva-Januário ME,Arruda E,Jamur MC,Oliver C,Aguiar RS,daSilva LL
MHCD0405 was used in flow cytometry and immunocytochemistry to test if Nef modifies the composition of exosomes released by T lymphocytes
Tue Aug 04 00:00:00 EDT 2015
Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a.
Journal of immunology (Baltimore, Md. : 1950)
Palin AC,Ramachandran V,Acharya S,Lewis DB
MHCD0405 was used in flow cytometry to test if impaired human neonatal CD4(+) T cell immunity is due to reduced signaling by naive CD4(+) T cells following engagement of the αβ-TCR/CD3 complex and CD28.
Fri Mar 15 00:00:00 EDT 2013
The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function.
Retrovirology
Kluge SF,Sauter D,Vogl M,Peeters M,Li Y,Bibollet-Ruche F,Hahn BH,Kirchhoff F
Published figure using CD4 monoclonal antibody (Product # MHCD0405) in Flow Cytometry
Wed Mar 20 00:00:00 EDT 2013
Subcutaneous versus intravenous administration of rituximab: pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys.
PloS one
Mao CP,Brovarney MR,Dabbagh K,Birnböck HF,Richter WF,Del Nagro CJ
MHCD0405 was used in flow cytometry to assess subcutaneous administration of rituximab.
Fri Jul 25 00:00:00 EDT 2014
Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein.
PLoS pathogens
Sauter D,Unterweger D,Vogl M,Usmani SM,Heigele A,Kluge SF,Hermkes E,Moll M,Barker E,Peeters M,Learn GH,Bibollet-Ruche F,Fritz JV,Fackler OT,Hahn BH,Kirchhoff F
MHCD0405 was used in flow cytometry to examine the function of Vpu proteins from seven HIV group N strains.
Sat Dec 01 00:00:00 EST 2012
Helicobacter pylori induces in-vivo expansion of human regulatory T cells through stimulating interleukin-1β production by dendritic cells.
Clinical and experimental immunology
Mitchell PJ,Afzali B,Fazekasova H,Chen D,Ali N,Powell N,Lord GM,Lechler RI,Lombardi G
MHCD0405 was used in flow cytometry to elucidate the influence of H. pylori on T(reg) function and proliferation.
Sat Dec 01 00:00:00 EST 2012
Characterization of an HIV-targeted transcriptional gene-silencing RNA in primary cells.
Human gene therapy
Turner AM,Ackley AM,Matrone MA,Morris KV
MHCD0405 was used in flow cytometry to demonstrate that transcriptional gene silencing reduces HIV transcription in primary human CD4(+) T cells.
Tue May 01 00:00:00 EDT 2012
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.
Blood
Gardam S,Turner VM,Anderton H,Limaye S,Basten A,Koentgen F,Vaux DL,Silke J,Brink R
MHCD0405 was used in flow cytometry to determine the role of cIAP1 and cIAP2 to B-cell physiology in vivo.
Thu Apr 14 00:00:00 EDT 2011
A new protocol for multiple inhalation of IFN-gamma successfully treats MDR-TB: a case study.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Grahmann PR,Braun RK
MHCD0405 was used in flow cytometry to demonstrate that aerosolized interferon-gamma results in the transient conversion of sputum smears in multidrug-resistant pulmonary tuberculosis
Sun Jun 01 00:00:00 EDT 2008
Phenotypic and molecular characterization of CD103+ CD4+ T cells in bronchoalveolar lavage from patients with interstitial lung diseases.
Cytometry. Part B, Clinical cytometry
Braun RK,Foerster M,Grahmann PR,Haefner D,Workalemahu G,Kroegel C
MHCD0405 was used in flow cytometry to test if CD103 has a regulatory role in the microenvironment of the epithelial cell layer.
Tue Jul 01 00:00:00 EDT 2003
Graft-versus-leukemia effect after suicide-gene-mediated control of graft-versus-host disease.
Blood
Litvinova E,Maury S,Boyer O,Bruel S,Benard L,Boisserie G,Klatzmann D,Cohen JL
MHCD0405 was used in flow cytometry to investigate graft-versus-leukemia.
Sun Sep 15 00:00:00 EDT 2002
Reduced cell surface expression of CCR5 in CCR5Delta 32 heterozygotes is mediated by gene dosage, rather than by receptor sequestration.
The Journal of biological chemistry
Venkatesan S,Petrovic A,Van Ryk DI,Locati M,Weissman D,Murphy PM
MHCD0405 was used in flow cytometry to determine how CCR5 expression is reduced in cells from ccr5Delta32 heterozygotes.
Fri Jan 18 00:00:00 EST 2002
A membrane-proximal basic domain and cysteine cluster in the C-terminal tail of CCR5 constitute a bipartite motif critical for cell surface expression.
The Journal of biological chemistry
Venkatesan S,Petrovic A,Locati M,Kim YO,Weissman D,Murphy PM
MHCD0405 was used in flow cytometry to characterize CCR5 truncations.
Fri Oct 26 00:00:00 EDT 2001
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Lee B,Sharron M,Montaner LJ,Weissman D,Doms RW
MHCD0405 was used in flow cytometry to determine the number of CD4, CCR5, and CXCR4 antibody-binding sites on various T cells and macrophages.
Tue Apr 27 00:00:00 EDT 1999
