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Product Details
A33550
Species
Expression System
Amino acid sequence
Tag
Molecular weight
Class
Type
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This ABL1 F317L recombinant human protein (27-end) was expressed in insect cells.
ABL1 F317L recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Z'-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Recombinant, Active, Mutant
Target Information
ABL1 cytoplasmic tyrosine kinase protooncogene encodes a cytoplasmic and nuclear kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of ABL protein is negatively regulated by its SH3 domain and deletion of the SH3 domain turns ABL1 into an oncogene. Translocation and head-to-tail fusion of the BCR and ABL1 genes is present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDK1-mediated phosphorylation, suggesting a cell cycle function for ABL1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; ABL1; bcr/c-abl oncogene protein; c-abl oncogene 1, receptor tyrosine kinase; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; Tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1
Gene Aliases: ABL; ABL1; bcr/abl; c-ABL; c-ABL1; JTK7; p150; v-abl
UniProt ID: (Human) P00519
Entrez Gene ID: (Human) 25
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