Product References
The endosomal system of primary human vascular endothelial cells and albumin-FcRn trafficking.
Journal of cell science
Pannek A,Becker-Gotot J,Dower SK,Verhagen AM,Gleeson PA
A-21270 was used in Immunocytochemistry to investigate FcRn-albumin trafficking in physiologically relevant endothelial cells.
Tue Aug 01 00:00:00 EDT 2023
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries.
Nature genetics
Banday AR,Stanifer ML,Florez-Vargas O,Onabajo OO,Papenberg BW,Zahoor MA,Mirabello L,Ring TJ,Lee CH,Albert PS,Andreakos E,Arons E,Barsh G,Biesecker LG,Boyle DL,Brahier MS,Burnett-Hartman A,Carrington M,Chang E,Choe PG,Chisholm RL,Colli LM,Dalgard CL,Dude CM,Edberg J,Erdmann N,Feigelson HS,Fonseca BA,Firestein GS,Gehring AJ,Guo C,Ho M,Holland S,Hutchinson AA,Im H,Irby L,Ison MG,Joseph NT,Kim HB,Kreitman RJ,Korf BR,Lipkin SM,Mahgoub SM,Mohammed I,Paschoalini GL,Pacheco JA,Peluso MJ,Rader DJ,Redden DT,Ritchie MD,Rosenblum B,Ross ME,Anna HPS,Savage SA,Sharma S,Siouti E,Smith AK,Triantafyllia V,Vargas JM,Vargas JD,Verma A,Vij V,Wesemann DR,Yeager M,Yu X,Zhang Y,Boulant S,Chanock SJ,Feld JJ,Prokunina-Olsson L
A-21270 was used in Immunocytochemistry-immunoflourescence to report genetic, functional and clinical insights into this locus in relation to COVID-19 severity.
Mon Aug 01 00:00:00 EDT 2022
ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype.
Frontiers in cell and developmental biology
Olea-Flores M,Kan J,Carlson A,Syed SA,McCann C,Mondal V,Szady C,Ricker HM,McQueen A,Navea JG,Caromile LA,Padilla-Benavides T
A-21270 was used in Immunocytochemistry-immunoflourescence to hypothesize that ZIP11 is essential to maintaining nuclear Zinc homeostasis in mammalian cells.
Fri Dec 16 00:00:00 EST 2022
De novo missense variants in FBXO11 alter its protein expression and subcellular localization.
Human molecular genetics
Gregor A,Meerbrei T,Gerstner T,Toutain A,Lynch SA,Stals K,Maxton C,Lemke JR,Bernat JA,Bombei HM,Foulds N,Hunt D,Kuechler A,Beygo J,Stöbe P,Bouman A,Palomares-Bralo M,Santos-Simarro F,Garcia-Minaur S,Pacio-Miguez M,Popp B,Vasileiou G,Hebebrand M,Reis A,Schuhmann S,Krumbiegel M,Brown NJ,Sparber P,Melikyan L,Bessonova L,Cherevatova T,Sharkov A,Shcherbakova N,Dabir T,Kini U,Schwaibold EMC,Haack TB,Bertoli M,Hoffjan S,Falb R,Shinawi M,Sticht H,Zweier C
A-21270 was used in Immunocytochemistry to suggest that most missense variants likely lead to a loss of the original FBXO11 function and thereby highlight haploinsufficiency as the most likely disease mechanism for FBXO11-associated NDDs.
Thu Feb 03 00:00:00 EST 2022
Retro-2 alters Golgi structure.
Scientific reports
Yue X,Gim B,Zhu L,Tan C,Qian Y,Graham M,Liu X,Lee I
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Fri Sep 02 00:00:00 EDT 2022
Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish.
Nature communications
Fasano G,Muto V,Radio FC,Venditti M,Mosaddeghzadeh N,Coppola S,Paradisi G,Zara E,Bazgir F,Ziegler A,Chillemi G,Bertuccini L,Tinari A,Vetro A,Pantaleoni F,Pizzi S,Conti LA,Petrini S,Bruselles A,Prandi IG,Mancini C,Chandramouli B,Barth M,Bris C,Milani D,Selicorni A,Macchiaiolo M,Gonfiantini MV,Bartuli A,Mariani R,Curry CJ,Guerrini R,Slavotinek A,Iascone M,Dallapiccola B,Ahmadian MR,Lauri A,Tartaglia M
A-21270 was used in Electron crystallography to report that de novo missense variants in ARF3, encoding a small GTPase regulating Golgi dynamics, cause a developmental disease in humans impairing nervous system and skeletal formation.
Fri Nov 11 00:00:00 EST 2022
Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish.
Nature communications
Fasano G,Muto V,Radio FC,Venditti M,Mosaddeghzadeh N,Coppola S,Paradisi G,Zara E,Bazgir F,Ziegler A,Chillemi G,Bertuccini L,Tinari A,Vetro A,Pantaleoni F,Pizzi S,Conti LA,Petrini S,Bruselles A,Prandi IG,Mancini C,Chandramouli B,Barth M,Bris C,Milani D,Selicorni A,Macchiaiolo M,Gonfiantini MV,Bartuli A,Mariani R,Curry CJ,Guerrini R,Slavotinek A,Iascone M,Dallapiccola B,Ahmadian MR,Lauri A,Tartaglia M
A-21270 was used in Electron crystallography to report that de novo missense variants in ARF3, encoding a small GTPase regulating Golgi dynamics, cause a developmental disease in humans impairing nervous system and skeletal formation.
Fri Nov 11 00:00:00 EST 2022
Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy.
Journal for immunotherapy of cancer
Liu X,Wills CA,Chen L,Zhang J,Zhao Y,Zhou M,Sundstrom JM,Schell T,Spiegelman VS,Young MM,Wang HG
A-21270 was used in Western Blotting to demonstrate that neuroblastoma-derived sEVs suppress splenic NK cell maturation in vivo and dinutuximab-induced NK cell-mediated antibody-dependent cellular cytotoxicity in vitro.
Fri Apr 01 00:00:00 EDT 2022
Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy.
Journal for immunotherapy of cancer
Liu X,Wills CA,Chen L,Zhang J,Zhao Y,Zhou M,Sundstrom JM,Schell T,Spiegelman VS,Young MM,Wang HG
A-21270 was used in Western Blotting to demonstrate that neuroblastoma-derived sEVs suppress splenic NK cell maturation in vivo and dinutuximab-induced NK cell-mediated antibody-dependent cellular cytotoxicity in vitro.
Fri Apr 01 00:00:00 EDT 2022
Diclofenac: A Nonsteroidal Anti-Inflammatory Drug Inducing Cancer Cell Death by Inhibiting Microtubule Polymerization and Autophagy Flux.
Antioxidants (Basel, Switzerland)
Choi S,Kim S,Park J,Lee SE,Kim C,Kang D
A-21270 was used in Immunocytochemistry-immunofluorescence to investigate whether diclofenac induces cancer cell death and the mechanism by which diclofenac causes cell death.
Fri May 20 00:00:00 EDT 2022
mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1.
Nature communications
Kaeser-Pebernard S,Vionnet C,Mari M,Sankar DS,Hu Z,Roubaty C,Martínez-Martínez E,Zhao H,Spuch-Calvar M,Petri-Fink A,Rainer G,Steinberg F,Reggiori F,Dengjel J
A-21270 was used in Immunocytochemistry-immunoflourescence to conclude that the mTORC1-controlled phosphorylation status of SCYL1 is an important determinant regulating subcellular distribution and function of endolysosomal compartments.
Wed Aug 10 00:00:00 EDT 2022
TFG binds LC3C to regulate ULK1 localization and autophagosome formation.
The EMBO journal
Carinci M,Testa B,Bordi M,Milletti G,Bonora M,Antonucci L,Ferraina C,Carro M,Kumar M,Ceglie D,Eck F,Nardacci R,le Guerroué F,Petrini S,Soriano ME,Caruana I,Doria V,Manifava M,Peron C,Lambrughi M,Tiranti V,Behrends C,Papaleo E,Pinton P,Giorgi C,Ktistakis NT,Locatelli F,Nazio F,Cecconi F
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Mon May 17 00:00:00 EDT 2021
TFG binds LC3C to regulate ULK1 localization and autophagosome formation.
The EMBO journal
Carinci M,Testa B,Bordi M,Milletti G,Bonora M,Antonucci L,Ferraina C,Carro M,Kumar M,Ceglie D,Eck F,Nardacci R,le Guerroué F,Petrini S,Soriano ME,Caruana I,Doria V,Manifava M,Peron C,Lambrughi M,Tiranti V,Behrends C,Papaleo E,Pinton P,Giorgi C,Ktistakis NT,Locatelli F,Nazio F,Cecconi F
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Mon May 17 00:00:00 EDT 2021
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Aging and disease
Li D,Liu M,Li Z,Zheng G,Chen A,Zhao L,Yang P,Wei L,Chen Y,Ruan XZ
A-21270 was used in Immunohistochemistry to explore whether sterol-resistant SCAP (D443N mutation) in vascular smooth muscle cells (VSMCs) of mice promotes vascular inflammation and accelerates the occurrence and progression of atherosclerosis.
Tue Jun 01 00:00:00 EDT 2021
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Aging and disease
Li D,Liu M,Li Z,Zheng G,Chen A,Zhao L,Yang P,Wei L,Chen Y,Ruan XZ
A-21270 was used in Immunohistochemistry to explore whether sterol-resistant SCAP (D443N mutation) in vascular smooth muscle cells (VSMCs) of mice promotes vascular inflammation and accelerates the occurrence and progression of atherosclerosis.
Tue Jun 01 00:00:00 EDT 2021
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Aging and disease
Li D,Liu M,Li Z,Zheng G,Chen A,Zhao L,Yang P,Wei L,Chen Y,Ruan XZ
A-21270 was used in Immunohistochemistry to explore whether sterol-resistant SCAP (D443N mutation) in vascular smooth muscle cells (VSMCs) of mice promotes vascular inflammation and accelerates the occurrence and progression of atherosclerosis.
Tue Jun 01 00:00:00 EDT 2021
Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus.
Cellular and molecular life sciences : CMLS
Lingelem ABD,Kavaliauskiene S,Halsne R,Klokk TI,Surma MA,Klose C,Skotland T,Sandvig K
A-21270 was used in Immunocytochemistry-Immunofluorescence to find that several isoforms of PLD and DGK are involved in regulating ricin transport to the Golgi.
Mon Feb 01 00:00:00 EST 2021
Dbnl and β-catenin promote pro-N-cadherin processing to maintain apico-basal polarity.
The Journal of cell biology
Herrera A,Menendez A,Torroba B,Ochoa A,Pons S
A-21270 was used in Immunocytochemistry to demonstrate that Dbnl and Drebrin-like β-catenin assist in the maturation of pro-N-cadherin, which is critical for AJ formation and for the recruitment AC components like aPKC and, consequently, for the maintenance of apico-basal polarity.
Mon Jun 07 00:00:00 EDT 2021
Dbnl and β-catenin promote pro-N-cadherin processing to maintain apico-basal polarity.
The Journal of cell biology
Herrera A,Menendez A,Torroba B,Ochoa A,Pons S
A-21270 was used in Immunocytochemistry to demonstrate that Dbnl and Drebrin-like β-catenin assist in the maturation of pro-N-cadherin, which is critical for AJ formation and for the recruitment AC components like aPKC and, consequently, for the maintenance of apico-basal polarity.
Mon Jun 07 00:00:00 EDT 2021
Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.
The Journal of cell biology
Zhang Y,Seemann J
A-21270 was used in Immunocytochemistry to dissect the respective roles of GRASP55 and GRASP65 on golgi structure formation.
Mon Jan 04 00:00:00 EST 2021
Biallelic loss-of-function variants in WDR11 are associated with microcephaly and intellectual disability.
European journal of human genetics : EJHG
Haag N,Tan EC,Begemann M,Buschmann L,Kraft F,Holschbach P,Lai AHM,Brett M,Mochida GH,DiTroia S,Pais L,Neil JE,Al-Saffar M,Bastaki L,Walsh CA,Kurth I,Knopp C
A-21270 was used in Immunohistochemistry to investigate if biallelic WD repeat domain 11 (WDR11) variants in humans result in an overlapping but milder phenotype compared to Wdr11-deficient animals.
Mon Nov 01 00:00:00 EDT 2021
Hijacking of the host cell Golgi by Plasmodium berghei liver stage parasites.
Journal of cell science
De Niz M,Caldelari R,Kaiser G,Zuber B,Heo WD,Heussler VT,Agop-Nersesian C
A-21270 was used in Immunocytochemistry to show an interplay between the pre-erythrocytic stages of Plasmodium berghei and the host cell Golgi during liver stage development.
Sat May 15 00:00:00 EDT 2021
Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia.
Nature communications
Goldfarb AN,Freeman KC,Sahu RK,Elagib KE,Holy M,Arneja A,Polanowska-Grabowska R,Gru AA,White Z,Khalil S,Kerins MJ,Ooi A,Leitinger N,Luckey CJ,Delehanty LL
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Fri Mar 12 00:00:00 EST 2021
Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia.
Nature communications
Goldfarb AN,Freeman KC,Sahu RK,Elagib KE,Holy M,Arneja A,Polanowska-Grabowska R,Gru AA,White Z,Khalil S,Kerins MJ,Ooi A,Leitinger N,Luckey CJ,Delehanty LL
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Fri Mar 12 00:00:00 EST 2021
The Secreted Protein C10orf118 Is a New Regulator of Hyaluronan Synthesis Involved in Tumour-Stroma Cross-Talk.
Cancers
Caon I,D'Angelo ML,Bartolini B,Caravà E,Parnigoni A,Contino F,Cancemi P,Moretto P,Karamanos NK,Passi A,Vigetti D,Karousou E,Viola M
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Fri Mar 05 00:00:00 EST 2021
The Secreted Protein C10orf118 Is a New Regulator of Hyaluronan Synthesis Involved in Tumour-Stroma Cross-Talk.
Cancers
Caon I,D'Angelo ML,Bartolini B,Caravà E,Parnigoni A,Contino F,Cancemi P,Moretto P,Karamanos NK,Passi A,Vigetti D,Karousou E,Viola M
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Fri Mar 05 00:00:00 EST 2021
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells.
Nature communications
Low BSJ,Lim CS,Ding SSL,Tan YS,Ng NHJ,Krishnan VG,Ang SF,Neo CWY,Verma CS,Hoon S,Lim SC,Tai ES,Teo AKK
A-21270 was used in Immunocytochemistry to reveal the importance of HNF1A in regulating GLUT2 and several genes involved in insulin secretion that can account for the insulin secretory defect clinically observed in MODY3 patients.
Tue May 25 00:00:00 EDT 2021
Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies.
Nature medicine
Unlu G,Qi X,Gamazon ER,Melville DB,Patel N,Rushing AR,Hashem M,Al-Faifi A,Chen R,Li B,Cox NJ,Alkuraya FS,Knapik EW
A-21270 was used in Immunocytochemistry to uncover a new mechanism for rare and common diseases resulting from collagen secretion deficits.
Wed Jan 01 00:00:00 EST 2020
Chromogranin A preferential interaction with Golgi phosphatidic acid induces membrane deformation and contributes to secretory granule biogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Carmon O,Laguerre F,Riachy L,Delestre-Delacour C,Wang Q,Tanguy E,Jeandel L,Cartier D,Thahouly T,Haeberlé AM,Fouillen L,Rezazgui O,Schapman D,Haefelé A,Goumon Y,Galas L,Renard PY,Alexandre S,Vitale N,Anouar Y,Montero-Hadjadje M
A-21270 was used in Western Blot to demonstrate the CgA interaction with the anionic glycerophospholipid phosphatidic acid during secretory granule budding initiation.
Fri May 01 00:00:00 EDT 2020
Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting.
Journal of cell science
Evans AJ,Daly JL,Anuar ANK,Simonetti B,Cullen PJ
A-21270 was used in Immunocytochemistry-immunoflourescence to show the role for retromer in ESCPE-1-mediated CI-MPR retrograde sorting, and establish a methodology for acute retromer and ESCPE-1 inactivation that will aid the time-resolved dissection of their function role in endosomal cargo sorting.
Mon Aug 03 00:00:00 EDT 2020
The golgin family exhibits a propensity to form condensates in living cells.
FEBS letters
Ziltener P,Rebane AA,Graham M,Ernst AM,Rothman JE
A-21270 was used in Immunocytochemistry-Immunofluorescence to show that the overexpression of each of the remaining cis (golgin160, GMAP210)- and trans (golgin97, golgin245, GCC88, GCC185)-golgins results in novel protein condensates.
Thu Oct 01 00:00:00 EDT 2020
The golgin family exhibits a propensity to form condensates in living cells.
FEBS letters
Ziltener P,Rebane AA,Graham M,Ernst AM,Rothman JE
A-21270 was used in Immunocytochemistry-Immunofluorescence to show that the overexpression of each of the remaining cis (golgin160, GMAP210)- and trans (golgin97, golgin245, GCC88, GCC185)-golgins results in novel protein condensates.
Thu Oct 01 00:00:00 EDT 2020
Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production.
Molecular biology of the cell
Tan JZA,Fourriere L,Wang J,Perez F,Boncompain G,Gleeson PA
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Wed Jan 01 00:00:00 EST 2020
Human mastadenovirus-B (HAdV-B)-specific E3-CR1β and E3-CR1γ glycoproteins interact with each other and localize at the plasma membrane of non-polarized airway epithelial cells.
Virology
Lakshmi Narayan PK,Kajon AE
A-21270 was used in Immunocytochemistry to show that HAdV-3 E3-CR1β and E3-CR1γ are type I transmembrane proteins that are produced predominantly at late times post infection, are glycosylated, co-localize at the plasma membrane of non-polarized epithelial cells, and interact with each other.
Wed Jul 01 00:00:00 EDT 2020
Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis.
The Journal of biological chemistry
Baker MJ,Cooke M,Kreider-Letterman G,Garcia-Mata R,Janmey PA,Kazanietz MG
A-21270 was used in Immunocytochemistry to establish that this antibody does not recognize Rac1 but rather detects the intermediate filament protein vimentin.
Fri Oct 02 00:00:00 EDT 2020
Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis.
The Journal of biological chemistry
Baker MJ,Cooke M,Kreider-Letterman G,Garcia-Mata R,Janmey PA,Kazanietz MG
A-21270 was used in Immunocytochemistry to establish that this antibody does not recognize Rac1 but rather detects the intermediate filament protein vimentin.
Fri Oct 02 00:00:00 EDT 2020
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis.
Nature communications
Muzio L,Sirtori R,Gornati D,Eleuteri S,Fossaghi A,Brancaccio D,Manzoni L,Ottoboni L,Feo L,Quattrini A,Mastrangelo E,Sorrentino L,Scalone E,Comi G,Marinelli L,Riva N,Milani M,Seneci P,Martino G
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Western Blot
Fri Jul 31 00:00:00 EDT 2020
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis.
Nature communications
Muzio L,Sirtori R,Gornati D,Eleuteri S,Fossaghi A,Brancaccio D,Manzoni L,Ottoboni L,Feo L,Quattrini A,Mastrangelo E,Sorrentino L,Scalone E,Comi G,Marinelli L,Riva N,Milani M,Seneci P,Martino G
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Western Blot
Fri Jul 31 00:00:00 EDT 2020
G protein-regulated endocytic trafficking of adenylyl cyclase type 9.
eLife
Lazar AM,Irannejad R,Baldwin TA,Sundaram AB,Gutkind JS,Inoue A,Dessauer CW,Von Zastrow M
A-21270 was used in Immunocytochemistry to show dynamic and isoform-specific trafficking of adenylyl cyclase in the endocytic network and regulatory role of heterotrimeric G protein.
Tue Jun 09 00:00:00 EDT 2020
Rab6 regulates recycling and retrograde trafficking of MR1 molecules.
Scientific reports
Huber ME,Kurapova R,Heisler CM,Karamooz E,Tafesse FG,Harriff MJ
A-21270 was used in Immunocytochemistry to demonstrate that Rab6 regulates the recycling of MR1 molecules from the cell surface through endosomal trafficking compartments to the TGN.
Fri Nov 27 00:00:00 EST 2020
TMEM16K is an interorganelle regulator of endosomal sorting.
Nature communications
Petkovic M,Oses-Prieto J,Burlingame A,Jan LY,Jan YN
A-21270 was used in Immunocytochemistry-immunoflourescence to report that TMEM16K, an endoplasmic reticulum lipid scramblase causative for spinocerebellar ataxia (SCAR10), is an interorganelle regulator of the endolysosomal pathway.
Fri Jul 03 00:00:00 EDT 2020
Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response.
Cell death & disease
Díaz MI,Díaz P,Bennett JC,Urra H,Ortiz R,Orellana PC,Hetz C,Quest AFG
A-21270 was used in Immunocytochemistry to elucidate the tumour suppressor function of caveolin-1.
Mon Aug 03 00:00:00 EDT 2020
TMEM98 is a negative regulator of FRAT mediated Wnt/ß-catenin signalling.
PloS one
van der Wal T,Lambooij JP,van Amerongen R
A-21270 was used in Immunocytochemistry-immunoflourescence to demonstrate FRAT2-mediated induction of ß-catenin/TCF signalling is reduced by putative transmembrane protein TMEM98.
Mon Apr 06 00:00:00 EDT 2020
The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of α-synuclein.
The Journal of biological chemistry
Underwood R,Wang B,Carico C,Whitaker RH,Placzek WJ,Yacoubian TA
A-21270 was used in Western Blot to indicate a role for Rab27b in the release, clearance, and toxicity of αsyn and, ultimately, in the pathogenesis of synucleinopathies.
Fri Jun 05 00:00:00 EDT 2020
Overexpression-mediated activation of MET in the Golgi promotes HER3/ERBB3 phosphorylation.
Oncogene
Frazier NM,Brand T,Gordan JD,Grandis J,Jura N
A-21270 was used in Immunocytochemistry-immunoflourescence to investigate the mechanism by which MET phosphorylates the human epidermal growth factor receptor-3.
Fri Mar 01 00:00:00 EST 2019
ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.
The Journal of cell biology
Ishida M,Bonifacino JS
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Mon Nov 04 00:00:00 EST 2019
ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.
The Journal of cell biology
Ishida M,Bonifacino JS
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Mon Nov 04 00:00:00 EST 2019
ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.
The Journal of cell biology
Ishida M,Bonifacino JS
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Mon Nov 04 00:00:00 EST 2019
Canalicular domain structure and function in matrix-free hepatic spheroids.
Biomaterials science
Sharma VR,Shrivastava A,Gallet B,Karepina E,Charbonnier P,Chevallet M,Jouneau PH,Deniaud A
A-21270 was used in Immunocytochemistry to show that this study is the first comprehensive and in-depth functional and structural study of bile canaliculi in a physiological-relevant context.
Tue Dec 17 00:00:00 EST 2019
Visualization of Protein Sorting at the Trans-Golgi Network and Endosomes Through Super-Resolution Imaging.
Frontiers in cell and developmental biology
Huang Y,Ma T,Lau PK,Wang J,Zhao T,Du S,Loy MMT,Guo Y
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Wed Sep 30 00:00:00 EDT 2020
Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus.
The Journal of biological chemistry
Cejas RB,Lorenz V,Garay YC,Irazoqui FJ
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Fri Mar 01 00:00:00 EST 2019
Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus.
The Journal of biological chemistry
Cejas RB,Lorenz V,Garay YC,Irazoqui FJ
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Fri Mar 01 00:00:00 EST 2019
Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus.
The Journal of biological chemistry
Cejas RB,Lorenz V,Garay YC,Irazoqui FJ
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Fri Mar 01 00:00:00 EST 2019
FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops.
Nature communications
Silva B,Pentz R,Figueira AM,Arora R,Lee YW,Hodson C,Wischnewski H,Deans AJ,Azzalin CM
A-21270 was used in Western Blotting to study the effect of the ATPase/translocase activity of FANCM on telomeric replicative stress in alternative lengthening of telomeres cells.
Tue May 28 00:00:00 EDT 2019
Effects of Stuffer DNA on the Suppression of Choroidal Neovascularization by a rAAV Expressing a mTOR-Inhibiting shRNA.
Molecular therapy. Methods & clinical development
Lee SHS,Chang H,Kim HJ,Choi JS,Kim J,Kim JH,Woo HN,Nah SK,Jung SJ,Lee JY,Park K,Park TK,Lee H
A-21270 was used in Immunohistochemistry-wholemount to demonstrate the effectiveness of a recombinant adeno-associated virus (rAAV) packaged short hairpin RNA targeting mTOR in treatment of choroidal neovascularization in mouse retinas.
Fri Sep 13 00:00:00 EDT 2019
Effects of Long-Term Citrate Treatment in the PC3 Prostate Cancer Cell Line.
International journal of molecular sciences
Caiazza C,D'Agostino M,Passaro F,Faicchia D,Mallardo M,Paladino S,Pierantoni GM,Tramontano D
A-21270 was used in Immunocytochemistry-immunoflourescence to conclude that chronic administration of citrate might select resistant cells, which could jeopardize the benefits of citrate anticancer treatment.
Tue May 28 00:00:00 EDT 2019
Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish.
Nature communications
Siekierska A,Stamberger H,Deconinck T,Oprescu SN,Partoens M,Zhang Y,Sourbron J,Adriaenssens E,Mullen P,Wiencek P,Hardies K,Lee JS,Giong HK,Distelmaier F,Elpeleg O,Helbig KL,Hersh J,Isikay S,Jordan E,Karaca E,Kecskes A,Lupski JR,Kovacs-Nagy R,May P,Narayanan V,Pendziwiat M,Ramsey K,Rangasamy S,Shinde DN,Spiegel R,Timmerman V,von Spiczak S,Helbig I,Weckhuysen S,Francklyn C,Antonellis A,de Witte P,De Jonghe P
A-21270 was used in Immunocytochemistry-immunoflourescence to characterise an allelic series consisting of seven novel biallelic variants in valyl-tRNA synthetase in ten patients with a developmental encephalopathy with microcephaly, often associated with early-onset epilepsy.
Tue Feb 12 00:00:00 EST 2019
HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells.
iScience
Ng NHJ,Jasmen JB,Lim CS,Lau HH,Krishnan VG,Kadiwala J,Kulkarni RN,Ræder H,Vallier L,Hoon S,Teo AKK
A-21270 was used in Immunocytochemistry-immunoflourescence to suggest that in MODY1, liver and pancreas development is perturbed early on, contributing to altered hepatic proteins and Β cell defects in patients.
Fri Jun 28 00:00:00 EDT 2019
Restoration of F508-del Function by Transcomplementation: The Partners Meet in the Endoplasmic Reticulum.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Bergbower EAS,Sabirzhanova I,Boinot C,Guggino WB,Cebotaru L
A-21270 was used in Immunocytochemistry-immunoflourescence to determine where in the cell transcomplementation occurs and how it results in close association between the endogenous F508-del and truncated CFTR.
Fri May 17 00:00:00 EDT 2019
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors.
Nature communications
Koike S,Jahn R
A-21270 was used in Immunocytochemistry to conclude that SNAREs use a combinatorial code for recruiting tethering factors, revealing a key function in targeting that is independent of SNARE pairing during fusion.
Mon Apr 08 00:00:00 EDT 2019
A Novel Role for Triglyceride Metabolism in Foxp3 Expression.
Frontiers in immunology
Howie D,Ten Bokum A,Cobbold SP,Yu Z,Kessler BM,Waldmann H
A-21270 was used in Flow cytometry/Cell sorting to demonstrate Tregs utilize a positive feedback mechanism to promote sustained expression of Foxp3 associated with control of LD formation.
Wed Sep 30 00:00:00 EDT 2020
Correction: Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130CAS/Src inhibition by eribulin.
Oncotarget
Dybdal-Hargreaves NF,Risinger AL,Mooberry SL
A-21270 was used in Immunocytochemistry-immunoflourescence to evaluate the effects of microtubule targeting agents to test the hypothesis that these drugs rapidly and differentially disrupt epithelial-to-mesenchymal transition (EMT)-related signaling.
Tue Jul 23 00:00:00 EDT 2019
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton.
EMBO reports
Song OR,Queval CJ,Iantomasi R,Delorme V,Marion S,Veyron-Churlet R,Werkmeister E,Popoff M,Ricard I,Jouny S,Deboosere N,Lafont F,Baulard A,Yeramian E,Marsollier L,Hoffmann E,Brodin P
A-21270 was used in Immunocytochemistry-immunoflourescence to understand how cortical actin plays the role of a barrier to prevent mycobacterial entry into epithelial cells and determine the role of ADP-ribosylation factor GTPase-activating protein 1.
Mon Jan 01 00:00:00 EST 2018
Upon Infection, Cellular WD Repeat-Containing Protein 5 (WDR5) Localizes to Cytoplasmic Inclusion Bodies and Enhances Measles Virus Replication.
Journal of virology
Ma D,George CX,Nomburg JL,Pfaller CK,Cattaneo R,Samuel CE
A-21270 was used in Immunocytochemistry-immunoflourescence to identify WDR5 as a host factor that enhances the replication of measles virus.
Thu Mar 01 00:00:00 EST 2018
Intravitreal Injection of AAV Expressing Soluble VEGF Receptor-1 Variant Induces Anti-VEGF Activity and Suppresses Choroidal Neovascularization.
Investigative ophthalmology & visual science
Lee SHS,Kim HJ,Shin OK,Choi JS,Kim J,Cho YH,Ha J,Park TK,Lee JY,Park K,Lee H
A-21270 was used in Immunohistochemistry to suggest gene therapy as an effective and convenient treatment for sustained VEGF suppression.
Thu Nov 01 00:00:00 EDT 2018
Dynamic changes in copper homeostasis and post-transcriptional regulation of Atp7a during myogenic differentiation.
Metallomics : integrated biometal science
Vest KE,Paskavitz AL,Lee JB,Padilla-Benavides T
A-21270 was used in Immunocytochemistry-immunoflourescence to study the role of of Copper in the development of skeletal muscle.
Wed Feb 21 00:00:00 EST 2018
Reinterpretation of the localization of the ATP binding cassette transporter ABCG1 in insulin-secreting cells and insights regarding its trafficking and function.
PloS one
Harris MT,Hussain SS,Inouye CM,Castle AM,Castle JD
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Mon Feb 25 00:00:00 EST 2019
Golgin-97 Targets Ectopically Expressed Inward Rectifying Potassium Channel, Kir2.1, to the trans-Golgi Network in COS-7 Cells.
Frontiers in physiology
Taneja TK,Ma D,Kim BY,Welling PA
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Tue Jan 25 00:00:00 EST 2022
Golgin-97 Targets Ectopically Expressed Inward Rectifying Potassium Channel, Kir2.1, to the trans-Golgi Network in COS-7 Cells.
Frontiers in physiology
Taneja TK,Ma D,Kim BY,Welling PA
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Tue Jan 25 00:00:00 EST 2022
Golgin-97 Targets Ectopically Expressed Inward Rectifying Potassium Channel, Kir2.1, to the trans-Golgi Network in COS-7 Cells.
Frontiers in physiology
Taneja TK,Ma D,Kim BY,Welling PA
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Tue Jan 25 00:00:00 EST 2022
Endoplasmic reticulum, Golgi, and lysosomes are disorganized in lung fibroblasts from chronic obstructive pulmonary disease patients.
Physiological reports
Weidner J,Jarenbäck L,Åberg I,Westergren-Thorsson G,Ankerst J,Bjermer L,Tufvesson E
A-21270 was used in Immunocytochemistry-immunoflourescence to show that COPD patients have phenotypic changes in the lung fibroblasts endomembrane pathway, and respond differently to stress.
Thu Mar 01 00:00:00 EST 2018
PAQR3 Regulates Endoplasmic Reticulum-to-Golgi Trafficking of COPII Vesicle via Interaction with Sec13/Sec31 Coat Proteins.
iScience
Cao Q,Wang Z,Wan H,Xu L,You X,Liao L,Chen Y
A-21270 was used in Immunocytochemistry-immunoflourescence to demonstrate that PAQR3 can facilitate the tethering of COPII vesicles to the Golgi.
Fri Nov 30 00:00:00 EST 2018
Amnionless-mediated glycosylation is crucial for cell surface targeting of cubilin in renal and intestinal cells.
Scientific reports
Udagawa T,Harita Y,Miura K,Mitsui J,Ode KL,Morishita S,Urae S,Kanda S,Kajiho Y,Tsurumi H,Ueda HR,Tsuji S,Saito A,Oka A
A-21270 was used in Immunocytochemistry-immunoflourescence to delineate the molecular mechanisms of membrane trafficking of cubilin in renal and intestinal cells.
Mon Feb 05 00:00:00 EST 2018
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Molecular neurodegeneration
Madero-Pérez J,Fdez E,Fernández B,Lara Ordóñez AJ,Blanca Ramírez M,Gómez-Suaga P,Waschbüsch D,Lobbestael E,Baekelandt V,Nairn AC,Ruiz-Martínez J,Aiastui A,López de Munain A,Lis P,Comptdaer T,Taymans JM,Chartier-Harlin MC,Beilina A,Gonnelli A,Cookson MR,Greggio E,Hilfiker S
A-21270 was used in Immunocytochemistry to reveal a new function of LRRK2 mediated by Rab8a phosphorylation and related to various centrosomal defects.
Tue Jan 23 00:00:00 EST 2018
COPI-TRAPPII activates Rab18 and regulates its lipid droplet association.
The EMBO journal
Li C,Luo X,Zhao S,Siu GK,Liang Y,Chan HC,Satoh A,Yu SS
A-21270 was used in Immunoprecipitation to study how the interaction between COPI and transport protein particle II helps to facilitate its functions in lipid droplet homeostasis.
Wed Feb 15 00:00:00 EST 2017
Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.
Journal of cell science
Zanini IM,Soneson C,Lorenzi LE,Azzalin CM
A21270 was used in western blot to find depletion of human Cactin leads to premature sister chromatid separation, genome instability and cell proliferation arrest
Wed Feb 15 00:00:00 EST 2017
High levels of the AR-V7 Splice Variant and Co-Amplification of the Golgi Protein Coding YIPF6 in AR Amplified Prostate Cancer Bone Metastases.
The Prostate
Djusberg E,Jernberg E,Thysell E,Golovleva I,Lundberg P,Crnalic S,Widmark A,Bergh A,Brattsand M,Wikström P
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Mon May 01 00:00:00 EDT 2017
High levels of the AR-V7 Splice Variant and Co-Amplification of the Golgi Protein Coding YIPF6 in AR Amplified Prostate Cancer Bone Metastases.
The Prostate
Djusberg E,Jernberg E,Thysell E,Golovleva I,Lundberg P,Crnalic S,Widmark A,Bergh A,Brattsand M,Wikström P
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Mon May 01 00:00:00 EDT 2017
Organelle membrane derived patches: reshaping classical methods for new targets.
Scientific reports
Shapovalov G,Ritaine A,Bidaux G,Slomianny C,Borowiec AS,Gordienko D,Bultynck G,Skryma R,Prevarskaya N
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Western Blot
Thu Oct 26 00:00:00 EDT 2017
Inhibitors of GLUT/SLC2A Enhance the Action of BCNU and Temozolomide against High-Grade Gliomas.
Neoplasia (New York, N.Y.)
Azzalin A,Nato G,Parmigiani E,Garello F,Buffo A,Magrassi L
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Western Blot
Sat Apr 01 00:00:00 EDT 2017
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness.
Scientific reports
Nishita M,Park SY,Nishio T,Kamizaki K,Wang Z,Tamada K,Takumi T,Hashimoto R,Otani H,Pazour GJ,Hsu VW,Minami Y
A-21270 was used in Immunocytochemistry-immunoflourescence to shed new insights into how Ror2 signaling promotes tumor invasiveness, and also advance the understanding of how Golgi structure and transport can be regulated.
Thu Jan 26 00:00:00 EST 2017
Rab33B Controls Hepatitis B Virus Assembly by Regulating Core Membrane Association and Nucleocapsid Processing.
Viruses
Bartusch C,Döring T,Prange R
A-21270 was used in Immunocytochemistry-immunoflourescence to demonstrate that Rab33B is required for hepatitis B virus propagation in hepatoma cell lines.
Wed Jun 21 00:00:00 EDT 2017
Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory.
eLife
Niu Y,Dai Z,Liu W,Zhang C,Yang Y,Guo Z,Li X,Xu C,Huang X,Wang Y,Shi YS,Liu JJ
A21270 was used in immunohistochemistry to find that CNS-specific snx6-knockout mice exhibit deficits in spatial learning and memory, accompanied with loss of spines from distal dendrites of hippocampal CA1 pyramidal cells
Mon Jan 30 00:00:00 EST 2017
Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes.
Autophagy
Aizawa S,Fujiwara Y,Contu VR,Hase K,Takahashi M,Kikuchi H,Kabuta C,Wada K,Kabuta T
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Western Blot
Mon Dec 26 00:00:00 EST 2016
Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes.
Autophagy
Aizawa S,Fujiwara Y,Contu VR,Hase K,Takahashi M,Kikuchi H,Kabuta C,Wada K,Kabuta T
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Western Blot
Mon Dec 26 00:00:00 EST 2016
Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure.
Autophagy
Corcelle-Termeau E,Vindeløv SD,Hämälistö S,Mograbi B,Keldsbo A,Bräsen JH,Favaro E,Adam D,Szyniarowski P,Hofman P,Krautwald S,Farkas T,Petersen NH,Rohde M,Linkermann A,Jäättelä M
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Tue May 03 00:00:00 EDT 2016
A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.
Science signaling
Srikanth S,Kim KD,Gao Y,Woo JS,Ghosh S,Calmettes G,Paz A,Abramson J,Jiang M,Gwack Y
A-21270 was used in Immunocytochemistry to examine the role of CRACR2A in the activation of the Ca(2+) and c-Jun N-terminal kinase signalling pathways in response to T cell receptor stimulation.
Tue Mar 22 00:00:00 EDT 2016
Two-Step Mechanism of Cellular Uptake of Cationic Gold Nanoparticles Modified by (16-Mercaptohexadecyl)trimethylammonium Bromide.
Bioconjugate chemistry
Zarska M,Novotny F,Havel F,Sramek M,Babelova A,Benada O,Novotny M,Saran H,Kuca K,Musilek K,Hvezdova Z,Dzijak R,Vancurova M,Krejcikova K,Gabajova B,Hanzlikova H,Kyjacova L,Bartek J,Proska J,Hodny Z
A21270 was used in immunohistochemistry to investigate the cellular uptake of gold nanorods
Wed Oct 19 00:00:00 EDT 2016
Disruption of Golgi morphology and altered protein glycosylation in PLA2G6-associated neurodegeneration.
Journal of medical genetics
Davids M,Kane MS,He M,Wolfe LA,Li X,Raihan MA,Chao KR,Bone WP,Boerkoel CF,Gahl WA,Toro C
A-21270 was used in Immunocytochemistry-immunoflourescence to demonstrate that Golgi morphology, O-linked glycosylation and sialylation may play a role in the pathogenesis of PLA2G6-associated neurodegeneration and perhaps other neurodegenerative disorders.
Tue Mar 01 00:00:00 EST 2016
The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses.
Scientific reports
Gräßel L,Fast LA,Scheffer KD,Boukhallouk F,Spoden GA,Tenzer S,Boller K,Bago R,Rajesh S,Overduin M,Berditchevski F,Florin L
A21270 was used in immunocytochemistry to study the role of the CD63-syntenin-1-ALIX complex in the post-endocytic trafficking of human papillomavirus
Wed Aug 31 00:00:00 EDT 2016
Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion.
The Journal of biological chemistry
Eiseler T,Wille C,Koehler C,Illing A,Seufferlein T
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Fri Jan 01 00:00:00 EST 2016
Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ.
Nature communications
Pagliuso A,Valente C,Giordano LL,Filograna A,Li G,Circolo D,Turacchio G,Marzullo VM,Mandrich L,Zhukovsky MA,Formiggini F,Polishchuk RS,Corda D,Luini A
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunomicroscopy
Tue Jul 12 00:00:00 EDT 2016
Caveolin-1 is an aggresome-inducing protein.
Scientific reports
Tiwari A,Copeland CA,Han B,Hanson CA,Raghunathan K,Kenworthy AK
A21270 was used in immunocytochemistry to elucidate how cells handle and respond to misfolded Caveolin-1
Thu Dec 08 00:00:00 EST 2016
Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2.
Nature communications
Barretta ML,Spano D,D'Ambrosio C,Cervigni RI,Scaloni A,Corda D,Colanzi A
A-21270 was used in Immunocytochemistry-immunoflourescence to show that, in G2, Aurora-A recruitment is promoted by activated Src at the Golgi.
Tue May 31 00:00:00 EDT 2016
Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover.
The Journal of biological chemistry
Roberts BJ,Svoboda RA,Overmiller AM,Lewis JD,Kowalczyk AP,Mahoney MG,Johnson KR,Wahl JK
A21270 was used in immunocytochemistry to explore contribution of palmitoylation to the localization and stability of Dsg2
Fri Nov 25 00:00:00 EST 2016
The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein.
The Journal of biological chemistry
Prior KK,Wittig I,Leisegang MS,Groenendyk J,Weissmann N,Michalak M,Jansen-Dürr P,Shah AM,Brandes RP
A-21270 was used in Western Blotting to suggest that endogenous NOX4 forms macromolecular complexes with calnexin, enabling maturation, processing, and functioning of NOX4 in the endoplasmic reticulum.
Fri Mar 25 00:00:00 EDT 2016
Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay.
Autophagy
Aits S,Kricker J,Liu B,Ellegaard AM,Hämälistö S,Tvingsholm S,Corcelle-Termeau E,Høgh S,Farkas T,Holm Jonassen A,Gromova I,Mortensen M,Jäättelä M
A-21270 was used in Immunocytochemistry to characterize and validate the detection of galectin puncta at leaky lysosomes as a highly sensitive and easily manageable assay for lysosomal membrane permeabilization (LMP).
Mon Jun 20 00:00:00 EDT 2016
IGF-1 drives chromogranin A secretion via activation of Arf1 in human neuroendocrine tumour cells.
Journal of cellular and molecular medicine
Münzberg C,Höhn K,Krndija D,Maaß U,Bartsch DK,Slater EP,Oswald F,Walther P,Seufferlein T,von Wichert G
A-21270 was used in immunocytochemistry to study the regulatory role of Arf1 in the Golgi and in hypersecretion in neuroendocrine cancer cells.
Fri May 01 00:00:00 EDT 2015
HSP47 and FKBP65 cooperate in the synthesis of type I procollagen.
Human molecular genetics
Duran I,Nevarez L,Sarukhanov A,Wu S,Lee K,Krejci P,Weis M,Eyre D,Krakow D,Cohn DH
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Wed Apr 01 00:00:00 EDT 2015
Memory and PTPIP51--a new protein in hippocampus and cerebellum.
Molecular and cellular neurosciences
Brobeil A,Viard M,Petri MK,Steger K,Tag C,Wimmer M
A-21270 was used in immunohistochemistry - paraffin section and proximity ligation assay to study the role of PTPIP51 in memory processing.
Thu Jan 01 00:00:00 EST 2015
Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport.
Molecular biology of the cell
Hirata T,Fujita M,Nakamura S,Gotoh K,Motooka D,Murakami Y,Maeda Y,Kinoshita T
A-21270 was used in immunocytochemistry to determine the requirement for GARP-dependent endosome-to-TGN retrograde transport in post-golgi anterograde transport
Tue Sep 01 00:00:00 EDT 2015
RC/BTB2 is essential for formation of primary cilia in mammalian cells.
Cytoskeleton (Hoboken, N.J.)
Zhang L,Li W,Ni J,Wu J,Liu J,Zhang Z,Zhang Y,Li H,Shi Y,Teves ME,Song S,Strauss JF,Zhang Z
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Wed Apr 01 00:00:00 EDT 2015
Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5.
Molecular neurodegeneration
O'Brien CE,Bonanno L,Zhang H,Wyss-Coray T
A-21270 was used in immunocytochemistry to discuss the role of Beclin 1 in neurodegeneration
Mon Dec 21 00:00:00 EST 2015
Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer.
Journal of extracellular vesicles
Pospichalova V,Svoboda J,Dave Z,Kotrbova A,Kaiser K,Klemova D,Ilkovics L,Hampl A,Crha I,Jandakova E,Minar L,Weinberger V,Bryja V
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Western Blot
Thu Apr 02 00:00:00 EDT 2015
Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.
Scientific reports
David JP,Stas JI,Schmitt N,Bocksteins E
A-21270 was used in immunocytochemistry to characterize Kv2.1/Kv6.4/KCNE5 channel complexes
Wed Aug 05 00:00:00 EDT 2015
LAPTM5 promotes lysosomal degradation of intracellular CD3ζ but not of cell surface CD3ζ.
Immunology and cell biology
Kawai Y,Ouchida R,Yamasaki S,Dragone L,Tsubata T,Wang JY
A-21270 was used in immunocytochemistry to investigate how LAPTM5 negatively regulates cell surface T cell receptor expression and T-cell activation.
Tue Jul 01 00:00:00 EDT 2014
CCHCR1 interacts with EDC4, suggesting its localization in P-bodies.
Experimental cell research
Ling YH,Wong CC,Li KW,Chan KM,Boukamp P,Liu WK
A-21270 was used in immunocytochemistry to study the physical interaction of CCHCR1 with the P-body protein EDC4.
Wed Sep 10 00:00:00 EDT 2014
An L2 SUMO interacting motif is important for PML localization and infection of human papillomavirus type 16.
Cellular microbiology
Bund T,Spoden GA,Koynov K,Hellmann N,Boukhallouk F,Arnold P,Hinderberger D,Florin L
A-21270 was used in immunocytochemistry to study the effect of SUMOylation on HPV L2 localization.
Fri Aug 01 00:00:00 EDT 2014
Nile Tilapia Neu3 sialidases: molecular cloning, functional characterization and expression in Oreochromis niloticus.
Gene
Chigwechokha PK,Komatsu M,Itakura T,Shiozaki K
A-21270 was used in immunocytochemistry to elucidate the role of fish Neu3 sialidases
Sat Nov 15 00:00:00 EST 2014
Characterization of Rabaptin-5 γ isoform.
Biochemistry. Biokhimiia
Korobko EV,Kiselev SL,Korobko IV
A-21270 was used in immunocytochemistry to characterize the rabaptin-5gamma isoform
Mon Sep 01 00:00:00 EDT 2014
Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.
Nature communications
Zavodszky E,Seaman MN,Moreau K,Jimenez-Sanchez M,Breusegem SY,Harbour ME,Rubinsztein DC
A-21270 was used in immunocytochemistry to demonstrate that the Parkinson's disease-causing D620N mutation in VPS35 restricts WASH complex recruitment to endosomes and alters autophagosome formation.
Tue May 13 00:00:00 EDT 2014
Arf4 is required for Mammalian development but dispensable for ciliary assembly.
PLoS genetics
Follit JA,San Agustin JT,Jonassen JA,Huang T,Rivera-Perez JA,Tremblay KD,Pazour GJ
A-21270 was used in immunocytochemistry to elucidate the role of Arf4 in ciliary protein trafficking.
Sat Feb 01 00:00:00 EST 2014
Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.
Cell
Hao YH,Doyle JM,Ramanathan S,Gomez TS,Jia D,Xu M,Chen ZJ,Billadeau DD,Rosen MK,Potts PR
A-21270 was used in immunocytochemistry to report the K63-linked ubiquitination regulation of MAGE-L2-TRIM27-mediated retrograde transport.
Thu Feb 28 00:00:00 EST 2013
Partial IFN-γR2 deficiency is due to protein misfolding and can be rescued by inhibitors of glycosylation.
Blood
Moncada-Vélez M,Martinez-Barricarte R,Bogunovic D,Kong XF,Blancas-Galicia L,Tirpan C,Aksu G,Vincent QB,Boisson B,Itan Y,Ramírez-Alejo N,Okada S,Kreins AY,Bryant VL,Franco JL,Migaud M,Espinosa-Padilla S,Yamazaki-Nakashimada M,Espinosa-Rosales F,Kutukculer N,Abel L,Bustamante J,Vogt G,Casanova JL,Boisson-Dupuis S
A-21270 was used in immunocytochemistry to study mutations that result in IFN-γR2 deficiency.
Thu Oct 03 00:00:00 EDT 2013
Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition.
Small (Weinheim an der Bergstrasse, Germany)
Yanes RE,Tarn D,Hwang AA,Ferris DP,Sherman SP,Thomas CR,Lu J,Pyle AD,Zink JI,Tamanoi F
A-21270 was used in Immunocytochemistry to identify lysosomal exocytosis as the mechanism responsible for the exocytosis of phosphonate modified mesoporous silica nanoparticles.
Mon Mar 11 00:00:00 EDT 2013
Intracellular itinerary of internalised β-secretase, BACE1, and its potential impact on β-amyloid peptide biogenesis.
Traffic (Copenhagen, Denmark)
Chia PZ,Toh WH,Sharples R,Gasnereau I,Hill AF,Gleeson PA
A-21270 was used in immunocytochemistry to examine the intracellular trafficking of β-Secretase.
Sun Sep 01 00:00:00 EDT 2013
Versican is upregulated in circulating monocytes in patients with systemic sclerosis and amplifies a CCL2-mediated pathogenic loop.
Arthritis research & therapy
Masuda A,Yasuoka H,Satoh T,Okazaki Y,Yamaguchi Y,Kuwana M
A-21270 was used in immunocytochemistry to identify molecules expressed by systemic sclerosis monocytes and elucidate their contribution to disease.
Thu Jul 11 00:00:00 EDT 2013
Expression of conventional and novel glucose transporters, GLUT1, -9, -10, and -12, in vascular smooth muscle cells.
American journal of physiology. Cell physiology
Pyla R,Poulose N,Jun JY,Segar L
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Western Blot
Fri Mar 01 00:00:00 EST 2013
Molecular cloning and biochemical characterization of two novel Neu3 sialidases, neu3a and neu3b, from medaka (Oryzias latipes).
Biochimie
Shiozaki K,Takeshita K,Ikeda M,Ikeda A,Harasaki Y,Komatsu M,Yamada S,Yamaguchi K,Miyagi T
A-21270 was used in immunocytochemistry to study Neu3 sialidase in fishes.
Fri Feb 01 00:00:00 EST 2013
Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent steps.
Molecular biology of the cell
Holloway ZG,Velayos-Baeza A,Howell GJ,Levecque C,Ponnambalam S,Sztul E,Monaco AP
A-21270 was used in immunocytochemistry to elucidate mechanisms that regulate ATP7A trafficking
Sat Jun 01 00:00:00 EDT 2013
A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems.
PloS one
Gödel M,Ostendorf BN,Baumer J,Weber K,Huber TB
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Fri Aug 23 00:00:00 EDT 2013
Alternative transcripts and 3'UTR elements govern the incorporation of selenocysteine into selenoprotein S.
PloS one
Bubenik JL,Miniard AC,Driscoll DM
A-21270 was used in immunocytochemistry to report mechanisms that regulate SelS expression.
Thu Nov 14 00:00:00 EST 2013
Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs.
Nucleic acids research
Torres AG,Fabani MM,Vigorito E,Williams D,Al-Obaidi N,Wojciechowski F,Hudson RH,Seitz O,Gait MJ
A-21270 was used in western blot to characterize microRNA oligonucleotide inhibitors.
Thu Mar 01 00:00:00 EST 2012
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network.
Proceedings of the National Academy of Sciences of the United States of America
Choy RW,Cheng Z,Schekman R
A-21270 was used in immunocytochemistry to investigate the intracellular transport of amyloid precursor protein
Tue Jul 24 00:00:00 EDT 2012
Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells.
European journal of cell biology
Magister S,Obermajer N,Mirković B,Svajger U,Renko M,Softić A,Romih R,Colbert JD,Watts C,Kos J
A-21270 was used in immunocytochemistry to investigate how cystatin F modulates cathepsin activity in DCs.
Tue May 01 00:00:00 EDT 2012
Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription.
International journal of molecular medicine
Dieriks B,Van Oostveldt P
A-21270 was used in Immunohistochemistry-immunofluorescence to investigate the interactions of cyclophilin B with various proteins involved in ribosome biogenesis during the more transcriptionally active phases of the cell cycle.
Fri Jun 01 00:00:00 EDT 2012
Differential regulation of myosin X movements by its cargos, DCC and neogenin.
Journal of cell science
Liu Y,Peng Y,Dai PG,Du QS,Mei L,Xiong WC
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Wed Feb 01 00:00:00 EST 2012
GM130 gain-of-function induces cell pathology in a model of lysosomal storage disease.
Human molecular genetics
Roy E,Bruyère J,Flamant P,Bigou S,Ausseil J,Vitry S,Heard JM
A-21270 was used in immunocytochemistry to investigate the role of GM30 during lysosomal biogenesis.
Sun Apr 01 00:00:00 EDT 2012
An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis.
Journal of proteomics
Karhemo PR,Ravela S,Laakso M,Ritamo I,Tatti O,Mäkinen S,Goodison S,Stenman UH,Hölttä E,Hautaniemi S,Valmu L,Lehti K,Laakkonen P
A-21270 was used in western blot to investigate the existence of novel proteins in cancer metastasis.
Fri Dec 21 00:00:00 EST 2012
Down-regulation of oestrogen receptor-β associates with transcriptional co-regulator PATZ1 delocalization in human testicular seminomas.
The Journal of pathology
Esposito F,Boscia F,Franco R,Tornincasa M,Fusco A,Kitazawa S,Looijenga LH,Chieffi P
A-21270 was used in immunocytochemistry to study ERβ interactions with PATZ in the testes.
Sun May 01 00:00:00 EDT 2011
A method to separate nuclear, cytosolic, and membrane-associated signaling molecules in cultured cells.
Science signaling
Liu X,Fagotto F
A-21270 was used in western blot to describe a method to separate the cytosolic, nucleosolic, nuclear insoluble, and membrane components of various mammalian cell lines.
Tue Dec 13 00:00:00 EST 2011
Cytomegalovirus UL103 controls virion and dense body egress.
Journal of virology
Ahlqvist J,Mocarski E
A-21270 was used in immunocytochemistry to investigate the contribution of human cytomegalovirus UL103 to various aspects of the virus life cycle.
Sun May 01 00:00:00 EDT 2011
Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus.
Journal of virology
Taguwa S,Kambara H,Fujita N,Noda T,Yoshimori T,Koike K,Moriishi K,Matsuura Y
A-21270 was used in immunocytochemistry to investigate the contribution of autophagy to the life cycle of HCV.
Thu Dec 01 00:00:00 EST 2011
Chemical chaperone therapy: chaperone effect on mutant enzyme and cellular pathophysiology in β-galactosidase deficiency.
Human mutation
Higaki K,Li L,Bahrudin U,Okuzawa S,Takamuram A,Yamamoto K,Adachi K,Paraguison RC,Takai T,Ikehata H,Tominaga L,Hisatome I,Iida M,Ogawa S,Matsuda J,Ninomiya H,Sakakibara Y,Ohno K,Suzuki Y,Nanba E
A-21270 was used in immunocytochemistry to investigate the impact of N-octyl-4-epi-beta-valienamine on beta-Galactosidase mutations.
Fri Jul 01 00:00:00 EDT 2011
Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture.
Molecular biology of the cell
Ramabhadran V,Korobova F,Rahme GJ,Higgs HN
A-21270 was used in immunocytochemistry to determine the localization pattern and cellular function of the CAAX isoforms.
Thu Dec 01 00:00:00 EST 2011
Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA.
American journal of physiology. Regulatory, integrative and comparative physiology
Dmitrieva NI,Malide D,Burg MB
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Western Blot
Thu Sep 01 00:00:00 EDT 2011
The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence.
The Journal of cell biology
Follit JA,Li L,Vucica Y,Pazour GJ
A-21270 was used in immunocytochemistry to investigate how receptors are targeted to the cilium
Mon Jan 11 00:00:00 EST 2010
Open reading frame E3-10.9K of subspecies B1 human adenoviruses encodes a family of late orthologous proteins that vary in their predicted structural features and subcellular localization.
Journal of virology
Frietze KM,Campos SK,Kajon AE
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Mon Nov 01 00:00:00 EDT 2010
LG186: An inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells.
Traffic (Copenhagen, Denmark)
Boal F,Guetzoyan L,Sessions RB,Zeghouf M,Spooner RA,Lord JM,Cherfils J,Clarkson GJ,Roberts LM,Stephens DJ
A-21270 was used in immunocytochemistry to engineer Exo2 to create a more selective, reversible inhibitor of Arf-GEF function
Wed Dec 01 00:00:00 EST 2010
Storage vesicles in neurons are related to Golgi complex alterations in mucopolysaccharidosis IIIB.
The American journal of pathology
Vitry S,Bruyère J,Hocquemiller M,Bigou S,Ausseil J,Colle MA,Prévost MC,Heard JM
A-21270 was used in immunohistochemistry to examine the origin of storage vesicles in a mouse model of mucopolysaccharidosis type IIIB disease
Wed Dec 01 00:00:00 EST 2010
Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy.
The American journal of pathology
Nakatsukasa M,Kawasaki S,Yamasaki K,Fukuoka H,Matsuda A,Tsujikawa M,Tanioka H,Nagata-Takaoka M,Hamuro J,Kinoshita S
A-21270 was used in immunohistochemistry to determine the relationship between the TACSTD2 gene and epithelial barrier function
Wed Sep 01 00:00:00 EDT 2010
Tumor protein D52 expression and Ca2+-dependent phosphorylation modulates lysosomal membrane protein trafficking to the plasma membrane.
American journal of physiology. Cell physiology
Thomas DD,Martin CL,Weng N,Byrne JA,Groblewski GE
A-21270 was used in immunocytochemistry to investigate the role of D52 in lysosomal membrane trafficking
Mon Mar 01 00:00:00 EST 2010
Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia.
PloS one
Yoshikawa F,Banno Y,Otani Y,Yamaguchi Y,Nagakura-Takagi Y,Morita N,Sato Y,Saruta C,Nishibe H,Sadakata T,Shinoda Y,Hayashi K,Mishima Y,Baba H,Furuichi T
A-21270 was used in immunocytochemistry to investigate the expression, structure, and function of PLD4
Thu Nov 11 00:00:00 EST 2010
HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: novel prevention target.
PloS one
Cheshenko N,Trepanier JB,Segarra TJ,Fuller AO,Herold BC
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Western Blot
Tue Jul 27 00:00:00 EDT 2010
PIST regulates the intracellular trafficking and plasma membrane expression of cadherin 23.
BMC cell biology
Xu Z,Oshima K,Heller S
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Tue Oct 19 00:00:00 EDT 2010
Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells.
Marine drugs
Cheung FW,Li C,Che CT,Liu BP,Wang L,Liu WK
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Tue Jan 19 00:00:00 EST 2010
Hepatitis B virus and hepatitis C virus interaction in Huh-7 cells.
Journal of hepatology
Eyre NS,Phillips RJ,Bowden S,Yip E,Dewar B,Locarnini SA,Beard MR
A-21270 was used in immunocytochemistry to discuss the use of HBV/HCV co-infection studies
Tue Sep 01 00:00:00 EDT 2009
Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.
Molecular cell
Aslan JE,You H,Williamson DM,Endig J,Youker RT,Thomas L,Shu H,Du Y,Milewski RL,Brush MH,Possemato A,Sprott K,Fu H,Greis KD,Runckel DN,Vogel A,Thomas G
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Thu May 14 00:00:00 EDT 2009
Optimization of immunoprecipitation-western blot analysis in detecting GW182-associated components of GW/P bodies.
Nature protocols
Moser JJ,Chan EK,Fritzler MJ
A-21270 was used in immunoprecipitation and western blot to describe methods to isolate and detect GW182 and GW body-associated proteins
Tue Jun 30 00:00:00 EDT 2009
Optimization of immunoprecipitation-western blot analysis in detecting GW182-associated components of GW/P bodies.
Nature protocols
Moser JJ,Chan EK,Fritzler MJ
A-21270 was used in immunoprecipitation and western blot to describe methods to isolate and detect GW182 and GW body-associated proteins
Tue Jun 30 00:00:00 EDT 2009
Subcellular localization of Nox4 and regulation in diabetes.
Proceedings of the National Academy of Sciences of the United States of America
Block K,Gorin Y,Abboud HE
A-21270 was used in immunocytochemistry to characterize Nox4 regulation and subcellular localization in diabetes
Tue Aug 25 00:00:00 EDT 2009
IFAP syndrome is caused by deficiency in MBTPS2, an intramembrane zinc metalloprotease essential for cholesterol homeostasis and ER stress response.
American journal of human genetics
Oeffner F,Fischer G,Happle R,König A,Betz RC,Bornholdt D,Neidel U,Boente Mdel C,Redler S,Romero-Gomez J,Salhi A,Vera-Casaño A,Weirich C,Grzeschik KH
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Wed Apr 01 00:00:00 EDT 2009
Primary ciliogenesis defects are associated with human astrocytoma/glioblastoma cells.
BMC cancer
Moser JJ,Fritzler MJ,Rattner JB
A-21270 was used in immunocytochemistry to compare the structure and expression of primary cilia in a normal human astrocyte cell line with five human astrocytoma/glioblastoma cell lines
Thu Dec 17 00:00:00 EST 2009
Microenvironmental pH is a key factor for exosome traffic in tumor cells.
The Journal of biological chemistry
Parolini I,Federici C,Raggi C,Lugini L,Palleschi S,De Milito A,Coscia C,Iessi E,Logozzi M,Molinari A,Colone M,Tatti M,Sargiacomo M,Fais S
A-21270 was used in immunocytochemistry to study exosomes using melanoma cells
Fri Dec 04 00:00:00 EST 2009
Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1.
Biochimica et biophysica acta
Hirano T,Kishi M,Sugimoto H,Taguchi R,Obinata H,Ohshima N,Tatei K,Izumi T
A-21270 was used in immunocytochemistry to study substrate selectivity and the intracellular function of acylprotein thioesterase 1
Sat Aug 01 00:00:00 EDT 2009
A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation.
Angewandte Chemie (International ed. in English)
Hangauer MJ,Bertozzi CR
A-21270 was used in immunocytochemistry to elucidate a novel method for live-cell imaging with the Staudinger ligation and a FRET-based fluorogenic phosphine
Wed Apr 23 00:00:00 EDT 2008
HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA).
PLoS pathogens
McCormick AL,Roback L,Mocarski ES
A-21270 was used in immunocytochemistry to demonstrate that vMIA regulates a serine protease-dependent CMV-infected cell-specific programmed cell death pathway
Fri May 09 00:00:00 EDT 2008
Envelope protein palmitoylations are crucial for murine coronavirus assembly.
Journal of virology
Boscarino JA,Logan HL,Lacny JJ,Gallagher TM
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunofluorescence
Sat Mar 01 00:00:00 EST 2008
Caveolin-1-dependent infectious entry of human papillomavirus type 31 in human keratinocytes proceeds to the endosomal pathway for pH-dependent uncoating.
Journal of virology
Smith JL,Campos SK,Wandinger-Ness A,Ozbun MA
A-21270 was used in immunocytochemistry to identify the downstream trafficking events after caveolar entry of HPV31 into human keratinocytes
Wed Oct 01 00:00:00 EDT 2008
A dynamic view of hepatitis C virus replication complexes.
Journal of virology
Wölk B,Büchele B,Moradpour D,Rice CM
A-21270 was used in immunocytochemistry to investigate hepatitis C virus replication complex and membranous web formation
Sat Nov 01 00:00:00 EDT 2008
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36.
Journal of leukocyte biology
Nilsen NJ,Deininger S,Nonstad U,Skjeldal F,Husebye H,Rodionov D,von Aulock S,Hartung T,Lien E,Bakke O,Espevik T
A-21270 was used in immunocytochemistry to investigate the signaling, uptake, and trafficking pattern of LTA in relation to TLR2 signaling components
Tue Jul 01 00:00:00 EDT 2008
A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2.
American journal of physiology. Cell physiology
Nunes P,Hasler U,McKee M,Lu HA,Bouley R,Brown D
A-21270 was used in immunocytochemistry to study vasopressin-induced exocytosis in native and aquaporin-2-expressing renal LLC-PK(1) cells
Mon Dec 01 00:00:00 EST 2008
Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB5 toxin that targets the endoplasmic reticulum chaperone BiP.
Cellular microbiology
Chong DC,Paton JC,Thorpe CM,Paton AW
A-21270 was used in immunocytochemistry to investigate if SubAB is trafficked from the cell surface to the ER via a retrograde pathway similar to those of Shiga toxin and cholera toxin
Sat Mar 01 00:00:00 EST 2008
Identification and characterization of an alternatively spliced variant of the MHC class I-related porcine neonatal Fc receptor for IgG.
Developmental and comparative immunology
Ye L,Tuo W,Liu X,Simister NE,Zhu X
A-21270 was used in immunocytochemistry to study porcine neonatal Fc receptor for immunoglobulin G
Tue Jun 24 00:00:00 EDT 2008
The cytoplasmic domain of proEGF negatively regulates motility and elastinolytic activity in thyroid carcinoma cells.
Neoplasia (New York, N.Y.)
Glogowska A,Pyka J,Kehlen A,Los M,Perumal P,Weber E,Cheng SY,Hoang-Vu C,Klonisch T
A-21270 was used in Immunocytochemistry to determine the role of proEGF cytoplasmic domain in the regulation of motility and elastinolytic invasion in thyroid cancer.
Wed Oct 01 00:00:00 EDT 2008
Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling.
PloS one
Li W,Bengtson MH,Ulbrich A,Matsuda A,Reddy VA,Orth A,Chanda SK,Batalov S,Joazeiro CA
A-21270 was used in Immunocytochemistry to suggest the existence of a new, ubiquitin mediated mechanism responsible for integration of mitochondria into the cellular environment.
Wed Jan 23 00:00:00 EST 2008
Altered cellular distribution and sub-cellular sorting of doppel (Dpl) protein in human astrocytoma cell lines.
Cellular oncology : the official journal of the International Society for Cellular Oncology
Sbalchiero E,Azzalin A,Palumbo S,Barbieri G,Arias A,Simonelli L,Ferretti L,Comincini S
A-21270 was used in immunocytochemistry and western blot to determine Doppel localization and trafficking in astrocytic tumor cells
Fri Oct 10 00:00:00 EDT 2008
The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.
PLoS genetics
Follit JA,San Agustin JT,Xu F,Jonassen JA,Samtani R,Lo CW,Pazour GJ
A-21270 was used in immunocytochemistry to test if the Golgi pool of IFT20 contributes to the sorting of proteins to the ciliary membrane
Mon Dec 01 00:00:00 EST 2008
Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4.
Nature immunology
Ménager MM,Ménasché G,Romao M,Knapnougel P,Ho CH,Garfa M,Raposo G,Feldmann J,Fischer A,de Saint Basile G
A-21270 was used in immunocytochemistry to investigate the roles of Rab27a and hMunc13-4 in the release of cytotoxic granules by effector cytotoxic T lymphocytes
Thu Mar 01 00:00:00 EST 2007
Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation.
Blood
Coupel S,Moreau A,Hamidou M,Horejsi V,Soulillou JP,Charreau B
A-21270 was used in immunocytochemistry to identify cells that express human leukocyte antigen-E and study its function in the endothelium
Sun Apr 01 00:00:00 EDT 2007
NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells.
Cancer research
Das S,Hahn Y,Nagata S,Willingham MC,Bera TK,Lee B,Pastan I
A-21270 was used in immunocytochemistry to study the expression and function of NGEP in prostate cancer cells
Thu Feb 15 00:00:00 EST 2007
Redox-signaling transmitted in trans to neighboring cells by melanoma-derived TNF-containing exosomes.
Free radical biology & medicine
Söderberg A,Barral AM,Söderström M,Sander B,Rosén A
A-21270 was used in immunocytochemistry to study the secretion of TNF-containing vesicles of rab9+ endosomal origin
Sun Jul 01 00:00:00 EDT 2007
Rab11-FIP2 regulates differentiable steps in transcytosis.
American journal of physiology. Cell physiology
Ducharme NA,Williams JA,Oztan A,Apodaca G,Lapierre LA,Goldenring JR
A-21270 was used in immunocytochemistry to describe a point mutant in Rab11 family interacting protein 2 that alters the function of Rab11a-containing trafficking systems
Sat Sep 01 00:00:00 EDT 2007
Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin.
Journal of cell science
Ketema M,Wilhelmsen K,Kuikman I,Janssen H,Hodzic D,Sonnenberg A
A-21270 was used in immunocytochemistry to examine the requirements for the localization of nesprin-3alpha at the outer nuclear membrane
Mon Oct 01 00:00:00 EDT 2007
beta-dystrobrevin, a kinesin-binding receptor, interacts with the extracellular matrix components pancortins.
Journal of neuroscience research
Veroni C,Grasso M,Macchia G,Ramoni C,Ceccarini M,Petrucci TC,Macioce P
A-21270 was used in immunocytochemistry to determine the role of beta-dystrobrevin in the brain
Sat Sep 01 00:00:00 EDT 2007
Multiple receptor interactions trigger release of membrane and intracellular calcium stores critical for herpes simplex virus entry.
Molecular biology of the cell
Cheshenko N,Liu W,Satlin LM,Herold BC
A-21270 was used in immunocytochemistry to elucidate how calcium contributes to herpes simplex virus entry
Wed Aug 01 00:00:00 EDT 2007
Multiple receptor interactions trigger release of membrane and intracellular calcium stores critical for herpes simplex virus entry.
Molecular biology of the cell
Cheshenko N,Liu W,Satlin LM,Herold BC
A-21270 was used in immunocytochemistry to elucidate how calcium contributes to herpes simplex virus entry
Wed Aug 01 00:00:00 EDT 2007
Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains.
PloS one
Ignoul S,Simaels J,Hermans D,Annaert W,Eggermont J
A-21270 was used in immunocytochemistry to discuss functions regulated by human ClC-6
Wed May 30 00:00:00 EDT 2007
Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos.
The Journal of biological chemistry
Kizhatil K,Davis JQ,Davis L,Hoffman J,Hogan BL,Bennett V
A-21270 was used in immunocytochemistry to propose an ankyrin/spectrin-based mechanism for coordinating membrane assembly with extracellular interactions of E-cadherin at sites of cell-cell contact
Fri Sep 07 00:00:00 EDT 2007
Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor.
Molecular endocrinology (Baltimore, Md.)
Grasberger H,De Deken X,Miot F,Pohlenz J,Refetoff S
A-21270 was used in immunocytochemistry characterize DUOX2 missense variants by assessing their impact on H2O2 generation, trafficking, stability, folding, and interaction with dual oxidase 2
Fri Jun 01 00:00:00 EDT 2007
Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter.
Blood
Helmus Y,Denecke J,Yakubenia S,Robinson P,Lühn K,Watson DL,McGrogan PJ,Vestweber D,Marquardt T,Wild MK
A-21270 was used in immunocytochemistry to analyze a dual defect of the GDP-fucose transporter in leukocyte adhesion deficiency II patients
Mon May 15 00:00:00 EDT 2006
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.
Proceedings of the National Academy of Sciences of the United States of America
Shillingford JM,Murcia NS,Larson CH,Low SH,Hedgepeth R,Brown N,Flask CA,Novick AC,Goldfarb DA,Kramer-Zucker A,Walz G,Piontek KB,Germino GG,Weimbs T
A-21270 was used in immunocytochemistry to analyze regulation of polycystin-1 and inhibition that reverses renal cytogenesis in polycystic kidney disease by the mTOR pathway
Tue Apr 04 00:00:00 EDT 2006
A trans-Golgi network resident protein, golgin-97, accumulates in viral factories and incorporates into virions during poxvirus infection.
Journal of virology
Alzhanova D,Hruby DE
A-21270 was used in immunocytochemistry and western blot to discuss the role and functions of golgin-97 in poxvirus replication and propose a couple of working models
Fri Dec 01 00:00:00 EST 2006
The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly.
Molecular biology of the cell
Follit JA,Tuft RA,Fogarty KE,Pazour GJ
A-21270 was used in immunocytochemistry to propose that IFT20 aids in ciliary membrane protein delivery from the Golgi complex to the cilium
Fri Sep 01 00:00:00 EDT 2006
Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes.
The Journal of biological chemistry
Ghosh M,Loper R,Gelb MH,Leslie CC
A-21270 was used in immunocytochemistry to study splice variants of human cytosolic phospholipase A(2)beta
Fri Jun 16 00:00:00 EDT 2006
Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.
The Journal of biological chemistry
Dixit VD,Weeraratna AT,Yang H,Bertak D,Cooper-Jenkins A,Riggins GJ,Eberhart CG,Taub DD
A-21270 was used in immunocytochemistry to assess the constitution of a novel autocrine pathway in astrocytoma motility by growth hormone secretagogue receptor and ghrelin
Fri Jun 16 00:00:00 EDT 2006
Molecular characterization of pannexins in the lens.
Molecular vision
Dvoriantchikova G,Ivanov D,Pestova A,Shestopalov V
A-21270 was used in immunohistochemistry to discuss the role of Panx1 and Panx2 gap junction proteins in the lens
Fri Nov 17 00:00:00 EST 2006
Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases.
Blood
Scapini P,Carletto A,Nardelli B,Calzetti F,Roschke V,Merigo F,Tamassia N,Pieropan S,Biasi D,Sbarbati A,Sozzani S,Bambara L,Cassatella MA
A-21270 was used in immunocytochemistry to investigate neutrophil-dependent BLyS release in skin window exudates of patients with rheumatoid arthritis
Sat Jan 15 00:00:00 EST 2005
Intracellular localization and trafficking of fluorescein-labeled cisplatin in human ovarian carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Safaei R,Katano K,Larson BJ,Samimi G,Holzer AK,Naerdemann W,Tomioka M,Goodman M,Howell SB
A-21270 was used in immunocytochemistry to study the storage and export of cisplatin by human ovarian carcinoma cells
Sat Jan 15 00:00:00 EST 2005
Dynamic fluorescent imaging of human immunodeficiency virus type 1 gag in live cells by biarsenical labeling.
Journal of virology
Rudner L,Nydegger S,Coren LV,Nagashima K,Thali M,Ott DE
A-21270 was used in immunocytochemistry to utilize biarsenical labeling as a way to perform dynamic fluorescent imaging of human immunodeficiency virus type 1 gag in live cells
Fri Apr 01 00:00:00 EST 2005
Differentiation- and maturation-dependent content, localization, and secretion of cystatin C in human dendritic cells.
Journal of leukocyte biology
Zavasnik-Bergant T,Repnik U,Schweiger A,Romih R,Jeras M,Turk V,Kos J
A-21270 was used in immunocytochemistry to test if endogenous inhibitor cystatin C modulates cathepsins present in human antigen presenting cells
Fri Jul 01 00:00:00 EDT 2005
The transmembrane domain is essential for the microtubular trafficking of membrane type-1 matrix metalloproteinase (MT1-MMP).
Journal of cell science
Remacle AG,Rozanov DV,Baciu PC,Chekanov AV,Golubkov VS,Strongin AY
A-21270 was used in immunocytochemistry to elucidate the mechanisms that regulate the presentation of membrane type-1 matrix metalloproteinase at the cell surface
Tue Nov 01 00:00:00 EST 2005
Proteasome inhibition activates the transport and the ectodomain shedding of TNF-alpha receptors in human endothelial cells.
Journal of cell science
Peiretti F,Canault M,Bernot D,Bonardo B,Deprez-Beauclair P,Juhan-Vague I,Nalbone G
A-21270 was used in immunocytochemistry to test if signaling mediated by TNF-alpha-transmembrane receptors is regulated by the cleavage of their transmembrane forms in a proteasome-dependent manner in human endothelial cells
Tue Mar 01 00:00:00 EST 2005
Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D.
Journal of cell science
Jansen S,Stefan C,Creemers JW,Waelkens E,Van Eynde A,Stalmans W,Bollen M
A-21270 was used in immunocytochemistry to investigate the maturation of autotaxin
Fri Jul 15 00:00:00 EDT 2005
Functional analysis of Arl1 and golgin-97 in endosome-to-TGN transport using recombinant Shiga toxin B fragment.
Methods in enzymology
Tai G,Lu L,Johannes L,Hong W
A-21270 was used in immunocytochemistry to investigate the role of Arl1 and golgin-97 in transport from the early/recycling endosome to the trans-Golgi network
Tue Mar 14 00:00:00 EST 2006
The caveolae-mediated sv40 entry pathway bypasses the golgi complex en route to the endoplasmic reticulum.
Virology journal
Norkin LC,Kuksin D
A-21270 was used in immunocytochemistry to characterize the bypassing of the golgi complex en route to the endoplasmic reticulum due to the caveolae-mediated sv40 entry pathway
Tue Apr 19 00:00:00 EDT 2005
Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system.
Biochimica et biophysica acta
Fernández-Ayala DJ,Brea-Calvo G,López-Lluch G,Navas P
A-21270 was used in western blot to study the role of endomembrane system in coenzyme Q distribution in HL-60 human cells
Sat Jul 30 00:00:00 EDT 2005
Activation of endogenous Cdc42 visualized in living cells.
Science (New York, N.Y.)
Nalbant P,Hodgson L,Kraynov V,Toutchkine A,Hahn KM
A-21270 was used in immunocytochemistry to visualize the activation of endogenous Cdc42 in living cells
Fri Sep 10 00:00:00 EDT 2004
Translocation of the inhibitor of apoptosis protein c-IAP1 from the nucleus to the Golgi in hematopoietic cells undergoing differentiation: a nuclear export signal-mediated event.
Blood
Plenchette S,Cathelin S,Rébé C,Launay S,Ladoire S,Sordet O,Ponnelle T,Debili N,Phan TH,Padua RA,Dubrez-Daloz L,Solary E
A-21270 was used in Immunocytochemistry to associate c-IAP1 cellular location with cell differentiation, which opens new perspectives on the functions of the protein.
Fri Oct 01 00:00:00 EDT 2004
PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome.
International journal of cancer
Lachmann M,Gelbmann D,Kálmán E,Polgár B,Buschle M,Von Gabain A,Szekeres-Barthó J,Nagy E
A-21270 was used in immunocytochemistry and western blot to measure the expression of PIBF in malignant cell lines and primary tumors
Wed Oct 20 00:00:00 EDT 2004
Cross-presentation of a human tumor antigen delivered to dendritic cells by HSV VP22-mediated protein translocation.
European journal of immunology
Chhabra A,Mehrotra S,Chakraborty NG,Mukherji B,Dorsky DI
A-21270 was used in immunocytochemistry to optimize the delivery of antigens to antigen-presenting cells
Fri Oct 01 00:00:00 EDT 2004
Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities.
The American journal of pathology
Jin LW,Shie FS,Maezawa I,Vincent I,Bird T
A-21270 was used in immunohistochemistry to determine if there is an abnormal accumulation and aggregation of amyloid-beta precursor protein fragments in Niemann-Pick type C disease
Mon Mar 01 00:00:00 EST 2004
Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells.
Toxicology and applied pharmacology
Huan JY,Streicher JM,Bleyle LA,Koop DR
A-21270 was used in immunocytochemistry to study the degradation of ethanol-inducible cytochrome P450 2E1 and phenobarbital-inducible cytochrome P450 2B1
Wed Sep 15 00:00:00 EDT 2004
An MDR-EGFP gene fusion allows for direct cellular localization, function and stability assessment of P-glycoprotein.
Current drug delivery
Pétriz J,Gottesman MM,Aran JM
A-21270 was used in immunocytochemistry to explore P-glycoprotein expression and physiology
Thu Jan 01 00:00:00 EST 2004
Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network.
Molecular biology of the cell
Lu L,Tai G,Hong W
A-21270 was used in immunocytochemistry to perform a functional study of Golgin-97
Fri Oct 01 00:00:00 EDT 2004
Lipid-dependent bidirectional traffic of apolipoprotein B in polarized enterocytes.
Molecular biology of the cell
Morel E,Demignot S,Chateau D,Chambaz J,Rousset M,Delers F
A-21270 was used in immunocytochemistry to elucidate polarized enterocytes and lipid-dependent bidirectional traffic of apolipoprotein B
Thu Jan 01 00:00:00 EST 2004
Vimentin is secreted by activated macrophages.
Nature cell biology
Mor-Vaknin N,Punturieri A,Sitwala K,Markovitz DM
A-21270 was used in immunocytochemistry to report that activated human macrophages secrete vimentin
Wed Jan 01 00:00:00 EST 2003
Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII.
The Journal of biological chemistry
Lavictoire SJ,Parolin DA,Klimowicz AC,Kelly JF,Lorimer IA
A-21270 was used in immunocytochemistry to study the interaction of nascent EGFRvIII with Hsp90 and its importance for maintaining EGFRvIII expression
Fri Feb 14 00:00:00 EST 2003
The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex.
The Journal of biological chemistry
Rohde HM,Cheong FY,Konrad G,Paiha K,Mayinger P,Boehmelt G
A-21270 was used in immunocytochemistry to study the function of cloned human SAC.
Fri Dec 26 00:00:00 EST 2003
The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins.
Traffic (Copenhagen, Denmark)
De Mazière AM,Muehlethaler K,van Donselaar E,Salvi S,Davoust J,Cerottini JC,Lévy F,Slot JW,Rimoldi D
A-21270 was used in immunocytochemistry to elucidate the role of the melanocyte lineage-specific protein Melan-A/MART-1 in melanogenic functions.
Sun Sep 01 00:00:00 EDT 2002
Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase.
EMBO reports
López-Fraga M,Fernández R,Albar JP,Hahne M
Published figure using Golgin-97 monoclonal antibody (Product # A-21270) in Immunocytochemistry
Mon Oct 01 00:00:00 EDT 2001
Subcellular localization of the melanoma-associated protein Melan-AMART-1 influences the processing of its HLA-A2-restricted epitope.
The Journal of biological chemistry
Rimoldi D,Muehlethaler K,Salvi S,Valmori D,Romero P,Cerottini JC,Levy F
A-21270 was used in immunocytochemistry to investigate the intracellular processing of melanoma-associated protein Melan-A.
Fri Nov 16 00:00:00 EST 2001
Intracellular calcium signals regulating cytosolic phospholipase A2 translocation to internal membranes.
The Journal of biological chemistry
Evans JH,Spencer DM,Zweifach A,Leslie CC
A-21270 was used in immunocytochemistry to identify the specific membranes to which cPLA(2) translocates and the intracellular calcium signals required
Fri Aug 10 00:00:00 EDT 2001
Intracellular redirection of plasma membrane trafficking after loss of epithelial cell polarity.
Molecular biology of the cell
Low SH,Miura M,Roche PA,Valdez AC,Mostov KE,Weimbs T
A-21270 was used in immunocytochemistry to identify syntaxin 11 as a novel apical and basolateral plasma membrane t-SNARE
Fri Sep 01 00:00:00 EDT 2000
A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins.
Current biology : CB
Barr FA
A-21270 was used in immunocytochemistry and western blot to investigate the targeting of golgin-230/245/256 and golgin-97 to the Golgi apparatus
Thu Apr 08 00:00:00 EDT 1999
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.jpg?time=20220826?time=20220826 "Golgin-97 Antibody (A-21270) in ICC/IF")
