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Invitrogen
DNAJC13 Recombinant Rabbit Monoclonal Antibody (11H13L5)
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 6
DNAJC13 Antibody (702773) in ICC/IF
Product Details
702773
Species Reactivity
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Conjugate
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Product Specific Information
This antibody is predicted to react with Monkey, Cat, Goat, Sheep
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans. It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles. DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: DnaJ (Hsp40) homolog, subfamily C, member 13; DnaJ domain-containing protein RME-8; DnaJ homolog subfamily C member 13; j-domain containing protein, required for endocytosis; receptor mediated endocytosis RME-8; Required for receptor-mediated endocytosis 8; RME-8
Gene Aliases: D030002L11Rik; DNAJC13; Gm1124; KIAA0678; mKIAA0678; PARK21; RME-8; RME8
UniProt ID: (Human) O75165
Entrez Gene ID: (Human) 23317, (Mouse) 235567
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