Product References
SARS-CoV-2 Lysate Stimulation Impairs the Release of Platelet-like Particles and Megakaryopoiesis in the MEG-01 Cell Line.
International journal of molecular sciences
Lopardo V,Montella F,Esposito RM,Zannella C,Aliberti SM,Capunzo M,Franci G,Puca AA,Ciaglia E
700392 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to provide new insight into the role of SARS-CoV-2 in affecting megakaryocyte-platelet compartment, possibly unlocking another avenue by which SARS-CoV-2 moves.
Wed Mar 01 00:00:00 EST 2023
Empagliflozin maintains capillarization and improves cardiac function in a murine model of left ventricular pressure overload.
Scientific reports
Nakao M,Shimizu I,Katsuumi G,Yoshida Y,Suda M,Hayashi Y,Ikegami R,Hsiao YT,Okuda S,Soga T,Minamino T
700392 was used in Immunohistochemistry to elucidate the underlying mechanisms of the beneficial effects of Sodium glucose transporter 2 (SGLT2) inhibitors on the failing heart.
Wed Sep 15 00:00:00 EDT 2021
Empagliflozin maintains capillarization and improves cardiac function in a murine model of left ventricular pressure overload.
Scientific reports
Nakao M,Shimizu I,Katsuumi G,Yoshida Y,Suda M,Hayashi Y,Ikegami R,Hsiao YT,Okuda S,Soga T,Minamino T
700392 was used in Immunohistochemistry to elucidate the underlying mechanisms of the beneficial effects of Sodium glucose transporter 2 (SGLT2) inhibitors on the failing heart.
Wed Sep 15 00:00:00 EDT 2021
Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells.
Pharmaceutics
Kim HJ,Kim TJ,Kim YG,Seong C,Cho JH,Kim W,Lee KH,Kim DY
700392 was used in Western Blot to test the possibility that finasteride has the potential to be developed as an anti-glioblastoma drug and determine the detailed intracellular mechanisms of finasteride in glioblastoma cells.
Mon Sep 06 00:00:00 EDT 2021
Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression.
Journal of immunology (Baltimore, Md. : 1950)
Villegas-Mendez A,Khandelwal G,McGowan LM,Dookie RS,Haley MJ,George C,Sims D,Lord GM,Sinclair LV,Jenner RG,Couper KN
700392 was used in Flow cytometry/Cell sorting to show that Ag-experienced (Ag-exp) CD4+ T cell exhaustion during Plasmodium yoelii nonlethal infection occurs alongside the reduction in mammalian target of rapamycin (mTOR) activity and restriction in CD4+ T cell glycolytic capacity.
Tue Sep 15 00:00:00 EDT 2020
Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression.
Journal of immunology (Baltimore, Md. : 1950)
Villegas-Mendez A,Khandelwal G,McGowan LM,Dookie RS,Haley MJ,George C,Sims D,Lord GM,Sinclair LV,Jenner RG,Couper KN
700392 was used in Flow cytometry/Cell sorting to show that Ag-experienced (Ag-exp) CD4+ T cell exhaustion during Plasmodium yoelii nonlethal infection occurs alongside the reduction in mammalian target of rapamycin (mTOR) activity and restriction in CD4+ T cell glycolytic capacity.
Tue Sep 15 00:00:00 EDT 2020
AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease.
Human molecular genetics
Conduit SE,Davies EM,Ooms LM,Gurung R,McGrath MJ,Hakim S,Cottle DL,Smyth IM,Dyson JM,Mitchell CA
700392 was used in Immunohistochemistry (Paraffin) to to demonstrate AKT and mTORC1 hyperactivation in two representative murine PKD models (renal epithelial-specific Inpp5e knockout and collecting duct-specific Pkd1 deletion) and identify a downstream signaling network that contributes to DNA damage accumulation.
Wed Jan 01 00:00:00 EST 2020
Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming.
Epigenetics & chromatin
Chang RC,Wang H,Bedi Y,Golding MC
Published figure using Phospho-AKT1 (Ser473) recombinant monoclonal antibody (Product # 700392) in Western Blot
Tue Jan 22 00:00:00 EST 2019
Programmed increases in LXRα induced by paternal alcohol use enhance offspring metabolic adaptation to high-fat diet induced obesity.
Molecular metabolism
Chang RC,Thomas KN,Bedi YS,Golding MC
700392 was used in Western Blotting to study LXR-alpha in metabolic changes in children due to prenatal paternal alcohol consumption.
Sun Dec 01 00:00:00 EST 2019
Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion.
Journal of immunology (Baltimore, Md. : 1950)
Ibrahim M,Scozzi D,Toth KA,Ponti D,Kreisel D,Menna C,De Falco E,D'Andrilli A,Rendina EA,Calogero A,Krupnick AS,Gelman AE
700392 was used in Flow cytometry/Cell sorting to demonstrate that CD4+ T cells that sequester Pam3Cys4 are capable of Th1 differentiation in the presence of TGF-Β, suggesting a novel approach to adoptive cell therapy.
Mon Jan 15 00:00:00 EST 2018
Significance of PYK2 level as a prognosis predictor in patients with colon adenocarcinoma after surgical resection.
OncoTargets and therapy
Liu S,Chen L,Xu Y
700392 was used in Immunohistochemistry to investigate the clinical significance and mechanisms of PYK2 in colon adenocarcinoma.
Wed Mar 30 00:00:00 EDT 2022
Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model.
PloS one
Rebolleda N,Losada-Fernandez I,Perez-Chacon G,Castejon R,Rosado S,Morado M,Vallejo-Cremades MT,Martinez A,Vargas-Nuñez JA,Perez-Aciego P
700392 was used in flow cytometry to study the synergistic activity of fludarabine and deguelin in chronic lymphocytic leukemia patient cells in the New Zealand Black Murine model
Wed Apr 05 00:00:00 EDT 2017
Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model.
PloS one
Rebolleda N,Losada-Fernandez I,Perez-Chacon G,Castejon R,Rosado S,Morado M,Vallejo-Cremades MT,Martinez A,Vargas-Nuñez JA,Perez-Aciego P
700392 was used in flow cytometry to study the synergistic activity of fludarabine and deguelin in chronic lymphocytic leukemia patient cells in the New Zealand Black Murine model
Wed Apr 05 00:00:00 EDT 2017
Snail heterogeneity in clear cell renal cell carcinoma.
BMC cancer
Zaldumbide L,Erramuzpe A,Guarch R,Pulido R,Cortés JM,López JI
700392 was used in immunohistochemistry - paraffin section to study clear cell renal cell carcinoma and snail heterogeneity
Tue Mar 08 00:00:00 EST 2016
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.
Cancer discovery
Seashore-Ludlow B,Rees MG,Cheah JH,Cokol M,Price EV,Coletti ME,Jones V,Bodycombe NE,Soule CK,Gould J,Alexander B,Li A,Montgomery P,Wawer MJ,Kuru N,Kotz JD,Hon CS,Munoz B,Liefeld T,Dančík V,Bittker JA,Palmer M,Bradner JE,Shamji AF,Clemons PA,Schreiber SL
700392 was used in western blot to learn the connections between sensitivity in a small-molecule dataset
Sun Nov 01 00:00:00 EDT 2015
Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex.
The Journal of cell biology
Coon BG,Baeyens N,Han J,Budatha M,Ross TD,Fang JS,Yun S,Thomas JL,Schwartz MA
700392 was used in western blot to study the role of VE-cadherin in fluid shear stress
Mon Mar 30 00:00:00 EDT 2015
Expression of EGFR and molecules downstream to PI3K/Akt, Raf-1-MEK-1-MAP (Erk1/2), and JAK (STAT3) pathways in invasive lung adenocarcinomas resected at a single institution.
Analytical cellular pathology (Amsterdam)
Torres AF,Nogueira C,Magalhaes J,Costa IS,Aragao A,Gomes Neto A,Martins F,Tavora F
700392 was used in immunohistochemistry (paraffin) to analyze retrospectively the protein expression of EGFR, Stat3, phospho-Akt, and phospho-Erk1/2 in tumors.
Fri Oct 30 00:00:00 EDT 2015
Experimentally validated novel inhibitors of Helicobacter pylori phosphopantetheine adenylyltransferase discovered by virtual high-throughput screening.
PloS one
Cheng CS,Jia KF,Chen T,Chang SY,Lin MS,Yin HS
700392 was used in Functional assays to develop novel antibiotics against Helicobacter pylori by targeting phosphopantetheine adenylyltransferase (HpPPAT).
Tue Jun 03 00:00:00 EDT 2014
Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth.
Proceedings of the National Academy of Sciences of the United States of America
Steketee MB,Moysidis SN,Jin XL,Weinstein JE,Pita-Thomas W,Raju HB,Iqbal S,Goldberg JL
Tue Nov 22 00:00:00 EST 2011