Invitrogen

VGLUT2 Polyclonal Antibody

VGLUT2 Antibody in Immunocytochemistry (ICC/IF)

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VGLUT2 Antibody (42-7800) in ICC/IF

Nature 2014 - Extended Data Fig. 4 Characterization of Piezo2 fl/fl (WT) and Krt14Cre;Piezo2 fl/fl (cKO) adult skin a, b, H&E staining of WT and Piezo2 cKO dorsal skin. c, d, Immunofluorescence of Krt14 and a-SMA (alpha smooth muscle actin) in WT and cKO dorsal skin. e-g, j-l, Epidermal touch domes co-stained with Krt8, Nefh, and VGLUT2 (vesicular glutamate transporter 2, a marker for Merkel cells) in WT and cKO dorsal s... View More

VGLUT2 Antibody in Immunohistochemistry (IHC)

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Product Details

42-7800

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide derived from the C-terminal of the mouse VGLUT2 protein (accession# NP_543129), which is identical to rat sequence and 93% homologous to human. Compared to VGLUT2 (C-term) antibody, this immunogen sequence is further away from the very C-terminus of the protein

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533537

Target Information

VGLU2 mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. This protein may also mediate the transport of inorganic phosphate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Long-Term Hyperglycemia Causes Depressive Behaviors in Mice with Hypoactive Glutamatergic Activity in the Medial Prefrontal Cortex, Which Is Not Reversed by Insulin Treatment.

Cells

Baek JH,Son H,Kang JS,Yoo DY,Chung HJ,Lee DK,Kim HJ

42-7800 was used in Immunohistochemistry-immunofluorescence to suggest that hypoactive glutamatergic activity in the mPFC is involved in diabetic-associated depressive behaviors, and it is difficult to cure with glycemic regulation alone.

Mon Dec 12 00:00:00 EST 2022

Long-Term Hyperglycemia Causes Depressive Behaviors in Mice with Hypoactive Glutamatergic Activity in the Medial Prefrontal Cortex, Which Is Not Reversed by Insulin Treatment.

Cells

Baek JH,Son H,Kang JS,Yoo DY,Chung HJ,Lee DK,Kim HJ

Mon Dec 12 00:00:00 EST 2022

Ataxic Symptoms in Huntington's Disease Transgenic Mouse Model Are Alleviated by Chlorzoxazone.

Frontiers in neuroscience

Egorova PA,Gavrilova AV,Bezprozvanny IB

42-7800 was used in Immunohistochemistry-immunofluorescence to study effects of the SK channels modulator chlorzoxazone (CHZ) on the motor behavior of YAC128 Huntington's disease (HD) mice.

Mon Sep 28 00:00:00 EDT 2020

Ataxic Symptoms in Huntington's Disease Transgenic Mouse Model Are Alleviated by Chlorzoxazone.

Frontiers in neuroscience

Egorova PA,Gavrilova AV,Bezprozvanny IB

42-7800 was used in Immunohistochemistry-immunofluorescence to study effects of the SK channels modulator chlorzoxazone (CHZ) on the motor behavior of YAC128 Huntington's disease (HD) mice.

Mon Sep 28 00:00:00 EDT 2020

Differential visual system organization and susceptibility to experimental models of optic neuropathies in three commonly used mouse strains.

Experimental eye research

De Groef L,Dekeyster E,Geeraerts E,Lefevere E,Stalmans I,Salinas-Navarro M,Moons L

42-7800 was used in immunohistochemistry to characterize susceptibility to experimental models of optic neuropathies and differential visual system organization in three commonly used mouse strains

Fri Apr 01 00:00:00 EDT 2016

MMP-2 mediates Purkinje cell morphogenesis and spine development in the mouse cerebellum.

Brain structure & function

Verslegers M,Van Hove I,Dekeyster E,Gantois I,Hu TT,D'Hooge R,Arckens L,Moons L

42-7800 was used in immunohistochemistry to investigate the role of MMP-2 in development of the central nervous system and dendritogenesis.

Fri Jan 15 00:00:00 EST 2016

Piezo2 is required for Merkel-cell mechanotransduction.

Nature

Woo SH,Ranade S,Weyer AD,Dubin AE,Baba Y,Qiu Z,Petrus M,Miyamoto T,Reddy K,Lumpkin EA,Stucky CL,Patapoutian A

42-7800 was used in immunohistochemistry to show that Piezo2 is a Merkel-cell mechanotransduction channel.

Thu May 29 00:00:00 EDT 2014

An aberrant cerebellar development in mice lacking matrix metalloproteinase-3.

Molecular neurobiology

Van Hove I,Verslegers M,Buyens T,Delorme N,Lemmens K,Stroobants S,Gantois I,D'Hooge R,Moons L

42-7800 was used in immunohistochemistry to report a role for MMP-3 in the histogenesis of the mouse cerebellar cortex.

Wed Feb 01 00:00:00 EST 2012

Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Oakman SA,Faris PL,Kerr PE,Cozzari C,Hartman BK

42-7800 was used in Immunohistochemistry to characterise the pontomesencephalic cholinergic projection neurons from the laterodorsal tegmental and pedunculopontine tegmental nuclei to midbrain dopaminergic nuclei.

Fri Sep 01 00:00:00 EDT 1995

Bioinformatics

Protein Aliases: differentation-associated Na-dependent inorganic phosphate cotransporter; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; differentiation-associated Na-dependent inorganic phosphate cotransporter; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; solute carrier family 17 (vesicular glutamate transporter), member 6; Solute carrier family 17 member 6; Vesicular glutamate transporter 2; VGlU2; VGluT2

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Gene Aliases: 2900073D12Rik; DNPI; SLC17A6; VGLUT2

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UniProt ID: (Human) Q9P2U8, (Mouse) Q8BLE7, (Rat) Q9JI12

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Entrez Gene ID: (Human) 57084, (Mouse) 140919, (Rat) 84487

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Function(s)

L-glutamate transmembrane transporter activity symporter activity secondary carrier transporter

Process(es)

ion transport sodium ion transport neurotransmitter transport L-glutamate transmembrane transport neurotransmitter uptake transport transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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VGLUT2 Polyclonal Antibody

VGLUT2 Antibody (42-7800) in ICC/IF

Product Details

42-7800

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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