Product References
Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells.
Cancer research communications
Islam SMR,Maeda T,Tamaoki N,Good ML,Kishton RJ,Paria BC,Yu Z,Bosch-Marce M,Bedanova NM,Liu C,Kruhlak MJ,Restifo NP,Vizcardo R
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Mon May 01 00:00:00 EDT 2023
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.
Nature communications
Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X
12-9969-42 was used in Flow cytometry/Cell sorting to demonstrate that the PRDM1-USP22-SPI1 axis regulates PD-L1 levels, resulting in infiltrated CD8+ T cell exhaustion.
Mon Dec 12 00:00:00 EST 2022
Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
Cell
Béziat V,Rapaport F,Hu J,Titeux M,Bonnet des Claustres M,Bourgey M,Griffin H,Bandet É,Ma CS,Sherkat R,Rokni-Zadeh H,Louis DM,Changi-Ashtiani M,Delmonte OM,Fukushima T,Habib T,Guennoun A,Khan T,Bender N,Rahman M,About F,Yang R,Rao G,Rouzaud C,Li J,Shearer D,Balogh K,Al Ali F,Ata M,Dabiri S,Momenilandi M,Nammour J,Alyanakian MA,Leruez-Ville M,Guenat D,Materna M,Marcot L,Vladikine N,Soret C,Vahidnezhad H,Youssefian L,Saeidian AH,Uitto J,Catherinot É,Navabi SS,Zarhrate M,Woodley DT,Jeljeli M,Abraham T,Belkaya S,Lorenzo L,Rosain J,Bayat M,Lanternier F,Lortholary O,Zakavi F,Gros P,Orth G,Abel L,Prétet JL,Fraitag S,Jouanguy E,Davis MM,Tangye SG,Notarangelo LD,Marr N,Waterboer T,Langlais D,Doorbar J,Hovnanian A,Christensen N,Bossuyt X,Shahrooei M,Casanova JL
12-9969-42 was used in Flow cytometry/Cell sorting to conclude that human CD28-dependent T cell responses are largely redundant for protective immunity.
Thu Jul 08 00:00:00 EDT 2021
Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.
Signal transduction and targeted therapy
Zheng G,Guo Z,Li W,Xi W,Zuo B,Zhang R,Wen W,Yang AG,Jia L
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Wed Jun 23 00:00:00 EDT 2021
Construction of Novel lncRNA-miRNA-mRNA Network Associated With Recurrence and Identification of Immune-Related Potential Regulatory Axis in Hepatocellular Carcinoma.
Frontiers in oncology
Zhan T,Gao X,Wang G,Li F,Shen J,Lu C,Xu L,Li Y,Zhang J
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Tue Aug 03 00:00:00 EDT 2021
Construction of Novel lncRNA-miRNA-mRNA Network Associated With Recurrence and Identification of Immune-Related Potential Regulatory Axis in Hepatocellular Carcinoma.
Frontiers in oncology
Zhan T,Gao X,Wang G,Li F,Shen J,Lu C,Xu L,Li Y,Zhang J
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Tue Aug 03 00:00:00 EDT 2021
Imaging Changes and Immune-Checkpoint Expression on T Cells in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis.
Biomedicines
Kotetsu Y,Yanagihara T,Suzuki K,Ando H,Eto D,Hata K,Arimura-Omori M,Yamamoto Y,Harada E,Hamada N
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Thu Sep 16 00:00:00 EDT 2021
Imaging Changes and Immune-Checkpoint Expression on T Cells in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis.
Biomedicines
Kotetsu Y,Yanagihara T,Suzuki K,Ando H,Eto D,Hata K,Arimura-Omori M,Yamamoto Y,Harada E,Hamada N
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Thu Sep 16 00:00:00 EDT 2021
Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors.
eLife
Xu X,Masubuchi T,Cai Q,Zhao Y,Hui E
12-9969-42 was used in Flow cytometry/Cell sorting to provide a molecular interpretation of the SHP1/SHP2-binding specificities of PD-1 and BTLA, with implications for the mechanisms of a large family of therapeutically relevant receptors.
Thu Nov 04 00:00:00 EDT 2021
Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.
Frontiers in immunology
Yeku OO,Rao TD,Laster I,Kononenko A,Purdon TJ,Wang P,Cui Z,Liu H,Brentjens RJ,Spriggs D
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Thu Oct 21 00:00:00 EDT 2021
An unexpected role for p53 in regulating cancer cell-intrinsic PD-1 by acetylation.
Science advances
Cao Z,Kon N,Liu Y,Xu W,Wen J,Yao H,Zhang M,Wu Z,Yan X,Zhu WG,Gu W,Wang D
12-9969-42 was used in Flow Cytometry to reveal a mechanism for activating cancer cell-intrinsic PD-1 and indicates that p53-mediated PD-1 activation is critically involved in tumor suppression in an immunity-independent manner.
Mon Mar 01 00:00:00 EST 2021
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology
Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E
12-9969 was used in Flow cytometry/Cell sorting to compare the abilities of BTLA and PD-1 to recruit effector molecules and to regulate T cell signalling.
Mon Jun 01 00:00:00 EDT 2020
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology
Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E
12-9969 was used in Flow cytometry/Cell sorting to compare the abilities of BTLA and PD-1 to recruit effector molecules and to regulate T cell signalling.
Mon Jun 01 00:00:00 EDT 2020
Mesenchymal stem cells protect against malaria pathogenesis by reprogramming erythropoiesis in the bone marrow.
Cell death discovery
Thakur RS,Awasthi V,Sanyal A,Chatterjee S,Rani S,Chauhan R,Kalkal M,Tiwari M,Pande V,Das J
12-9969 was used in Flow cytometry/Cell sorting to suggest that MSCs play a critical role in host protection against malaria infection by modulating erythropoiesis and lymphopoiesis.
Sun Nov 15 00:00:00 EST 2020
Immunogenic neoantigens derived from gene fusions stimulate T cell responses.
Nature medicine
Yang W,Lee KW,Srivastava RM,Kuo F,Krishna C,Chowell D,Makarov V,Hoen D,Dalin MG,Wexler L,Ghossein R,Katabi N,Nadeem Z,Cohen MA,Tian SK,Robine N,Arora K,Geiger H,Agius P,Bouvier N,Huberman K,Vanness K,Havel JJ,Sims JS,Samstein RM,Mandal R,Tepe J,Ganly I,Ho AL,Riaz N,Wong RJ,Shukla N,Chan TA,Morris LGT
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Wed May 01 00:00:00 EDT 2019
Enhanced IL-6/phosphorylated STAT3 signaling is related to the imbalance of circulating T follicular helper/T follicular regulatory cells in patients with rheumatoid arthritis.
Arthritis research & therapy
Niu Q,Huang ZC,Wu XJ,Jin YX,An YF,Li YM,Xu H,Yang B,Wang LL
12-9969 was used in Flow cytometry/Cell sorting to demonstrate that enhanced IL-6/pSTAT3 signalling may contribute to promotion of Tfh cells, consequently skewing the ratio of Tfh to Tfr cells, which may be crucial for disease progression in rheumatoid arthritis.
Wed Aug 29 00:00:00 EDT 2018
Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells.
Cell reports
Zhao Y,Harrison DL,Song Y,Ji J,Huang J,Hui E
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Tue Jul 10 00:00:00 EDT 2018
Increased levels of CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells, and associated factors Bcl-6, CXCR5, IL-21 and IL-6 contribute to repeated implantation failure.
Experimental and therapeutic medicine
Gong Q,Zhu Y,Pang N,Ai H,Gong X,La X,Ding J
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Fri Dec 01 00:00:00 EST 2017
Tumor-infiltrating Tim-3+ T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk.
Oncoimmunology
Li J,Shayan G,Avery L,Jie HB,Gildener-Leapman N,Schmitt N,Lu BF,Kane LP,Ferris RL
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis.
mAbs
Cheng L,Tang X,Liu L,Peng J,Nishiura K,Cheung AK,Guo J,Wu X,Tang HY,An M,Zhou J,Cheung KW,Wang H,Guan X,Wu Z,Chen Z
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Tue Mar 22 00:00:00 EDT 2016
MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres.
Nature communications
Pratama A,Srivastava M,Williams NJ,Papa I,Lee SK,Dinh XT,Hutloff A,Jordan MA,Zhao JL,Casellas R,Athanasopoulos V,Vinuesa CG
12-9969 was used in Flow cytometry/Cell sorting to study how miR-146a emerges as a post-transcriptional brake to limit Tfh cells and GC responses.
Fri Mar 06 00:00:00 EST 2015
A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells.
Cancer research
Barsoum IB,Smallwood CA,Siemens DR,Graham CH
12-9969 was used in Flow cytometry/Cell sorting to investigate whether exposure of mouse and human tumour cells to hypoxia increases their resistance to T cell-mediated immunity.
Sat Feb 01 00:00:00 EST 2014
Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.
Journal of leukocyte biology
Hutchins NA,Wang F,Wang Y,Chung CS,Ayala A
12-9969 was used in Flow cytometry/Cell sorting to study Kupffer cell-mediated potentiation of liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.
Fri Nov 01 00:00:00 EDT 2013
Neuroinflammation and brain functional disconnection in Alzheimer's disease.
Frontiers in aging neuroscience
Baglio F,Saresella M,Preti MG,Cabinio M,Griffanti L,Marventano I,Piancone F,Calabrese E,Nemni R,Clerici M
12-9969 was used in Flow cytometry/Cell sorting to investigate how monitoring of immune cells in peripheral blood could have a prognostic value in AD.
Tue Dec 10 00:00:00 EST 2013
Phase I clinical trial combining imatinib mesylate and IL-2: HLA-DR+ NK cell levels correlate with disease outcome.
Oncoimmunology
Chaput N,Flament C,Locher C,Desbois M,Rey A,Rusakiewicz S,Poirier-Colame V,Pautier P,Le Cesne A,Soria JC,Paci A,Rosenzwajg M,Klatzmann D,Eggermont A,Robert C,Zitvogel L
12-9969 was used in Flow cytometry/Cell sorting to show that the combination of IM and IL-2 promoted rapid expansion of HLA-DR+NK cells and increased the CD4+:CD8+T-cell ratio.
Fri Feb 01 00:00:00 EST 2013
Incomplete normalization of regulatory t-cell frequency in the gut mucosa of Colombian HIV-infected patients receiving long-term antiretroviral treatment.
PloS one
Rueda CM,Velilla PA,Chougnet CA,Rugeles MT
12-9969 was used in Flow cytometry/Cell sorting to assess the frequency and phenotype of regulatory T-cells within CMV and HIV patients on different treatment regimes.
Tue Sep 23 00:00:00 EDT 2014
Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer.
Blood
Ramsay AG,Clear AJ,Fatah R,Gribben JG
12-9969 was used in Flow cytometry/Cell sorting to study a feature of cancer pathology which allows the evasion of normal immune function via impairment at the T-cell immunologic synapse.
Thu Aug 16 00:00:00 EDT 2012
HIV-induced T-cell activation/exhaustion in rectal mucosa is controlled only partially by antiretroviral treatment.
PloS one
Rueda CM,Velilla PA,Chougnet CA,Montoya CJ,Rugeles MT
12-9969 was used in Flow cytometry/Cell sorting to investigate the effect of chronic HIV infection on the immune cell phenotype.
Mon Jun 04 00:00:00 EDT 2012
Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients.
Critical care (London, England)
Zhang Y,Li J,Lou J,Zhou Y,Bo L,Zhu J,Zhu K,Wan X,Cai Z,Deng X
12-9969 was used in Flow cytometry/Cell sorting to demonstrate that lymphocyte apoptosis is markedly increased in septic shock patients, and suggest an essential role for the PD-1/PD-L1 pathway in sepsis-induced immunosuppression.
Wed Dec 07 00:00:00 EST 2011
Programmed death ligand 1 is expressed by non-hodgkin lymphomas and inhibits the activity of tumor-associated T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Andorsky DJ,Yamada RE,Said J,Pinkus GS,Betting DJ,Timmerman JM
12-9969 was used in Flow cytometry/Cell sorting to characterise the spectrum of PD-L1 expression in non-Hodgkin lymphomas and evaluate the role of PD-L1 in suppressing tumour-associated T-cell responses.
Fri Jul 01 00:00:00 EDT 2011
Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction.
Journal of immunology (Baltimore, Md. : 1950)
Kim YJ,Park SJ,Broxmeyer HE
12-9969 was used in Flow cytometry/Cell sorting to identify a potential mechanism by which IFN-γ-producing CD8(+) T cells are tolerised after type 1 immune responses to chronic virus or tumour.
Thu Sep 01 00:00:00 EDT 2011
Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kleijwegt FS,Laban S,Duinkerken G,Joosten AM,Koeleman BP,Nikolic T,Roep BO
12-9969 was used in Flow cytometry/Cell sorting to study the mechanism by which infectious tolerance applies to human dendritic cells.
Thu Dec 15 00:00:00 EST 2011
The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody.
Blood
Benson DM,Bakan CE,Mishra A,Hofmeister CC,Efebera Y,Becknell B,Baiocchi RA,Zhang J,Yu J,Smith MK,Greenfield CN,Porcu P,Devine SM,Rotem-Yehudar R,Lozanski G,Byrd JC,Caligiuri MA
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9969-42) in Flow Cytometry
Thu Sep 30 00:00:00 EDT 2010
Neuron-interacting satellite glial cells in human trigeminal ganglia have an APC phenotype.
Journal of immunology (Baltimore, Md. : 1950)
van Velzen M,Laman JD,Kleinjan A,Poot A,Osterhaus AD,Verjans GM
12-9969 was used in Flow cytometry/Cell sorting to indicate a role for TG-glial cells as resident APCs with potential T cell modulatory properties.
Sat Aug 15 00:00:00 EDT 2009
PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors.
Blood
Zhang JY,Zhang Z,Wang X,Fu JL,Yao J,Jiao Y,Chen L,Zhang H,Wei J,Jin L,Shi M,Gao GF,Wu H,Wang FS
Fri Jun 01 00:00:00 EDT 2007
