Product References
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing.
Nature cell biology
Mitchell CA,Verovskaya EV,Calero-Nieto FJ,Olson OC,Swann JW,Wang X,Hérault A,Dellorusso PV,Zhang SY,Svendsen AF,Pietras EM,Bakker ST,Ho TT,Göttgens B,Passegué E
12-1271-82 was used in Flow cytometry/Cell sorting to characterize the inflammatory milieu that drives both niche and haematopoietic remodelling.
Sun Jan 01 00:00:00 EST 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.
iScience
Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X
12-1271-82 was used in Flow cytometry/Cell sorting to demonstrate that Phf6R274X plays a critical role in fine-tuning T cells and HSC homeostasis.
Fri Jun 16 00:00:00 EDT 2023
A Myb enhancer-guided analysis of basophil and mast cell differentiation.
Nature communications
Matsumura T,Totani H,Gunji Y,Fukuda M,Yokomori R,Deng J,Rethnam M,Yang C,Tan TK,Karasawa T,Kario K,Takahashi M,Osato M,Sanda T,Suda T
12-1271-82 was used in Flow Cytometry to identify the Myb -68 enhancer, a regulatory element which marks basophils and mast cells, and show a population of granulocyte-macrophage progenitors with higher potential to differentiate into basophils and mast cells.
Fri Nov 18 00:00:00 EST 2022
Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments.
Proceedings of the National Academy of Sciences of the United States of America
McCorkell KA,Jayachandran N,Cully MD,Freund-Brown J,Weinkopff T,Monslow J,Hu Y,Puré E,Freedman BD,Alvarez JI,Cancro MP,May MJ
12-1271-82 was used in Flow cytometry/Cell sorting to reveal that IKK-α in distinct EC-derived compartments is uniquely required to promote B cell homeostasis and LN development, and establish that LEC-intrinsic IKK-α is absolutely essential for LN formation.
Tue Nov 30 00:00:00 EST 2021
MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo.
Molecular medicine reports
Huo J,Liu T,Li F,Song X,Hou X
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice.
JCI insight
Yun JH,Lee C,Liu T,Liu S,Kim EY,Xu S,Curtis JL,Pinello L,Bowler RP,Silverman EK,Hersh CP,Zhou X
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Wed Sep 08 00:00:00 EDT 2021
Chronic stress physically spares but functionally impairs innate-like invariant T cells.
Cell reports
Rudak PT,Choi J,Parkins KM,Summers KL,Jackson DN,Foster PJ,Skaro AI,Leslie K,McAlister VC,Kuchroo VK,Inoue W,Lantz O,Haeryfar SMM
12-1271-82 was used in Flow Cytometry to report that long-term stress surprisingly abrogates both T helper 1 (TH1)- and TH2-type responses orchestrated by invariant natural killer T (iNKT) cells.
Tue Apr 13 00:00:00 EDT 2021
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
Immunity
Milner JJ,Toma C,He Z,Kurd NS,Nguyen QP,McDonald B,Quezada L,Widjaja CE,Witherden DA,Crowl JT,Shaw LA,Yeo GW,Chang JT,Omilusik KD,Goldrath AW
12-1271 was used in Flow cytometry/Cell sorting to identify discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infection time points.
Tue May 19 00:00:00 EDT 2020
Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development.
Developmental cell
Dege C,Fegan KH,Creamer JP,Berrien-Elliott MM,Luff SA,Kim D,Wagner JA,Kingsley PD,McGrath KE,Fehniger TA,Palis J,Sturgeon CM
12-1271 was used in Flow cytometry/Cell sorting to identify an extra-embryonic origin of potently cytotoxic NK cells, suggesting that ontogenic origin is a relevant factor in designing hPSC-derived adoptive immunotherapies.
Mon Apr 20 00:00:00 EDT 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.
Cell reports
Martin MD,Sompallae R,Winborn CS,Harty JT,Badovinac VP
12-1271 was used in Flow cytometry/Cell sorting to advance the utility of the Collaborative Cross (CC) as a tool to analyze the immune response to viral infection.
Tue Apr 14 00:00:00 EDT 2020
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Immunity
Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Tue Apr 16 00:00:00 EDT 2019
Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells.
Immunity
Pokrovskii M,Hall JA,Ochayon DE,Yi R,Chaimowitz NS,Seelamneni H,Carriero N,Watters A,Waggoner SN,Littman DR,Bonneau R,Miraldi ER
12-1271 was used in Flow cytometry/Cell sorting to study regulatory interactions between transcription factors and genes within intestinal type 1, 2, and 3 innate lymphoid cells subsets.
Tue Jul 16 00:00:00 EDT 2019
Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells.
Nature immunology
Twohig JP,Cardus Figueras A,Andrews R,Wiede F,Cossins BC,Derrac Soria A,Lewis MJ,Townsend MJ,Millrine D,Li J,Hill DG,Uceda Fernandez J,Liu X,Szomolay B,Pepper CJ,Taylor PR,Pitzalis C,Tiganis T,Williams NM,Jones GW,Jones SA
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Mon Apr 01 00:00:00 EDT 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
12-1271 was used in Flow cytometry/Cell sorting to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.
Haematologica
Zhang Z,Huang Z,Ong B,Sahu C,Zeng H,Ruan HB
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Sun Sep 01 00:00:00 EDT 2019
Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells.
Cell reports
Magen A,Nie J,Ciucci T,Tamoutounour S,Zhao Y,Mehta M,Tran B,McGavern DB,Hannenhalli S,Bosselut R
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Tue Dec 03 00:00:00 EST 2019
Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity.
Cell reports
DeVorkin L,Pavey N,Carleton G,Comber A,Ho C,Lim J,McNamara E,Huang H,Kim P,Zacharias LG,Mizushima N,Saitoh T,Akira S,Beckham W,Lorzadeh A,Moksa M,Cao Q,Murthy A,Hirst M,DeBerardinis RJ,Lum JJ
12-1271-82 was used in Flow Cytometry to demonstrate a cell-autonomous role for autophagy in the regulation of CD8+ T-cell-mediated control of tumors.
Tue Apr 09 00:00:00 EDT 2019
Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production.
PloS one
Mathä L,Shim H,Steer CA,Yin YH,Martinez-Gonzalez I,Takei F
12-1271-82 was used in Flow Cytometry to suggest that female ILC2s are more readily activated than male ILC2s due to their gene expression at the naïve state, which is potentially influenced by the lung environment.
Mon Dec 16 00:00:00 EST 2019
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.
Nature communications
Khattar E,Maung KZY,Chew CL,Ghosh A,Mok MMH,Lee P,Zhang J,Chor WHJ,Cildir G,Wang CQ,Mohd-Ismail NK,Chin DWL,Lee SC,Yang H,Shin YJ,Nam DH,Chen L,Kumar AP,Deng LW,Ikawa M,Gunaratne J,Osato M,Tergaonkar V
12-1271-82 was used in Flow Cytometry to provide the genetic evidence that mammalian Rap1 plays a major role in hematopoietic stem cell survival, oncogenesis and response to chemotherapy.
Fri Dec 13 00:00:00 EST 2019
Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.
Frontiers in immunology
Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ
12-1271-82 was used in Flow Cytometry to indicate that CFH, through its function as a complement repressor, acts as a negative regulator of BCR signaling and limits autoimmunity.
Tue Oct 13 00:00:00 EDT 2020
Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity.
Immunity
Šestan M,Marinović S,Kavazović I,Cekinović Đ,Wueest S,Turk Wensveen T,Brizić I,Jonjić S,Konrad D,Wensveen FM,Polić B
12-1271 was used in Flow cytometry/Cell sorting to study how viral infection effects insulin resistance.
Tue Jul 17 00:00:00 EDT 2018
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
12-1271 was used in Flow Cytometry to indicate that the VHL-HIF-glycolysis axis is essential for the late-stage maturation and function of ILC2s via targeting IL-33-ST2 pathway.
Tue Feb 20 00:00:00 EST 2018
Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
The interplay of BMP4 and IL‑7 regulates the apoptosis of intestinal intraepithelial lymphocytes under conditions of ischemia̸reperfusion.
International journal of molecular medicine
Luo B,Chen K,Feng Q,Xiao W,Ma D,Yang H,Zhang C
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Tue May 01 00:00:00 EDT 2018
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Nature communications
Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z
Wed Mar 28 00:00:00 EDT 2018
CD4 T cell autophagy is integral to memory maintenance.
Scientific reports
Murera D,Arbogast F,Arnold J,Bouis D,Muller S,Gros F
12-1271 was used in Flow cytometry/Cell sorting to propose that memory CD4+ T-cells rely on autophagy for their survival to regulate toxicity of mitochondrial activity and lipid overload.
Fri Apr 13 00:00:00 EDT 2018
Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.
Immunity
Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts TH
12-1271-82 was used in Flow Cytometry to investigate how different subtypes of T cell antigen-presenting cell contribute to determining viral set point and disease outcome.
Tue Nov 21 00:00:00 EST 2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
12-1271 was used in Flow cytometry/Cell sorting to demonstrate that the effects of cytokines regulating haematopoietic stem cell functions are dependent on the producing cell sources.
Wed Mar 01 00:00:00 EST 2017
Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling.
PLoS pathogens
Seshadri S,Allan DSJ,Carlyle JR,Zenewicz LA
12-1271 was used in Flow cytometry/Cell sorting to study the effects of MAPK signalling pathways in group 3 innate immune lymphocytes using Bacillus anthracis.
Sun Oct 01 00:00:00 EDT 2017
Role of Prolactin in Promotion of Immune Cell Migration into the Mammary Gland.
Journal of mammary gland biology and neoplasia
Dill R,Walker AM
12-1271 was used in Flow cytometry/Cell sorting to investigate the role of prolactin in immune cell recruitment.
Wed Mar 01 00:00:00 EST 2017
MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.
The Journal of clinical investigation
Zhu N,Chen M,Eng R,DeJong J,Sinha AU,Rahnamay NF,Koche R,Al-Shahrour F,Minehart JC,Chen CW,Deshpande AJ,Xu H,Chu SH,Ebert BL,Roeder RG,Armstrong SA
12-1271 was used in Flow cytometry/Cell sorting to show that loss of JMJD1C substantially decreased LSC frequency and caused differentiation of MLL-AF9- and homeobox A9-driven leukemias.
Tue Mar 01 00:00:00 EST 2016
Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells.
The Journal of allergy and clinical immunology
Kim JH,Choi YJ,Lee BH,Song MY,Ban CY,Kim J,Park J,Kim SE,Kim TG,Park SH,Kim HP,Sung YC,Kim SC,Shin EC
12-1271 was used in Flow cytometry/Cell sorting to investigate how PD-1 is overexpressed in IL-17A-producing T cells in both imiquimod-treated mice and patients with psoriasis.
Sun May 01 00:00:00 EDT 2016
IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing.
The Journal of investigative dermatology
Rak GD,Osborne LC,Siracusa MC,Kim BS,Wang K,Bayat A,Artis D,Volk SW
12-1271 was used in Flow cytometry/Cell sorting to demonstrate that cutaneous injury promotes an IL-33-dependent group 2 ILC response and that abrogation of this response can impair efficient wound closure.
Mon Feb 01 00:00:00 EST 2016
A simple, accurate and universal method for quantification of PCR.
BMC biotechnology
Boulter N,Suarez FG,Schibeci S,Sunderland T,Tolhurst O,Hunter T,Hodge G,Handelsman D,Simanainen U,Hendriks E,Duggan K
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Wed Mar 09 00:00:00 EST 2016
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.
Cell reports
Barrett NA,Malouf C,Kapeni C,Bacon WA,Giotopoulos G,Jacobsen SEW,Huntly BJ,Ottersbach K
12-1271 was used in Flow cytometry/Cell sorting to elucidate the contribution of MII-AF4 in B cell acute lymphoblastic leukaemia early development in the mouse embryo.
Tue Jul 26 00:00:00 EDT 2016
The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.
PloS one
Braun J,Meixner A,Brachner A,Foisner R
12-1271 was used in Flow cytometry/Cell sorting to test whether ANKLE1 may contribute to Holliday junction resolution during DNA repair in mice.
Fri Aug 12 00:00:00 EDT 2016
ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.
eLife
Pearson C,Thornton EE,McKenzie B,Schaupp AL,Huskens N,Griseri T,West N,Tung S,Seddon BP,Uhlig HH,Powrie F
12-1271 was used in Flow cytometry/Cell sorting to investigate how a small population of innate lymphoid cells (ILCs) has large effects on immune homeostasis, showing that ILC3s produce GM-CSF to orchestrate acute intestinal inflammation.
Mon Jan 18 00:00:00 EST 2016
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Nature immunology
Laidlaw BJ,Cui W,Amezquita RA,Gray SM,Guan T,Lu Y,Kobayashi Y,Flavell RA,Kleinstein SH,Craft J,Kaech SM
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.
EMBO molecular medicine
Li C,Li W,Xiao J,Jiao S,Teng F,Xue S,Zhang C,Sheng C,Leng Q,Rudd CE,Wei B,Wang H
12-1271 was used in Flow cytometry/Cell sorting to investigate the effects of the ADAP-SKAP55 signaling module on cytotoxicity, PD-1 expression, and anti-tumour immunity.
Mon Jun 01 00:00:00 EDT 2015
Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors.
Development (Cambridge, England)
Karamitros D,Patmanidi AL,Kotantaki P,Potocnik AJ,Bähr-Ivacevic T,Benes V,Lygerou Z,Kioussis D,Taraviras S
12-1271 was used in Flow cytometry/Cell sorting to investigate the role of geminin in hematopoiesis.
Thu Jan 01 00:00:00 EST 2015
IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells.
Journal of immunology (Baltimore, Md. : 1950)
Gandhapudi SK,Tan C,Marino JH,Taylor AA,Pack CC,Gaikwad J,Van De Wiele CJ,Wren JD,Teague TK
12-1271 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which IL-18 affects T lymphopoiesis, bone marrow lymphopoiesis and T cell development.
Wed Apr 15 00:00:00 EDT 2015
A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice.
Journal of immunology (Baltimore, Md. : 1950)
Nakamura M,Shibata K,Hatano S,Sato T,Ohkawa Y,Yamada H,Ikuta K,Yoshikai Y
12-1271 was used in Flow cytometry/Cell sorting to investigate additional roles for the Notch axis in the homeostasis of γδ T cells.
Thu Jan 01 00:00:00 EST 2015
Alleviation of skin inflammation after Lin(-) cell transplantation correlates with their differentiation into myeloid-derived suppressor cells.
Scientific reports
Jeong Ryu S,Ju JM,Kim W,Bum Kim M,Hee Oh K,Sup Lee D,Lee H,Eun Oh J,Soo Park K,Young Choi E
12-1271 was used in Magnetic cell separation to study the migration, expansion and differentiation of hematopoietic stem cells in response to inflammation following HSC transplantation.
Tue Oct 06 00:00:00 EDT 2015
Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.
mBio
Jensen KD,Camejo A,Melo MB,Cordeiro C,Julien L,Grotenbreg GM,Frickel EM,Ploegh HL,Young L,Saeij JP
12-1271 was used in Flow cytometry/Cell sorting to investigate the interaction between infected host and Toxoplasma gondii strains in endemic regions, showing that secondary infection correlates with the ROP5/ROP18 allele combinations.
Tue Feb 24 00:00:00 EST 2015
Programmed death 1 regulates memory phenotype CD4 T cell accumulation, inhibits expansion of the effector memory phenotype subset and modulates production of effector cytokines.
PloS one
Charlton JJ,Tsoukatou D,Mamalaki C,Chatzidakis I
12-1271 was used in Flow cytometry/Cell sorting to demonstrate that PD-1 has an important role in determining the composition and functional aspects of the memory phenotype CD4 T cell pool.
Wed Apr 13 00:00:00 EDT 2016
Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.
Nature
Nakada D,Oguro H,Levi BP,Ryan N,Kitano A,Saitoh Y,Takeichi M,Wendt GR,Morrison SJ
12-1271 was used in Flow cytometry/Cell sorting to assess the effect of oestradiol administration on division of haematopoietic stem cells in males and females.
Thu Jan 23 00:00:00 EST 2014
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Nature immunology
Salmond RJ,Brownlie RJ,Morrison VL,Zamoyska R
12-1271 was used in Flow cytometry/Cell sorting to study how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity.
Mon Sep 01 00:00:00 EDT 2014
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.
The Journal of clinical investigation
Li J,Razumilava N,Gores GJ,Walters S,Mizuochi T,Mourya R,Bessho K,Wang YH,Glaser SS,Shivakumar P,Bezerra JA
12-1271 was used in Flow cytometry/Cell sorting to demonstrate the role of the Th2-promoting cytokine, IL-33, in cholangiocyte proliferation.
Tue Jul 01 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Molecular and cellular biology
Kahlfuß S,Simma N,Mankiewicz J,Bose T,Lowinus T,Klein-Hessling S,Sprengel R,Schraven B,Heine M,Bommhardt U
12-1271 was used in Flow cytometry/Cell sorting to investigate the effect of NMDAR antagonists on T-cell function, showing that antagonists cause immunosuppression via inhibition of Kv1.3 and KCa3.1 channels in T-cells.
Sat Mar 01 00:00:00 EST 2014
Autophagy is a critical regulator of memory CD8(+) T cell formation.
eLife
Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK
12-1271 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.
Tue Nov 11 00:00:00 EST 2014
Vector transmission regulates immune control of Plasmodium virulence.
Nature
Spence PJ,Jarra W,Lévy P,Reid AJ,Chappell L,Brugat T,Sanders M,Berriman M,Langhorne J
12-1271 was used in Flow cytometry/Cell sorting to interrogate the regulation of parasite virulence using mosquito transmission of serially blood passaged Plasmodium chabaudi chabaudi.
Thu Jun 13 00:00:00 EDT 2013
The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.
Nature immunology
Bell BD,Kitajima M,Larson RP,Stoklasek TA,Dang K,Sakamoto K,Wagner KU,Kaplan DH,Reizis B,Hennighausen L,Ziegler SF
12-1271 was used in Flow cytometry/Cell sorting to investigate how type-2 immunity is affected by STAT5 transcription factor in dendritic cells.
Mon Apr 01 00:00:00 EDT 2013
A cell-intrinsic requirement for NF-κB-inducing kinase in CD4 and CD8 T cell memory.
Journal of immunology (Baltimore, Md. : 1950)
Rowe AM,Murray SE,Raué HP,Koguchi Y,Slifka MK,Parker DC
12-1271 was used in Flow cytometry/Cell sorting to assess the cell-intrinsic role of NF-κB-inducing kinase in murine T cell function.
Tue Oct 01 00:00:00 EDT 2013
Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L
12-1271 was used in Flow cytometry/Cell sorting to elucidate the role of LSECtin in pathogenesis of viral infection, showing that its absence led to increased frequency in intrahepatic CTLs, leading to accelerated liver adenovirus clearance.
Mon Apr 15 00:00:00 EDT 2013
IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Kamijo S,Takeda H,Tokura T,Suzuki M,Inui K,Hara M,Matsuda H,Matsuda A,Oboki K,Ohno T,Saito H,Nakae S,Sudo K,Suto H,Ichikawa S,Ogawa H,Okumura K,Takai T
12-1271 was used in Flow cytometry/Cell sorting to examine the role of protease allergens in the induction of Ab production and airway inflammation.
Wed May 01 00:00:00 EDT 2013
A non-redundant function of cyclin E1 in hematopoietic stem cells.
Cell cycle (Georgetown, Tex.)
Campaner S,Viale A,De Fazio S,Doni M,De Franco F,D'Artista L,Sardella D,Pelicci PG,Amati B
12-1271 was used in Flow cytometry/Cell sorting to support a role for cyclin E1 in controlling the exit from quiescence in hematopoietic stem cells.
Sun Dec 01 00:00:00 EST 2013
Ontogeny and localization of the cells produce IL-2 in healthy animals.
Cytokine
Yamamoto M,Seki Y,Iwai K,Ko I,Martin A,Tsuji N,Miyagawa S,Love RB,Iwashima M
12-1271 was used in Flow cytometry/Cell sorting to study how a group of Tr1 cells may have additional roles in immune homeostasis through IL-2 production to aid in the maintenance of other regulatory T cells..
Fri Mar 01 00:00:00 EST 2013
A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation.
Nature immunology
Ochiai K,Maienschein-Cline M,Mandal M,Triggs JR,Bertolino E,Sciammas R,Dinner AR,Clark MR,Singh H
Published figure using CD127 monoclonal antibody (Product # 12-1271-82) in Flow Cytometry
Sun Jan 22 00:00:00 EST 2012
Transcription factor RORα is critical for nuocyte development.
Nature immunology
Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN
12-1271 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.
Sun Jan 22 00:00:00 EST 2012
IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis.
PLoS pathogens
Owens BM,Beattie L,Moore JW,Brown N,Mann JL,Dalton JE,Maroof A,Kaye PM
12-1271 was used in Flow cytometry/Cell sorting to demonstrate that only CD11c(hi) dendritic cells that produce both IL-10 and IL-27 are capable of inducing IL-10-producing Th1 cells in vivo.
Tue Jan 29 00:00:00 EST 2013
Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors.
Journal of immunology (Baltimore, Md. : 1950)
Notake T,Horisawa S,Sanjo H,Miyagawa S,Hida S,Taki S
12-1271 was used in Flow cytometry/Cell sorting to investigate the mechanisms behind the generation and function of NKR(+) T cells.
Tue May 15 00:00:00 EDT 2012
Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4.
International immunology
Iseki M,Omori-Miyake M,Xu W,Sun X,Takaki S,Rawlings DJ,Ziegler SF
12-1271 was used in Flow cytometry/Cell sorting to demonstrate that thymic stromal lymphopoietin levels are an important factor in B-cell homeostasis and humoral autoimmunity.
Thu Mar 01 00:00:00 EST 2012
The recall response induced by genital challenge with Chlamydia muridarum protects the oviduct from pathology but not from reinfection.
Infection and immunity
Riley MM,Zurenski MA,Frazer LC,O'Connell CM,Andrews CW,Mintus M,Darville T
12-1271 was used in Flow cytometry/Cell sorting to indicate that exposure to a live vaccine with virulent chlamydiae promotes anamnestic antibody and T cell responses that protect the oviduct from pathology.
Fri Jun 01 00:00:00 EDT 2012
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
The Journal of experimental medicine
Mortensen M,Soilleux EJ,Djordjevic G,Tripp R,Lutteropp M,Sadighi-Akha E,Stranks AJ,Glanville J,Knight S,Jacobsen SE,Kranc KR,Simon AK
12-1271 was used in Flow cytometry/Cell sorting to show that Atg7 is an essential regulator of adult hematopoietic stem cell maintenance.
Mon Mar 14 00:00:00 EDT 2011
Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress.
Antioxidants & redox signaling
Lorenzo LP,Chen H,Shatynski KE,Clark S,Yuan R,Harrison DE,Yarowsky PJ,Williams MS
12-1271 was used in Flow cytometry/Cell sorting to identify a link between oxidative stress and diminished IL-7Rα expression and function associated with defective haematologic development in a DS mouse model.
Sat Oct 15 00:00:00 EDT 2011
IL-7 determines the homeostatic fitness of T cells by distinct mechanisms at different signalling thresholds in vivo.
European journal of immunology
Pearson C,Silva A,Saini M,Seddon B
12-1271 was used in Flow cytometry/Cell sorting to study the molecular mechanisms by which IL-7 regulates the homeostatic fitness of T cells.
Thu Dec 01 00:00:00 EST 2011
One naive T cell, multiple fates in CD8+ T cell differentiation.
The Journal of experimental medicine
Gerlach C,van Heijst JW,Swart E,Sie D,Armstrong N,Kerkhoven RM,Zehn D,Bevan MJ,Schepers K,Schumacher TN
12-1271 was used in Flow cytometry/Cell sorting to assess the potential for development of single naive T cells into different subsets.
Mon Jun 07 00:00:00 EDT 2010
Immunization with live attenuated influenza viruses that express altered NS1 proteins results in potent and protective memory CD8+ T-cell responses.
Journal of virology
Mueller SN,Langley WA,Carnero E,García-Sastre A,Ahmed R
12-1271 was used in Flow cytometry/Cell sorting to assess the generation of prime protective immunity by live attenuated influenza viruses expressing truncated NS1 proteins.
Mon Feb 01 00:00:00 EST 2010
Heterogeneity among viral antigen-specific CD4+ T cells and their de novo recruitment during persistent polyomavirus infection.
Journal of immunology (Baltimore, Md. : 1950)
Lin E,Kemball CC,Hadley A,Wilson JJ,Hofstetter AR,Pack CD,Lukacher AE
12-1271 was used in Flow cytometry/Cell sorting to investigate the heterogeneity in the viral antigen-specific CD4+ T cell responses to chronic polyomavirus infection.
Sun Aug 01 00:00:00 EDT 2010
Qualitatively different memory CD8+ T cells are generated after lymphocytic choriomeningitis virus and influenza virus infections.
Journal of immunology (Baltimore, Md. : 1950)
Mueller SN,Langley WA,Li G,García-Sastre A,Webby RJ,Ahmed R
12-1271 was used in Flow cytometry/Cell sorting to characterise memory CD8(+) T cells generated after respiratory influenza virus infection and compare them with memory T cells generated after lymphocytic choriomeningitis virus infection.
Sun Aug 15 00:00:00 EDT 2010
The interaction of LCK and the CD4 co-receptor alters the dose response of T-cells to interleukin-7.
Immunology letters
Kittipatarin C,Tschammer N,Khaled AR
12-1271 was used in Flow cytometry/Cell sorting to determine that CD4 can directly sequester the co-receptor associated kinase LCK, therefore demonstrating that LCK availability modulates the response of a T-cell to IL-7.
Thu Jul 08 00:00:00 EDT 2010
iNKT cell development is orchestrated by different branches of TGF-beta signaling.
The Journal of experimental medicine
Doisne JM,Bartholin L,Yan KP,Garcia CN,Duarte N,Le Luduec JB,Vincent D,Cyprian F,Horvat B,Martel S,Rimokh R,Losson R,Benlagha K,Marie JC
12-1271 was used in Flow cytometry/Cell sorting to show that TGF-beta controls the differentiation program of iNKT cells.
Mon Jun 08 00:00:00 EDT 2009
A differentiation pathway for B1 cells in adult bone marrow.
Proceedings of the National Academy of Sciences of the United States of America
Esplin BL,Welner RS,Zhang Q,Borghesi LA,Kincade PW
12-1271 was used in Flow cytometry/Cell sorting to investigate the developmental origins of the B1-specified progenitor population in adult bone marrow.
Tue Apr 07 00:00:00 EDT 2009
c-Myb is required for pro-B cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fahl SP,Crittenden RB,Allman D,Bender TP
12-1271 was used in Flow cytometry/Cell sorting to demonstrate that c-Myb is absolutely required for the survival and differentiation of CD19(+) B-lineage cells.
Sun Nov 01 00:00:00 EDT 2009
LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen.
Journal of immunology (Baltimore, Md. : 1950)
Vondenhoff MF,Greuter M,Goverse G,Elewaut D,Dewint P,Ware CF,Hoorweg K,Kraal G,Mebius RE
Fri May 01 00:00:00 EDT 2009
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.
Journal of immunology (Baltimore, Md. : 1950)
Lal G,Zhang N,van der Touw W,Ding Y,Ju W,Bottinger EP,Reid SP,Levy DE,Bromberg JS
12-1271 was used in Flow cytometry/Cell sorting to investigate Foxp3 as the master switch for Tregs, showing that expression is regulated by DNA methylation in Tregs.
Thu Jan 01 00:00:00 EST 2009
Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin.
Journal of immunology (Baltimore, Md. : 1950)
French JD,Roark CL,Born WK,O'Brien RL
12-1271 was used in Flow cytometry/Cell sorting to investigate the role of β2-microglobulin in regulating gamma-delta T lymphocyte homeostasis.
Sun Feb 15 00:00:00 EST 2009
Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut.
Immunity
Tsuji M,Suzuki K,Kitamura H,Maruya M,Kinoshita K,Ivanov II,Itoh K,Littman DR,Fagarasan S
12-1271 was used in Flow cytometry/Cell sorting to investigate the sites and mechanisms for T cell-independent IgA synthesis.
Fri Aug 15 00:00:00 EDT 2008
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
12-1271 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection.
Blood
Welner RS,Pelayo R,Nagai Y,Garrett KP,Wuest TR,Carr DJ,Borghesi LA,Farrar MA,Kincade PW
12-1271 was used in Flow cytometry/Cell sorting to show that common lymphoid progenitors from mice with active HSV-1 infection are biased to dendritic cell differentiation.
Sat Nov 01 00:00:00 EDT 2008
TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis.
The Journal of clinical investigation
Wang H,Peters T,Sindrilaru A,Kess D,Oreshkova T,Yu XZ,Seier AM,Schreiber H,Wlaschek M,Blakytny R,Röhrbein J,Schulz G,Weiss JM,Scharffetter-Kochanek K
12-1271 was used in Flow cytometry/Cell sorting to investigate the role of Tregs in the pathogenesis of psoriasis, showing that the TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18.
Tue Jul 01 00:00:00 EDT 2008
Dicer-dependent microRNA pathway safeguards regulatory T cell function.
The Journal of experimental medicine
Liston A,Lu LF,O'Carroll D,Tarakhovsky A,Rudensky AY
12-1271 was used in Flow cytometry/Cell sorting to study regulatory T cell-mediated tolerance, showing that it is dependent on the Dicer-controlled microRNA pathway.
Mon Sep 01 00:00:00 EDT 2008
Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input.
European journal of immunology
White AJ,Withers DR,Parnell SM,Scott HS,Finke D,Lane PJ,Jenkinson EJ,Anderson G
12-1271 was used in Flow cytometry/Cell sorting to analyse the cellular and molecular requirements for the initial appearance of Aire+ medullary thymic epithelial cells in the embryonic thymus, in addition to their persistence in the adult thymus.
Tue Apr 01 00:00:00 EDT 2008
Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow.
Stem cells (Dayton, Ohio)
Singh P,Yao Y,Weliver A,Broxmeyer HE,Hong SC,Chang CH
12-1271 was used in Flow cytometry/Cell sorting to show that in vivo VV infection results in the expansion of c-Kit(hi)Sca-1+Lin- (KSL) haematopoietic stem cells.
Tue Apr 01 00:00:00 EDT 2008
Activated CD8 T cells redistribute to antigen-free lymph nodes and exhibit effector and memory characteristics.
Journal of immunology (Baltimore, Md. : 1950)
Brinkman CC,Sheasley-O'Neill SL,Ferguson AR,Engelhard VH
12-1271 was used in Flow cytometry/Cell sorting to characterise the activation and differentiation of CD8 T cells in individual lymphoid compartments over time, and their migration between compartments.
Fri Aug 01 00:00:00 EDT 2008
Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950)
Haring JS,Jing X,Bollenbacher-Reilley J,Xue HH,Leonard WJ,Harty JT
12-1271-82 was used in Sample Prep to indicate that constitutive expression of IL-7Ralpha alone was not enough to impart an expansion or survival advantage to CD8 T cells responding to infection, and did not increase memory CD8 T cell numbers over those observed in wild-type controls.
Sat Mar 01 00:00:00 EST 2008
Tumor growth decreases NK and B cells as well as common lymphoid progenitor.
PloS one
Richards J,McNally B,Fang X,Caligiuri MA,Zheng P,Liu Y
12-1271 was used in Flow cytometry/Cell sorting to analyse the effects of tumour growth on lymphopoiesis in mice.
Thu Sep 11 00:00:00 EDT 2008
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.
The Journal of experimental medicine
Rossi SW,Kim MY,Leibbrandt A,Parnell SM,Jenkinson WE,Glanville SH,McConnell FM,Scott HS,Penninger JM,Jenkinson EJ,Lane PJ,Anderson G
12-1271 was used in Flow cytometry/Cell sorting to demonstrate a novel role for a CD4(+)3(-) inducer cell population, showing that RANK signals regulate development of Aire-expressing epithelial cells in the thymic medulla.
Mon Jun 11 00:00:00 EDT 2007
Rapid default transition of CD4 T cell effectors to functional memory cells.
The Journal of experimental medicine
McKinstry KK,Golech S,Lee WH,Huston G,Weng NP,Swain SL
12-1271 was used in Flow cytometry/Cell sorting to follow well-defined cohorts of CD4 T cells through the effector-to-memory transition by analyzing phenotype, important functional properties, and gene expression profiles.
Mon Sep 03 00:00:00 EDT 2007
Induction of potent CD8+ T-cell responses by novel biodegradable nanoparticles carrying human immunodeficiency virus type 1 gp120.
Journal of virology
Wang X,Uto T,Akagi T,Akashi M,Baba M
12-1271 was used in Flow cytometry/Cell sorting to attempt to construct an efficient protein-based vaccine using gamma-PGA nanoparticles, showing induction of potent CD8+ T-cell responses.
Sat Sep 01 00:00:00 EDT 2007
Beta-catenin expression enhances IL-7 receptor signaling in thymocytes during positive selection.
Journal of immunology (Baltimore, Md. : 1950)
Yu Q,Xu M,Sen JM
12-1271 was used in Flow cytometry/Cell sorting to show that beta-catenin expression augments IL-7R signaling in thymocytes during positive selection and promotes the development of CD8SP thymocytes.
Sun Jul 01 00:00:00 EDT 2007
Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.
Cell stem cell
Arinobu Y,Mizuno S,Chong Y,Shigematsu H,Iino T,Iwasaki H,Graf T,Mayfield R,Chan S,Kastner P,Akashi K
12-1271 was used in Flow cytometry/Cell sorting to investigate the mechanism and molecules involved in the initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.
Thu Oct 11 00:00:00 EDT 2007
STAT3 positively regulates an early step in B-cell development.
Blood
Chou WC,Levy DE,Lee CK
12-1271 was used in Flow cytometry/Cell sorting to study the transcription factors required for B lymphocyte development from progenitors in the bone marrow, showing that STAT3 positively regulates an early step in B-cell development.
Wed Nov 01 00:00:00 EST 2006
Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.
The American journal of pathology
Leithäuser F,Meinhardt-Krajina T,Fink K,Wotschke B,Möller P,Reimann J
Thu Jun 01 00:00:00 EDT 2006
Cytosolic entry controls CD8+-T-cell potency during bacterial infection.
Infection and immunity
Bahjat KS,Liu W,Lemmens EE,Schoenberger SP,Portnoy DA,Dubensky TW,Brockstedt DG
12-1271 was used in Flow cytometry/Cell sorting to investigate microbial invasion of the cytosol as a key factor in inducing CD8+- T cell-mediated protection against L.monocytogenes.
Wed Nov 01 00:00:00 EST 2006
Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor.
Infection and immunity
Haring JS,Harty JT
12-1271 was used in Flow cytometry/Cell sorting to investigate the role of IFN-gamma in regulating the contraction of Ag-specific CD4 T cells, showing that the absence of IFN-gamma or its receptor after infection led to aberrant contraction of antigen-specific CD4 T cells.
Wed Nov 01 00:00:00 EST 2006
Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells.
Blood
Lawrence HJ,Christensen J,Fong S,Hu YL,Weissman I,Sauvageau G,Humphries RK,Largman C
12-1271 was used in Flow cytometry/Cell sorting to suggest that Hoxa-9 is specifically required for normal hematopoietic stem cell function both in vitro and in vivo.
Thu Dec 01 00:00:00 EST 2005
Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation.
Blood
Arber C,BitMansour A,Sparer TE,Higgins JP,Mocarski ES,Weissman IL,Shizuru JA,Brown JM
12-1271 was used in Flow cytometry/Cell sorting to support the potential for composing grafts with committed progenitors to reduce susceptibility to viral infection following hematopoietic cell transplantation.
Tue Jul 15 00:00:00 EDT 2003
