Product References
A platinum@polymer-catechol nanobraker enables radio-immunotherapy for crippling melanoma tumorigenesis, angiogenesis, and radioresistance.
Bioactive materials
Li W,Yan J,Tian H,Li B,Wang G,Sang W,Zhang Z,Zhang X,Dai Y
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
Microbiota-assisted iron uptake promotes immune tolerance in the intestine.
Nature communications
Zhu L,Li G,Liang Z,Qi T,Deng K,Yu J,Peng Y,Zheng J,Song Y,Chang X
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Mon May 15 00:00:00 EDT 2023
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.
Nature communications
Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Wed Feb 16 00:00:00 EST 2022
Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates.
NPJ vaccines
Seenappa LM,Jakubowski A,Steinbuck MP,Palmer E,Haqq CM,Carter C,Fontenot J,Villinger F,McNeil LK,DeMuth PC
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Fri Oct 28 00:00:00 EDT 2022
Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
eLife
Tomasek K,Leithner A,Glatzova I,Lukesch MS,Guet CC,Sixt M
12-0621-82 was used in flow cytometry to identify CD14, the major co-receptor for lipopolysaccharide detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein located at the tip of the type 1 pilus of Escherichia coli.
Tue Jul 26 00:00:00 EDT 2022
Cytosolic Nuclear Sensor Dhx9 Controls Medullary Thymic Epithelial Cell Differentiation by p53-Mediated Pathways.
Frontiers in immunology
Dong X,Zhang J,Zhang Q,Liang Z,Xu Y,Zhao Y,Zhang B
12-0621-82 was used in Flow cytometry/Cell sorting to reveal that Dhx9, a cytosolic nuclear sensor recognizes viral DNA or RNA, playing an important role in mTEC development and function in mice.
Tue Jun 21 00:00:00 EDT 2022
Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination.
EMBO molecular medicine
Müller K,Gibbins MP,Roberts M,Reyes-Sandoval A,Hill AVS,Draper SJ,Matuschewski K,Silvie O,Hafalla JCR
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Fri Apr 09 00:00:00 EDT 2021
Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.
Frontiers in cell and developmental biology
Zhang Q,Liang Z,Zhang J,Lei T,Dong X,Su H,Chen Y,Zhang Z,Tan L,Zhao Y
12-0621-82 was used in Flow Cytometry to reveal that the expression of epigenetic regulator Sirt6 in TECs is crucial for the development and differentiation of mTECs, which highlights the importance of Sirt6 in the establishment of central immune tolerance.
Wed Apr 21 00:00:00 EDT 2021
Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.
Frontiers in cell and developmental biology
Zhang Q,Liang Z,Zhang J,Lei T,Dong X,Su H,Chen Y,Zhang Z,Tan L,Zhao Y
12-0621-82 was used in Flow Cytometry to reveal that the expression of epigenetic regulator Sirt6 in TECs is crucial for the development and differentiation of mTECs, which highlights the importance of Sirt6 in the establishment of central immune tolerance.
Wed Apr 21 00:00:00 EDT 2021
Trichinella spiralis Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease.
Frontiers in cell and developmental biology
Hao C,Wang W,Zhan B,Wang Z,Huang J,Sun X,Zhu X
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue Aug 03 00:00:00 EDT 2021
CD8+ T cells in the central nervous system of mice with herpes simplex infection are highly activated and express high levels of CCR5 and CXCR3.
Journal of neurovirology
Lind L,Svensson A,Thörn K,Krzyzowska M,Eriksson K
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
cDC1 Dependent Accumulation of Memory T Cells Is Required for Chronic Autoimmune Inflammation in Murine Testis.
Frontiers in immunology
Jing Y,Cao M,Zhang B,Long X,Wang X
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Fri Sep 24 00:00:00 EDT 2021
Evaluation of DNA-Launched Virus-Like Particle Vaccines in an Immune Competent Mouse Model of Chikungunya Virus Infection.
Vaccines
Rayner JO,Kim JH,Roberts RW,Wood RR,Fouty B,Solodushko V
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Fri Apr 02 00:00:00 EDT 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.
iScience
AbuEid M,McAllister DM,McOlash L,Harwig MC,Cheng G,Drouillard D,Boyle KA,Hardy M,Zielonka J,Johnson BD,Hill RB,Kalyanaraman B,Dwinell MB
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.
Nature communications
Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Thu Dec 09 00:00:00 EST 2021
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Cell reports
Budhu S,Giese R,Gupta A,Fitzgerald K,Zappasodi R,Schad S,Hirschhorn D,Campesato LF,De Henau O,Gigoux M,Liu C,Mazo G,Deng L,Barker CA,Wolchok JD,Merghoub T
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation.
Frontiers in immunology
Liu J,Liu Y,Panda S,Liu A,Lei J,Burd I
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Fri Dec 17 00:00:00 EST 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy.
Journal of neuroinflammation
Oladiran O,Shi XQ,Yang M,Fournier S,Zhang J
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Mon Mar 22 00:00:00 EDT 2021
STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.
Cellular and molecular gastroenterology and hepatology
Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Mon Jan 24 00:00:00 EST 2022
A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.
Nature communications
Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Thu Sep 30 00:00:00 EDT 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue Jan 11 00:00:00 EST 2022
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue Jan 11 00:00:00 EST 2022
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
12-0621-82 was used in Flow Cytometry to provide a protocol for analysis of T cell activation and cytokine production in the thymus, spleen, and blood.
Fri Mar 19 00:00:00 EDT 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
12-0621-82 was used in Flow Cytometry to provide a protocol for analysis of T cell activation and cytokine production in the thymus, spleen, and blood.
Fri Mar 19 00:00:00 EDT 2021
Superoxide Dismutase 3 Controls the Activation and Differentiation of CD4+T Cells.
Frontiers in immunology
Agrahari G,Sah SK,Bang CH,Kim YH,Kim TY
12-0621-82 was used in Flow Cytometry to show that SOD3 can attenuate CD4+T cell activation through modulation of the downstream signalings and restrict CD4+T cell differentiation.
Tue Aug 03 00:00:00 EDT 2021
B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.
Cell reports
Biram A,Winter E,Denton AE,Zaretsky I,Dassa B,Bemark M,Linterman MA,Yaari G,Shulman Z
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue Feb 11 00:00:00 EST 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue Jan 14 00:00:00 EST 2020
Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury.
Cell & bioscience
Mao L,Zhou Y,Chen L,Hu L,Liu S,Zheng W,Zhao J,Guo M,Chen C,He Z,Xu L
12-0621-82 was used in Flow Cytometry to reveal an unknown role of atypical MAPKs member MAPK4 in the pathology of acute lung injury.
Sun Apr 17 00:00:00 EDT 2022
Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells.
Cell reports
Morelli AE,Sumpter TL,Rojas-Canales DM,Bandyopadhyay M,Chen Z,Tkacheva O,Shufesky WJ,Wallace CT,Watkins SC,Berger A,Paige CJ,Falo LD,Larregina AT
12-0621 was used in Flow cytometry/Cell sorting to demonstrate an effect of the NK1R in T cells that is relevant for immunotherapies based on pro-inflammatory neuropeptides and its receptors.
Tue Mar 10 00:00:00 EDT 2020
Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.
Science advances
Chao Y,Liang C,Tao H,Du Y,Wu D,Dong Z,Jin Q,Chen G,Xu J,Xiao Z,Chen Q,Wang C,Chen J,Liu Z
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2020
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.
Immunity
Martínez-López M,Iborra S,Conde-Garrosa R,Mastrangelo A,Danne C,Mann ER,Reid DM,Gaboriau-Routhiau V,Chaparro M,Lorenzo MP,Minnerup L,Saz-Leal P,Slack E,Kemp B,Gisbert JP,Dzionek A,Robinson MJ,Rupérez FJ,Cerf-Bensussan N,Brown GD,Bernardo D,LeibundGut-Landmann S,Sancho D
12-0621-82 was used in Flow Cytometry to conclude that sensing of commensals by Mincle and Syk signaling in CD11c+ cells reinforces intestinal immune barrier and promotes host-microbiota mutualism, preventing systemic inflammation.
Tue Feb 19 00:00:00 EST 2019
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
Nature communications
Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Wed Mar 20 00:00:00 EDT 2019
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
Nature communications
Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Wed Mar 20 00:00:00 EDT 2019
Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.
Cell reports
Choi H,Deng J,Li S,Silk T,Dong L,Brea EJ,Houghton S,Redmond D,Zhong H,Boiarsky J,Akbay EA,Smith PD,Merghoub T,Wong KK,Wolchok JD
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue Apr 16 00:00:00 EDT 2019
Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome.
Nature communications
Komban RJ,Strömberg A,Biram A,Cervin J,Lebrero-Fernández C,Mabbott N,Yrlid U,Shulman Z,Bemark M,Lycke N
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Mon Jun 03 00:00:00 EDT 2019
Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome.
Nature communications
Komban RJ,Strömberg A,Biram A,Cervin J,Lebrero-Fernández C,Mabbott N,Yrlid U,Shulman Z,Bemark M,Lycke N
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Mon Jun 03 00:00:00 EDT 2019
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
Cell reports
Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS
12-0621-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.
Tue Sep 17 00:00:00 EDT 2019
ImmGen report: sexual dimorphism in the immune system transcriptome.
Nature communications
Gal-Oz ST,Maier B,Yoshida H,Seddu K,Elbaz N,Czysz C,Zuk O,Stranger BE,Ner-Gaon H,Shay T
12-0621 was used in Flow cytometry/Cell sorting to show transcriptional sexual dimorphism in macrophages.
Fri Sep 20 00:00:00 EDT 2019
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.
Cell reports
Ciecko AE,Foda B,Barr JY,Ramanathan S,Atkinson MA,Serreze DV,Geurts AM,Lieberman SM,Chen YG
12-0621-82 was used in Flow Cytometry to reveal that IL-27 contributes to autoimmunity in NOD mice through multiple mechanisms and provides substantial evidence to support its pathogenic role in human T1D.
Tue Dec 03 00:00:00 EST 2019
Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells.
Cell reports
Tomaru U,Konno S,Miyajima S,Kimoto R,Onodera M,Kiuchi S,Murata S,Ishizu A,Kasahara M
12-0621 was used in Flow cytometry/Cell sorting to find that thymoproteasomes are essential for positive selection but that the subsequent change in peptide repertoire in the medulla is also crucial for thymic selection and that β5t-derived peptide must be confined to the thymus to avoid autoimmunity in peripheral tissues.
Tue Jan 15 00:00:00 EST 2019
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Nature neuroscience
Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J
12-0621 was used in Flow cytometry/Cell sorting to demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner.
Mon Oct 01 00:00:00 EDT 2018
MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.
Autophagy
Liang Z,Zhang L,Su H,Luan R,Na N,Sun L,Zhao Y,Zhang X,Zhang Q,Li J,Zhang L,Zhao Y
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Fri Mar 22 00:00:00 EDT 2019
Stimulator of Interferon Genes in Classical Dendritic Cells Controls Mucosal Th17 Responses to Cyclic Dinucleotides for Host Defenses Against Microbial Infections in Gut.
Frontiers in immunology
Liu S,Xia Q,Wu X,Sun F,Hu Q,Wu J,Wang M,Rao Q,Guan W
12-0621 was used in Flow cytometry/Cell sorting to show that STING in mucosal cDCs controls Th17 subspecification, essential for host defence against microbial infection in gut-associated immune system.
Wed Nov 20 00:00:00 EST 2019
The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts.
Frontiers in immunology
Baur J,Otto C,Steger U,Klein-Hessling S,Muhammad K,Pusch T,Murti K,Wismer R,Germer CT,Klein I,Müller N,Serfling E,Avots A
12-0621 was used in Flow cytometry/Cell sorting to show that the activity of nuclear factors of activated T cells-c1 supports the acute rejection of heterotopic heart allografts.
Wed Nov 20 00:00:00 EST 2019
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
12-0621-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans.
JCI insight
Verghese DA,Chun N,Paz K,Fribourg M,Woodruff TM,Flynn R,Hu Y,Xiong H,Zhang W,Yi Z,Du J,Blazar BR,Heeger PS
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Thu Dec 20 00:00:00 EST 2018
Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection.
Nature communications
Rolot M,Dougall AM,Chetty A,Javaux J,Chen T,Xiao X,Machiels B,Selkirk ME,Maizels RM,Hokke C,Denis O,Brombacher F,Vanderplasschen A,Gillet L,Horsnell WGC,Dewals BG
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue Oct 30 00:00:00 EDT 2018
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.
Nature communications
Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y
12-0621 was used in Flow cytometry/Cell sorting to assess the efficacy of a personalised cancer vaccine for eliciting postsurgical tumour specific-immunity.
Wed Apr 18 00:00:00 EDT 2018
Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens.
Cell host & microbe
Bouziat R,Biering SB,Kouame E,Sangani KA,Kang S,Ernest JD,Varma M,Brown JJ,Urbanek K,Dermody TS,Ng A,Hinterleitner R,Hwang S,Jabri B
12-0621-82 was used in Flow cytometry/Cell sorting to show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces TH1 immunity to dietary antigen.
Wed Nov 14 00:00:00 EST 2018
Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.
Immunity, inflammation and disease
Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P
Fri Jun 01 00:00:00 EDT 2018
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Nature
Levine AG,Mendoza A,Hemmers S,Moltedo B,Niec RE,Schizas M,Hoyos BE,Putintseva EV,Chaudhry A,Dikiy S,Fujisawa S,Chudakov DM,Treuting PM,Rudensky AY
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Thu Jun 15 00:00:00 EDT 2017
Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells.
Immunity
Mildner A,Schönheit J,Giladi A,David E,Lara-Astiaso D,Lorenzo-Vivas E,Paul F,Chappell-Maor L,Priller J,Leutz A,Amit I,Jung S
12-0621 was used in Flow cytometry/Cell sorting to characterise the population and single cell transcriptomes, as well as enhancer and promoter landscapes of the murine monocyte compartment.
Tue May 16 00:00:00 EDT 2017
Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.
Immunity
Essig K,Hu D,Guimaraes JC,Alterauge D,Edelmann S,Raj T,Kranich J,Behrens G,Heiseke A,Floess S,Klein J,Maiser A,Marschall S,Hrabĕ de Angelis M,Leonhardt H,Calkhoven CF,Noessner E,Brocker T,Huehn J,Krug AB,Zavolan M,Baumjohann D,Heissmeyer V
12-0621-82 was used in Flow Cytometry to show Roquin-mediated control of PI3K-mTOR signaling prevents autoimmunity by restraining activation and differentiation of conventional T cells and specialization of Treg cells.
Tue Dec 19 00:00:00 EST 2017
Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.
Cancer cell
Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Mon Dec 11 00:00:00 EST 2017
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
12-0621 was used in Flow cytometry/Cell sorting to show that miR-27 has a role in regulating Treg immune cells and that correct control of miR-27 expression is important to safeguard immunological tolerance..
Wed Feb 01 00:00:00 EST 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
12-0621 was used in Flow cytometry/Cell sorting to define a fundamental function of Egr2 and Egr3, operating as a checkpoint controlling the transition between clonal expansion and differentiation of effector T cells.
Mon Jun 05 00:00:00 EDT 2017
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
The Journal of experimental medicine
Lehmann CHK,Baranska A,Heidkamp GF,Heger L,Neubert K,Lühr JJ,Hoffmann A,Reimer KC,Brückner C,Beck S,Seeling M,Kießling M,Soulat D,Krug AB,Ravetch JV,Leusen JHW,Nimmerjahn F,Dudziak D
12-0621 was used in Flow cytometry/Cell sorting to suggest that targeting antigens to FcγRs on DCs may be a promising approach to raise immunogenic or tolerogenic T cell responses to antigens of choice.
Mon May 01 00:00:00 EDT 2017
Modulation of Endoplasmic Reticulum Stress Controls CD4+ T-cell Activation and Antitumor Function.
Cancer immunology research
Thaxton JE,Wallace C,Riesenberg B,Zhang Y,Paulos CM,Beeson CC,Liu B,Li Z
12-0621 was used in Flow cytometry/Cell sorting to investigate whether the endoplasmic reticulum stress response may be important for CD4+ T-cell activation and whether gp96 is integral to this process.
Tue Aug 01 00:00:00 EDT 2017
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice.
Neurobiology of disease
MacPherson KP,Sompol P,Kannarkat GT,Chang J,Sniffen L,Wildner ME,Norris CM,Tansey MG
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Thu Jun 01 00:00:00 EDT 2017
The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue Aug 15 00:00:00 EDT 2017
Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.
EBioMedicine
Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H
12-0621 was used in Flow cytometry/Cell sorting to show that Batf3-/-Apoe-/- mice, lacking CD8α+ DCs, exhibited a significant reduction in atherogenesis and T help 1 (Th1) cells compared with Apoe-/- controls.
Sat Apr 01 00:00:00 EDT 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy.
EBioMedicine
Lázár-Molnár E,Scandiuzzi L,Basu I,Quinn T,Sylvestre E,Palmieri E,Ramagopal UA,Nathenson SG,Guha C,Almo SC
12-0621 was used in Flow cytometry/Cell sorting to highlight the value of structural considerations in the design of a PD-1 Ig fusion protein with immune modulatory properties.
Wed Mar 01 00:00:00 EST 2017
NFATc1 controls the cytotoxicity of CD8+ T cells.
Nature communications
Klein-Hessling S,Muhammad K,Klein M,Pusch T,Rudolf R,Flöter J,Qureischi M,Beilhack A,Vaeth M,Kummerow C,Backes C,Schoppmeyer R,Hahn U,Hoth M,Bopp T,Berberich-Siebelt F,Patra A,Avots A,Müller N,Schulze A,Serfling E
12-0621 was used in Flow cytometry/Cell sorting to indicate that NFATc1 is an important regulator of cytotoxic T lymphocyte effector functions.
Mon Sep 11 00:00:00 EDT 2017
The impact of environmental enrichment on the murine inflammatory immune response.
JCI insight
Brod S,Gobbetti T,Gittens B,Ono M,Perretti M,D'Acquisto F
12-0621 was used in Flow Cytometry to investigate the impact of environmental enrichment on the murine inflammatory immune response.
Thu Apr 06 00:00:00 EDT 2017
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
Nature immunology
Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC
12-0621 was used in Flow cytometry/Cell sorting to demonstrate that inflammatory signals and Foxp3 balance mTORC1 signaling and glucose metabolism to control the proliferation and suppressive function of Treg cells.
Thu Dec 01 00:00:00 EST 2016
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
12-0621 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4.
Frontiers in immunology
Zhao J,Chen C,Guo M,Tao Y,Cui P,Zhou Y,Qin N,Zheng J,Zhang J,Xu L
12-0621 was used in Flow cytometry/Cell sorting to study the role of microRNA-7 in acute lung injury, allowing the development of new therapeutic strategies against inflammatory lung disease.
Wed Mar 16 00:00:00 EDT 2022
Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.
Immunology
Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H
12-0621 was used in In vitro assays to identify a novel pathway of cross-talk between macrophages and dendritic cells.
Sat Oct 01 00:00:00 EDT 2016
Antigen-specific T cells fully conserve antitumour function following cryopreservation.
Immunology and cell biology
Galeano Niño JL,Kwan RY,Weninger W,Biro M
12-0621 was used in Flow cytometry/Cell sorting to show that cryopreservation fully conserves the antitumour function of antigen-specific T-cells.
Fri Apr 01 00:00:00 EDT 2016
Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade.
Disease models & mechanisms
Atkinson SM,Hoffmann U,Hamann A,Bach E,Danneskiold-Samsøe NB,Kristiansen K,Serikawa K,Fox B,Kruse K,Haase C,Skov S,Nansen A
12-0621 was used in Flow cytometry/Cell sorting to investigate the role of regulatory T cells in delayed-type hypersensitivity arthritis through depletion, and the rescuing effect of IL-7 in connection to regulatory T cell depletion.
Fri Apr 01 00:00:00 EDT 2016
G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way.
Journal of immunology (Baltimore, Md. : 1950)
Perobelli SM,Mercadante AC,Galvani RG,Gonçalves-Silva T,Alves AP,Pereira-Neves A,Benchimol M,Nóbrega A,Bonomo A
12-0621 was used in Flow cytometry/Cell sorting to study the role of incoming IL-10+ neutrophils from G-CSF-treated donor spleen in inhibiting acute graft-versus-host disease.
Tue Nov 01 00:00:00 EDT 2016
Helios Controls a Limited Subset of Regulatory T Cell Functions.
Journal of immunology (Baltimore, Md. : 1950)
Sebastian M,Lopez-Ocasio M,Metidji A,Rieder SA,Shevach EM,Thornton AM
12-0621 was used in Flow cytometry/Cell sorting to determine the beneficial effects of the transcription factor, Helios, for Treg maintenance, differentiation, and survival.
Fri Jan 01 00:00:00 EST 2016
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sood S,Brownlie RJ,Garcia C,Cowan G,Salmond RJ,Sakaguchi S,Zamoyska R
12-0621 was used in Flow cytometry/Cell sorting to show that small perturbations in TCR signal transduction pathways can have profound consequences on T cell differentiation and the development of autoimmune disease.
Fri Jul 15 00:00:00 EDT 2016
Dynamic regulation of effector IFN-γ-producing and IL-17-producing T cell subsets in the development of acute graft-versus-host disease.
Molecular medicine reports
Zhao K,Ruan S,Yin L,Zhao D,Chen C,Pan B,Zeng L,Li Z,Xu K
12-0621 was used in Flow cytometry/Cell sorting to investigate the dynamic changes of alloantigen-specific effector CD4+ T and CD8+ T cell subsets which produce inflammatory cytokines involved in the multistep GVHD pathogenesis progress.
Mon Feb 01 00:00:00 EST 2016
The impact of ranitidine on monocyte responses in the context of solid tumors.
Oncotarget
Vila-Leahey A,Rogers D,Marshall JS
12-0621 was used in Flow cytometry/Cell sorting to examine the impact of oral ranitidine treatment on multiple murine tumour models.
Tue Mar 08 00:00:00 EST 2016
Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease.
Nature medicine
Chimen M,McGettrick HM,Apta B,Kuravi SJ,Yates CM,Kennedy A,Odedra A,Alassiri M,Harrison M,Martin A,Barone F,Nayar S,Hitchcock JR,Cunningham AF,Raza K,Filer A,Copland DA,Dick AD,Robinson J,Kalia N,Walker LSK,Buckley CD,Nash GB,Narendran P,Rainger GE
12-0621 was used in Flow cytometry/Cell sorting to demonstrate that exogenous PEPITEM reduces T cell recruitment into inflamed tissues in multiple animal models of autoimmune, inflammatory diseases.
Fri May 01 00:00:00 EDT 2015
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Nature immunology
Basu R,Whitley SK,Bhaumik S,Zindl CL,Schoeb TR,Benveniste EN,Pear WS,Hatton RD,Weaver CT
12-0621 was used in Flow cytometry/Cell sorting to assess the ability of IL-1 to override retinoic acid-mediated expression of the transcription factor Foxp3 and induce protective TH17 cell responses.
Sun Mar 01 00:00:00 EST 2015
Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.
The Journal of experimental medicine
Sawada Y,Honda T,Hanakawa S,Nakamizo S,Murata T,Ueharaguchi-Tanada Y,Ono S,Amano W,Nakajima S,Egawa G,Tanizaki H,Otsuka A,Kitoh A,Dainichi T,Ogawa N,Kobayashi Y,Yokomizo T,Arita M,Nakamura M,Miyachi Y,Kabashima K
12-0621 was used in Flow cytometry/Cell sorting to study the inhibition of dendritic cell migration in the skin and the attenuation of contact hypersensitivity responses via Resolvin E1.
Mon Oct 19 00:00:00 EDT 2015
IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ.
PLoS pathogens
Liu G,Xu J,Wu H,Sun D,Zhang X,Zhu X,Magez S,Shi M
12-0621 was used in Flow cytometry/Cell sorting to investigate the role of IL-27 in African trypanosomes infection, showing that IL-27 signalling is crucial by preventing lethal effects of CD4+ T cells and IFN-γ.
Wed Jul 01 00:00:00 EDT 2015
ACTH controls thymocyte homeostasis independent of glucocorticoids.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Talaber G,Tuckermann JP,Okret S
12-0621 was used in Flow cytometry/Cell sorting to revise the old paradigm behind compensatory thymus growth following adrenalectomy (ADX).
Mon Jun 01 00:00:00 EDT 2015
Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.
Journal of immunology (Baltimore, Md. : 1950)
Li JT,Melton AC,Su G,Hamm DE,LaFemina M,Howard J,Fang X,Bhat S,Huynh KM,O'Kane CM,Ingram RJ,Muir RR,McAuley DF,Matthay MA,Sheppard D
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2015
Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.
BioMed research international
Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
12-0621 was used in Flow cytometry/Cell sorting to alter the tumor microenvironment using immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
Thu Apr 28 00:00:00 EDT 2016
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Nature immunology
Salmond RJ,Brownlie RJ,Morrison VL,Zamoyska R
12-0621 was used in Flow cytometry/Cell sorting to study how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity.
Mon Sep 01 00:00:00 EDT 2014
Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells.
Carcinogenesis
Ravindran A,Mohammed J,Gunderson AJ,Cui X,Glick AB
12-0621 was used in Flow cytometry/Cell sorting to study how TGFβ1 signalling has a tumour-promoting role in UVB-induced skin carcinogenesis, which is mediated in part through its role in UVB-induced migration of dDC and cutaneous inflammation.
Tue Apr 01 00:00:00 EDT 2014
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Virology
Wolf AI,Strauman MC,Mozdzanowska K,Williams KL,Osborne LC,Shen H,Liu Q,Garlick D,Artis D,Hensley SE,Caton AJ,Weiser JN,Erikson J
12-0621-82 was used in Flow Cytometry to investigate severity of influenza virus response with respiratory microbe presence.
Fri Aug 01 00:00:00 EDT 2014
Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms.
F1000Research
Niebling J,E Rünker A,Schallenberg S,Kretschmer K,Kempermann G
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Fri Mar 06 00:00:00 EST 2020
STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells.
JAK-STAT
Glosson-Byers NL,Sehra S,Kaplan MH
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2015
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.
Nature communications
Fu H,Kishore M,Gittens B,Wang G,Coe D,Komarowska I,Infante E,Ridley AJ,Cooper D,Perretti M,Marelli-Berg FM
12-0621 was used in Flow cytometry/Cell sorting to explain the mechanisms underlying the powerful migratory capacity of Treg cells and their ability to maintain optimal T cell ratios.
Fri Mar 14 00:00:00 EDT 2014
Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells.
PloS one
Workman AM,Jacobs AK,Vogel AJ,Condon S,Brown DM
12-0621 was used in Flow cytometry/Cell sorting to show that IL-2 signalling was necessary for induction of an immune response during influenza A infection.
Tue Jan 27 00:00:00 EST 2015
Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.
Blood
Leonhardt F,Grundmann S,Behe M,Bluhm F,Dumont RA,Braun F,Fani M,Riesner K,Prinz G,Hechinger AK,Gerlach UV,Dierbach H,Penack O,Schmitt-Gräff A,Finke J,Weber WA,Zeiser R
12-0621-82 was used in Flow Cytometry to identify negative regulation of GvHD-related neovascularization by miR-100.
Thu Apr 25 00:00:00 EDT 2013
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
The Journal of clinical investigation
Dai X,James RG,Habib T,Singh S,Jackson S,Khim S,Moon RT,Liggitt D,Wolf-Yadlin A,Buckner JH,Rawlings DJ
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Wed May 01 00:00:00 EDT 2013
TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity.
The Journal of investigative dermatology
Mohammed J,Gunderson AJ,Khong HH,Koubek RD,Udey MC,Glick AB
12-0621 was used in Flow cytometry/Cell sorting to highlight a role for keratinocyte-derived TGFβ1 in dendritic cell trafficking and in the initiation of skin inflammation.
Tue Jan 01 00:00:00 EST 2013
Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L
12-0621 was used in Flow cytometry/Cell sorting to elucidate the role of LSECtin in pathogenesis of viral infection, showing that its absence led to increased frequency in intrahepatic CTLs, leading to accelerated liver adenovirus clearance.
Mon Apr 15 00:00:00 EDT 2013
IFNAR1 controls progression to cerebral malaria in children and CD8+ T cell brain pathology in Plasmodium berghei-infected mice.
Journal of immunology (Baltimore, Md. : 1950)
Ball EA,Sambo MR,Martins M,Trovoada MJ,Benchimol C,Costa J,Antunes Gonçalves L,Coutinho A,Penha-Gonçalves C
12-0621 was used in Flow cytometry/Cell sorting to prove that IFN receptor 1 signalling unleashes CD8(+) T cell effector capacity, which is vital for cerebral malaria.
Wed May 15 00:00:00 EDT 2013
Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.
Immunity
Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK
12-0621 was used in Flow cytometry/Cell sorting to study the effect of prostaglandin E2 on the function of Th17 cells during differentiation.
Fri Apr 20 00:00:00 EDT 2012
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.
PLoS pathogens
Maelfait J,Roose K,Bogaert P,Sze M,Saelens X,Pasparakis M,Carpentier I,van Loo G,Beyaert R
12-0621 was used in Flow cytometry/Cell sorting to examine the role of the ubiquitin-editing protein A20 in the innate immune responses to IAV and other viruses.
Mon Jul 09 00:00:00 EDT 2012
Death receptor 3 is essential for generating optimal protective CD4⁺ T-cell immunity against Salmonella.
European journal of immunology
Buchan SL,Taraban VY,Slebioda TJ,James S,Cunningham AF,Al-Shamkhani A
12-0621 was used in Flow cytometry/Cell sorting to examine the role of death receptor 3 during infection with Salmonella enterica serovar Typhimurium.
Thu Mar 01 00:00:00 EST 2012
Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties.
Journal of immunology (Baltimore, Md. : 1950)
Kerzerho J,Yu ED,Barra CM,Alari-Pahissa E,Girardi E,Harrak Y,Lauzurica P,Llebaria A,Zajonc DM,Akbari O,Castaño AR
12-0621 was used in Flow cytometry/Cell sorting to assess the potential for the use of HS44 as a reagent for immune manipulation.
Thu Mar 01 00:00:00 EST 2012
Optimized protocol for the isolation of spleen-resident murine neutrophils.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Coquery CM,Loo W,Buszko M,Lannigan J,Erickson LD
12-0621 was used in Immunocytochemistry to develop a protocol to optimally isolate spleen-resistant murine neutrophils.
Sat Sep 01 00:00:00 EDT 2012
PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells.
Molecular systems biology
He F,Chen H,Probst-Kepper M,Geffers R,Eifes S,Del Sol A,Schughart K,Zeng AP,Balling R
12-0621 was used in Flow cytometry/Cell sorting to demonstrate how a new key gene, PLAU, is important for suppressor function of both human and murine Tregs.
Wed Jan 23 00:00:00 EST 2013
Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skin.
Blood
Bennett CL,Fallah-Arani F,Conlan T,Trouillet C,Goold H,Chorro L,Flutter B,Means TK,Geissmann F,Chakraverty R
12-0621 was used in Flow cytometry/Cell sorting to explore the role of Langerhans cells in the development of tissue injury using a tractable model of cutaneous graft-versus-host disease.
Thu Jun 30 00:00:00 EDT 2011
Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation.
The Journal of experimental medicine
Takizawa H,Regoes RR,Boddupalli CS,Bonhoeffer S,Manz MG
12-0621 was used in Flow cytometry/Cell sorting to investigate how often mouse hematopoietic stem cells (HSCs) divide and whether each HSC contributes simultaneously, sequentially, or repetitively to hematopoiesis, showing that entry into and exit out of the cell cycle is dynamic varies due to demand.
Mon Feb 14 00:00:00 EST 2011
Centrosome docking at the immunological synapse is controlled by Lck signaling.
The Journal of cell biology
Tsun A,Qureshi I,Stinchcombe JC,Jenkins MR,de la Roche M,Kleczkowska J,Zamoyska R,Griffiths GM
12-0621 was used in Flow cytometry/Cell sorting to investigate the role of Lck signalling in the control of centrosome docking at the immunological synapse.
Mon Feb 21 00:00:00 EST 2011
Impaired B cell development in the absence of Krüppel-like factor 3.
Journal of immunology (Baltimore, Md. : 1950)
Vu TT,Gatto D,Turner V,Funnell AP,Mak KS,Norton LJ,Kaplan W,Cowley MJ,Agenès F,Kirberg J,Brink R,Pearson RC,Crossley M
12-0621 was used in Flow cytometry/Cell sorting to examine the function of Klf3 in B cell development by studying B lymphopoiesis in a Klf3 knockout mouse model.
Tue Nov 15 00:00:00 EST 2011
Granzyme B regulates antiviral CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Salti SM,Hammelev EM,Grewal JL,Reddy ST,Zemple SJ,Grossman WJ,Grayson MH,Verbsky JW
12-0621 was used in Flow cytometry/Cell sorting to investigate the role of granzyme B in immune regulation in response to viral infections, showing it regulates antiviral CD8+ T cell responses.
Thu Dec 15 00:00:00 EST 2011
Modeling Sjögren's syndrome with Id3 conditional knockout mice.
Immunology letters
Guo Z,Li H,Han M,Xu T,Wu X,Zhuang Y
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Wed Mar 30 00:00:00 EDT 2011
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.
PloS one
Serre K,Bénézech C,Desanti G,Bobat S,Toellner KM,Bird R,Chan S,Kastner P,Cunningham AF,Maclennan IC,Mohr E
12-0621 was used in Flow cytometry/Cell sorting to reveal the selective upregulation of Helios during Th2 and TFh responses to alum-protein vaccines.
Mon Oct 17 00:00:00 EDT 2011
Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.
BMC immunology
Gustafsson K,Calounova G,Hjelm F,Kriz V,Heyman B,Grönvik KO,Mostoslavsky G,Welsh M
12-0621 was used in Flow cytometry/Cell sorting to suggest that Shb is an important modulator of TCR signalling, that can regulate the murine peripheral CD4+ Th2 cell response.
Tue Jan 11 00:00:00 EST 2011
T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.
PloS one
Moro H,Otero DC,Tanabe Y,David M
12-0621 was used in Flow cytometry/Cell sorting to demonstrate that type I interferons and STAT1 play an important role in the survival of MHC class I-restricted T cells.
Fri Feb 03 00:00:00 EST 2012
Interplay between CD8α+ dendritic cells and monocytes in response to Listeria monocytogenes infection attenuates T cell responses.
PloS one
Kapadia D,Sadikovic A,Vanloubbeeck Y,Brockstedt D,Fong L
12-0621 was used in Flow cytometry/Cell sorting to examine the contribution of different primary APCs during Listeria monocytogenes infection, showing interplay between dendritic cells and monocytes during infection.
Fri Apr 29 00:00:00 EDT 2011
Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.
The Journal of clinical investigation
Flutter B,Edwards N,Fallah-Arani F,Henderson S,Chai JG,Sivakumaran S,Ghorashian S,Bennett CL,Freeman GJ,Sykes M,Chakraverty R
12-0621 was used in Flow cytometry/Cell sorting to explore the role of recipient antigen expression by nonhaematopoietic cells in the failure to sustain effective cytotoxic T lymphocyte immunity following blood transplantation.
Mon Nov 01 00:00:00 EDT 2010
One naive T cell, multiple fates in CD8+ T cell differentiation.
The Journal of experimental medicine
Gerlach C,van Heijst JW,Swart E,Sie D,Armstrong N,Kerkhoven RM,Zehn D,Bevan MJ,Schepers K,Schumacher TN
12-0621 was used in Flow cytometry/Cell sorting to assess the potential for development of single naive T cells into different subsets.
Mon Jun 07 00:00:00 EDT 2010
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.
Journal of immunology (Baltimore, Md. : 1950)
Unsinger J,McGlynn M,Kasten KR,Hoekzema AS,Watanabe E,Muenzer JT,McDonough JS,Tschoep J,Ferguson TA,McDunn JE,Morre M,Hildeman DA,Caldwell CC,Hotchkiss RS
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2010
8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder.
Journal of immunology (Baltimore, Md. : 1950)
Singh TP,Schön MP,Wallbrecht K,Michaelis K,Rinner B,Mayer G,Schmidbauer U,Strohmaier H,Wang XJ,Wolf P
12-0621 was used in Flow cytometry/Cell sorting to elucidate the mechanism of PUVA for treatment of psoriasis, showing that inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involves CTLA4 signalling.
Tue Jun 15 00:00:00 EDT 2010
Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.
Journal of immunology (Baltimore, Md. : 1950)
Duong BH,Ota T,Aït-Azzouzene D,Aoki-Ota M,Vela JL,Huber C,Walsh K,Gavin AL,Nemazee D
12-0621 was used in Flow cytometry/Cell sorting to generate mice which ubiquitously expressed a membrane-bound IgD-superantigen, to provide a model which should facilitate studies of peripheral B cell tolerance in future.
Thu Apr 15 00:00:00 EDT 2010
Differential geminin requirement for proliferation of thymocytes and mature T cells.
Journal of immunology (Baltimore, Md. : 1950)
Karamitros D,Kotantaki P,Lygerou Z,Veiga-Fernandes H,Pachnis V,Kioussis D,Taraviras S
12-0621 was used in Flow cytometry/Cell sorting to gain insight into the in vivo role of Geminin in progenitor cell division and differentiation.
Mon Mar 01 00:00:00 EST 2010
Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Tait ED,Jordan KA,Dupont CD,Harris TH,Gregg B,Wilson EH,Pepper M,Dzierszinski F,Roos DS,Hunter CA
12-0621 was used in Flow cytometry/Cell sorting to show the dendritic cell response to T.gondii alters levels of CD8+ T cells which ultimately determine the outcome of infection.
Sun Aug 01 00:00:00 EDT 2010
Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Do JS,Fink PJ,Li L,Spolski R,Robinson J,Leonard WJ,Letterio JJ,Min B
12-0621 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the generation of gammadelta T cells, showing that it occurs via a TGF-beta 1-dependent mechanism.
Mon Feb 15 00:00:00 EST 2010
Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
Journal of immunological methods
Holl TM,Haynes BF,Kelsoe G
12-0621 was used in Flow cytometry/Cell sorting to describe a stromal cell independent culture system that efficiently supports pro-B cell to IgM+ B cell development with near normal levels of IgH and Igkappa diversity.
Wed Mar 31 00:00:00 EDT 2010
AUF1 is involved in splenic follicular B cell maintenance.
BMC immunology
Sadri N,Lu JY,Badura ML,Schneider RJ
12-0621 was used in Flow cytometry/Cell sorting to investigate the role of AUF1 in the immune system, showing that it is involved in splenic follicular B cell maintenance.
Mon Jan 11 00:00:00 EST 2010
Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis.
Cancer research
Du G,Jin L,Han X,Song Z,Zhang H,Liang W
12-0621 was used in Flow cytometry/Cell sorting to determine whether mouse models of idiopathic pulmonary fibrosis have high incidence of lung cancer, showing that Naringenin could treat lung fibrosis and metastasis.
Wed Apr 01 00:00:00 EDT 2009
Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg.
European journal of immunology
Shi Z,Okuno Y,Rifa'i M,Endharti AT,Akane K,Isobe K,Suzuki H
12-0621-82 was used in Flow Cytometry to suggest that human CD8(+)CXCR3(+) T cells are the counterparts of murine CD8(+)CD122(+) Treg.
Sat Aug 01 00:00:00 EDT 2009
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.
Journal of immunology (Baltimore, Md. : 1950)
Lal G,Zhang N,van der Touw W,Ding Y,Ju W,Bottinger EP,Reid SP,Levy DE,Bromberg JS
12-0621 was used in Flow cytometry/Cell sorting to investigate Foxp3 as the master switch for Tregs, showing that expression is regulated by DNA methylation in Tregs.
Thu Jan 01 00:00:00 EST 2009
Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen.
Journal of immunology (Baltimore, Md. : 1950)
Maroof A,Beattie L,Kirby A,Coles M,Kaye PM
12-0621 was used in Flow cytometry/Cell sorting to study how inflammation-matured DCs can induce Ag-independent T cell proliferation.
Tue Dec 01 00:00:00 EST 2009
Regulation of mature ADAM17 by redox agents for L-selectin shedding.
Journal of immunology (Baltimore, Md. : 1950)
Wang Y,Herrera AH,Li Y,Belani KK,Walcheck B
12-0621 was used in Flow cytometry/Cell sorting to investigate the target of induced ADAM17 in neutrophils.
Sun Feb 15 00:00:00 EST 2009
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
12-0621 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells.
The Journal of experimental medicine
Tajima M,Wakita D,Noguchi D,Chamoto K,Yue Z,Fugo K,Ishigame H,Iwakura Y,Kitamura H,Nishimura T
12-0621 was used in Flow cytometry/Cell sorting to reveal a critical role for interleukin 6 in the development of CD8+ T cell-dependent autoimmune colitis.
Mon May 12 00:00:00 EDT 2008
Activated CD8 T cells redistribute to antigen-free lymph nodes and exhibit effector and memory characteristics.
Journal of immunology (Baltimore, Md. : 1950)
Brinkman CC,Sheasley-O'Neill SL,Ferguson AR,Engelhard VH
12-0621 was used in Flow cytometry/Cell sorting to characterise the activation and differentiation of CD8 T cells in individual lymphoid compartments over time, and their migration between compartments.
Fri Aug 01 00:00:00 EDT 2008
Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
Journal of immunology (Baltimore, Md. : 1950)
Sahu N,Venegas AM,Jankovic D,Mitzner W,Gomez-Rodriguez J,Cannons JL,Sommers C,Love P,Sher A,Schwartzberg PL,August A
12-0621 was used in Flow cytometry/Cell sorting to determine that Itk and Txk exert their effects on Th cell differentiation/function at the level of expression.
Sat Nov 01 00:00:00 EDT 2008
Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection.
International journal for parasitology
Wanasen N,Xin L,Soong L
12-0621 was used in Flow cytometry/Cell sorting to suggest that B cell activity enhances L. amazonensis infection by promoting T cell priming and cellular migration to the infection site.
Sat Mar 01 00:00:00 EST 2008
Role of natural killer cells in modulating dendritic cell responses to Leishmania amazonensis infection.
Infection and immunity
Sanabria MX,Vargas-Inchaustegui DA,Xin L,Soong L
12-0621 was used in Flow cytometry/Cell sorting to suggest differential roles of DC-NK cell cross talk at different stages of Leishmania infection.
Sat Nov 01 00:00:00 EDT 2008
IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals.
Journal of immunology (Baltimore, Md. : 1950)
Li X,McKinstry KK,Swain SL,Dalton DK
12-0621 was used in Flow cytometry/Cell sorting to investigate IFN-γ-mediated apoptosis mechanisms of CD4+ T Cells during mycobacterial infection, which operate through induction of intra- and extracellular apoptosis signals.
Sun Jul 15 00:00:00 EDT 2007
Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.
Infection and immunity
Anis MM,Fulton SA,Reba SM,Harding CV,Boom WH
Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 12-0621-82) in Flow Cytometry
Tue May 01 00:00:00 EDT 2007
Role of interleukin-1beta in activating the CD11c(high) CD45RB- dendritic cell subset and priming Leishmania amazonensis-specific CD4+ T cells in vitro and in vivo.
Infection and immunity
Xin L,Li Y,Soong L
12-0621 was used in Flow cytometry/Cell sorting to investigate the mechanism by which the Leishmania amazonensis parasite modulates antigen-presenting cells and disrupts the immune system.
Mon Oct 01 00:00:00 EDT 2007
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.
Immunity
Nagai Y,Garrett KP,Ohta S,Bahrun U,Kouro T,Akira S,Takatsu K,Kincade PW
12-0621 was used in Flow cytometry/Cell sorting to investigate the expression of toll-like receptors on different hematopoietic stem cells and the mechanism by which they stimulate innate immune system replenishment.
Thu Jun 01 00:00:00 EDT 2006
Arming tumor-reactive T cells with costimulator B7-1 enhances therapeutic efficacy of the T cells.
Cancer research
Zheng G,Liu S,Wang P,Xu Y,Chen A
12-0621 was used in Flow cytometry/Cell sorting to establish that producing tumour-reactive T cells that ectopically express a costimulator can enhance the antitumour response.
Sat Jul 01 00:00:00 EDT 2006
Cytosolic entry controls CD8+-T-cell potency during bacterial infection.
Infection and immunity
Bahjat KS,Liu W,Lemmens EE,Schoenberger SP,Portnoy DA,Dubensky TW,Brockstedt DG
12-0621 was used in Flow cytometry/Cell sorting to investigate microbial invasion of the cytosol as a key factor in inducing CD8+- T cell-mediated protection against L.monocytogenes.
Wed Nov 01 00:00:00 EST 2006
