Antibodies for multi-color flow cytometry, functional assays, and immunohistochemistry
Invitrogen eBioscience antibodies are available conjugated to a variety of fluorophores to enable multi-color flow cytometry, functional assays, and immunohistochemistry applications. Additional antibodies to other mouse antigens including novel cell-surface molecules are available in our pipeline.
Invitrogen Immune Cell Guide
This guide provides detailed marker information for immune cell types and subtypes for both human and mouse cells, stem cells, and other cell types.
Mouse CD cellular antigens
| Antigen name | Other names | MW | Structure | Distribution | Function |
|---|---|---|---|---|---|
| CD1d | CD1.1/1.2, Ly-38 | 43-49kD | IgSF | leukocytes, intestinal epithelium | Ag presentation, mucosal immunity, with beta2m, ligand for NKT cells |
| CD2 | LFA-2, Ly-37, SRBC-R | 45-58kD | IgSF | thymocytes, T, NK, B, pre-B, myeloid, erythrocytes | adhesion, T activation, CD48 receptor |
| CD3d | T3d | 20kD | IgSF | T, thymocyte subset, NKT | TCR subunit, TCR expression & signaling |
| CD3e | T3e | 20kD | IgSF | T, thymocyte subset, NKT | TCR subunit, TCR expression & signaling |
| CD3g | T3g | 25kD | IgSF | T, thymocyte subset, NKT | TCR subunit, TCR expression & signaling |
| CD4 | Ly-4, L3T4 | 55kD | IgSF | thymocyte subset, T subset, DC | TCR coreceptor, thymic differentiation, T activation, MHC class II receptor |
| CD5 | Ly-1 | 67kD | SRCRSF | thymocytes, T, B subset (B1) | T activation, T-B interaction, CD72 receptor |
| CD6 | T12 | 100-130kD | SRCRSF | thymocytes, T, neurons, not on B | T differentiation & costimulation, CD166 receptor |
| CD7 | 40kD | IgSF | human early T marker, CD7KO has normal phenotype | ||
| CD8a | Ly-2 | 32-34kD | IgSF | thymocyte subset, T subset , DC subset, not fresh NK | TCR coreceptor, MHC class I receptor, T differentiation, homodimer or heterodimer with CD8b |
| CD8b | Ly-3 | 30kD | IgSF | thymocyte subset, T subset, not fresh NK | TCR coreceptor, MHC class I receptor, T differentiation, heterodimer with CD8a |
| CD9 | p24 | 24-27kD | TM4SF | myeloid, platelets, Tact, B subset | cell adhesion, migration, T costimulation |
| CD10 | CALLA, NEP, Mme | 100kD | type II TM | B precursors, fibroblasts, BM stromal cells | zinc-binding metalloproteinase, neutral endopeptidase ectoenzyme, B development |
| CD11a | integrin alphaL, Ly-15, Itgal | 80kD | IntgF | T, B, NK, gran, mono, mac, DC, thymocytes | CD11a / CD18 (LFA-1) receptor for ICAM-1 and ICAM-2, intercellular adhesion, T costimulation |
| CD11b | Mac-1, integrin alphaM, Itgam, CR3 | 170kD | IntgF | myeloid, NK, Tact, B subset | CD11b / CD18 receptor for CD54 and CD102, adhesion to ECM, fibrinogen, & complement iC3b |
| CD11c | p150, integrin alphaX, Itgax, CR4 | 150kD | IntgF | DC, myeloid, NK, T subset | CD11c / CD18 receptor for fibrinogen & iC3b, adhesion |
| CD13 | Aminopeptidase N, Lap1 | 150kD | Type II TM | myeloid, endothelial, DC | zinc-binding metalloproteinase, antigen processing |
| CD14 | LPS-R, Mo2 | 53-55kD | GPI-linked | mac, granlow | receptor for LPS/LBP, LPS recognition |
| CD15 | Lewis-X | CHO | transient in brain | fucosyl transferase (Fut4) | |
| CD16 | FcgammaRIII, Ly-17, Fcgr3 | 50-60kD | IgSF | NK, neutrophils, mast cells, mac | Fcgamma low affinity receptor, phagocytosis, ADCC, NK activation |
| CD18 | Integrin beta2, Itgb2 | 90-95kD | IntgF | leukocytes | with CD11a, b and c, adhesion |
| CD19 | B4 | 95kD | IgSF | B, FDC, good B lineage marker, not plasma cells | with CD21 & CD81, BCR coreceptor, B activation / differentiation |
| CD20 | Ly-44, B1, Ms4a2 | 33-37kD | TM4SF | B, T subset | B differentiation / activation |
| CD21 | CR2, CR1 | 150kD | CCRSF | B, DC | CD21 / CD35 other variants of CR2 gene, complement C3d receptor, with CD19 & CD81, BCR coreceptor |
| CD22 | Lyb-8, Siglec-2 | 140-160kD | IgSF / sialoadhesins | B | adhesion, B-mono & B-T interactions, B activation, BM homing receptor for IgD+ B cells, CD75 counter-receptor |
| CD23 | FcepsilonRII, Ly-42, Fcer1a | 45-49kD | C-type lectin | B, mono, mac, gran, platelets, FDC, not B1 cells | CD19/CD21/CD81 receptor, low affinity IgER, signaling |
| CD24a | HSA, Ly-52, Nectadrin | 35-52kD | GPI-linked | B, gran, mono, mac, Tact, erythrocytes, neurons | several isoforms, B differentiation & proliferation, adhesion, T costimulation, CD62P receptor |
| CD25 | Ly-43, p55, IL2Ralpha | 55kD | Type I TM | pre-B, pre-T, Tact, Bact, DC subset, mono, mac | low affinity IL-2 binding, with IL-2Rbeta & gamma forms IL-2 receptor high affinity, also soluble form |
| CD26 | DPP4, THAM | 110kD | Type II TM | thymocyte subset, Tact, B, NK, epithelial | dipeptidyl peptidase ectoenzyme, activation, adhesion |
| CD27 | T14, Tnfrsf7 | 45kD | TNFRSF | medullary thymocytes, T, NK, B subset | CD70 receptor, T costimulation |
| CD28 | Tp44 | 45kD | IgSF | T, thymocytes, NK | CD80 (B7-1) & B7-2 (CD86) receptor, T costimulation |
| CD29 | Integrin beta1, gpIIa, Itgb1 | 130kD | IntgF | leukocytes, fibroblasts, endothelial, epithelial | with CD49a-f (VLA-1-6), with CD51(alphavbeta1), CD29/CD49a ( VLA-1) receptor for VCAM-1, MAdCAM-1 & ECM, VLAb, adhesion, embryonic development |
| CD30 | Ki-1, Tnfrsf8 | 105-120kD | TNFRSF | Bact, Tact | CD153 receptor, lymphocyte proliferation, apoptosis, peripheral tolerance |
| CD31 | PECAM-1, pgIIa | 130-140kD | IgSF | platelets, gran, endothelial, DC, mono subset, T subset, B subset, LAK | multiple isoforms, CD38 receptor, signaling, platelet-endothelial adhesion |
| CD32 | FcgammaRII, Ly-17, Fcgr2b | 40-60kD | IgSF | mono, mac, gran, B, Tact, not NK | low affinity Fc receptor for aggregated Ig/immune complexes, ADCC |
| CD33 | Siglec-3, gp67 | 67kD | IgSF, sialoadhesins | myeloid progenitors; gran | possible role in hematopoiesis, binds sialic-acid |
| CD34 | Mucosialin | 90-120kD | Sialomucin family | hematopoietic precursors, capillary endothelial, BM stroma, mast cells | CD62L receptor, adhesion |
| CD35 | Cr1, Cr2 | 190kD | SRCRSF | B, granact, FDC | CD21 & CD35 alternative splice variants of Cr2 gene, binds C3b & C4b, adhesion, phagocytosis |
| CD36 | FAT, fatty acid translocase | 88kD | platelets, adipocytes, mono, mac, endothelial, erythrocyte | oxidized LDL receptor | |
| CD37 | TM4SF | mRNA: lymphoid, myeloid | T-B interaction | ||
| CD38 | Cd38-rs1, T10 | 42kD | Type II TM | B, marginal zone B (high), Tact, thymocyte subset, subsets in yolk sac, in fetal liver, in BM | B activation, CD31 receptor, ectoenzyme, ADP-ribosyl cyclase/hydrolase |
| CD39 | Entpd1 | 70-100kD | lymphocyteact, microglia, endothelial | ecto-nucleoside trisphosphate diphosphohydrolase | |
| CD40 | gp39 receptor, Tnfrsf5 | 45-50kD | TNFRSF | B, mono, mac, T subset, DC, endothelial, thymic epithelial, induced on cardiac myocytes | CD154 receptor, T-B interaction, B costimulation and survival, isotype-switching |
| CD41 | gpIIb, Itga2b, CD41b | 110-125kD | IntgF | platelets, megakaryocytes | with CD61 forms GPIIb/IIIa, binds fibrinogen, fibronectin, vWF & thrombospondin, platelet activation, aggregation |
| CD42 | Gp9, GPIX | 20kD | LRRF | platelets, megakaryocytes | platelet activation, aggregation |
| CD42a | GPIX, GP9 | 22 kDa | platelets, megakaryocytes | complex with CD42b, c, and d; platelet adhesion/activation | |
| CD42b | GPIbα | 145 kDa | platelets, megakaryocytes | complex with CD42b, c, and d; platelet adhesion/activation | |
| CD42c | GPIbβ | 24 kDa | platelets, megakaryocytes | complex with CD42b, c, and d; platelet adhesion/activation | |
| CD42d | GPV | 82 kDa | platelets, megakaryocytes | complex with CD42b, c, and d; platelet adhesion/activation | |
| CD43 | Leukosialin, Ly-48, Spn, sialophorin | 115 & 135kD | Type I TM | T, Tact, early B, B subset, plateletslow, not resting B, not DC | isoforms, signaling, CD54R, B survival, adhesion |
| CD44 | Pgp-1, Ly-24, HERMES | 80-95 & 130kD | broad, memory T, not platelets, or hepatocytes | binds hyaluronic acid, leukocyte adhesion/homing, T activation, tumor metastasis | |
| CD44R | variants of CD44 | restricted & varied | adhesion, metastasis, receptor for Hyaluronate | ||
| CD45 | LCA, Ly-5, Ptprc | 180-240kD | PTPR family, ASV | leukocytes, not mature erythrocytes | tyrosine phosphatase, leukocyte differentiation / activation, pan-leukocyte marker |
| CD45.1 | Ly-5.2 strains: SJL, DA, STS/A, RIII | ||||
| CD45.2 | Ly-5.1 strains: BALB/c, C3H, C57BL/6, DBA/1, DBA/2, AKR, A, 129 | ||||
| CD45R/CT1 | CT1 CHO | cytotoxic Tact | |||
| CD45R | B220 | 220kD | B, NK progenitors, LAK, Tact | ||
| CD45RA | exon A isoform | ||||
| CD45RB | 200-240kD | exon B isoform | T subset, B, mono, mac | ||
| CD45RC | 200-240kD | exon C isoform | T subset, B | ||
| CD45RO | 180kD | isoform not exons A, B, or C | Tact, Bact, DC subset | ||
| CD46 | MCP, membrane cofactor protein | CRRSF | broad | complement regulation, role in fertilization | |
| CD47 | IAP, Itgp | 50kD | IgSF | hematopoietic cells, epithelial, endothelial, fibroblasts, platelets | with beta3 integrins, leukocyte adhesion, migration, activation, extravasation of PMN, binds SIRPalpha |
| CD48 | Blast-1, BCM-1, Sgp-60 | 45kD | IgSF, GPI-linked | broad on lymphocytes, not fibroblasts | adhesion, T costimulation, CD2 and Ly-9 receptor |
| CD49a | VLA-1, Integrin alpha1, Itga1 | 180kD | IntgF | Tact, endothelial | adhesion, CD49a / CD29 binds collagen & laminin |
| CD49b | VLA-2, Integrin alpha2, Itga2 | 165kD | IntgF | platelets, T subset, megakaryocytes, NK subset | adhesion, CD49b / CD29 binds collagen & laminin |
| CD49c | VLA-3, Integrin alpha3, Itga3 | 125kD | IntgF | B subset, Tlow | CD49c/CD29 binds laminin, fibronectin, collagen |
| CD49d | VLA-4, Integrin alpha4, Itga4 | 150kD | IntgF | T, B, mono | CD49d / CD29 binds fibronectin, VCAM-1, with beta7 forms LPAM-1 & binds to MAdCAM-1, homing receptor |
| CD49e | VLA-5, Integrin alpha5, Itga5 | 135kD | IntgF | thymocytes, Tact | adhesion, CD49e / CD29 binds fibronectin |
| CD49f | VLA-6, Integrin alpha6, Itga6 | 120kD | IntgF | memory T, thymocytes, platelets | adhesion, CD49f / CD29 binds laminin |
| CD50 | Icam5, Ticn, Telencephalin | 130kD | IgSF | memory T, thymocytes, platelets | adhesion, CD49f / CD29 binds laminin |
| CD51 | VitronectinR, Integrin alphav, Itgav | 125, 24kD | IntgF | platelets, megakaryocytes, endothelial, osteoblasts, melanoma | adhesion, CD51 / CD61 binds vitronectin, von Willebrand factor, fibrinogen & thrombospondin |
| CD52 | CAMPATH-1, MB7, CLS1 | 12kD | GPI-linked | mature lymphocytes | |
| CD53 | OX-44 | 35-42kD | TM4SF | leukocytes, DC, osteoblasts, osteoclasts | signaling |
| CD54 | ICAM-1, Ly-47 | 85-110kD | IgSF | endoth, mono, resting lymph (high on activation) | CD11a / CD18 (LFA-1), CD11b / CD18 (Mac-1) & CD43 receptor, adhesion, T costimulation |
| CD55 | Decay Accelerating Factor | 60-70kD | CCRSF | broad, induced in uterus by estrogen | similar to Crry, protection from autologous complement attack |
| CD56 | NCAM | 20-185kD | IgSF | neural tissue, multiple isoforms | adhesion, neuron development, skeletal myogenesis |
| CD57 | B3GAT1 | Glucuronosyl-transferase P | |||
| CD58 (H) | LFA-3 | not defined in mouse | |||
| CD59 | Protectin, MAC-inhibitor | 19kD | GPI-linked | broad | binds complement C8 & C9, blocks membrane attack complex assembly |
| CD60 (H) | CHO | not defined in mouse | |||
| CD61 | GPIIIa, Integrin beta3, Itgb3 | 105kD | IntgF | platelets, megakaryocytes, mac, endothelial | CD41 / CD61 or CD51 / CD61 complexes adhere to ECM |
| CD62E | E-selectin, ELAM-1, Sele 97 | 107-115kD | Selectin | endothelial | sialyl-Lewis x receptor, leukocyte rolling & migration, tumor metastasis |
| CD62L | L-selectin, LECAM-1, sell | 74 & 95kD | Selectin | B, T, mono, gran, NK, thymocytes | CD34, GlyCAM, & MAdCAM-1 receptor, lymphocyte homing, leukocyte tethering & rolling |
| CD62P | P-selectin, Selp | 140kD | Selectin | plateletsact, endothelial | CD162 & sialyl LewisX receptor, adhesion, neutrophil rolling, platelet-neutrophil & platelet-mono interactions, binds to CD24 |
| CD63 | MLA1 | 53kD | TM4SF | plateletsact, mono, mac | activated platelets marker, lysosomal membrane protein, translocates to surface upon activation, melanoma associated antigen |
| CD64 | FcgammaRI | 72kD | IgSF | mono, mac, DC, granact | high affinity IgG receptor, phagocytosis, trypsin-sensitive, ADCC |
| CD65 (H) | not defined in mouse | ||||
| CD66a | Ceacam1, C-Cam | IgSF, CEA family | colon, liver, hematopoietic tissues | cell-cell interaction, hepatitis virus receptor | |
| CD68 | Macrosialin, gp110 | 87-115kD | Sialomucin | predominantly intracellular, tissue mac, DClow | lysosomal associated protein |
| CD69 | Activation Inducer Molecule, VEA | 35-39kD | C-type lectin | Tact, Bact, NKact, granact, thymocytes, platelets | activation, early activation marker |
| CD70 | Ki-24, Tnfsf7 | 50, 70, 90, 160kD | TNFSF | Bact, Tact, cardiac myocytes | CD27 receptor, T & B costimulation |
| CD71 | T9, Trfr | 95kD | Type II TM, dimer | proliferating cells, reticulocytes, erythroid precursors | transferrin receptor, iron uptake, cell activation |
| CD72 | Lyb-2 | 40-45kD | C-type lectin, homodimer | B, FDC, T subset, polymorphic extracellular portion | CD5 & CD100 receptor, B costimulation |
| CD73 | Nt5e | 69kD | GPI-linked | ecto-5’-nucleotidase, T costimulation, adhesion | |
| CD74 | Ii, Ia-invariant chain | 33-43kD | Type II TM | B, mac, mono | MHC class II traffic & function, antigen presentation |
| CD75 | BM homing of recirculating B cells, CD22 counter-receptor | ||||
| CD77 (H) | not defined in mouse | ||||
| CD79a | Iga, mb-1, Ly-54 | 33 & 45kD | IgSF | B | BCR subunit, BCR expression & signaling |
| CD79b | Igb, B29 | 37kD | IgSF | B | BCR subunit, BCR expression & signaling |
| CD80 | B7, B7-1, Ly-53 | 60kD | IgSF | Bact, Tact, mono, mac, DC, pancreatic beta cells | CD28 & CD152 receptor, costimulation, T-B interaction |
| CD81 | TAPA-1 | 26kD | TM4SF | T, B, NK, thymocytes, DC, endoth, fibroblast, neuroblastomas, melanomas | with CD19 & CD21, signaling, T costimulation |
| CD82 | KAI1, C33 | 50-53kD | TM4SF, ASV | Tact, mRNA: spleen, kidney | inhibits tumor cell mobility |
| CD83 | 43kD | IgSF, Siglec family | DC, Tact, mRNA: spleen & brain | regulation of T response, binds to a ligand on B cells | |
| CD84 | IgSF | B, mac, mRNA: hematopoietic tissue | |||
| CD85 | MHC class I recognition | ||||
| CD86 | B70, B7-2, Ly-58 | 80kD | IgSF | mono, Bact, Tact, DC | CD28/CD152 receptor, T costimulation, T-B interaction |
| CD87 | UPA-R, Plaur | GPI-linked | mRNA: muPAR1 luminal epithelial of gastric mucosa, muPAR2 basal epithelial, PAR2 secreted uPA binding protein | ||
| CD88 | C5aR, C5r1 | 40kD | TM7SF | gran, neurons, astrocytes, microglia | C5a receptor, granulocyte activation, neurodegeneration |
| CD89 | FcalphaR, IgA receptor | 55-75kD | IgSF | mono, mac, neutrophils, B subset, T subset | phagocytosis, degranulation, respiratory burst |
| CD90 | Thy-1 | 18kD | IgSF, GPI-linked | thymocytes, T, hematopoietic subset, neurons, not B | hematopoietic stem cell & neuron differentiation, T activation |
| CD90.1 | thy1a(thy1.1) strains: AKR & RF | ||||
| CD90.2 | thy1b(thy1.2) all other strains | ||||
| CD91 | lrp1, A2mr | 600kD | LDL receptor family | mono, mac, neurons, liver, fibroblasts | receptor for a-2- macroglobulin, LDL, HSPgp96, apolipoprotein, lipoprotein metabolism |
| CD92 (H) | not defined in mouse | ||||
| CD93 | AA4.1 antigen, C1qRp, early B lineage marker, Ly68 | 130-140kD | C-type lectin | hematopoietic progenitor marker for early B cells, endo, megakaryoblasts, platelets | phagocytic complement C1q receptor |
| CD94 | KP43, klrd1 | 43kD | C-type lectin | NK, T subset | with NKG2, inhibits NK function |
| CD95 | Apo-1, Fas | 35kD | TNFRSF | thymocytes, lymphocytesact | CD95L(CD178) receptor, apoptosis induction, immune system regulation, lpr mutation |
| CD96 | TACTILE, T cell ACTivation Increased Late Expression | 160kD | IgSF | mRNA: spleen, mammary gland | adhesion of activated T & NK |
| CD97 | TM7LN1 TM7S | lymphoid, myeloid | CD55 receptor | ||
| CD98 | 4F2, Ly-10 | 80, 40kD | thymocytes, lymphocytes, mono, BM | cell activation, calcium flux | |
| CD99 | Pilr-1, D4 | ||||
| CD100 | Sema4d, semaphorinH | 150kD | IgSF | mRNA: lymphoid & nervous tissues | CD72 receptor, role in immune & nervous systems |
| CD101 | IgSF3 | IgSF | role in susceptibility to type I diabetes | ||
| CD102 | ICAM-2, Ly-60 | 55-65kD | IgSF | lymphocytes, mono, platelets, endothelial | binds CD11a / CD18 (LFA-1), costimulation |
| CD103 | HML-1, alphaIEL, alphaE integrin, Itgae | 150kD | IntgF | intraepithelial lymphocytes, BM mast, lymphocytesact | with integrin beta7, binds E-cadherin, lymphocyte homing |
| CD104 | beta4 integrin, Itgb4 | 220kD | IntgF | epithelial, endothelial, immature thymocytes, Schwann cells, tumor cells, keratinocytes | with CD49f, cell adhesion / migration, differentiation, tumor metastasis, a6b4 is tumor associated Ag Tsp-180 |
| CD105 | Endoglin, Eng | 95kD | endothelial, BM cell subset, macact | response to TGF-beta1, ligand for TGF-beta, adhesion | |
| CD106 | VCAM-1 | 110kD | IgSF | endothelialact, FDC, BM myeloid | CD49d / CD29 receptor, adhesion / migration, costimulation |
| CD107a | LAMP-1 | 120kD | plateletsact, Tact, endothelialact | adhesion, metastasis | |
| CD107b | LAMP-2 | 110kD | plateletsact, Tact, endothelialact | adhesion, metastasis | |
| CD108 | Sema7a | 80kD | IgSF, GPI-linked | mRNA: nervous system(high), immune system | |
| CD109 | Gov platelet alloantigen | ||||
| CD110 | TPO-R, c-mpl | 82-84kD | CRSF | megakaryocytes, platelets | thrombopoietin receptor, megakaryocyte differentiation |
| CD111 | PRR1, Nectin-1, Pvrl | 64-72kD | IgSF, ASV | fibroblasts, epithelium, neurons | polio virus receptor-related protein1, mediates entry of herpes simplex virus (HSV) strains |
| CD112 | PRR2, Pvs, Nectin-2 | 64-72kD | IgSF, ASV | mRNA: brain, spinal cord, spleen, kidney, heart, liver | intercellular adhesion, not a receptor for poliovirus |
| CD113 | PVRL3, Nectin3 | 100kD | Ig-like, ASV | broad, epithelial | adhesion molecule, interacts with afadin |
| CD114 | G-CSFR, Csfgr, Csf3r | 95, 139kD | CRSF | progenitor & mature neutrophils, endothelial, placenta, some myeloid leukemia | myeloid proliferation & differentiation |
| CD115 | M-CSFR, c-fms, Csf1r | 150kD | RTKF | monocytic progenitors, osteoclasts | M-CSF receptor, monocytic lineage proliferation/ differentiation, role in differentiation of osteoclasts |
| CD116 | GM-Csf2ra | 70-85kD | CRSF | mono, gran, DC, endothelial | low affinity GM-CSF receptor, with common beta AIC2B form high affinity receptor, myeloid proliferation, differentiation |
| CD117 | c-kit, Steel factor | 145kD | IgSF, RTKF | hematopoietic stem & progenitors, neural crest-derived melanocytes, primordial germ cells, mast cells | Stem Cell Factor receptor, hematopoietic progenitor development & differentiation, dominant white spotting (w) mutation |
| CD118 | LIFR | 190kD | Type I cytokine receptor family, ASV | placenta, liver, kidney, heart, lung, brain epithelial | membrane-bound involved in signal transduction, soluble form inhibits activity of LIF |
| CD119 | IFNgammaR, ifgr1, Ifngr | 90-100kD | mac, mono, B, T, NK, neutrophils, endothelial | Interferon-gamma receptor alpha chain, with IFNgamma AF-1, host defense, high affinity IFNgamma binding | |
| CD120a | TNFR1, p55 | 50-60kD | TNFRSF | broad | TNF receptor, binds both TNFalpha & TNFbeta, apoptosis |
| CD120b | TNFR2, p75 | 75-85kD | TNFRSF | broad | TNF receptor, high affinity binding to TNFalpha & TNFbeta, apoptosis |
| CD121a | IL-1R type I | 80kD | IgSF | broadlow, fibroblasts, T, brain, pancreas, cardiac endothelial, epithelial, developing oocytes | Type I IL-1R, binds IL-1alpha & IL-1beta, IL-1 signaling |
| CD121b | IL-1R, type II | 68kD | IgSF | B, mac, mono, T subset (Th2), epidermis, dermis, vaginal basal epithelial, brain | Type II IL-1R, binds IL-1alpha & IL-1beta, a decoy receptor |
| CD122 | IL-2Rbeta, p70 | 75kD | CRSF | NK, T, B, mono | IL-2R & IL-15Rbeta chain, signaling, with CD25 & CD132 form high affinity IL-2R, lymphocyte development |
| CD123 | IL-3Ralpha | 70kD | CRSF | lymphocyte subset, basophils, hematopoietic progenitors, mac, DC, megakaryocytes | IL-3R alpha chain, low affinity binding to IL-3, with CDw131 form high affinity IL3 binding |
| CD124 | IL-4Ralpha | 140kD | CRSF | lymphocyteslow, mono, hematopoietic precursors, fibroblast, epithelial | IL-4Ralpha chain, with CD132 or IL-13Ralpha chain, with CD132 forms high affinity IL-4R, T growth & differentiation, soluble form |
| CD125 | IL-5Ralpha | 60kD | CRSF | eosinophils, basophils | IL-15Ralpha chain, with CDw131 for low affinity IL-5 binding, with beta subunit for high affinity IL-15 binding |
| CD126 | IL-6Ralpha | 80kD | IgSF, CRSF | Bact, plasma cells, most leukocyteslow, fibroblasts | IL-6Ralpha subunit, low affinity IL-6 binding, with CD130 for high affinity IL-6 binding, soluble form |
| CD127 | IL-7Ralpha | 65-75kD | CRSF | pro-B, T | IL-7Ralpha chain, with CD132 for high affinity IL-7 binding, T & B development |
| CD128 | see CD181 and CD182 | ||||
| CD130 | IL-6Rbeta, gp130 | 130kD | CRSF | broad in adult & embryonic cells | Common beta chain of IL-6R, IL-11R, LIFR, OSMR |
| CD131 | IL-3R, AIC2B/A, common beta, Csf2rb1, Csf2rb2 | 95-120kD | CRSF | mono, gran, early B | 2 genes in mouse, signaling, with alpha subunits of IL-3, IL-5, GM-CSF receptors |
| CD132 | IL-2R Common beta | 64kD | CRSF | T, B, NK, mono, gran, DC | Subunit of IL-2, IL-4, IL-7, IL-13, & IL-15R, signaling, mutation: X-linked SCID |
| CD133 | Prominin-1, AC133 | 115-120kD | TM5 glycoprotein | primitive cells like hematopoietic progenitors, neural, endothelial stem cells, retina, retinoblastoma, developing epithelial (apical surface) | unknown |
| CD134 | OX-40, Ly-70, Txgp1 | 48-50kD | TNFRSF | Tact | OX-40L receptor, apoptosis, T activation / differentiation |
| CD135 | Flt3/Flk2, EMS-like tyr kinase 3 | 130-150kD | RTK family | hematopoietic progenitors: myeloid & primitive B progenitors | binds FLT3 ligand, myeloid & lymphoid development, expands hematopoietic progenitors & DC |
| CD136 | STK, Mst1r, RON | 180kD | RTK family | hematopoietic cells | macrophage stimulatory 1 receptor |
| CD137 | 4-1BB, Tnfrsf9 | 30kD | TNFRSF | Tact | T costimulation, binds to 4-1BBL, fibronectin, vitronectin, laminin, collagen VI |
| CD138 | syndecan-1, Sdc1 | 80-150kD | Syndecan | epithelial, plasma cells, pre-B, neurons | receptor for ECM, cell morphology, B differentiation |
| CD139 (H) | not defined in mouse | ||||
| CD140a | PDGF receptor alpha | 180kD | RTK family | fibroblasts, smooth muscle, glial cells, chondrocytes | PDGFRaa binds PDGF AA, AB, BB, PDGFRab binds AB, BB, PDGFRbb binds PDGFBB, embryonic development, signaling |
| CD140b | PDGF receptor beta | 180kD | RTK family | fibroblasts, smooth muscle, glial cells, chondrocytes | see CD140a for ligands, signaling |
| CD141 | Thrombomodulin | 100kD | C-type lectin | mono, neutrophils, endothelial, smooth muscle | initiation of protein C anticoagulant pathway |
| CD142 | Tissue Factor, factor III, F3 | 45kD | mRNA: broad | binds clotting factor VIIa, embryonic development | |
| CD143 | ACE | 170kD | endothelial, epithelial, neuron, fibroblasts, macact | peptidyl-peptidase, angiotensin converting enzyme | |
| CD144 | Cadherin5, VECadherin | 130kD | Cadherins | endothelial | adhesion, intercellular interaction |
| CD146 | MUC18, S-endo, mcom | IgSF | embryonic tissue, mammary tumors | cell adhesion during development | |
| CD147 | Neurothelin, basigin, Bsg | IgSF | leukocytesact, erythrocytes, platelets, endothelial | adhesion, blood-brain barrier | |
| CD148 | HPTP-eta, M4, M56 | 240-260kD | mRNA: broad, high in brain, kidney | tyrosine phosphatase R Type III | |
| CD150 | SLAM, IPO-3 | 75kD | IgSF | T, B, maintained on Th1 | costimulation, proliferation, Ig production |
| CD151 | PETA-3, SFA-1 | 32kD | TM4SF | endothelial, megakaryocytes, platelets | adhesion, signaling |
| CD152 | CTLA-4, Ly-56 | 33kD | IgSF | Tact | CD80, CD86 receptor, negative T stimulation |
| CD153 | CD30L, Tnfsf8 | 40kD | TNFSF | Tact, macact, neutrophil, B, induced on cardiac myocyte | CD30 receptor, T costimulation |
| CD154 | CD40L, gp39, Ly-62, Tnfsf5 | 32-39kD | TNFSF | transiently on Tact, B subset (intracellular), platelets | CD40 receptor, B & DC costimulation, T activation |
| CD155 | PVR | 80-90kD | IgSF | mono, mac | Polio virus receptor |
| CD156a | ADAM8, MS2 | 69kD | Type I TM | neutrophils, mono | metalloprotease, leukocyte extravasation |
| CD156b | TACE/ ADAM 17 | 100kD | broad | zinc metalloprotease, TNF converting enzyme | |
| CD156c | ADAM10, kuz, kuzbanian, Madm | 60kD | Peptidase M12B family | neural precursors, fibroblasts | proteolytic cleavage of cell-surface molecules including Notch, TNF-alpha, APP & ephrin-A2 |
| CD157 | BST-1, Ly-65, Bp3 | 38-48kD | GPI-linked | gran, mono, early B, T subset, BM stroma | ADP-ribosyl-cyclic ADP-ribose hydrolase, pre-B growth |
| CD158 (H) | KIR | not defined in mouse | |||
| CD159a | NKG2A, Klrc1 | 43kD | NK & NKT cells | with CD94, Qa-1(b) receptor, inhibitory signaling | |
| CD159c | NKG2C | C-type lectin | NK & NKT cells | with CD94, Qa-1(b) receptor, stimulatory signaling | |
| CD160 | BY55 | 27kD | IgSF | NK subset, T subset | costimulation |
| CD161c | NKR-P1c, Ly-55, NK1.1 | 40kD | C-type lectin | NK, T subset | NK cell-mediated cytotoxicity |
| CD162 | PSGL-1, Slp1 | 120kD | Mucin family | myeloid cells, lymphocyte subset | CD62P & CD62L receptor, adhesion, leukocyte rolling |
| CD162R (H) | PEN-5 | not defined in mouse | |||
| CD163 | 100-130kD | SRCRSF | peritoneal mac | ||
| CD164 | MGC-24, A115, A24 | 80kD | Sialomucin | mRNA: broad various adult & embryonic tissues | hematopoietic progenitor-stroma interaction |
| CD165 | AD2, gp37 | not defined in mouse | |||
| CD166 | ALCAM | 120kD | IgSF | neurons, Tact, mono, epithelial, fibroblasts | CD6 receptor, adhesion, T development, T-B interaction, role in nervous system |
| CD167a | DDR1 | 120kD | RTK family | epithelial, myoblasts, brain, early marker neuroectoderma | discoidin domain receptor, tyrosine kinase, adhesion |
| CD168 | RHAMM, Hmmr | 70-73kD | broad | hyaluronan-mediated motility receptor, adhesion, cell locomotion, tumor metastasis (intracellular in human breast cancer) | |
| CD169 | sialoadhesin, Sn, Siglec-1 | 185kD | IgS | tissue mac subset | adhesion, cell-cell & cell-matrix interactions, binds alpha2,3-sialylated ligands CD43, CD227, SRBC-R |
| CD170 (H) | Siglec-5, CD33-like2 | 140kD | IgSF, sialoadhesins | mac subset, neutrophils | adhesion |
| CD171 | L1, cell adhesion molecule | 200-210kD | IgSF | CNS, PNS, glial cells, mono, T subset, B, DC, lymph node reticular fibroblasts, some epithelial | homotypic adhesion, T co-stimulation, integrin binding, KO has neuropathologies similar to CRASH disorder |
| CD172a | SIRPalpha, Ptpns1 | 110kD | IgSF | mono, mac, DC, T subset, stem cells | adhesion, with CD47, SHP substrate-1 |
| CD172b | SIRPbeta | 60-90kD | Ig-like Type I cell surface receptor | mac and other hematopoietic lineages | engagement of SIRPbeta promotes phagocytosis in mac |
| CD172g (H) | SIRPgamma | not defined in mouse | |||
| CD173-CD175 (H) | CHO | ||||
| CD176 | Trf, transferring, Tfn, HP | CHO | |||
| CD177 | NB1 | 56-62kD | GPI-linked | neutrophil subset (surface & intracellular) | |
| CD178 | Fas Ligand, CD95L,TNFSF6 | 38-42kD | TNFSF | Tact, testis | apoptosis of CD95+ cells, immune privilege, soluble form in serum, gld mutation nonfunctional FasL |
| CD179a | V pre B | 16kD | IgSF | pro- & early pre-B | B differentiation, signaling, pre-BCR with IgM/CD79alpha/beta |
| CD179b | Lambda 5 | 22kD | IgSF | pro- & early pre-B | B differentiation, signaling, pre-BCR with IgM/CD79alpha/beta |
| CD180 | RP105, Ly-78 | 95-105kD | LRRF, TLRSF | B, mono, DC | B recognition & signaling of LPS, with MD-1 |
| CD181 | CXCR1, IL8Ralpha | 39kD | GPCR family | neutrophils, basophils, NK, T subset, mono | binding of IL-8 induces chemotaxis of neutrophils |
| CD182 | CXCR2, IL8Rbeta | 40kD | GPCR family | neutrophils, basophils, NK, T subset, mono | binding of IL-8 induces chemotaxis of neutrophils, also binds GRO and NAP-2 |
| CD183 | CXCR3, Cmkar3, gpr9 | 40kD | TM7SF | Tact (Th1), NK, eosinophils, GM-CSF activated hematopoietic progenitors | 6Ckine, IP-10 , Mig & I-TAC receptor, T recruitment to inflammatory sites,Th1 response, allograft destruction |
| CD184 | CXCR4, Cmkar4, Fusin/LESTR | 45kD | TM7SF | T subset, B, DC, mono, endothelial | SDF-1 receptor, embryogenesis, (human: X4 HIV-1 coreceptor) |
| CD185 | CXCR5, BLR1 | 45kD | GPCR family | spleen, resting B, T, skin-derived DC | binds BLC, involved in B-cell migration into B-cell follicles of spleen and Peyer’s patches |
| CD186 | CXCR6, BONZO | 40kD | GPCR family | memory T | chemokine receptor for CXCL16, also a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1 |
| CD191 | CCR1, MIP-1alphaR, RANTES-R | 39kD | GPCR family | neutrophils, mono, lymph, eosinophils & osteoclasts | receptor for C-C type chemokines MIP-1alpha, RANTES, MIP-1beta, MCP-1 |
| CD192 | CCR2, MIP-1alphaR | 40kD | GPCR family | T subset, mono, B | receptor for the MCP-1, MCP-3 & MCP-4 chemokines |
| CD193 | CCR3, MIP-1alphaRL2 | 45kD | GPCR family | skeletal muscle & low amounts in leukocytes, T subset | receptor for C-C type chemokines eotaxin, MCP-3, MCP-4 and RANTES |
| CD195 | CCR5, Cmkbr5 | 45kD | TM7SF | T subset, NK, monolow | MIP-1alpha, MIP-1beta & RANTES receptor, (human: R5 HIV-1 coreceptor) |
| CD196 | CCR6, KY411 | 45kD | GPCR family | mainly B, T and DC subset | receptor for C-C type chemokines MIP-3alpha/LARC |
| CD197 | CCR7, Cmkbr7 | 45kD | TM7SF | T, DC subset | 6Ckine & MIP-2beta receptor |
| CD198 | CCR8, TER1 | 50kD | GPCR family | mono, mac, neutrophils, T subset | receptor for TCA-3/I-309 |
| CD199 | CCR9, CMKBR10 | 43kD | GPCR family | high in thymus, immature and mature T | receptor for chemokine SCYA25/TECK, role in T development |
| CD200 | OX-2 | 45-50kD | IgSF | thymocytes, B, Tact, DC, endothelial, neurons | T costimulation, regulation of oxidoreductase pathway |
| CD200R | OX-2R | myeloid cells, lymphocyte subsets, Langerhans DCs, dendritic epidermal T cells | inhibitory receptor, signal transduction | ||
| CD201 | Procr, EPCR | 50kD | endothelial & stem cell subset | activated protein C receptor | |
| CD202b | Tie2, Tek | 140kD | RTK family | stem cells, endothelial from early development | angiogenesis, Angiopoietin-1 receptor |
| CD203c | ENpp1, PC-1, TWY | 115kD | Type II TM | antibody secreting B, basophils, mast cells, megakaryocytes, glioma | plasma cell alloantigen, ectoenzyme, binding/clearance of extracellular nucleotides |
| CD204 | Macrophage scavenger-R, Scvr | 220kD | mac | endocytosis of macromolecules | |
| CD205 | DEC-205, Ly75 | 205kD | mac mannose receptor SF | DC, thymic epithelial, Blow, BM stromal, pulmonary epithelial, brain capillaries | antigen up-take/presentation, immune inhibition |
| CD206 | macrophage mannose-R, Mrc1 | 180kD | mac, mono, DC subset | phagocytosis / pinocytosis mannose containing molecules | |
| CD207 | Langerin | 40kD | Type II TM | Langerhans cells | Ag capture & endocytic receptor, with Birbeck granules |
| CD208 (H) | DC-LAMP, Lamp3 | 70-90kD | DCact, interdigitating DC | ||
| CD209 | DC-SIGN, CIRE | 44kD | DC subset | ICAM-3 receptor, HIV-1 binding protein, T-DC interaction | |
| CD209a | DC-SIGN, CIRE | 44 kDa | DC subsets | T cell and DC interaction | |
| CD209b | SIGN-R1 | macrophage subsets (splenic, LN) | |||
| CD209c | evidence at the transcript level | probable pathogen-recognition receptor | |||
| CD209d | evidence at the transcript level | probable pathogen-recognition receptor | |||
| CD209e | evidence at the transcript level | probable pathogen-recognition receptor | |||
| CD210 | IL-10R | 90-110kD | Th1, B, NK, mono, mast cells, mac | IL-10 receptor, signaling, related to IFN receptors | |
| CDw210b | IL-10Rβ | T cells, B cells, NK cells, monocytes, macrophages | |||
| CD212 | IL-12Rbeta1 | 100kD | dimer & oligomer Type I TM | Tact, NKact | high affinity binding to IL-12, with IL-12 receptor beta2, signaling, T & NK response to IL-12 |
| CD213a1 | IL-13Ralpha1, NR4 | 65kD | CRSF | mono, NK, fibroblasts, endothelial | binds IL-13 low affinity, with CD124 |
| CD213a2 | IL-13Ralpha2 | 65kD | CRSF | B, mono | binds IL-13 high affinity |
| CD215 | IL-15Rα | T and B cells | complexes with CD132 and CD122, development and survival of NK cells | ||
| CD217 | IL-17R | 120kD | broad | IL-17 receptor | |
| CD218a | IL-18Ralpha, IL1Rrp | 70kD | IL-1R family | T, NK & DCs | IL-18 binding leads to the activation of NF-kappaB |
| CD218b | IL-18Rbeta, IL18Rap | 70kD | IL-1R family | T, NK and DCs | forms heterodimeric receptor with IL-18Ralpha to enhance IL-18 binding |
| CD220 | InsulinR, Insr | 140 & 70kD | RTK family | broad | Insulin receptor, regulation of metabolism |
| CD221 | IGF-1R | 140 & 70kD | RTK family | broad | binds IGF high affinity, prolif/differentiation |
| CD222 | IGF-II R, M6P/IGF2R | 220-250kD | Type I TM | broad, 90-95% intracellular | cation-independent mannose 6-phosphate receptor, TGFbeta-LAP, plasminogen & proliferin receptor |
| CD223 | LAG-3 | 70kD | IgSF | Tact, Nkact | MHC class II ligand, role in natural killing |
| CD224 | GGT, Ggtp | 27, 68kD | yolk sac, protoplasmic astrocytes, endothelial, embryonic stem cell lines | gamma-glutamyl transpeptidase | |
| CD225 | Ifitm1, fragilis2, Mil2 | primordial germ cells | adhesion, differentiation, interferon-induced transmembrane protein 1 | ||
| CD226 | DNAM-1, PTA-1, TLiSA1 | IgSF | Th1, CD8 T, platelets | platelet activation, T differentiation, costimulation, Th1 function | |
| CD227 | Muc1, EMA | 300kD | Mucin family type I TM | lymphocytes, tumors, epithelial, increased in pregnancy | epithelial membrane antigen, organogensis |
| CD228 | Melanotransferrin, Mfi2 | 80-95kD | TransferrinSF | mRNA: cartilage(high), testis(moderate) | |
| CD229 | Ly-9, Lgp100 | 95, 110kD | IgSF | thymocytes, T, B, BM subset, not erythrocytes | adhesion |
| CD230 | Prion protein, PrnP | 35kD | neurons, lymphocytes, other cells | Scrapie-associated fibril protein | |
| CD231 | TALLA-1, A15 | 30-45kD | TM4SF | mRNA: brain, colon, muscle, heart, kidney, spleen | T cell acute lymphoblastic leukemia marker, neuronal function |
| CD232 | VESP-R, PlexinC1 | 200kD | broad | viral-encoded semaphorin protein receptor | |
| CD233 | Band3, SLC4A1 | 90kD | Anion exchanger F | erythrocytes, mRNA: epithelial, other tissues | anion pump, CO2 transport, linking membrane to cytoskeleton |
| CD234 | Duffy, Dfy, DARC | 36-37kD | mRNA: spleen, BM, liver, brain, not erythrocytes | Duffy blood group antigen chemokine receptor | |
| CD235a | Glycophorin A, Gypa | 36kD | erythrocytes | one gene only in mouse for Glycophorin A | |
| CD236R | Glycophorin C | 32kD | erythrocytes | ||
| CD238 | Kell blood group, Kel | 110kD | erythrocytes, mRNA: spleen | ||
| CD239 (H) | B-CAM, Lu | 78-85kD | IgSF | mRNA: broad, erythrocytes | Lutheran blood group, B adhesion to laminin |
| CD240CE (H) | Rhesus 30CE | 30-32kD | erythrocytes | Rh30CE & RH30D is one gene in the mouse: RH30 | |
| CD241 | Rhesus 50, RhAg | 50kD | TM12SF | erythrocytes | Rh antigens with CD47 & LW |
| CD242 (H) | ICAM-4, LW blood group | 42kD | IgSF | erythrocytes | adhesion, Landsteiner-Wiener blood group |
| CD243 | MDR-1, Abcb1, Pgp | 170kD | T subset, stem cells, small intestine, kidney | ion pump, cytokine export, CTL function | |
| CD244 | 2B4, Ly-90, Nmrk | 78kD | Type II TM, IgSF | NK, NKT, LAK | NK activation, CD48 receptor, MHC-unrestricted killing |
| CD246 | ALK, Ki-1 | 200kD | RTK family | mRNA: brain, not normal lymphocytes | anaplastic lymphoma kinase, brain development |
| CD247 | TCR zeta, cd3z | 16kD | RTK family | T, NK subset | TCR subunit, signaling, low level impaired immune function |
| CD248 | TEM1, Endosialin | 175kD | C-Type Lectin | endothelial tissue | may function in tumor progression and angiogenesis |
| CD249 (H) | Aminopeptidase A | not defined in mouse | |||
| CD252 | OX-40 Ligand, gp34 | 35kD | TNFSF | Bact, cardiac myocytes | T-B interaction, T costimulation |
| CD253 | TRAIL, APO-2L | TNFSF | NKact, liver NK | apoptosis | |
| CD254 | TRANCE, RANKL, OPGL | ~35kD | TNFSF | Tact, osteoblasts | T-DC communication, osteoclast differentiation |
| CD256 | APRIL, TALL-2 | 16kD | TNFSF | Tact, mono, mac | binds TACI and BCMA |
| CD257 | BLyS, BAFF, TALL-1 | 45kD | TNFSF | mono | binds TACI, BCMA & BAFFR to induce B proliferation |
| CD258 | LIGHT, HVEM-L | 28kD | TNFSF | Tact, immature DC | binds LTBR to induce T proliferation, also binds HVEM |
| CD261 (H) | TRAIL-R1 | not defined in mouse | |||
| CD262 | TRAIL-R2, DR5, Apo2, TRICK2, KILLER | TNFRSF | broad | ligand for TRAIL, activates NF-kappaB & mediates apoptosis, p53-dependent expression | |
| CD263 (H) | TRAIL-R3 | not defined in mouse | |||
| CD264 (H) | TRAIL-R4 | not defined in mouse | |||
| CD265 | RANK, TRANCE-R, ODFR | 97kD | TNFRSF | broad expression | binding of TRANCE mediates osteoclastogenesis & T-DC interactions |
| CD266 | TWEAK Receptor, Fn14 | 14kD | TNFRSF | mRNA in liver regeneration, Colon 26 cell line | cell migration, proliferation, angiogenesis, activates NF-kappaB pathway |
| CD267 | TACI, TNFRSF13b | 32kD | TNFRSF | Tact and B | binding of APRIL or BLyS stimulates B and T function |
| CD268 | BAFFR, Bcmd | 25kD | TNFRSF | B | BLyS binding promotes survival of mature B & B response |
| CD269 | BCMA, TNFRSF13B | 20kD | Type III TM, TNFRSF | mature B (membrane and perinuclear) | binds APRIL, BAFF, survival and proliferation |
| CD270 | TNFRSF14, HVEM | 30 kDa | T cells, monocytes, DCs, B cells, | stimulatory and inhibitory signaling | |
| CD271 | NGFR, TNFRSF16, p75 (NTR), Bex3, Ngfrap1 | 45kD | TNFRSF | neurons, mesenchymal stem cells | binds NGF, BDNF, NT-3 and NT-4, tumor suppressor mediate cell survival and death |
| CD272 | BTLA, B & T Lymphocyte Associated | 33kD | IgSF | T, B , BM, splenic macs, BM derived DC | binds HVEM, negative regulation |
| CD273 | B7DC, PD-L2, PDCD1L2 | 25kD | IgSF | DC subset, mono, mac | binds PD-1, co-stimulation or suppression of T cell proliferation |
| CD274 | B7-H1, PD-L1, PDCD1LG1 | 33kD | IgSF | leukocytes, decrease in mature thymic T cells | binds PD-1, proliferation and cytokine production |
| CD275 | B7-H2, GL50, ICOS-L, B7h, B7RP-1 | 60kD | B7 family | APC, B, DC, mac | lymphocyte costimulation, receptor for ICOS |
| CD276 | B7-H3, B7RP-2 | 40-45kD | B7 family | in vitro cultured DC and mono | negative regulator of T cell activation |
| CD277 (H) | BT3.1 | not defined in mouse | |||
| CD278 | ICOS, Inducible T cell costimulator , Ly115 | 55-60kD | CD28 family | Tact, Th2 | T costimulation, B7-H2 receptor, cytokine production |
| CD279 | PD-1, programmed death-1 | 55kD | IgSF | Tact, Bact | negatively regulates lymphocytes, T cell development |
| CD280 | ENDO180, UPARAP, MRC2 | 180kD | CD28 family | chondrocytes | binds uPAR, mannose receptor, collagen matrix remodeling & endocytic recycling |
| CD281 | TLR1 | 90kD | TLR family | low levels in leukocytes | innate immunity, with TLR2 |
| CD282 | TLR2 | 90kD | TLR family | myeloid lineage: mac & DC in spleen | response to bacterial lipoproteins |
| CD283 | TLR3 | 100kD | TLR family | DC subset, mac, fibroblasts, induced by LPS | binds dsRNA, activation of NK-kappaB |
| CD284 | TLR4, Ly87, Rasl2-8 | 100kD | TLR family, ASV | thioglycollate-elicited peritoneal mac | binds LPS, innate immunity |
| CD285 | TLR5 | 100kDa | thioglycolate-elicited peritoneal macrophages | ||
| CD286 | TLR6 | 90kDa | DCs, monocytes, epithelial subsets | pathogen recognition, activation of innate immunity | |
| CD288 | TLR7 | 85kDa | leukocytes, monocytes, DCs | pathogen recognition, activation of innate immunity | |
| CD289 | TLR9 | 120kD | TLR family | DC subset (intracellular) | binds CpG-DNA |
| CD292 | BMPR1A, ALK3 | 57kD | Type I, BMP receptor | bone progenitor, broad | binds BMP 2 & 4, bone development, germ layer specification |
| CD293 | BMPR1B, ALK6 | 57kD | Type I, BMP receptor | bone progenitor, developing retina | binds BMP, bone development, neurogenesis |
| CD294 | CRTH2, GPR44 | 55-70kD | GPCR-7TM | Th2, eosinophils, basophils | binds prostaglandin D2, chemotaxis |
| CD295 | LeptinR, LEPR | 132kD | Type I cytokine-like receptor, ASV | broad | adipose metabolism, may be involved in immune dysfunction in obesity |
| CD296 | ART1, RT6, ART2 | 37kD | ADP- ribosyltransferase | heart and skeletal muscle, peripheral T, NK subset | GPI linked protein modifies integrin during differentiation |
| CD297 | ART4, dombrock blood group | 38kD | ADP- ribosyltransferase | heart, lung, liver, and spleen, erythroid, monoact | |
| CD298 | Na+/K+-ATPase beta3 subunit, ATP1B3 | 52kD | broad | transporter | |
| CD299 (H) | DC-SIGN-related | not defined in mouse | |||
| CD300a | Clm8, LMIR1, MMAC8, Pigr4, MAIR-I, mcpir1 | 35 kDa | T and B cell subset, myeloid cells | ||
| CD300b | Irem3, Lmir5 | myeloid cells, mast cells | |||
| CD300c | Clm6 | evidence at the transcript level | |||
| CD300e | Clm2 | evidence at the transcript level | |||
| CD300f | Clm1, Lmir3 | myeloid cells, mast cells, B cells | |||
| CD301a | Macrophage galactose type-C lectin (MGL1) | macrophages, immature DCs | |||
| CD301b | Macrophage galactose type-C lectin (MGL2) | dermal DCs, BMDCs, connective tissue, macrophageslow | |||
| CD302 | DCL-1, Clec13A | 30 kDa | macrophages | ||
| CD303 | Clecsf10, dectin-2 | C-type lectin domain family 4 | tissue mac, DC, upregulated on blood mono | inflammatory lesion, UV-induced tolerance | |
| CD304 | BDCA4, | ||||
| neuropilin 1, | |||||
| Nrp, NP-1 | 130kD | semaphorin family | DC, neurons, endothelial & tumor cells, CD4+/CD25+ Treg | binds VEGF165, semaphorins, coreceptor with plexin, axonal guidance, angiogenesis, cell survival, migration | polyclonal |
| CD305 | LAIR1 | 32-40kD | IgSF, ASV | broad, NK, B, T, mono | inhibitory receptor on NK and T cells |
| CD307a | FCRL1 (Fc receptor-like 1), FCRH1, IFGP1, IRTA5, FCRL1 | ||||
| CD307b | FCRL2 (Fc receptor-like 2), FCRH2, IFGP4, IRTA4, SPAP1, SPAP1A, SPAP1B, SPAP1C | ||||
| CD307c | FCRL3, Fc receptor-like 3, FCRH3, IFGP3, IRTA3, SPAP2 | ||||
| CD307d | FCRL4, Fc receptor-like 4, FCRH4, IGFP2, IRTA1 | ||||
| CD307e | FCRL5, Fc receptor-like 5, CD307, FCRH5, IRTA2, BXMAS1, PRO820 | ||||
| CD309 | VEGFR2, Flk-1, KDR | 230kD | Type III TM tyr kinase | endothelial, angiogenic precursor cells; hemangioblast | binds VEGF, regulates adhesion and cell signaling |
| CD312 (H) | EMR2 | not defined in mouse | |||
| CD314 | NKG2D, KLRK1 | 42kD | Type II lectin-like receptor | NK, CD8+ activated, not CD4+ in the periphery, macact | binds MHC class I, Rae1 & ULBP4, cytolysis and cytokine production; costimulatory |
| CD315 | CD9P1, SMAP6, FPRP, PTGFRN | 135kD | IgSF | B subset, monoact | with CD81 and CD9 |
| CD316 | EWI2, PGRL, KASP | 63-75kD | TM4SF, IgSF8 | B, T, low on NK cells | with CD81 & CD9; involved in cell migration |
| CD317 | BST2 | 30-36kD | Type II | BM stromals, fibroblasts, plasmacytoid DC | pre-B cell growth, overexpressed in multiple myeloma |
| CD318 | CDCP1, CUB domain containing protein 1 | ||||
| CD319 | CRACC, SLAMF7 | 66kD | Ig TM | predicted: T, B and DC subset, NK, upregulated in DC | regulate T and NK cells |
| CD320 | 8D6, VLDL | ||||
| CD321 | JAM1, F11 receptor, KAR | 12.5kD | IgSF, Type I, AVS | epithelial and endothelial, platelets | tight junction, binds reovirus & LFA1, platelet receptor |
| CD322 | JAM2, VE-JAM | 45kD | IgSF | HEV and other endothelia | mediates transendothelial migration of lymphocytes |
| CD324 | E-Cadherin, Uvomorulin | 120kD | cadherin SF | non-neural epithelial | binding to integrin alphaE/beta7 & homotypic interactions mediate cell adhesion |
| CD325 | N-Cadherin, Cadherin-2 | 140kD | cadherin SF | brain, skeletal & cardiac muscle | adhesion, may be involved in neuronal recognition mechanism |
| CD326 | Ep-CAM, EGP, Ly-74 | 40kD | thymocytes, epithelial, DC | may function as growth factor receptor or adhesion molecule | |
| CD327 (H) | siglec6 | not defined in mouse | |||
| CD328 (H) | siglec7 | not defined in mouse | |||
| CD329 | siglec9, siglecl1 | IgSF | monocyte/myeloid cells | mediates sialic-acid dependent binding to cells | |
| CD331 | FGFR1, FLT2, N-SAM | 30kD | TM tyr kinase | fibroblasts, epithelial | binds FGF, wound healing, bone development |
| CD332 | FGFR2, KGFR, KSAM | 115-135kD | TM tyr kinase | fibroblasts, epithelial, ectoderm of embryo | binds FGF, embryonic limb development, AER |
| CD333 | FGFR3, ACH, CEK2 | 115kD | TM tyr kinase, ASV | fibroblasts, epithelial, astrocytes | binds FGF, bone & CNS development |
| CD334 | FGFR4, TKF | 110kD | TM tyr kinase | fibroblasts, epithelial, hepatocytes | binds FGF, bone development |
| CD335 | NKp46, Ly-94 homolog | 46kD | IgSF | NK | binds non-MHC, NK activation |
| CD336 (H) | NKp44 | not defined in mouse | |||
| CD337 (H) | Ncr3, IC7, Ly117 | mouse IC7 mRNA in liver | |||
| CD338 | ABCG2, Mxr, ABC15, BCRP1 | 73kD | GPCR 7TM | stem cell subset (side population) | Multi-drug resistance transporter |
| CD339 | Jagged-1, Serrate1 | 135kD | EGF TM | BM stromal & mac, stromal cell lines | receptor for Notch-1, 2, & 3, hematopoiesis, Th2 fate |
| CD340 | ErbB-2, c-neu, HER2 | 185 kDa | fetal heart, gonads, adult uterine epithelial cells, and in synaptic sites of muscle fibers | member of the ERBB family of receptor tyrosines; involved in a wide range of cellular responses | |
| CD344 | Frizzled-4, F24 | 59 kDa | embryonic and adult tissue | activation of the Wnt/β-catenin pathway; regulation of tissue and cell polarity | |
| CD349 | Frizzled-9, Fzd9 | 65 kDa | selectively expressed in the developing embryo and adult | activation of the Wnt/β-catenin pathway; regulation of tissue and cell polarity | |
| CD350 | Frizzled-10, Fzd10 | 64 kDa | embryonic and adult tissue | activation of the Wnt/β-catenin pathway; regulation of tissue and cell polarity | |
| CD351 | FCAMR | 70 kDa | oligodendrocytes, B cells, macrophages, T cells, Tact cells | ||
| CD352 | SLAMF6, Ly108, NTB-A | 60 kDa | T, B, and NK cells | enhances NK cell activity | |
| CD353 | SLAMF8, Blame | evidence at the transcript level | possible role in B-lineage commitment or modulation of BCR signaling | ||
| CD354 | TREM1 | 30 kDa | monocytes, DCs, macrophage subsets, platelets, megakaryocytes, microglia, hepatocytes, osteoclasts | innate immune response to infection | |
| CD355 | Class-I MHCrestricted T-cell associated molecule (CRTAM) | 70 kDa | NKact cells, CD8 Tact cells | adhesion | |
| CD357 | TNFRSF18, Gitr | 66–70 kDa | Tact and Treg cells | participation in dominant immunological self-tolerance | |
| CD358 | TNFRSF21, Dr6r | hematopoietic and nonhematopoietic cells; tumor cells | apoptosis | ||
| CD360 | IL-21R, Nilr | 60 kDa | T cells, B cells, NK cells, DCs | complex with CD132, activation, proliferation, development, apoptosis | |
| CD361 | EVI2B | widely expressed in hematopoietic cells | |||
| CD362 | Syndecan-2, SDC2, HSPG1, SYND2 | 25 kDa | epithelial cells, neuronal cells, mesenchymal cells | adhesion, migration | |
| CD363 | Sphingosine- 1-phosphate receptor 1 (S1PR1), EDG1, Lpb1 | 40 kDa | lymphocytes, endothelial cells monocytes/ macrophages neural cells | adhesion, migration, cytoskeletal organization | |
| CD364 | PI16, peptidase inhibitor 16, MSMBBP | 49 kDa | T cell subsets (Treg and memory) | putative serine protease inhibitor | |
| CD365 | TIM-1, HAVCR1, HAVCR-1, TIMD1 | 38 kDa | Activated CD4+ T cells, B cell subset | role in T-helper cell development, involved in hepatitis A virus entry into cells | |
| CD366 | TIM-3, HAVCR2, TIMD3 | 33 kDa | Th1 cells | inhibitory receptor on Th1 cells | |
| CD366 | TIM-3, HAVCR2, TIMD3 | 33 kDa | Th1 cells | inhibitory receptor on Th1 cells | |
| CD367 | CLEC4A, DCIR, DDB27, CLECSF63 | 27 kDa | B cells, monocytes, granulocytes, plasmacytoid DCs, monocyte DCs | inhibitory receptor on DCs and B cells | |
| CD368 | CLEC4D, MCL, CLECSF8, CLEC-6, MPCL | 24 kDa | monocytes, macrophages | endocytic receptor | |
| CD369 | CLEC7A, DECTIN-1, CLECSF12 | 27 kDa | monocytes, macrophages, DCs, neutrophils, lymphocyteslow | lectin, necessary for TLR2-mediated inflammatory response | |
| CD370 | CLEC9A, HEEE9341, UNQ9341, DNGR1 | 27 kDa | DCs (conventional DCs, plasmacytoid DCs) | endocytic receptor | |
| CD371 | CLEC12A, CLL-1, MICL, DCAL-2 | 30 kDa | neutrophils, eosinophils, monocytes, DC subset | signal transduction |
Mouse non-CD cellular antigens
| Antigen name | Other names | MW | Structure | Distribution | Function |
|---|---|---|---|---|---|
| 4-1BBL | Tnfsf9 | TNFSF | Bact, DCact, peritoneal macact | DC activation, cytokine production | |
| 33D1 antigen | DC-specific marker | DC subpopulations | upregulated by GM-CSF, downregulated by IL-4 | ||
| AA4.1 antigen | see CD93 | ||||
| ABCG2 | see CD338 | ||||
| AC133 | see CD133 | ||||
| AID | Aicda | RNA-editing deaminase family | Germinal Center B (low to undetectable levels) | Activation-Induced Deaminase, Ig class switch recombination | |
| B7-DC | see CD273 | ||||
| B7-H1 | see CD274 | ||||
| B7-H2 | see CD275 | ||||
| B7-H3 | see CD276 | ||||
| B7-H4 | B7S1, B7x, GPI-linkedF3 | T, B, mono, DC subsets | lymphocyte costimulation | ||
| BP-1 | Ly-51, 6C3, Enpep | 120-160kD | Type II TM | early B progenitors, BM stromal cells, thymic epith | zinc metalloproteinase, glutamyl aminopeptidase |
| BTLA | see CD272 | ||||
| CCR7 | see CD197 | ||||
| CIRE | see CD209 | ||||
| c-Met | Met, HGFR/SFR, Par4 | 190kD | heterodimer, PTK | epith, hematopoietic progenitors, early thymocytes, not detected in adult tissues | tumor growth/metastasis, Hepatocyte Growth Factor/Scatter Factor receptor, T development, hematopoiesis |
| CMKLR1 | chemokine-like receptor 1 | 42kD | GPCR 7TM | pDC (CD123+), in vitro derived moDC | binds chemerin, pDC recruitment, may be involved in bone development |
| DC maturation marker | mature DC, B, intracellular granules | ||||
| DR5 | see CD262 | ||||
| DX5 | see CD49b | ||||
| F4/80 antigen | Emr1, pan-macrophage marker | 125kD | TM7 | resident tissue mac, liver Kupffer cells, not blood mono, distinguishes mono/mac from fibroblasts | macrophage maturation |
| FIRE | emr4 | 90-100kD | EGF-7TM | mac, neutrophilsact, BM derived DC | myeloid-B cell interaction |
| Flk-1 | see CD309 | ||||
| Flt-4 | VEGFR3 | 170kD | RTK family | lymphatic endoth | endoth growth factor receptor, binds VEGF-C |
| Foxp3 | SCURFIN | 50kD | Fox family forkhead | T cells (CD4+/CD25+ subset and CD8+ subset) | transcription factor, may be upregulated in T regs |
| GITR | AITR, Tnfrsf18 | 30kD | TNFRSF | T subset, Tact | costimulator for CD4+CD25+ Treg subset, induction of apoptosis, regulation of Treg and mucosal immunity |
| GITRL | AITRL, Tnfsf18 TNFSF | DC, Mac, B | costimulation for T subset | ||
| Granzyme B | CCP1, Ctla1, Gzmb | 30kD | cytotoxic granules of NK & CTL (CD8+) | proteolysis, induction of perforin-mediated apoptosis | |
| HVEM | TNFRSF14, TR2 | 60kD | TNFRSF | broad expression | receptor for LIGHT, LTalpha, BTLA, Herpes Simplex Virus, involved in lymphocyte activation |
| ICOS | see CD278 | ||||
| IgD | peripheral mature B cells | ||||
| IgE Receptor high affinity | FcepsilonRIalpha | basophils, eosinophils, mono, mast, & Langerhans cells | high affinity binding to IgE | ||
| IgM | surface expression by mature B cells | ||||
| IL-15R alpha | Tact, dim expression | binds to IL-15, w/ IL-2Rbeta and common gamma, IL-15 trans-presentation | |||
| IL-21R | broad on T, B, NK, DC | induction of apoptosis in B, expansion of CD3 activated T, NK activation, inhibition of DC | |||
| Jagged-1 | see CD339 | ||||
| JAML | JAM family | IgSF | neutrophils, mono | junctional adhesion molecule 1-like protein, cell contact, neutrophil migration, binds to CAR (coxsackie and adenovirus receptor) | |
| KLRG1 | MAFA | 30-38kD | NK & T subset | inhibition of cytokine production and cytotoxicity | |
| Lymphotoxin beta Receptor | Tnfrsf3 | 47kD | TNFRSF | mast, stromal cells, epith | lymphoid organ development |
| Ly-6A/E | Sca-1 | 18kD | GPI-linked | hematopoietic progenitors, myeloid subset, peripheral lymphoid, mast cells | T activation |
| Ly-6B | |||||
| Ly-6C | 14-17kD | GPI-linked | endoth, T, NK, mono, mac | ||
| Ly-6D | ThB, Ly-61 | 15kD | GPI-linked | B, T, thymic epith | |
| Ly-6F | |||||
| Ly-6G | Gr-1 | 21-25kD | GPI-linked | myeloid cells, upregulated in gran | |
| Ly-49A | A1, Klra1 | 85kD | Type II TM C-type lectin | T subset, NK subset | regulation of cytotoxicity, binds MHC class I |
| Ly-49B | Klra2 | ||||
| Ly-49C | Klra3, 5E6 | 110kD | Type II TM C-type lectin | T subset, NK subset | regulation of cytotoxicity, binds MHC class I |
| Ly-49D | Klra4 | Type II TM C-type lectin | NK subset | NK activation | |
| Ly-49E | Klra5 | ||||
| Ly-49F | Klra6 | ||||
| Ly-49G | LGL1, Klra7 | 85kD | Type II TM C-type lectin | T subset, NK subset | regulation of cytotoxicity |
| Ly-49H | Klra8 | Type II TM C-type lectin | |||
| Ly-49I | Klra9 | Type II TM C-type lectin | |||
| Mac-3 | 93-110kD | mac (surface & intracellular) related to CD107b | |||
| MAdCAM-1 | 50kD | IgSF, Type I TM | endoth subset | mucosal vascular addressin cell adhesion molecule, adhesion, lymph homing, binds CD49d & CD62L | |
| MCP-1 | monocyte chemoattractant protein; CCL2 | 16kD | splenocytes | chemoattractant for mac and basophils | |
| MD-1 | Ly86 | 28kD | mature B, mono/mac, DC | w/ RP105 (CD180), regulates CD180 surface expression & B cell response to LPS, also secreted | |
| Nanog | embryonic stem cells | transcription factor, ES self renewal | |||
| NKG2A | see CD159a | ||||
| NKG2A B6 | CD159a, Klrc1 | 38kD | C-type lectin | C57BL/6 mouse strain | w/ CD94, Qa-1(b) receptor, inhibitory signaling |
| NKG2B | C-type lectin | splice variant of NKG2A | |||
| NKG2C | see CD159c | ||||
| NKG2D | see CD314 | ||||
| NKG2E | C-type lectin | NK & NKT cells | w/ CD94, Qa-1(b) receptor, stimulatory signaling | ||
| Notch-1 | Lin-12, Tan1 | developing embryo, variety of adult tissues | cell-cell interaction, cell fate determination | ||
| OX40 Ligand | see CD252 | ||||
| PD-1 | see CD279 | ||||
| Perforin | Perforin1, Pfp, Prf1 | 70kD | intracellular, NK and CTL (CD8+) | cytolysis, apoptosis | |
| Plexin B2 | Plxnb2, Debt | Semaphorin/Plexin Family | mRNA in nervous system | ||
| Prominin-1 | see CD133 | ||||
| RAE-1 gamma | mRNA in early embryo, not adult tissues; upregulated by retinoic acid or certain disease conditions, RAE-1alpha, -beta, and -gamma are expressed in BALB/c mice, but not in C57BL/6, whereas RAE-1delta and -epsilon are expressed in C57BL/6 mice | ligand for NKG2D | |||
| RANK | see CD265 | ||||
| ROR gamma (t) | 58kD | ROR family Transcription Factor | Th17 cells, thymus | transcriptional regulation | |
| ROR gamma(t) Products | |||||
| SAP | SLAM-associated protein | 14kD | adaptor protein | T, NK | negatively regulates SLAM-family receptors |
| Sca-1 | see Ly6-A/E | ||||
| Sema4A | Sema b, SemB | semaphorin family | DC, B, Tact | T costimulation, may not be ligand for Tim-2? | |
| SLP-76 | 76kD | T, low in B | T cell receptor mediated signaling | ||
| SSEA-1 | stage-specific embryonic antigen-1 | mouse ES cells, embryonic carcinomas, germ cells | down regulated by differentiation | ||
| T-bet | Th1 cells | transcription factor, T development / differentiation | |||
| TCR alpha beta | T subset | antigen recognition | |||
| TCR gamma delta | T subset | antigen recognition | |||
| TCR-HY | Transgenic H-Y T cells | ||||
| Ter-119 | Ly-76 | early proerythroblast to mature erythrocyte | w/ glycophorinA, but not a typical glycophorin | ||
| TIE2 | see CD202b | ||||
| TIM-1 | Timd1, Havcr1 | Type I TM, IgSF | mRNA activated T cells | ||
| TIM-2 | Timd2 | Type I TM, IgSF | mRNA activated T cells | receptor for Sema4A | |
| TIM-3 | Th1-speci.c marker, Havcr2 | Type I TM | late stage of T cell differentiation, CD4+ Th1, CD8+ Tc1 | effector function of Th1, macrophage activation, regulation of autoimmunity, hepatitis A virus cellular receptor 2 | |
| TLR1 - TLR4 | see CD281 - CD284 | ||||
| TLR5 | mRNA: liver, lung, lower level in MOLF/Ei mice | Gram-negative bacterial infection | |||
| TLR6 | mRNA: spleen, thymus, ovary, lung | activation of NF-kappaB & JunK | |||
| TLR7 | PRO285 | 125kD | TLR family | many tissues, DC subset | innate immune response to microbial agents |
| TLR8 | PRO286 | 126kD | TLR family | many tissues, DC subset | innate immune response to microbial agents |
| TLR9 | see CD289 | ||||
| TLR11 | |||||
| TLR13 | |||||
| TRAIL | see CD253 | ||||
| TRANCE | see CD254 | ||||
| TWEAK | TNF-related weak inducer of apoptosis | TNFSF, Type II TM | mRNA in many adult and fetal tissues | membrane-bound and secreted forms, apoptosis, binds Fn14 | |
| TWEAK Receptor | see CD266 | ||||
| ZAP-70 | TCR zeta-associated kinase | 70kD | Syk family | T (intracellular), NK | TCR signaling & development |
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