Lipid nanoparticles: Enabling revolutionary therapeutics
Lipid nanoparticle (LNP) technology has established itself as a safe and effective delivery method for several successful nucleic acid therapeutics. With its versatility in delivering nucleic acids to multiple targets with therapeutic effect, LNP technology is becoming a cornerstone in the delivery of these novel medicines. Now, this technology is set to undergo further advancements, opening doors to new therapeutics by targeting the specific delivery of nucleic acids to many different targets for treating a wide array of diseases. Thermo Fisher Scientific is at the forefront of this exploration and development of lipid nanoparticle technology, helping pave the way for groundbreaking new medicines.
Discover the Vivofectamine advantage in lipid nanoparticles
Discover a world of possibilities with Invitrogen Vivofectamine Delivery Solutions for utilizing lipid nanoparticle (LNP) technology. Rationally designed for in vivo delivery of nucleic acid vaccines and therapeutics, Vivofectamine products and services offer you a distinct edge in basic research and therapeutic development. These LNPs offer versatility, safety, and acceleration of your project timelines.
Versatility—chemical diversity, flexible formats, and adaptable licensing
Leveraging over 30 years of experience in lipid-based delivery, we’ve curated the Vivofectamine Delivery Solutions LNP portfolio. Drawing upon a vast library of more than 5,000 ionizable lipids, that were designed with complex multistep organic synthesis to maximize chemical diversity, the LNPs were selected for various applications. They were purposefully chosen through repeated cycles of lipid design, synthesis, formulation optimization, and both in vitro and in vivo screening for key characteristics like safety, delivery efficiency, and specificity.
Development of Vivofectamine Delivery Solutions
Figure 1. Lipids used in Vivofectamine lipid nanoparticles were selected by directed synthesis and rigorous screening.
We are planning to continually expand our ionizable lipid library and related delivery technologies to enable broader applications for Vivofectamine Delivery Solutions.
Vivofectamine Delivery Solutions tailored for basic researchers or drug developers
Figure 2. Vivofectamine lipid nanoparticles are available for a variety of applications in several formats.
For basic researchers, we offer off-the-shelf, easy-to-use LNP reagents in ethanol. One of these formulations is optimized for intramuscular mRNA vaccine delivery and the other is optimized for intravenous delivery to the liver.
Both reagents have demonstrated in vivo performance competitive with clinical benchmarks in rodent studies. These products are specifically designed with optimized lipid selection and composition tailored for each application. This can help to speed up your research by reducing the time required to find an appropriate LNP reagent to deliver your payload.
For drug developers, we have selected safe and effective ionizable lipids and designed formulations for intramuscular mRNA vaccine and intravenous liver delivery. These lipids offer an exceptional safety profile with delivery efficiency competitive with clinical benchmarks in rodents and non-human primates (NHP). We also offer solutions to explore in vivo delivery applications for systems such as CNS, eye, and tumors using a local route of delivery for potential nucleic acid therapeutics.
Flexible formats are available to meet your needs. Our drug development portfolio offers individual ionizable lipids to craft your own formulation, custom LNP compositions optimized for specific applications, and LNP formulation services to help accelerate your path to preclinical evaluations.
Adaptive licensing support
We offer you the flexibility to obtain a license for your chosen lipids for therapeutic use at your convenience. We prioritize tailoring our licenses to fit your unique business needs, providing scalable solutions that evolve with your growth.
Safety—maximize the window of your payload delivery success
Our solutions are well-characterized in animal models at a broad range of doses. The lipids in our drug development portfolio have been further tested in large animals (rats and non-human primates (NHP)), supporting their promise for further clinical development. Our data highlight that lipids in our drug development portfolio are tolerated at high or repeated doses.
Safety in animal studies
Figure 3.1. Vivofectamine VF232 Liver LNPs from the basic research portfolio are well tolerated at 1 mg/kg dose in mice.
Figure 3.2. Vivofectamine lipid nanoparticles from the drug development portfolio are well tolerated in repeated doses in rats and non-human primates.
Accelerate your program with proven in vivo delivery solutions
Trusted in vivo delivery solutions can help accelerate your program. The meticulous selection and comprehensive testing that underpins the development of these LNP technologies helps reduce the time and resources often needed to identify the right LNP delivery solutions for your specific payload and application.
Efficacy in animal studies
Figure 4.1. Vivofectamine lipid nanoparticles from the basic research portfolio match or exceed clinical benchmark LNPs for in vivo delivery performance.
Figure 4.2. Vivofectamine lipid nanoparticles from the drug development portfolio match or exceed clinical benchmark LNPs for in vivo delivery performance in non-human primates.
Lipfectamine and Vivofectamine delivery solutions support your programs
Leverage our extensive Invitrogen Lipofectamine transfection reagents and Vivofectamine Delivery Solutions to help accelerate your progress. Use Invitrogen Lipofectamine MessengerMAX reagent for in vitro mRNA target screening and/or quality control, then utilize Vivofectamine Delivery Solutions for efficient in vivo nucleic acid delivery. Whether you’re conducting basic research or developing breakthrough medicines, we’re here to support your journey.
Stay a step ahead with Vivofectamine Delivery Solutions
Join the growing community of researchers leveraging the power of Vivofectamine Delivery Solutions to enable your innovation. At Thermo Fisher Scientific, we are committed to providing you with high-quality delivery solutions that offer versatility, performance, quality, and licensing flexibility—all designed to help you accelerate your research and drug development timelines.
Ordering information
Vivofectamine lipid nanoparticle catalog products (RUO) for basic researchers
Vivofectamine custom products and services (RUO) for drug developers
The Vivofectamine Lipid Nanoparticle Delivery Solutions for drug developer portfolio is offered exclusively through our Vivofectamine Services team. For more information or to answer any questions you may have, contact our specialists today.
For Research Use Only. Not for use in diagnostic procedures.