For researchers pursuing the next scientific breakthrough, the Thermo Scientific Vanquish Neo UHPLC system delivers maximum performance 24/7 for reproducible nano-, capillary-, and micro-flow LC-MS. Combining a high degree of innovation with the best-in-class Vanquish platform enhances productivity for novice and expert LC-MS users alike.
Highlights
All-in-one nano-, capillary-, and micro-flow LC
Thermo Scientific ProFlow™ XR active flow control pump technology delivers excellent retention time precision from nano up to 100 μL/min at pressures up to 1500 bar. Vial bottom detection enables injections from volume-limited samples.
Accelerated productivity
Fast sample loading, column equilibration and ultra-low system gradient delay volume reduce method overhead time, improving sample throughput while enhancing MS utilization. The tandem direct injection workflow accelerates productivity further by eliminating sample loading, gradient delay, column washing, and column equilibration from method cycle time.
Maximized performance
Unique low-flow split-loop autosampler design limits sample dispersion, reduces system carryover, and maximizes sample usage. The metering device improves quantitation through high injection volume linearity, precision, and accuracy.
Long-term, trouble-free analysis
Next-generation Thermo Scientific SmartInject technology improves column lifetime and retention time precision. Maintenance-free 1500 bar compatible ceramic valves and near-zero dead volume Thermo Scientific Viper and nanoViper fittings minimize leaks with robust long-term operation.
Intelligent operation
The Thermo Scientific Vanquish User Interface provides walk-up and remote system monitoring and control with automated procedures and guided instrument maintenance and troubleshooting scripts, improving productivity for all users. The intelligent method editor wizard ensures compatibility of method parameters with installed consumables.
Seamless LC-MS integration
The Vanquish Neo UHPLC system excels at high-sensitivity LC-MS applications and seamlessly integrates with the Thermo Scientific mass spectrometry portfolio through a comprehensive suite of ESI sources. Harness speed, robustness and sensitivity with triple quadrupole MS systems or resolution, mass accuracy, and versatility with Thermo Scientific Orbitrap MS systems.
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System specifications
The table below provides an overview of the Vanquish Neo UHPLC system specifications for a standard set up. Not all specifications are listed. For additional information, download the Vanquish Neo UHPLC System specifications sheet.
Category |
Vanquish Neo UHPLC System |
|---|---|
System pressure, maximum |
1500 bar |
Flow range |
1 nL/min – 100 μL/min, in 1 nL increments (100 nL/min – 100 μL/min, recommended) |
Pump options (default gradient delay volume) |
Binary (< 25 nL) |
Biocompatible |
Yes |
pH range |
2 – 10 |
System design |
Integrated, with slide-in modules |
Touchscreen user interface display compatible |
Yes |
Active flow control for maximum retention time precision |
Yes, Thermo Scientific ProFlow XR pump technology |
SmartInject technology for maximum injection precision and improved column lifetime |
Yes |
Injection volume range |
Standard: 0.01–25 μL |
Sample cooling |
Yes, 4 – 40°C |
Sample capacity (standard) Based on standard 12 mm OD vials (≤ 1.5 mL) |
4 racks of 54 vials (≤ 1.5 mL) each, other rack formats available |
Sampler extension available (optional) |
No |
Column compartment thermostatting |
Yes (optional) |
Column compartment pre-heater |
Passive (optional) |
Column compartment post-column cooler |
No |
| Workflows | Direct injection Tandem direct injection Trap-and-elute Heated trap-and-elute |
Detector choices |
|
| Optional add-on components | Column Compartment N Binary Pump N |
For Research Use Only. Not for use in diagnostic procedures.