FTIR is an analytical technique used to identify organic (and in some cases inorganic) materials. This technique measures the absorption of infrared radiation by the sample material versus wavelength. The infrared absorption bands identify molecular components and structures.
FTIR is a fast and nondestructive analytical method. Associated with chemometrics, it can become a powerful tool for the pharmaceutical industry. It is suitable for analysis of solid, liquid, and biologics pharmaceutical forms. It can be implemented during pharmaceutical development, in production for process monitoring, and in quality control laboratories.
FTIR microscopy offers many unique advantages in studying pharmaceutical packaging materials and formulations because of its sensitivity and variety of measurement modes with precise control of the area to the analyzed.
Applications covered by FTIR spectroscopy/microscopy in pharmaceutical drug development, drug formulation and manufacturing are: hyphenated technique TGA-IR for analysis of decomposition of drug product, rheometry with FTIR for understanding morphology and molecular structure simultaneously during drug formulation, stage compendial identification of raw materials based on worldwide Pharmacopeia, qualitative and quantitative evaluation of formulations, pharmaceutical packaging evaluation, and determination of quantity of active ingredients in solids and liquid dosage forms.
FTIR microscopy and imaging are used to troubleshoot manufacturing problems, identify product contaminants, image solid dosage form to evaluate and quantify distribution of API and excipients, protein secondary structure elucidation in biologics formulations, and manufacturing.
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