Vanquish UHPLC
System
The high-pressure Vanquish system provides a standardized LC method for consistent retention time performance.
Stay one step ahead. The Tox Explorer Collection helps the world's toxicology community navigate with ease to solve complex analytical challenges and increase laboratory productivity. Built upon a single software solution, the Tox Explorer Collection comes equipped with a standardized LC-MS method with retention times, (U)HPLC column, experimentally obtained compound database and library, as well as on-site LC-MS/MS instrument set-up and Tox Explorer application training, enabling smooth start-up and implementation.
For increased confidence in data and productivity in your laboratory, the Tox Explorer Collection is now available with Thermo Scientific Orbitrap MS and Thermo Scientific TSQ Plus triple quadrupole mass spectrometer platform options.
Choose from two LC-MS Platforms
Comprehensive LC-MS Solutions: Sample Collection to Reporting of Toxicology Analytes
Improve efficiency and productivity by capitalizing on an optimal combination of preparation guidelines, outstanding LC, robust MS, intuitive software, an extensive compound library and easy-to-implement methods—all backed by comprehensive training and application support. And, the flexibility to choose the mass spectrometer option that meets your needs.
Get excellent dynamic range and highly accurate mass measurements. HRAM option includes experimentally obtained compound database and HRAM spectral library with retention times of over 1800 compounds.
Increase productivity with SRM acquisition speeds enabling faster polarity switching of both positive and negative compounds. Triple quadrupole option includes experimentally obtained compound database and retention times of over 1100 compounds.
Tox Explorer Collection Components
Vanquish UHPLC
Orbitrap Exploris 120
MS
Ultra-high-resolution MS delivers high confidence results for a broad range of toxicology compounds.
TSQ Quantis Plus Triple Quadrupole MS
Fast SRM acquisition speed maximizes productivity and quantitative performance for toxicology analyses.
Accucore UHPLC Columns
Solid core 2.6µm particles deliver optimum resolution and separation for a broad range of toxicology compounds.
Tox Explorer HRAM Solution
High resolution and mass accuracy
Thermo Scientific Orbitrap technology platforms offer high resolution mass spectrometry and better mass accuracy without loss of sensitivity and provide positive/negative polarity switching in one analytical run, saving time and offering greater confidence in data output. Screening, identification, confirmation and quantitation can all be performed on one mass spectrometry platform. One of the key benefits of using high resolution accurate mass (HRAM) mass detection for toxicology analyses is the ability to use retrospective data to help with the identification of novel designer drugs.
- Screen, identify, confirm, and quantitate – all with one instrument
- Analyze a broad spectrum of compounds in one run
- Perform retrospective analysis without requiring additional experiments
- Obtain comprehensive MS/MS spectra without the need to average, while accessing positive and negative compounds in one run
- Utilize data-dependent acquisition for the identification of unknown structures via MS/MS spectra
- Exceptional mass accuracy and stability within and between runs—even at low mass ranges— ensures confidence in results
Extracted ion chromatogram of 100+ compounds covering a range of drug classes hydrophobicities, and polarities.
Data from full-scan spectrum demonstrating low ppm mass accuracy at different points under the chromatography peak of an early eluter (nicotine, left) and a later eluter (THC-COOH, right).
What experienced users are saying
"Tox Explorer Collection for Orbitrap Exploris 120 MS provides a powerful solution for forensic toxicology.
We have developed an in-house broad coverage ‘open’ screen for NPS, drugs of abuse and medications based on Q Exactive Orbitrap mass spectrometers that has allowed us to successfully deliver forensic toxicology services for the past 10 years."
The Tox Explorer Collection on the Orbitrap Exploris 120 MS has significantly enhanced the screening service. Additional analytes in the database have provided enhanced coverage helping in the identification of unique compounds in various coroner’s cases; the greater scan speed of the Orbitrap Exploris also allows complex acquisition workflows including polarity switching and targeted data dependent MS2 (ddMS2) in a single analysis.
Simon Hudson
Technical Director, LGC ASSURE
Fordham, U.K.
Resources
Tox Explorer Collection - Simplifying targeted screening with Orbitrap technology
Making the most of software
Watch a brief demonstration of how TraceFinder software can be used in conjunction with Thermo Scientifc mzVault library manager to acquire, monitor, process, review, and report data.
Targeted screening and quantitation with a Tox Explorer triple quadrupole LC-MS workflow
Whiteboard video highlighting the benefits of the Tox Explorer all-in-one toxicology solution and advantages of triple quadrupole mass spectrometry for drug screening and quantitation.
Identify the mass spectrometer option that best meets your needs and solves your toxicology challenges
For postmortem toxicological analysis, LC–HRMS assay delivers significant benefits
HRAM screening, quantitation, and confirmation of drugs with Tox Explorer Orbitrap Exploris platform
Drugs of abuse: Reliable analysis through Orbitrap mass spectrometry
Comprehensive LC-MS Platform for Increased Confidence in Toxicology
Screening and semi-quantitation of 212 fentanyl analog compounds by the Orbitrap Exploris 120 mass spectrometer
LC-MS technology enables rapid, accurate, easy-to-use methods to ensure success in toxicology analysis.
All-in-one LC-MS/MS toxicology solution for drugs of abuse quantitation using the TSQ Quantis Plus mass spectrometer
Additional resources
White papers
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For General Lab Use Only. Not for use in diagnostic procedures.
Style Sheet for Global Design System
Style Sheet for Komodo Tabs
CMD Wide-format style fixes