Product References
N-homocysteinylation of α-synuclein promotes its aggregation and neurotoxicity.
Aging cell
Zhou L,Guo T,Meng L,Zhang X,Tian Y,Dai L,Niu X,Li Y,Liu C,Chen G,Liu C,Ke W,Zhang Z,Bao A,Zhang Z
MA5-12272 was used in Immunohistochemistry to suggest that the covalent modification of α-synuclein by HTL promotes its aggregation.
Wed Mar 01 00:00:00 EST 2023
N-homocysteinylation of α-synuclein promotes its aggregation and neurotoxicity.
Aging cell
Zhou L,Guo T,Meng L,Zhang X,Tian Y,Dai L,Niu X,Li Y,Liu C,Chen G,Liu C,Ke W,Zhang Z,Bao A,Zhang Z
MA5-12272 was used in Immunohistochemistry to suggest that the covalent modification of α-synuclein by HTL promotes its aggregation.
Wed Mar 01 00:00:00 EST 2023
Angiotensin-(1-7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson's disease.
Neural regeneration research
Gao Q,Chen R,Wu L,Huang Q,Wang XX,Tian YY,Zhang YD
MA5-12272 was used in Immunocytochemistry-immunofluorescence to conclude that angiotensin-(1-7) reduces α-synuclein aggregation by alleviating autophagy dysfunction in Parkinson's disease.
Sun May 01 00:00:00 EDT 2022
Angiotensin-(1-7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson's disease.
Neural regeneration research
Gao Q,Chen R,Wu L,Huang Q,Wang XX,Tian YY,Zhang YD
MA5-12272 was used in Immunocytochemistry-immunofluorescence to conclude that angiotensin-(1-7) reduces α-synuclein aggregation by alleviating autophagy dysfunction in Parkinson's disease.
Sun May 01 00:00:00 EDT 2022
Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration.
Movement disorders : official journal of the Movement Disorder Society
Yuan X,Yang Y,Liu C,Tian Y,Xia D,Liu Z,Pan L,Xiong M,Xiong J,Meng L,Zhang Z,Ye K,Jiang H,Zhang Z
MA5-12272 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, In Vitro Assay to demonstrate that PM2.5 exposure promotes α-Syn pathology, promoting neuronal degeneration and increasing the risk for PD.
Thu Sep 01 00:00:00 EDT 2022
Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration.
Movement disorders : official journal of the Movement Disorder Society
Yuan X,Yang Y,Liu C,Tian Y,Xia D,Liu Z,Pan L,Xiong M,Xiong J,Meng L,Zhang Z,Ye K,Jiang H,Zhang Z
MA5-12272 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, In Vitro Assay to demonstrate that PM2.5 exposure promotes α-Syn pathology, promoting neuronal degeneration and increasing the risk for PD.
Thu Sep 01 00:00:00 EDT 2022
Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson's disease.
NPJ Parkinson's disease
Yan M,Xiong M,Dai L,Zhang X,Zha Y,Deng X,Yu Z,Zhang Z
MA5-12272 was used in Immunomicroscopy to illustrate the important role of cofilin 1 in the pathogenicity and transmission of α-synuclein during the onset and progression of Parkinson's disease.
Mon Jan 10 00:00:00 EST 2022
Mechanism assay of interaction between blood vessels-near infrared probe and cell surface marker proteins of endothelial cells.
Materials today. Bio
Abdul Sisak MA,Louis F,Miyao T,Lee SH,Chang YT,Matsusaki M
MA5-12272 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, In Vitro Assay to study i the competition assays of CyA-B2 using several potential surface markers of endothelial cells found through the chemical database (ChEMBL) and manually selected, CD133 gave the lowest IC50 (half maximal inhibitory concentration) value.
Wed Jun 01 00:00:00 EDT 2022
Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives.
Frontiers in immunology
Bogale TA,Faustini G,Longhena F,Mitola S,Pizzi M,Bellucci A
MA5-12272 was used in Immunocytochemistry to summarize the main findings supporting how α-synuclein can affect ECs and/or BAMs function as well as their interplay and effect on other cells in the brain perivascular environment in physiological and pathological conditions.
Wed Jun 30 00:00:00 EDT 2021
Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives.
Frontiers in immunology
Bogale TA,Faustini G,Longhena F,Mitola S,Pizzi M,Bellucci A
MA5-12272 was used in Immunocytochemistry to summarize the main findings supporting how α-synuclein can affect ECs and/or BAMs function as well as their interplay and effect on other cells in the brain perivascular environment in physiological and pathological conditions.
Wed Jun 30 00:00:00 EDT 2021
Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.
Cell death & disease
Ma Z,Liu K,Li XR,Wang C,Liu C,Yan DY,Deng Y,Liu W,Xu B
MA5-12272 was used in Western Blotting to whether Mn-dependent enhanced alpha-synuclein expression accounts for interference with BDNF/TrkB signaling.
Thu Oct 08 00:00:00 EDT 2020
Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.
Cell death & disease
Ma Z,Liu K,Li XR,Wang C,Liu C,Yan DY,Deng Y,Liu W,Xu B
MA5-12272 was used in Western Blotting to whether Mn-dependent enhanced alpha-synuclein expression accounts for interference with BDNF/TrkB signaling.
Thu Oct 08 00:00:00 EDT 2020
Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson's Disease: An In Situ Proximity Ligation Assay Study.
International journal of molecular sciences
Longhena F,Faustini G,Missale C,Pizzi M,Bellucci A
Published figure using alpha Synuclein monoclonal antibody (Product # MA5-12272) in Proximity Ligation Assay (PLA)
Wed May 30 00:00:00 EDT 2018
Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson's Disease: An In Situ Proximity Ligation Assay Study.
International journal of molecular sciences
Longhena F,Faustini G,Missale C,Pizzi M,Bellucci A
Published figure using alpha Synuclein monoclonal antibody (Product # MA5-12272) in Proximity Ligation Assay (PLA)
Wed May 30 00:00:00 EDT 2018
Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson's Disease: An In Situ Proximity Ligation Assay Study.
International journal of molecular sciences
Longhena F,Faustini G,Missale C,Pizzi M,Bellucci A
Published figure using alpha Synuclein monoclonal antibody (Product # MA5-12272) in Proximity Ligation Assay (PLA)
Wed May 30 00:00:00 EDT 2018
Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson's disease patients.
Acta neuropathologica communications
Recasens A,Carballo-Carbajal I,Parent A,Bové J,Gelpi E,Tolosa E,Vila M
MA5-12272 was used in Immunohistochemistry to study the pathogenic capacity of Parkinson's disease-derived a-synuclein aggregates.
Thu Feb 08 00:00:00 EST 2018
Cortical phosphorylated α-Synuclein levels correlate with brain wave spectra in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society
Caviness JN,Lue LF,Hentz JG,Schmitz CT,Adler CH,Shill HA,Sabbagh MN,Beach TG,Walker DG
MA5-12272 was used in western blot to analyze the correlation between brain wave spectra in Parkinson's disease and cortical phosphorylated alpha-synuclein levels
Fri Jul 01 00:00:00 EDT 2016
Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.
Stem cell reports
Schwab AJ,Ebert AD
MA5-12272 was used in immunocytochemistry to study the effect of G2019S on neuronal subtypes
Tue Dec 08 00:00:00 EST 2015
A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.
Molecular neurodegeneration
Spencer B,Valera E,Rockenstein E,Trejo-Morales M,Adame A,Masliah E
MA5-12272 was used in western blot to reduce alpha-synuclein accumulation in a mouse model of multiple system atrophy by using a brain-targeted, modified neurosin (kallikrein-6)
Wed Sep 23 00:00:00 EDT 2015
Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease.
Journal of neuroinflammation
Kim C,Ojo-Amaize E,Spencer B,Rockenstein E,Mante M,Desplats P,Wrasidlo W,Adame A,Nchekwube E,Oyemade O,Okogun J,Chan M,Cottam H,Masliah E
MA5-12272 was used in immunohistochemistry to study a mouse model of Parkinson's disease for hypoestoxide to reduce neuroinflammation and alpha-synuclein accumulation
Fri Dec 18 00:00:00 EST 2015
Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.
Acta neuropathologica communications
Bourdenx M,Dovero S,Engeln M,Bido S,Bastide MF,Dutheil N,Vollenweider I,Baud L,Piron C,Grouthier V,Boraud T,Porras G,Li Q,Baekelandt V,Scheller D,Michel A,Fernagut PO,Georges F,Courtine G,Bezard E,Dehay B
MA5-12272 was used in immunohistochemistry to study alpha-synuclein overexpression by lack of an additive role of aging in nigrostriatal neurodegeneration
Sat Jul 25 00:00:00 EDT 2015
Differential expression of alpha-synuclein in hippocampal neurons.
PloS one
Taguchi K,Watanabe Y,Tsujimura A,Tatebe H,Miyata S,Tokuda T,Mizuno T,Tanaka M
MA5-12272 was used in immunocytochemistry to study the hippocampal neuronal expression of alpha-synuclein under normal and pathological conditions
Mon Dec 22 00:00:00 EST 2014
α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.
The Journal of biological chemistry
Chen RHC,Wislet-Gendebien S,Samuel F,Visanji NP,Zhang G,Marsilio D,Langman T,Fraser PE,Tandon A
MA5-12272 was used in western blot to study the role of Rab3a and synaptic activity in the membrane association of alpha-synuclein
Fri Mar 15 00:00:00 EDT 2013
α-synuclein phosphorylation and truncation are normal events in the adult human brain.
Neuroscience
Muntané G,Ferrer I,Martinez-Vicente M
MA5-12272 was used in western blot to study the constitutive truncation and phosphorylation of alpha-synuclein in normal human brain
Tue Jan 03 00:00:00 EST 2012
Neuropathology in mice expressing mouse alpha-synuclein.
PloS one
Rieker C,Dev KK,Lehnhoff K,Barbieri S,Ksiazek I,Kauffmann S,Danner S,Schell H,Boden C,Ruegg MA,Kahle PJ,van der Putten H,Shimshek DR
MA5-12272 was used in western blot to characterize mice that over express murine alpha-Synuclein
Thu Mar 01 00:00:00 EST 2012
Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability.
The European journal of neuroscience
Feng LR,Federoff HJ,Vicini S,Maguire-Zeiss KA
MA5-12272 was used in immunocytochemistry to study direct synuclein-induced cell membrane changes
Thu Jul 01 00:00:00 EDT 2010
Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progression.
The American journal of pathology
Shi M,Bradner J,Bammler TK,Eaton DL,Zhang J,Ye Z,Wilson AM,Montine TJ,Pan C,Zhang J
MA5-12272 was used in Immunohistochemistry to study the role of the levels of glutathione S-transferase Pi in modulating the progression of Parkinson's disease.
Wed Jul 01 00:00:00 EDT 2009
A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3.
Journal of neuropathology and experimental neurology
Holm IE,Englund E,Mackenzie IR,Johannsen P,Isaacs AM
MA5-12272 was used in immunohistochemistry to re-evaluate the neuropathology of frontotemporal dementia linked to chromosome 3 in a Danish family
Mon Oct 01 00:00:00 EDT 2007
Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease.
Neuroscience letters
Dalfó E,Martinez A,Muntané G,Ferrer I
MA5-12272 was used in western blot to study the distinct changes in the solubility, aggregation and tyrosine nitration of alpha-synuclein observed in the frontal cortex in Pick' disease
Mon May 29 00:00:00 EDT 2006
.jpg?time=20220826)
.jpg?time=20220826?time=20220826 "alpha Synuclein Antibody (MA5-12272) in ICC/IF")
