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Product Details
10936-1-AP
Species Reactivity
Host/Isotype
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Type
Immunogen
Conjugate
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Purification
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Product Specific Information
This antibody was raised against the N-terminal region of human YWHAB.
Immunogen sequence: MNDLICFLD NTFKNNVLSQ AWWCVHLVPT IWEAEAGGSL EPRSLKLQCP VVAPVNNCTP AWAT (1-63 aa encoded by BC010352)
Target Information
14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms(beta, gamma, epsilon, eta, zeta, sigma and tau/theta) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cup-shaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 14-3-3 alpha; 14-3-3 protein beta; 14-3-3 protein beta-subtype; 14-3-3 protein beta/alpha; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; brain protein 14-3-3, beta isoform; epididymis secretory protein Li 1; KCIP 1; KCIP-1; KCIP1; Prepronerve growth factor RNH-1; Protein 1054; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; RP1-148E22.1; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide
Gene Aliases: 1300003C17Rik; GW128; HEL-S-1; HS1; KCIP-1; YWHAA; YWHAB
UniProt ID: (Human) P31946, (Mouse) Q9CQV8, (Rat) P35213
Entrez Gene ID: (Human) 7529, (Mouse) 54401, (Rat) 56011
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