Invitrogen

VCP Polyclonal Antibody

Advanced Verification

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

View all (37) VCP antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-82472

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (IHC)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human VCP. Recombinant protein control fragment (Product #RP-89944).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Anitgen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2789630

Product Specific Information

Immunogen sequence: PVAKDVDLEF LAKMTNGFSG ADLTEICQRA CKLAIRESIE SEIRRERERQ TNPSAMEVEE DDPVPEIRRD HFEEAMRFAR RSVSDNDIRK YEMFAQTLQQ SRGFGSFRF

Target Information

The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 15S Mg(2+)-ATPase p97 subunit; epididymis luminal protein 220; epididymis secretory protein Li 70; or HEL-S-70; p97 atpase; TER ATPase; Transitional endoplasmic reticulum ATPase; Valosin-containing protein; VCP; yeast Cdc48p homolog

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Gene Aliases: ALS14; CMT2Y; HEL-220; HEL-S-70; IBMPFD; IBMPFD1; p97; TERA; VCP

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UniProt ID: (Human) P55072

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Entrez Gene ID: (Human) 7415

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Function(s)
protein binding ATP binding lipid binding ATPase activity protein phosphatase binding protein domain specific binding polyubiquitin binding ubiquitin protein ligase binding deubiquitinase activator activity K48-linked polyubiquitin binding MHC class I protein binding identical protein binding ADP binding ubiquitin-like protein ligase binding poly(A) RNA binding BAT3 complex binding ubiquitin-specific protease binding
Process(es)
DNA repair double-strand break repair NADH metabolic process ER to Golgi vesicle-mediated transport autophagy activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus positive regulation of mitochondrial membrane potential protein ubiquitination protein N-linked glycosylation via asparagine viral genome replication translesion synthesis ER-associated ubiquitin-dependent protein catabolic process endoplasmic reticulum unfolded protein response retrograde protein transport, ER to cytosol positive regulation of protein complex assembly positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein hexamerization ERAD pathway regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process establishment of protein localization positive regulation of protein catabolic process ATP metabolic process protein homooligomerization aggresome assembly error-free translesion synthesis ER-associated misfolded protein catabolic process flavin adenine dinucleotide catabolic process autophagosome maturation positive regulation of protein K63-linked deubiquitination positive regulation of Lys63-specific deubiquitinase activity regulation of aerobic respiration positive regulation of oxidative phosphorylation positive regulation of ubiquitin-specific protease activity positive regulation of ATP biosynthetic process
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