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TWEAK Antibody (PA5-20211) in IHC (P)
Product Details
PA5-20211
Species Reactivity
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Immunogen
Conjugate
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Product Specific Information
A suggested positive control is human brain tissue lysate.
Target Information
TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: APO3 ligand; APO3/DR3 ligand; MGC129581; MGC20669; TNF-related WEAK inducer of apoptosis; tumor necrosis factor (ligand) superfamily member 12; tumor necrosis factor (ligand) superfamily, member 12; tumor necrosis factor ligand 4A; Tumor necrosis factor ligand superfamily member 12; TWEAK
Gene Aliases: APO3L; Dr3l; DR3LG; TNFSF12; TNLG4A; TWEAK; UNQ181/PRO207
UniProt ID: (Human) O43508, (Mouse) O54907
Entrez Gene ID: (Human) 8742, (Mouse) 21944
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