Invitrogen

TNFR1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-86258

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to amino acids 370-420 of Human TNF-R1
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803047

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD120a; CD120a antigen; MGC19588; n-smase activation assoc. factor; p55; p60; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TNF receptor alpha chain; TNF-alpha-R1; TNF-R1; TNF-RI; TNFR; TNFR I; TNFR-I; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor; Tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; Tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor

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Gene Aliases: CD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR; TNFR-1; Tnfr-2; TNFR1; TNFR1-d2; TNFR55; TNFR60; TNFRI; TNFRp55; TNFRSF1A

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UniProt ID: (Human) P19438, (Rat) P22934, (Mouse) P25118

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Entrez Gene ID: (Human) 7132, (Rat) 25625, (Mouse) 21937

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Function(s)
tumor necrosis factor-activated receptor activity protein binding tumor necrosis factor binding protease binding protein complex binding transmembrane signal receptor
Process(es)
prostaglandin metabolic process inflammatory response immune response I-kappaB kinase/NF-kappaB signaling extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage regulation of tumor necrosis factor-mediated signaling pathway viral process cytokine-mediated signaling pathway response to lipopolysaccharide tumor necrosis factor-mediated signaling pathway regulation of cell proliferation positive regulation of tyrosine phosphorylation of Stat1 protein defense response to bacterium regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response positive regulation of inflammatory response cellular response to mechanical stimulus death-inducing signaling complex assembly establishment of protein localization to plasma membrane regulation of establishment of endothelial barrier positive regulation of ceramide biosynthetic process response to hypoxia defense response cell surface receptor signaling pathway response to wounding positive regulation of gene expression negative regulation of gene expression programmed cell death negative regulation of interleukin-6 production positive regulation of tumor necrosis factor production tetrapyrrole metabolic process positive regulation of protein import into nucleus, translocation negative regulation of apoptotic process response to amino acid response to alkaloid positive regulation of neuron apoptotic process response to ethanol positive regulation of angiogenesis protein heterooligomerization cellular response to estradiol stimulus apoptotic process signal transduction
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