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Product Details
H00051284-M02
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Storage conditions
Shipping conditions
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: ARWFPKTLPC DVTLDVPKNH VIVDCTDKHL TEIPGGIPTN TTNLTLTINH IPDISPASFH RLDHLVEIDF RCNCVPIPLG SKNNMCIKRL QIKPRSFSGL
Target Information
TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: RP23-139P21.3; Toll-like receptor 7; toll-like receptor 7-like
Gene Aliases: TLR7; TLR7-like; UNQ248/PRO285
UniProt ID: (Human) Q9NYK1
Entrez Gene ID: (Human) 51284
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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