Invitrogen

TAK1 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

1 Published Figure
1 Reference
View all (49) TAK1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-17507

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
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Product Specifications

Species Reactivity

Bovine, Human, Mouse, Non-human primate, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues near the carboxy-terminus of human TAK1
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

29 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10979591

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

TAK1 (also known as MAP3K7), a part of the serine/threonine kinase family, is a versatile protein with many signaling functions. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin beta1 and integrin beta5, promoting proper wound healing. TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 is autophosphorylated at Thr178, Thr184, Thr187 and Ser192, and finally TAK1 phosphorylates IKK- beta. Additionally, TAK1 represses human telomerase reverse transcriptase suggesting a role in regulation of cell lifespan.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: M3K7; mitogen activated protein kinase kinase kinase 7; Mitogen-activated protein kinase kinase kinase 7; RP1-154G14.1; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1

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Gene Aliases: B430101B05; C87327; MAP3K7; MEKK7; TAK1; TGF1a

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UniProt ID: (Bovine) A2VDU3, (Human) O43318, (Mouse) Q62073, (Rat) P0C8E4

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Entrez Gene ID: (Bovine) 529146, (Human) 6885, (Mouse) 26409, (Rat) 313121

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Function(s)
magnesium ion binding MAP kinase kinase kinase activity ATP binding protein kinase activity protein serine/threonine kinase activity protein binding scaffold protein binding nucleotide binding MAP kinase kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding non-receptor serine/threonine protein kinase protein modifying enzyme
Process(es)
activation of MAPKK activity apoptotic process I-kappaB phosphorylation JNK cascade positive regulation of JUN kinase activity activation of MAPK activity stimulatory C-type lectin receptor signaling pathway positive regulation of T cell cytokine production MyD88-dependent toll-like receptor signaling pathway transcription, DNA-templated transforming growth factor beta receptor signaling pathway Wnt signaling pathway, calcium modulating pathway I-kappaB kinase/NF-kappaB signaling activation of NF-kappaB-inducing kinase activity positive regulation of interleukin-2 production Fc-epsilon receptor signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling histone H3 acetylation T cell receptor signaling pathway positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade nucleotide-binding oligomerization domain containing signaling pathway MAPK cascade angiogenesis neural tube formation regulation of transcription, DNA-templated protein phosphorylation phosphorylation positive regulation of JNK cascade negative regulation of necroptotic process negative regulation of ripoptosome assembly involved in necroptotic process regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of apoptotic signaling pathway
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