Proteintech

STAT6 Polyclonal Antibody

STAT6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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STAT6 Antibody (51073-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human spleen using 51073-1-AP (STAT6 antibody) at dilution of 1:50 (under 40x lens).

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Product Details

51073-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody could identify about 100 kDa band.

Target Information

STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.

Molecular immunology

Xu M,Hu J,Yang L,Gen G,Fu Z,Luo Z,Zou W

Sun Jan 01 00:00:00 EST 2023

Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.

Cellular signalling

Tian J,Zhang L,La X,Fan X,Li A,Wu C,An Y,Yan S,Dong X,Wu H,Li Z

Tue Aug 01 00:00:00 EDT 2023

Determination of WWOX Function in Modulating Cellular Pathways Activated by AP-2α and AP-2γ Transcription Factors in Bladder Cancer.

Cells

Kołat D,Kałuzińska Ż,Bednarek AK,Płuciennik E

Tue Apr 19 00:00:00 EDT 2022

miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression.

Proceedings of the National Academy of Sciences of the United States of America

Ma C,He D,Tian P,Wang Y,He Y,Wu Q,Jia Z,Zhang X,Zhang P,Ying H,Jin ZB,Hu G

Tue Feb 08 00:00:00 EST 2022

Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells.

Cell death & disease

Chen L,Chen D,Li J,He L,Chen T,Song D,Shan S,Wang J,Lu X,Lu B

Mon Nov 28 00:00:00 EST 2022

Intestinal Epithelial STAT6 Activation Rescues the Defective Anti-Helminth Responses Caused by Ogt Deletion.

International journal of molecular sciences

Xiong X,Huang R,Li Z,Yang C,Wang Q,Ruan HB,Xu L

Thu Sep 22 00:00:00 EDT 2022

Intestinal Epithelial STAT6 Activation Rescues the Defective Anti-Helminth Responses Caused by Ogt Deletion.

International journal of molecular sciences

Xiong X,Huang R,Li Z,Yang C,Wang Q,Ruan HB,Xu L

Thu Sep 22 00:00:00 EDT 2022

Schisandra chinensis Lignans Exert Antidepressant Effects by Promoting BV2 Microglia Polarization toward the M2 Phenotype through the Activation of the Cannabinoid Receptor Type-2-Signal Transducer and Activator of Transcription 6 Pathway.

Journal of agricultural and food chemistry

Wang J,Zhang G,Yang Y,Zhang X,Shi K,Zhang X,Yan T,Jia Y

Wed Nov 09 00:00:00 EST 2022

Activation of STAT6 by intranasal allergens correlated with the development of eosinophilic chronic rhinosinusitis in a mouse model.

International journal of immunopathology and pharmacology

Wei H,Xu L,Sun P,Xing H,Zhu Z,Liu J

Wed Jun 22 00:00:00 EDT 2022

Long non-coding RNA nuclear paraspeckle assembly transcript 1 promotes activation of T helper 2 cells via inhibiting STAT6 ubiquitination.

Human cell

Huang S,Dong D,Zhang Y,Chen Z,Geng J,Zhao Y

Sat May 01 00:00:00 EDT 2021

A miR-129-5P/ARID3A Negative Feedback Loop Modulates Diffuse Large B Cell Lymphoma Progression and Immune Evasion Through Regulating the PD-1/PD-L1 Checkpoint.

Frontiers in cell and developmental biology

Zheng W,Lai G,Lin Q,Issah MA,Fu H,Shen J

Wed Nov 17 00:00:00 EST 2021

Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.

Life sciences

Yang T,Wang R,Liu H,Wang L,Li J,Wu S,Chen X,Yang X,Zhao Y

Mon Feb 01 00:00:00 EST 2021

Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.

Life sciences

Yang T,Wang R,Liu H,Wang L,Li J,Wu S,Chen X,Yang X,Zhao Y

Mon Feb 01 00:00:00 EST 2021

Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.

Life sciences

Yang T,Wang R,Liu H,Wang L,Li J,Wu S,Chen X,Yang X,Zhao Y

Mon Feb 01 00:00:00 EST 2021

Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.

Life sciences

Yang T,Wang R,Liu H,Wang L,Li J,Wu S,Chen X,Yang X,Zhao Y

Mon Feb 01 00:00:00 EST 2021

CTHRC1 in Ovarian Cancer Promotes M2-Like Polarization of Tumor-Associated Macrophages via Regulation of the STAT6 Signaling Pathway.

OncoTargets and therapy

Bai Y,Yin K,Su T,Ji F,Zhang S

Fri Apr 15 00:00:00 EDT 2022

IL-4 Switches Microglia/macrophage M1/M2 Polarization and Alleviates Neurological Damage by Modulating the JAK1/STAT6 Pathway Following ICH.

Neuroscience

He Y,Gao Y,Zhang Q,Zhou G,Cao F,Yao S

Mon Jun 15 00:00:00 EDT 2020

Study on the Inhibitory Effects of Ephedra Aconite Asarum Decoction on LPS-Induced Dendritic Cells.

Evidence-based complementary and alternative medicine : eCAM

Ji W,Hu J,Yu X,Zhang L,Liu M,Wang Q

Wed Sep 30 00:00:00 EDT 2020

Study on the Inhibitory Effects of Ephedra Aconite Asarum Decoction on LPS-Induced Dendritic Cells.

Evidence-based complementary and alternative medicine : eCAM

Ji W,Hu J,Yu X,Zhang L,Liu M,Wang Q

Wed Sep 30 00:00:00 EDT 2020

Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection.

Frontiers in cellular and infection microbiology

Luo T,Dunphy PS,McBride JW

Thu Jan 11 00:00:00 EST 2018

Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection.

Frontiers in cellular and infection microbiology

Luo T,Dunphy PS,McBride JW

Thu Jan 11 00:00:00 EST 2018

IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis.

BMC microbiology

Shen P,Li Q,Ma J,Tian M,Hong F,Zhai X,Li J,Huang H,Shi C

Wed Aug 23 00:00:00 EDT 2017

IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis.

BMC microbiology

Shen P,Li Q,Ma J,Tian M,Hong F,Zhai X,Li J,Huang H,Shi C

Wed Aug 23 00:00:00 EDT 2017

Mechanism of Corilagin interference with IL-13/STAT6 signaling pathways in hepatic alternative activation macrophages in schistosomiasis-induced liver fibrosis in mouse model.

European journal of pharmacology

Du P,Ma Q,Zhu ZD,Li G,Wang Y,Li QQ,Chen YF,Shang ZZ,Zhang J,Zhao L

Thu Dec 15 00:00:00 EST 2016

Mechanism of Corilagin interference with IL-13/STAT6 signaling pathways in hepatic alternative activation macrophages in schistosomiasis-induced liver fibrosis in mouse model.

European journal of pharmacology

Du P,Ma Q,Zhu ZD,Li G,Wang Y,Li QQ,Chen YF,Shang ZZ,Zhang J,Zhao L

Thu Dec 15 00:00:00 EST 2016

Molecular analysis of curcumin-induced polarization of murine RAW264.7 macrophages.

Journal of cardiovascular pharmacology

Chen F,Guo N,Cao G,Zhou J,Yuan Z

Sun Jun 01 00:00:00 EDT 2014

Molecular analysis of curcumin-induced polarization of murine RAW264.7 macrophages.

Journal of cardiovascular pharmacology

Chen F,Guo N,Cao G,Zhou J,Yuan Z

Sun Jun 01 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: 12S1644; IL-4 Stat; IL4 STAT; Signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; Signal transducer and transcription activator 6; STAT; STAT, interleukin4-induced; STAT-6; transcription factor IL-4 STAT

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Gene Aliases: D12S1644; IL-4-STAT; STAT6; STAT6B; STAT6C

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UniProt ID: (Human) P42226, (Mouse) P52633

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Entrez Gene ID: (Human) 6778, (Rat) 362896, (Mouse) 20852

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Function(s)

RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding signal transducer activity protein binding protein phosphatase binding identical protein binding DNA binding sequence-specific DNA binding DNA-binding transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter T-helper 1 cell lineage commitment negative regulation of type 2 immune response transcription, DNA-templated regulation of transcription from RNA polymerase II promoter signal transduction positive regulation of type I interferon production mammary gland epithelial cell proliferation interleukin-4-mediated signaling pathway regulation of cell proliferation positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgE isotypes mammary gland morphogenesis cellular response to hydrogen peroxide cellular response to reactive nitrogen species cytokine-mediated signaling pathway response to cytokine regulation of transcription, DNA-templated

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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STAT6 Polyclonal Antibody

STAT6 Antibody (51073-1-AP) in IHC (P)

Product Details

51073-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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