Proteintech

SOX2 Monoclonal Antibody (4B9B10)

SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 17

SOX2 Antibody (66411-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 66411-1-IG ( SOX2 Antibody) at dilution of 1:500 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

SOX2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

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Product Details

66411-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

View 19 publications 19 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 10 publications 10 publications

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4B9B10

Immunogen

SOX2 Fusion Protein Ag13635 (1-317 aa encoded by BC013923)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is raised against an internal region of human SOX2.

Immunogen sequence: MYNMMETEL KPPGPQQTSG GGGGNSTAAA AGGNQKNSPD RVKRPMNAFM VWSRGQRRKM AQENPKMHNS EISKRLGAEW KLLSETEKRP FIDEAKRLRA LHMKEHPDYK YRPRRKTKTL MKKDKYTLPG GLLAPGGNSM ASGVGVGAGL GAGVNQRMDS YAHMNGWSNG SYSMMQDQLG YPQHPGLNAH GAAQMQPMHR YDVSALQYNS MTSSQTYMNG SPTYSMSYSQ QGTPGMALGS MGSVVKSEAS SSPPVVTSSS HSRAPCQAGD LRDMISMYLP GAEVPEPAAP SRLHMSQHYQ SGPVPGTAIN GTLPLSHM (1-317 aa encoded by BC013923)

Target Information

SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Cell death & disease

Li Q,Kong F,Cong R,Ma J,Wang C,Ma X

Fri Mar 03 00:00:00 EST 2023

Culture of cerebrospinal fluid-contacting neurons from neonatal mouse spinal cord.

Cell and tissue banking

Cao L,Zhang HQ,He YQ,An PJ,Yang LL,Tan W,Liu G,Wang CQ,Dou XW,Li Q

Tue Jun 27 00:00:00 EDT 2023

Overexpression of NT3^P75-2 gene modified bone marrow mesenchymal stem cells supernatant promotes neurological function recovery in ICH rats.

Neuroscience letters

Huang D,Bao H,Wu J,Zhuge Q,Yang J,Ye S

Mon Feb 06 00:00:00 EST 2023

Supramolecular Hydrogel Microspheres of Platelet-Derived Growth Factor Mimetic Peptide Promote Recovery from Spinal Cord Injury.

ACS nano

Wu W,Jia S,Xu H,Gao Z,Wang Z,Lu B,Ai Y,Liu Y,Liu R,Yang T,Luo R,Hu C,Kong L,Huang D,Yan L,Yang Z,Zhu L,Hao D

Tue Feb 28 00:00:00 EST 2023

Enhanced binding of β-catenin and β-TrCP mediates LMPt's anti-CSCs activity in colorectal cancer.

Biochemical pharmacology

Wang M,Wang X,Zhao W,Li Y,Cai M,Wang K,Xi X,Zhao C,Zhou H,Shao R,Xia G,Zhang Y,Zhao W

Thu Jun 01 00:00:00 EDT 2023

FAK downregulation suppresses stem-like properties and migration of human colorectal cancer cells.

PloS one

Xu C,Zhang W,Liu C

Mon May 08 00:00:00 EDT 2023

Commercial dishes with gelatin-free microstructured inserts for elongated stem cell self-renewal and pluripotency.

iScience

Ban Q,Hui W,Duan Q,Liu W,Zhang M,Li X,Kang H,Shi Z,Zhang Y,Hou J,Xu X,Ye S,Zhang B,Xu X

Fri Apr 21 00:00:00 EDT 2023

Commercial dishes with gelatin-free microstructured inserts for elongated stem cell self-renewal and pluripotency.

iScience

Ban Q,Hui W,Duan Q,Liu W,Zhang M,Li X,Kang H,Shi Z,Zhang Y,Hou J,Xu X,Ye S,Zhang B,Xu X

Fri Apr 21 00:00:00 EDT 2023

Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3.

Cancer gene therapy

Gong W,Guo Y,Yuan H,Chai R,Wan Z,Zheng B,Hu X,Chen B,Gao S,Dai Q,Yu P,Tu S

Thu Jun 01 00:00:00 EDT 2023

The Role of Purine Metabolism-Related Genes PPAT and IMPDH1 in the Carcinogenesis of Intrahepatic Cholangiocarcinoma Based on Metabonomic and Bioinformatic Analyses.

Journal of oncology

Liu CJ,Ma ZZ,Gong WZ,Mao XH,Wen HQ,Wang XH

Thu Feb 02 00:00:00 EST 2023

Bufalin Inhibits Tumorigenesis, Stemness, and Epithelial-Mesenchymal Transition in Colorectal Cancer through a C-Kit/Slug Signaling Axis.

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Ding L,Yang Y,Lu Q,Qu D,Chandrakesan P,Feng H,Chen H,Chen X,Liao Z,Du J,Cao Z,Weygant N

Tue Nov 01 00:00:00 EDT 2022

WTAP promotes oesophageal squamous cell carcinoma development by decreasing CPSF4 expression in an m⁶A-dependent manner.

Medical oncology (Northwood, London, England)

Luo Q,Zhan X,Kuang Y,Sun M,Dong F,Sun E,Chen B

Thu Sep 29 00:00:00 EDT 2022

Prdm14 promotes mouse ESC self-renewal and PGCLC specification through enhancement of Stat3 activity.

iScience

Li Y,Yang Z,Li X,Yu Y,Li X,Chen P,Li B,Wang X,Ye SD

Fri Nov 18 00:00:00 EST 2022

RNA-seq and ATAC-seq analyses of multilineage differentiating stress enduring cells: Comparison with dermal fibroblasts.

Cell biology international

Mao XQ,Cheng Y,Zhang RZ,Liu YB,Li Y,Ge K,Jin HL

Thu Sep 01 00:00:00 EDT 2022

An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression.

Nanoscale

Wang D,Tian Y,Zhang Y,Sun X,Wu Y,Liu R,Zeng F,Du J,Hu K

Thu Oct 27 00:00:00 EDT 2022

Addressing Doxorubicin Resistance in Bone Sarcomas Using Novel Drug-Resistant Models.

International journal of molecular sciences

Gallego B,Murillo D,Rey V,Huergo C,Estupiñán Ó,Rodríguez A,Tornín J,Rodríguez R

Wed Jun 08 00:00:00 EDT 2022

Type II collagen-positive progenitors are important stem cells in controlling skeletal development and vascular formation.

Bone research

Li X,Yang S,Yuan G,Jing D,Qin L,Zhao H,Yang S

Thu Jun 23 00:00:00 EDT 2022

The neural stem cell properties of Pkd2l1⁺ cerebrospinal fluid-contacting neurons in vivo.

Frontiers in cellular neuroscience

Cao L,Huang MZ,Zhang Q,Luo ZR,Zhang Y,An PJ,Yang LL,Tan W,Wang CQ,Dou XW,Li Q

Wed Sep 28 00:00:00 EDT 2022

The neural stem cell properties of Pkd2l1⁺ cerebrospinal fluid-contacting neurons in vivo.

Frontiers in cellular neuroscience

Cao L,Huang MZ,Zhang Q,Luo ZR,Zhang Y,An PJ,Yang LL,Tan W,Wang CQ,Dou XW,Li Q

Wed Sep 28 00:00:00 EDT 2022

Molecular Mechanisms Underlying the Inhibition of Proliferation and Differentiation by Florfenicol in P19 Stem Cells: Transcriptome Analysis.

Frontiers in pharmacology

Hu D,Zhang B,Suo Y,Li Z,Wan Z,Zhao W,Chen L,Yin Z,Ning H,Ge Y,Li W

Sat Apr 23 00:00:00 EDT 2022

Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells.

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The Neural Stem Cell Properties of PKD2L1⁺ Cerebrospinal Fluid-Contacting Neurons in vitro.

Frontiers in cellular neuroscience

Wang S,He Y,Zhang H,Chen L,Cao L,Yang L,Wang C,Pan Y,Tang Q,Tan W,Dou X,Li Q

Fri Apr 02 00:00:00 EDT 2021

Parthenolide inhibits the tumor characteristics of renal cell carcinoma.

International journal of oncology

Liu D,Han Y,Liu L,Ren X,Zhang H,Fan S,Qin T,Li L

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ESRRB Facilitates the Conversion of Trophoblast-Like Stem Cells From Induced Pluripotent Stem Cells by Directly Regulating CDX2.

Frontiers in cell and developmental biology

Yu S,Zhang R,Shen Q,Zhu Z,Zhang J,Wu X,Zhao W,Li N,Yang F,Wei H,Hua J

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Gadd45g initiates embryonic stem cell differentiation and inhibits breast cell carcinogenesis.

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Zhang X,Li Y,Ji J,Wang X,Zhang M,Li X,Zhang Y,Zhu Z,Ye SD,Wang X

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Mesenchymal stem/stromal cells-derived IL-6 promotes nasopharyngeal carcinoma growth and resistance to cisplatin via upregulating CD73 expression.

Journal of Cancer

Zeng J,Chen S,Li C,Ye Z,Lin B,Liang Y,Wang B,Ma Y,Chai X,Zhang X,Zhou K,Zhang Q,Zhang H

Mon Sep 28 00:00:00 EDT 2020

Mesenchymal stem/stromal cells-derived IL-6 promotes nasopharyngeal carcinoma growth and resistance to cisplatin via upregulating CD73 expression.

Journal of Cancer

Zeng J,Chen S,Li C,Ye Z,Lin B,Liang Y,Wang B,Ma Y,Chai X,Zhang X,Zhou K,Zhang Q,Zhang H

Mon Sep 28 00:00:00 EDT 2020

Mesenchymal stem/stromal cells-derived IL-6 promotes nasopharyngeal carcinoma growth and resistance to cisplatin via upregulating CD73 expression.

Journal of Cancer

Zeng J,Chen S,Li C,Ye Z,Lin B,Liang Y,Wang B,Ma Y,Chai X,Zhang X,Zhou K,Zhang Q,Zhang H

Mon Sep 28 00:00:00 EDT 2020

Mesenchymal stem/stromal cells-derived IL-6 promotes nasopharyngeal carcinoma growth and resistance to cisplatin via upregulating CD73 expression.

Journal of Cancer

Zeng J,Chen S,Li C,Ye Z,Lin B,Liang Y,Wang B,Ma Y,Chai X,Zhang X,Zhou K,Zhang Q,Zhang H

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Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis.

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Xu X,Zhang X,Wei C,Zheng D,Lu X,Yang Y,Luo A,Zhang K,Duan X,Wang Y

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MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer.

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Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.

Molecular medicine reports

He J,Shi J,Zhang K,Xue J,Li J,Yang J,Chen J,Wei J,Ren H,Liu X

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Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.

Molecular medicine reports

He J,Shi J,Zhang K,Xue J,Li J,Yang J,Chen J,Wei J,Ren H,Liu X

Sat Apr 01 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); sex determining region Y-box 2; SOX 2; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box 2; SRY-box 2; SOX2; SRY-box containing gene 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2

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Gene Aliases: ANOP3; lcc; MCOPS3; RGD1565646; Sox-2; SOX2; ysb

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UniProt ID: (Human) P48431, (Mouse) P48432

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Entrez Gene ID: (Human) 6657, (Pig) 407739, (Rat) 499593, (Mouse) 20674

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Function(s)

transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding miRNA binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function chromatin binding transcription factor binding protein heterodimerization activity chromatin DNA binding HMG box transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation eye development endodermal cell fate specification chromatin organization regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell cycle arrest response to wounding regulation of gene expression glial cell fate commitment pituitary gland development adenohypophysis development positive regulation of cell-cell adhesion forebrain development somatic stem cell population maintenance tissue regeneration regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade positive regulation of cell differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter inner ear development negative regulation of epithelial cell proliferation response to growth factor negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance cell fate specification positive regulation of neuroblast proliferation regulation of transcription from RNA polymerase II promoter sensory perception of sound response to organic substance stem cell population maintenance forebrain neuron differentiation cerebral cortex development negative regulation of Wnt signaling pathway male genitalia development positive regulation of epithelial cell differentiation olfactory placode formation response to retinoic acid inner ear morphogenesis tongue development cell fate commitment negative regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of Notch signaling pathway pigment biosynthetic process lung alveolus development embryonic organ development anatomical structure formation involved in morphogenesis neuron fate commitment diencephalon morphogenesis stem cell differentiation regulation of neurogenesis detection of mechanical stimulus involved in sensory perception of sound detection of mechanical stimulus involved in equilibrioception retina morphogenesis in camera-type eye lens induction in camera-type eye epithelial tube branching involved in lung morphogenesis transcription, DNA-templated multicellular organism development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SOX2 Monoclonal Antibody (4B9B10)

SOX2 Antibody (66411-1-IG) in IHC (P)

Product Details

66411-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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