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Product Details
MA5-35746
Species Reactivity
Host/Isotype
Expression System
Class
Type
Clone
Immunogen
Conjugate
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Storage buffer
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RRID
Product Specific Information
Immunogen sequence: HHKDDPPPPE DDENKEKRTD DIPVWDQEFL KVDQGTLFEL ILAANYLDIK GLLDVTCKTV ANMIKGKTPE EIRKTFNIKN DFTEEEEAQV RKENQWCEEK
Target Information
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteasome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: cyclin A/CDK2-associated p19; cyclin A/CDK2-associated protein p19; Cyclin-A/CDK2-associated protein p19; MGC34403; OCP-2; OCP-II; OCP-II protein; Organ of Corti protein 2; Organ of Corti protein II; p19A; p19skp1; polypeptide 1-like; RNA polymerase II elongation factor-like protein; RNA polymerase II elongation factor-like protein OCP2; S-phase kinase-associated protein 1; S-phase kinase-associated protein 1A; SIII; Transcription elongation factor B polypeptide 1-like
Gene Aliases: 15kDa; 2610043E24Rik; 2610206H23Rik; EMC19; OCP-II; OCP2; p19A; p19Skp1; SKP1; SKP1A; TCEB1L
UniProt ID: (Human) P63208, (Rat) Q6PEC4, (Mouse) Q9WTX5
Entrez Gene ID: (Human) 6500, (Rat) 287280, (Mouse) 21402
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