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Product Details
PA5-109520
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Immunogen sequence: CPTHGAWATW GPWTPCSASC HGGPHEPKET RSRKCSAPEP SQKPPGKPCP GLAYEQRRCT GLPPCPVAGG WGPWGPVSPC PVTCGLGQTM EQRTCNHPVP QHGGPFCAGD ATRTHICNTA VPCPVDGEWD SWGEWSPCIR RNMKSISCQE IPGQQSRGRT CRGRKFDGHR CAGQQQDIRH CYSIQHCPLK GSWSEWSTWG LCMPPCGPNP TRARQRLCTP LLPKYPPTVS MVEGQGEKNV TFWGRPLPRC EELQGQKLVV EEKRPCLHVP ACKDPEEEEL
Target Information
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Bf; C3 Proaccelerator; cfb; Complement factor P; H2-Bf; Properdin; properdin factor, complement; Properdin P factor, complement
Gene Aliases: BCFG; BFD; CFP; PFC; PFD; PROPERDIN
UniProt ID: (Human) P27918, (Mouse) P11680
Entrez Gene ID: (Human) 5199, (Rat) 299314, (Mouse) 18636
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