Product References
Type I and III interferons shape the retinal cytokine network and barrier function in an in vitro model of ocular toxoplasmosis.
Frontiers in immunology
Geiller B,Greigert V,Hillenbrand CA,Gommenginger C,Beal L,Brunet J,Filisetti D,Villard O,Denis J,Pfaff AW
33-3400 was used in Western Blotting to show that stimulation with type I and III interferons did not limit parasite proliferation in retinal cells we tested.
Mon May 22 00:00:00 EDT 2023
The μ2 and λ1 Proteins of Mammalian Reovirus Modulate Early Events Leading to Induction of the Interferon Signaling Network.
Viruses
Després GD,Ngo K,Lemay G
33-3400 was used in Western Blotting to conclude that proteins involved in viral RNA synthesis are thus involved in this likely critical aspect of the ability of different reovirus variants to infect various cell types, and to discriminate between parental and transformed/cancer cells.
Sat Nov 26 00:00:00 EST 2022
Signal transducer and activator of transcription (STAT) 1 and STAT3 are expressed in the human ovary and have Janus kinase 1-independent functions in the COV434 human granulosa cell line.
Reproduction, fertility, and development
Frost ER,Ford EA,Peters AE,Reed NL,McLaughlin EA,Baker MA,Lovell-Badge R,Sutherland JM
33-3400 was used in Western Blotting to implicate a conserved role for JAK/STAT signalling in human ovary development, warranting further investigation of this pathway in human granulosa cell function.
Sat Aug 01 00:00:00 EDT 2020
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma.
Nature communications
Liu XD,Kong W,Peterson CB,McGrail DJ,Hoang A,Zhang X,Lam T,Pilie PG,Zhu H,Beckermann KE,Haake SM,Isgandrova S,Martinez-Moczygemba M,Sahni N,Tannir NM,Lin SY,Rathmell WK,Jonasch E
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Western Blot
Fri May 01 00:00:00 EDT 2020
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma.
Nature communications
Liu XD,Kong W,Peterson CB,McGrail DJ,Hoang A,Zhang X,Lam T,Pilie PG,Zhu H,Beckermann KE,Haake SM,Isgandrova S,Martinez-Moczygemba M,Sahni N,Tannir NM,Lin SY,Rathmell WK,Jonasch E
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Western Blot
Fri May 01 00:00:00 EDT 2020
Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture.
Molecular vision
Keller KE,Yang YF,Sun YY,Walter MR,Wirtz MK
33-3400 was used in Western Blotting to study the role of IL-20 heterodimeric receptor complexes in the trabecular meshwork.
Wed Apr 22 00:00:00 EDT 2020
TWEAK blockade decreases atherosclerotic lesion size and progression through suppression of STAT1 signaling in diabetic mice.
Scientific reports
Fernández-Laso V,Sastre C,Méndez-Barbero N,Egido J,Martín-Ventura JL,Gómez-Guerrero C,Blanco-Colio LM
33-3400 was used in Western Blotting to demonstrate that TWEAK blockade delay plaque progression and alter plaque composition in diabetic atherosclerotic mice.
Thu Apr 27 00:00:00 EDT 2017
TWEAK blockade decreases atherosclerotic lesion size and progression through suppression of STAT1 signaling in diabetic mice.
Scientific reports
Fernández-Laso V,Sastre C,Méndez-Barbero N,Egido J,Martín-Ventura JL,Gómez-Guerrero C,Blanco-Colio LM
33-3400 was used in Western Blotting to demonstrate that TWEAK blockade delay plaque progression and alter plaque composition in diabetic atherosclerotic mice.
Thu Apr 27 00:00:00 EDT 2017
Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2.
PLoS pathogens
Stuart JH,Sumner RP,Lu Y,Snowden JS,Smith GL
33-3400 was used in Immunocytochemistry-immunoflourescence to show that vaccinia virus strain Western Reserve protein C6, is a dual function protein that inhibits the cellular response to type I IFNs in addition to its published function as an inhibitor of IRF-3 activation.
Thu Dec 01 00:00:00 EST 2016
Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2.
PLoS pathogens
Stuart JH,Sumner RP,Lu Y,Snowden JS,Smith GL
33-3400 was used in Immunocytochemistry-immunoflourescence to show that vaccinia virus strain Western Reserve protein C6, is a dual function protein that inhibits the cellular response to type I IFNs in addition to its published function as an inhibitor of IRF-3 activation.
Thu Dec 01 00:00:00 EST 2016
PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis.
Nature communications
He C,Medley SC,Hu T,Hinsdale ME,Lupu F,Virmani R,Olson LE
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Western Blot
Fri Jul 17 00:00:00 EDT 2015
STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes.
Science signaling
Xiang M,Birkbak NJ,Vafaizadeh V,Walker SR,Yeh JE,Liu S,Kroll Y,Boldin M,Taganov K,Groner B,Richardson AL,Frank DA
33-3400 was used in western blot to identify an epigenetic mechanism of crosstalk between STAT3 and NF-κB that regulates constitutive STAT3 activation in oncogenesis.
Tue Jan 28 00:00:00 EST 2014
Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface.
Science (New York, N.Y.)
Nancy P,Tagliani E,Tay CS,Asp P,Levy DE,Erlebacher A
Fri Jun 08 00:00:00 EDT 2012
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.
The Journal of clinical investigation
Marotta LL,Almendro V,Marusyk A,Shipitsin M,Schemme J,Walker SR,Bloushtain-Qimron N,Kim JJ,Choudhury SA,Maruyama R,Wu Z,Gönen M,Mulvey LA,Bessarabova MO,Huh SJ,Silver SJ,Kim SY,Park SY,Lee HE,Anderson KS,Richardson AL,Nikolskaya T,Nikolsky Y,Liu XS,Root DE,Hahn WC,Frank DA,Polyak K
33-3400 was used in Western Blotting to identify 15 genes required for cell growth and proliferation in CD44+CD24- human breast cancer cells.
Fri Jul 01 00:00:00 EDT 2011
PDlim2 selectively interacts with the PDZ binding motif of highly pathogenic avian H5N1 influenza A virus NS1.
PloS one
Yu J,Li X,Wang Y,Li B,Li H,Li Y,Zhou W,Zhang C,Wang Y,Rao Z,Bartlam M,Cao Y
33-3400 was used in western blot to characterize the PDZ domain binding motif of influenza NS1.
Mon Nov 28 00:00:00 EST 2011
IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities.
Journal of immunology (Baltimore, Md. : 1950)
Ho MY,Leu SJ,Sun GH,Tao MH,Tang SJ,Sun KH
Sun Nov 15 00:00:00 EST 2009
Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques.
PLoS pathogens
de Lang A,Baas T,Teal T,Leijten LM,Rain B,Osterhaus AD,Haagmans BL,Katze MG
33-3400 was used in immunocytochemistry and immunohistochemistry - paraffin section propose that induction of early IFN signaling may confer protection against severe acute respiratory syndrome coronavirus infection
Fri Aug 10 00:00:00 EDT 2007
Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques.
PLoS pathogens
de Lang A,Baas T,Teal T,Leijten LM,Rain B,Osterhaus AD,Haagmans BL,Katze MG
33-3400 was used in immunocytochemistry and immunohistochemistry - paraffin section propose that induction of early IFN signaling may confer protection against severe acute respiratory syndrome coronavirus infection
Fri Aug 10 00:00:00 EDT 2007
IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3.
Journal of immunology (Baltimore, Md. : 1950)
Albanesi C,Fairchild HR,Madonna S,Scarponi C,De Pità O,Leung DY,Howell MD
33-3400 was used in ChIP Assay, ELISA, Immunohistochemistry (Paraffin), Western Blot to suggest that targeting the STAT-1-signaling pathway or suppressor of cytokine signaling expression enhances beta-defensin expression and represents a new therapeutic strategy for reduction of infection in human diseases associated with beta-defensin deficiency.
Sun Jul 15 00:00:00 EDT 2007
Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.
The Journal of biological chemistry
Nelson EA,Walker SR,Li W,Liu XS,Frank DA
33-3400 was used in Chromatin immunoprecipitation to identify NCAM2 as both a STAT4- and STAT5-regulated gene.
Fri Sep 08 00:00:00 EDT 2006
Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.
The Journal of biological chemistry
Nelson EA,Walker SR,Li W,Liu XS,Frank DA
33-3400 was used in Chromatin immunoprecipitation to identify NCAM2 as both a STAT4- and STAT5-regulated gene.
Fri Sep 08 00:00:00 EDT 2006
Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways.
Molecular and cellular biology
Alblas J,Honing H,de Lavalette CR,Brown MH,Dijkstra CD,van den Berg TK
33-3400 was used in western blot to analyze the induction of macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways by signal regulatory protein alpha ligation
Mon Aug 01 00:00:00 EDT 2005
Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells.
The Journal of biological chemistry
Aksoy E,Zouain CS,Vanhoutte F,Fontaine J,Pavelka N,Thieblemont N,Willems F,Ricciardi-Castagnoli P,Goldman M,Capron M,Ryffel B,Trottein F
33-3400 was used in western blot to analyze activation of TLR3 in dendritic cells by double-stranded RNAs from the helminth parasite Schistosoma
Fri Jan 07 00:00:00 EST 2005
Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).
Oncogene
Duensing A,Medeiros F,McConarty B,Joseph NE,Panigrahy D,Singer S,Fletcher CD,Demetri GD,Fletcher JA
Thu May 13 00:00:00 EDT 2004
The protective effect of moderate hypothermia during intestinal ischemia-reperfusion is associated with modification of hepatic transcription factor activation.
Journal of pediatric surgery
Parkinson EJ,Townsend PA,Stephanou A,Latchman DS,Eaton S,Pierro A
33-3400 was used in western blot to study the mechanism of hypothermic protection during intestinal ischemia-reperfusion
Sat May 01 00:00:00 EDT 2004
Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas.
Cancer research
Nepomuceno RR,Balatoni CE,Natkunam Y,Snow AL,Krams SM,Martinez OM
33-3400 was used in western blot to report that rapamycin limits B-cell lymphoma growth while simultaneously providing immunosuppression to prevent graft rejection in patients and protection from EBV-associated post transplant lymphoproliferative disorder.
Fri Aug 01 00:00:00 EDT 2003
Constitutive activation of Jak/STAT proteins in Epstein-Barr virus-infected B-cell lines from patients with posttransplant lymphoproliferative disorder.
Transplantation
Nepomuceno RR,Snow AL,Robert Beatty P,Krams SM,Martinez OM
33-3400 was used in immunoprecipitation to investigate signaling pathways in posttransplant lymphoproliferative disease.
Thu Aug 15 00:00:00 EDT 2002
Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity.
The Journal of biological chemistry
Zhang Y,Turkson J,Carter-Su C,Smithgall T,Levitzki A,Kraker A,Krolewski JJ,Medveczky P,Jove R
Fri Aug 11 00:00:00 EDT 2000
