Product References
Export of Diverse and Bioactive Small Proteins through a Type I Secretion System.
Applied and environmental microbiology
Kim SY,Parker JK,Gonzalez-Magaldi M,Telford MS,Leahy DJ,Davies BW
Published figure using Phospho-EGFR (Tyr1068) polyclonal antibody (Product # 44-788G) in Western Blot
Wed May 31 00:00:00 EDT 2023
Dual Targeting of EGFR and MTOR Pathways Inhibits Glioblastoma Growth by Modulating the Tumor Microenvironment.
Cells
Sidorov M,Dighe P,Woo RWL,Rodriguez-Brotons A,Chen M,Ice RJ,Vaquero E,Jian D,Desprez PY,Nosrati M,Galvez L,Leng L,Dickinson L,Kashani-Sabet M,McAllister SD,Soroceanu L
44-788G was used in Immunohistochemistry (Paraffin) to demonstrate that pharmacological co-targeting of EGFR and MTOR using clinically available drugs represents an effective treatment paradigm for EGFR-driven GBMs, acting both by inhibiting tumor cell growth and modulating the immune tumor microenvironment.
Wed Feb 08 00:00:00 EST 2023
Dual Targeting of EGFR and MTOR Pathways Inhibits Glioblastoma Growth by Modulating the Tumor Microenvironment.
Cells
Sidorov M,Dighe P,Woo RWL,Rodriguez-Brotons A,Chen M,Ice RJ,Vaquero E,Jian D,Desprez PY,Nosrati M,Galvez L,Leng L,Dickinson L,Kashani-Sabet M,McAllister SD,Soroceanu L
44-788G was used in Immunohistochemistry (Paraffin) to demonstrate that pharmacological co-targeting of EGFR and MTOR using clinically available drugs represents an effective treatment paradigm for EGFR-driven GBMs, acting both by inhibiting tumor cell growth and modulating the immune tumor microenvironment.
Wed Feb 08 00:00:00 EST 2023
Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors.
Oncogene
Dieter SM,Lovecchio D,Pataskar A,Zowada MK,Körner PR,Khalizieva A,van Tellingen O,Jäger D,Glimm H,Agami R
44-788G was used in Western Blotting to show that targeting heparan sulfation via SLC35B2 represents a novel approach for breaking receptor tyrosine kinase-mediated resistance to MAPK pathway inhibitors.
Mon Aug 01 00:00:00 EDT 2022
EWI-2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis.
Molecular oncology
Fu C,Zhang Q,Wang A,Yang S,Jiang Y,Bai L,Wei Q
44-788G was used in Western Blot to provide new insights into the molecular function of EWI-2 on PCa metastasis, and highlights EWI-2 as a potential PCa biomarker.
Sat May 01 00:00:00 EDT 2021
EWI-2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis.
Molecular oncology
Fu C,Zhang Q,Wang A,Yang S,Jiang Y,Bai L,Wei Q
44-788G was used in Western Blot to provide new insights into the molecular function of EWI-2 on PCa metastasis, and highlights EWI-2 as a potential PCa biomarker.
Sat May 01 00:00:00 EDT 2021
Lamellipodin-RICTOR Signaling Mediates Glioblastoma Cell Invasion and Radiosensitivity Downstream of EGFR.
Cancers
Moritz S,Krause M,Schlatter J,Cordes N,Vehlow A
44-788G was used in Western Blot to show that the cytoskeleton regulator Lamellipodin mediates invasiveness, proliferation and radiosensitivity of glioblastoma cells.
Sun Oct 24 00:00:00 EDT 2021
Lamellipodin-RICTOR Signaling Mediates Glioblastoma Cell Invasion and Radiosensitivity Downstream of EGFR.
Cancers
Moritz S,Krause M,Schlatter J,Cordes N,Vehlow A
44-788G was used in Western Blot to show that the cytoskeleton regulator Lamellipodin mediates invasiveness, proliferation and radiosensitivity of glioblastoma cells.
Sun Oct 24 00:00:00 EDT 2021
FAM188B Downregulation Sensitizes Lung Cancer Cells to Anoikis via EGFR Downregulation and Inhibits Tumor Metastasis In Vivo.
Cancers
Jang EJ,Sung JY,Yoo HE,Jang H,Shim J,Oh ES,Goh SH,Kim YN
44-788G was used in Western Blotting to indicate that FAM188B plays an important role in anoikis resistance and metastatic characteristics by maintaining the levels of oncogenic proteins and their activity, leading to tumour maliganancy.
Mon Jan 11 00:00:00 EST 2021
Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase.
The Journal of cell biology
Armistead J,Hatzold J,van Roye A,Fahle E,Hammerschmidt M
44-788G was used in Immunocytochemistry-immunoflourescence to elucidate the mechanisms underlying the double face of Matriptase function in vivo and reveal the potential use of combinatorial carcinoma treatments when such double-face mechanisms are involved.
Mon Feb 03 00:00:00 EST 2020
Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase.
The Journal of cell biology
Armistead J,Hatzold J,van Roye A,Fahle E,Hammerschmidt M
44-788G was used in Immunocytochemistry-immunoflourescence to elucidate the mechanisms underlying the double face of Matriptase function in vivo and reveal the potential use of combinatorial carcinoma treatments when such double-face mechanisms are involved.
Mon Feb 03 00:00:00 EST 2020
IGF2 Autocrine-Mediated IGF1R Activation Is a Clinically Relevant Mechanism of Osimertinib Resistance in Lung Cancer.
Molecular cancer research : MCR
Manabe T,Yasuda H,Terai H,Kagiwada H,Hamamoto J,Ebisudani T,Kobayashi K,Masuzawa K,Ikemura S,Kawada I,Hayashi Y,Fukui K,Horimoto K,Fukunaga K,Soejima K
44-788G was used in Immunohistochemistry to find that IGF2 autocrine-mediated IGF1R pathway activation is a clinically relevant and common mechanism of acquired resistance to osimertinib.
Wed Apr 01 00:00:00 EDT 2020
RNF144a induces ERK-dependent cell death under oxidative stress via downregulation of vaccinia-related kinase 3.
Journal of cell science
Han SH,Kim KT
44-788G was used in Western Blot to investigate if vaccinia-related kinase 3 protects cells by suppressing oxidative stress-induced ERK, and if RNF144a sensitively regulates this process.
Mon Nov 09 00:00:00 EST 2020
Model-based analysis of response and resistance factors of cetuximab treatment in gastric cancer cell lines.
PLoS computational biology
Raimúndez E,Keller S,Zwingenberger G,Ebert K,Hug S,Theis FJ,Maier D,Luber B,Hasenauer J
44-788G was used in Western Blotting to render the model a basis for the assessment of gastric cancer signaling and possibly for the development and discovery of predictive biomarkers.
Sun Mar 01 00:00:00 EST 2020
MET as resistance factor for afatinib therapy and motility driver in gastric cancer cells.
PloS one
Ebert K,Mattes J,Kunzke T,Zwingenberger G,Luber B
44-788G was used in Western Blotting to show amplification of MET is a resistance factor in gastric cancer cells.
Thu Apr 02 00:00:00 EDT 2020
Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer.
BMC cancer
Mumin NH,Drobnitzky N,Patel A,Lourenco LM,Cahill FF,Jiang Y,Kong A,Ryan AJ
44-788G was used in Western Blotting to identify the molecular basis of acquired resistance to heat shock protein 90 inhibitors, and potential therapeutic approaches to overcome resistance.
Thu Jan 24 00:00:00 EST 2019
Effects of trastuzumab and afatinib on kinase activity in gastric cancer cell lines.
Molecular oncology
Keller S,Zwingenberger G,Ebert K,Hasenauer J,Wasmuth J,Maier D,Haffner I,Schierle K,Weirich G,Luber B
Published figure using Phospho-EGFR (Tyr1068) polyclonal antibody (Product # 44-788G) in Western Blot
Sun Apr 01 00:00:00 EDT 2018
Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions.
Molecular cancer therapeutics
Floc'h N,Martin MJ,Riess JW,Orme JP,Staniszewska AD,Ménard L,Cuomo ME,O'Neill DJ,Ward RA,Finlay MRV,McKerrecher D,Cheng M,Vang DP,Burich RA,Keck JG,Gandara DR,Mack PC,Cross DAE
44-788G was used in Western Blotting to characterise the activities of osimertinib and AZ5104 against non-small cell lung cancer harbouring EGFR exon 20 insertions.
Tue May 01 00:00:00 EDT 2018
YXQ-EQ Induces Apoptosis and Inhibits Signaling Pathways Important for Metastasis in Non-Small Cell Lung Carcinoma Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Yan X,Shen H,Jiang H,Hu D,Wang J,Wu X
44-788G was used in Western Blotting to suggest that YXQ-EQ could exert anti-lung cancer effects via inhibiting signaling pathways that are important for NSCLC cell survival and NSCLC metastasis.
Fri Oct 12 00:00:00 EDT 2018
Amplification of EGFR Wild-Type Alleles in Non-Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors.
Cancer research
Nukaga S,Yasuda H,Tsuchihara K,Hamamoto J,Masuzawa K,Kawada I,Naoki K,Matsumoto S,Mimaki S,Ikemura S,Goto K,Betsuyaku T,Soejima K
44-788G was used in Western Blotting to characterise the contribution of the Src-AKT pathway in acquired resistance to third-generation EGFR tyrosine kinase inhibitors.
Sat Apr 15 00:00:00 EDT 2017
Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines.
Journal of cancer research and clinical oncology
Kneissl J,Hartmann A,Pfarr N,Erlmeier F,Lorber T,Keller S,Zwingenberger G,Weichert W,Luber B
44788G was used in western blot to assess the contribution of amphiregulin, epidermal growth factor, heparin-binding epidermal growth factor, and transforming growth factor alpha in the responsiveness of gastric cancer cell lines to cetuximab and trastuzumab
Sat Apr 01 00:00:00 EDT 2017
E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning.
Nature communications
Rübsam M,Mertz AF,Kubo A,Marg S,Jüngst C,Goranci-Buzhala G,Schauss AC,Horsley V,Dufresne ER,Moser M,Ziegler W,Amagai M,Wickström SA,Niessen CM
Published figure using Phospho-EGFR (Tyr1068) polyclonal antibody (Product # 44-788G) in Western Blot
Wed Nov 01 00:00:00 EDT 2017
Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis.
BMC cancer
Keller S,Kneissl J,Grabher-Meier V,Heindl S,Hasenauer J,Maier D,Mattes J,Winter P,Luber B
Published figure using Phospho-EGFR (Tyr1068) polyclonal antibody (Product # 44-788G) in Western Blot
Wed Dec 13 00:00:00 EST 2017
Characterization of the efficacies of osimertinib and nazartinib against cells expressing clinically relevant epidermal growth factor receptor mutations.
Oncotarget
Masuzawa K,Yasuda H,Hamamoto J,Nukaga S,Hirano T,Kawada I,Naoki K,Soejima K,Betsuyaku T
Published figure using Phospho-EGFR (Tyr1068) polyclonal antibody (Product # 44-788G) in Western Blot
Fri Dec 01 00:00:00 EST 2017
Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification.
Oncotarget
Ren Y,Zheng J,Fan S,Wang L,Cheng M,Shi D,Zhang W,Tang R,Yu Y,Jiao L,Ni J,Yang H,Cai H,Yin F,Chen Y,Zhou F,Zhang W,Qing W,Su W
44-788G was used in Western Blotting to demonstrate that theliatinib could benefit esophageal cancer patients with high epidermal growth factor receptor expression without mutations or aberrant activities of associated factors.
Tue Aug 01 00:00:00 EDT 2017
Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II.
Hypertension (Dallas, Tex. : 1979)
Takayanagi T,Forrester SJ,Kawai T,Obama T,Tsuji T,Elliott KJ,Nuti E,Rossello A,Kwok HF,Scalia R,Rizzo V,Eguchi S
44-788G was used in Western Blot to investigate whether activation of vascular ADAM17 is indispensable for vascular remodelling but not for hypertension induced by Angiotensin II.
Sat Oct 01 00:00:00 EDT 2016
Activation of EGFR Bypass Signaling by TGFα Overexpression Induces Acquired Resistance to Alectinib in ALK-Translocated Lung Cancer Cells.
Molecular cancer therapeutics
Tani T,Yasuda H,Hamamoto J,Kuroda A,Arai D,Ishioka K,Ohgino K,Miyawaki M,Kawada I,Naoki K,Hayashi Y,Betsuyaku T,Soejima K
44-788G was used in Western Blotting to characterise the mechanism of acquired resistance to alectinib in ALK-translocated lung cancer cells.
Fri Jan 01 00:00:00 EST 2016
ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.
PloS one
Yoshida T,Song L,Bai Y,Kinose F,Li J,Ohaegbulam KC,Muñoz-Antonia T,Qu X,Eschrich S,Uramoto H,Tanaka F,Nasarre P,Gemmill RM,Roche J,Drabkin HA,Haura EB
44-788G was used in western blot to study how ZEB1 drives the epithelial-mesenchymal transition-related resistance to EGFR-tyrosine kinases inhibitors in non-small cell lung cancer
Thu Aug 11 00:00:00 EDT 2016
ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.
PloS one
Yoshida T,Song L,Bai Y,Kinose F,Li J,Ohaegbulam KC,Muñoz-Antonia T,Qu X,Eschrich S,Uramoto H,Tanaka F,Nasarre P,Gemmill RM,Roche J,Drabkin HA,Haura EB
44-788G was used in western blot to study how ZEB1 drives the epithelial-mesenchymal transition-related resistance to EGFR-tyrosine kinases inhibitors in non-small cell lung cancer
Thu Aug 11 00:00:00 EDT 2016
Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines.
Journal of cancer research and clinical oncology
Holland WS,Chinn DC,Lara PN,Gandara DR,Mack PC
44-788G was used in western blot to determine if inhibition of AKT signaling augments erlotinib activity and abrogates HGF-mediated resistance.
Wed Apr 01 00:00:00 EDT 2015
Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1α.
American journal of hypertension
Obama T,Takayanagi T,Kobayashi T,Bourne AM,Elliott KJ,Charbonneau M,Dubois CM,Eguchi S
Thu Jan 01 00:00:00 EST 2015
Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1α.
American journal of hypertension
Obama T,Takayanagi T,Kobayashi T,Bourne AM,Elliott KJ,Charbonneau M,Dubois CM,Eguchi S
Thu Jan 01 00:00:00 EST 2015
In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer.
Oncotarget
Hirano T,Yasuda H,Tani T,Hamamoto J,Oashi A,Ishioka K,Arai D,Nukaga S,Miyawaki M,Kawada I,Naoki K,Costa DB,Kobayashi SS,Betsuyaku T,Soejima K
44-788G was used in western blot to study a non-small-cell lung cancer and relevant EGFR mutants in an in vitro model to determine mutation specificity of EGFR tyrosine kinase inhibitors
Tue Nov 17 00:00:00 EST 2015
Short-course treatment with gefitinib enhances curative potential of radiation therapy in a mouse model of human non-small cell lung cancer.
International journal of radiation oncology, biology, physics
Bokobza SM,Jiang Y,Weber AM,Devery AM,Ryan AJ
44-788G was used in western blot to assess the combination of radiation and an epidermal growth factor receptor tyrosine kinase inhibitor in preclinical models of human non-small cell lung cancer.
Sat Mar 15 00:00:00 EDT 2014
Activation of the FGF2-FGFR1 autocrine pathway: a novel mechanism of acquired resistance to gefitinib in NSCLC.
Molecular cancer research : MCR
Terai H,Soejima K,Yasuda H,Nakayama S,Hamamoto J,Arai D,Ishioka K,Ohgino K,Ikemura S,Sato T,Yoda S,Satomi R,Naoki K,Betsuyaku T
44-788G was used in western blot to identify mechanism of acquired resistance to EGFR-tyrosine kinase inhibitors.
Mon Jul 01 00:00:00 EDT 2013
ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells.
Journal of molecular and cellular cardiology
Elliott KJ,Bourne AM,Takayanagi T,Takaguri A,Kobayashi T,Eguchi K,Eguchi S
44-788G was used in western blot to examine the roles of disintegrin and metalloprotease 7 in angiotensin II signal transduction.
Sun Sep 01 00:00:00 EDT 2013
A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation.
Journal of cell science
George AJ,Purdue BW,Gould CM,Thomas DW,Handoko Y,Qian H,Quaife-Ryan GA,Morgan KA,Simpson KJ,Thomas WG,Hannan RD
44-788G was used in western blot to identify factors that mediate ATR-EGFR transactivation.
Sun Dec 01 00:00:00 EST 2013
Activated EGFR stimulates MUC1 expression in human uterine and pancreatic cancer cell lines.
Journal of cellular biochemistry
Engel BJ,Carson DD
44-788G was used in western blot to examine the role that EGFR activation plays in modulating MUC1 levels.
Tue Oct 01 00:00:00 EDT 2013
Association of amphiregulin with the cetuximab sensitivity of gastric cancer cell lines.
International journal of oncology
Kneissl J,Keller S,Lorber T,Heindl S,Keller G,Drexler I,Hapfelmeier A,Höfler H,Luber B
44-788G was used in Western Blotting to assess the activity of cetuximab in eight gastric cancer cell lines, and identify factors associated with susceptibility or resistance.
Wed Aug 01 00:00:00 EDT 2012
EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer.
Molecular cancer
Singh S,Trevino J,Bora-Singhal N,Coppola D,Haura E,Altiok S,Chellappan SP
44-788G was used in western blot to test if the self-renewal of side population cells is dependent on EGFR mediated signaling and assess their contribution to generate tumors.
Tue Sep 25 00:00:00 EDT 2012
MAPK and PI3K signalling differentially regulate angiogenic and lymphangiogenic cytokine secretion in squamous cell carcinoma of the head and neck.
European journal of cancer (Oxford, England : 1990)
Luangdilok S,Box C,Harrington K,Rhŷs-Evans P,Eccles S
44-788G was used in western blot to investigate signaling pathways that regulate the induction of VEGF-C and VEGF-A
Tue Mar 01 00:00:00 EST 2011
Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck.
The Journal of pathology
Rogers SJ,Box C,Chambers P,Barbachano Y,Nutting CM,Rhŷs-Evans P,Workman P,Harrington KJ,Eccles SA
44-788G was used in western blot to assess the sensitivity of 8 squamous cell carcinoma of the head and neck cell lines to gefitinib.
Fri May 01 00:00:00 EDT 2009
Wounding-induced synthesis of hyaluronic acid in organotypic epidermal cultures requires the release of heparin-binding egf and activation of the EGFR.
The Journal of investigative dermatology
Monslow J,Sato N,Mack JA,Maytin EV
44-788G was used in western blot to elucidate how hyaluronic acid accumulates following skin wounding in rats
Sat Aug 01 00:00:00 EDT 2009
Quantitative measurement of epidermal growth factor receptor-mitogen-activated protein kinase signal transduction using a nine-plex, peptide-based immunoassay.
Analytical biochemistry
Rauh-Adelmann C,Moskow JM,Graham JR,Yen LG,Boucher JI,Murphy CE,Nadler TK,Gordon NF,Radding JA
44-788G was used in western blot to develop an assay to measure temporal, site-specific phosphorylation of key members of the EGFR pathway in A431 cells stimulated with epidermal growth factor
Tue Apr 15 00:00:00 EDT 2008
Tumor growth inhibition with cetuximab and chemotherapy in non-small cell lung cancer xenografts expressing wild-type and mutated epidermal growth factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research
Steiner P,Joynes C,Bassi R,Wang S,Tonra JR,Hadari YR,Hicklin DJ
Thu Mar 01 00:00:00 EST 2007
Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine.
Pediatric research
Kajanne R,Leppä S,Luukkainen P,Ustinov J,Thiel A,Ristimäki A,Miettinen PJ
44-788G was used in immunocytochemistry to examine if EGF-R contributes to the hydrocortisone and indomethacin-induced intestinal perforations of preterm infants
Thu Nov 01 00:00:00 EDT 2007
G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor.
The Journal of biological chemistry
Mifune M,Ohtsu H,Suzuki H,Nakashima H,Brailoiu E,Dun NJ,Frank GD,Inagami T,Higashiyama S,Thomas WG,Eckhart AD,Dempsey PJ,Eguchi S
Fri Jul 15 00:00:00 EDT 2005
Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.
The Journal of biological chemistry
Cuadrado A,Garcia-Fernandez LF,Gonzalez L,Suarez Y,Losada A,Alcaide V,Martinez T,Fernandez-Sousa JM,Sanchez-Puelles JM,Munoz A
Fri Jan 03 00:00:00 EST 2003
