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Phospho-Caveolin 2 (Ser36) Antibody (PA5-118636) in IHC (P)
Product Details
PA5-118636
Species Reactivity
Host/Isotype
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Type
Immunogen
Conjugate
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Product Specific Information
Antibody detects endogenous levels of Caveolin 2 only when phosphorylated at Ser36.
Target Information
Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: caveolae; caveolae protein, 20-kD; caveolin 2 isoform a and b; Caveolin-2; MGC12294; Phospho-CAV2
Gene Aliases: AI447843; CAV; CAV2
UniProt ID: (Human) P51636, (Mouse) Q9WVC3, (Rat) Q2IBC5
Entrez Gene ID: (Human) 858, (Mouse) 12390, (Rat) 363425
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