Product References
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis.
Nature communications
Reichelt J,Sachs W,Frömbling S,Fehlert J,Studencka-Turski M,Betz A,Loreth D,Blume L,Witt S,Pohl S,Brand J,Czesla M,Knop J,Florea BI,Zielinski S,Sachs M,Hoxha E,Hermans-Borgmeyer I,Zahner G,Wiech T,Krüger E,Meyer-Schwesinger C
PA1-977 was used in Western Blotting to investigate the mechanistic significance of the ubiquitin proteasome system (UPS) in membranous nephropathy (MN) and to uncover that the deubiquitinase Ubiquitin C-terminal hydrolase L1 (UCH-L1) is induced by oxidative stress in podocytes and directly involved in proteasome substrate accumulation, leading to podocyte injury and proteinuria.
Thu Apr 13 00:00:00 EDT 2023
A protein-protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity.
PLoS pathogens
Fu M,Liu Y,Wang G,Wang P,Zhang J,Chen C,Zhao M,Zhang S,Jiao J,Ouyang X,Yu Y,Wen B,He C,Wang J,Zhou D,Xiong X
PA1-977 was used in Immunocytochemistry-immunoflourescence to demonstrate that CirB functions as an inhibitor of host proteasome activity, revealing that proteasome activity is important for intracellular survival of C. burnetii.
Fri Jul 01 00:00:00 EDT 2022
A protein-protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity.
PLoS pathogens
Fu M,Liu Y,Wang G,Wang P,Zhang J,Chen C,Zhao M,Zhang S,Jiao J,Ouyang X,Yu Y,Wen B,He C,Wang J,Zhou D,Xiong X
PA1-977 was used in Immunocytochemistry-immunoflourescence to demonstrate that CirB functions as an inhibitor of host proteasome activity, revealing that proteasome activity is important for intracellular survival of C. burnetii.
Fri Jul 01 00:00:00 EDT 2022
Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates.
Immune network
Kim S,Park SH,Choi WH,Lee MJ
PA1-977 was used in Western Blotting to show that the most accurate assessment of immunoproteasome activity could be achieved by combining β5i-targeting substrate Ac-ANW-AMC and immunoproteasome inhibitor ONX-0914.
Wed Jun 01 00:00:00 EDT 2022
Oxidative-Stress-Associated Proteostasis Disturbances and Increased DNA Damage in the Hippocampal Granule Cells of the Ts65Dn Model of Down Syndrome.
Antioxidants (Basel, Switzerland)
Puente-Bedia A,Berciano MT,Martínez-Cué C,Lafarga M,Rueda N
PA1-977 was used in Immunohistochemistry (PFA fixed) to indicate that TS GCs show important OS-associated alterations in the systems essential for neuronal homeostasis: DNA damage response and proteostasis, particularly of the proteasome and lysosomal system.
Fri Dec 09 00:00:00 EST 2022
Novel missense mutations in PTCHD1 alter its plasma membrane subcellular localization and cause intellectual disability and autism spectrum disorder.
Human mutation
Halewa J,Marouillat S,Dixneuf M,Thépault RA,Ung DC,Chatron N,Gérard B,Ghoumid J,Lesca G,Till M,Smol T,Couque N,Ruaud L,Chune V,Grotto S,Verloes A,Vuillaume ML,Toutain A,Raynaud M,Laumonnier F
PA1-977 was used in Immunocytochemistry to find that six variants impaired the expression level of the PTCHD1 protein, and were retained in the endoplasmic reticulum suggesting abnormal protein folding.
Thu Jul 01 00:00:00 EDT 2021
Skeletal muscle denervation investigations: selecting an experimental control wisely.
American journal of physiology. Cell physiology
Liu H,Thompson LV
PA1-977 was used in Western Blotting to investigate whether skeletal denervation unilaterally alters the proteolytic system in the contralateral-innervated muscles.
Fri Mar 01 00:00:00 EST 2019
H727 cells are inherently resistant to the proteasome inhibitor carfilzomib, yet require proteasome activity for cell survival and growth.
Scientific reports
Lee MJ,Miller Z,Park JE,Bhattarai D,Lee W,Kim KB
PA1-977 was used in Western Blotting to assess the use of H727 human bronchial carcinoid cells as a model for de novo carfilzomib resistance.
Mon Mar 11 00:00:00 EDT 2019
Novel Potent Capsid Assembly Modulators Regulate Multiple Steps of the Hepatitis B Virus Life Cycle.
Antimicrobial agents and chemotherapy
Lahlali T,Berke JM,Vergauwen K,Foca A,Vandyck K,Pauwels F,Zoulim F,Durantel D
PA1-977 was used in Immunocytochemistry-immunoflourescence to demonstrate that some capsid assembly modulators could interfere with multiple functions of Hepatitis B virus core protein in the viral life cycle.
Mon Oct 01 00:00:00 EDT 2018
Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders.
EBioMedicine
Ugras S,Daniels MJ,Fazelinia H,Gould NS,Yocum AK,Luk KC,Luna E,Ding H,McKennan C,Seeholzer S,Martinez D,Evans P,Brown D,Duda JE,Ischiropoulos H
PA1-977 was used in Western Blotting to examine the role of the Lmp7 subunit of the immunoproteasome in the degradation of α-synuclein aggregates.
Tue May 01 00:00:00 EDT 2018
Denervation-Induced Activation of the Ubiquitin-Proteasome System Reduces Skeletal Muscle Quantity Not Quality.
PloS one
Baumann CW,Liu HM,Thompson LV
PA1-977 was used in western blot investigate the role of the ubiquitin-proteasome system in skeletal muscle
Fri Jul 28 00:00:00 EDT 2017
A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice.
British journal of cancer
Wehenkel M,Ban JO,Ho YK,Carmony KC,Hong JT,Kim KB
PA1-977 was used in western blot to study the role of immunoproteasome subunit LMP2 in apoptosis of PC-3 cells and tumor growth in nude mice
Tue Jun 26 00:00:00 EDT 2012
Persistent hijacking of brain proteasomes in HIV-associated dementia.
The American journal of pathology
Nguyen TP,Soukup VM,Gelman BB
PA1-977 was used in western blot to study the effect of HIV infection on brain proteasomes and its role in dementia
Mon Feb 01 00:00:00 EST 2010
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies.
Neurobiology of disease
Barrachina M,Castaño E,Dalfó E,Maes T,Buesa C,Ferrer I
PA1-977 was used in western blot to investigate the changes of UCHL-1 in samples from dementia patients with Lewy bodies
Mon May 01 00:00:00 EDT 2006
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.
The Journal of biological chemistry
Marambaud P,Zhao H,Davies P
PA1-977 was used in western blot to demonstrate a proteasome-dependent anti-amyloidogenic activity of resveratrol.
Fri Nov 11 00:00:00 EST 2005
