Proteintech

OLIG2 Polyclonal Antibody

OLIG2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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OLIG2 Antibody (13999-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 13999-1-AP (OLIG2 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

OLIG2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

OLIG2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13999-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400-1:1,600

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:800

Immunocytochemistry (ICC/IF)

View 36 publications 36 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OLIG2 Fusion Protein Ag5089 (1-323 aa encoded by BC047511)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.61 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDSDASLVS SRPSSPEPDD LFLPARSKGS SGSAFTGGTV SSSTPSDCPP ELSAELRGAM GSAGAHPGDK LGGSGFKSSS SSTSSSTSSA AASSTKKDKK QMTEPELQQL RLKINSRERK RMHDLNIAMD GLREVMPYAH GPSVRKLSKI TTLLLARNYI LMLTNSLEEM KRLVSEIYGG HHAGFHPSAC GGLAHSAPLP AATAHPAAAA HAAHHPAVHH PILPPAAAAA AAAAAAAAVS SASLPGSGLP SVGSIRPPHG LLKSPSAAAA APLGGGGGGS GASGGFQHWG GMPCPCSMCQ VPPPHHHVSA MGAGSLPRLT SDAK (1-323 aa encoded by BC047511)

Target Information

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Molecules of senescent glial cells differentiate Alzheimer's disease from ageing.

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Baicalin facilitates remyelination and suppresses neuroinflammation in rats with chronic cerebral hypoperfusion by activating Wnt/β-catenin and inhibiting NF-κB signaling.

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Baicalin facilitates remyelination and suppresses neuroinflammation in rats with chronic cerebral hypoperfusion by activating Wnt/β-catenin and inhibiting NF-κB signaling.

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RSL3 triggers glioma stem cell differentiation via the Tgm2/AKT/ID1 signaling axis.

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RSL3 triggers glioma stem cell differentiation via the Tgm2/AKT/ID1 signaling axis.

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RSL3 triggers glioma stem cell differentiation via the Tgm2/AKT/ID1 signaling axis.

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Transplantation of hypoxic preconditioned neural stem cells benefits functional recovery via enhancing neurotrophic secretion after spinal cord injury in rats.

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Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.

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Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.

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Antibody incubation at 37°C improves fluorescent immunolabeling in free-floating thick tissue sections.

BioTechniques

Xiao X,Feng YP,Du B,Sun HR,Ding YQ,Qi JG

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Resetting cancer stem cell regulatory nodes upon MYC inhibition.

EMBO reports

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Fri May 13 00:00:00 EDT 2016

Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells.

Scientific reports

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Fri May 13 00:00:00 EDT 2016

Poly-L-ornithine enhances migration of neural stem/progenitor cells via promoting α-Actinin 4 binding to actin filaments.

Scientific reports

Ge H,Yu A,Chen J,Yuan J,Yin Y,Duanmu W,Tan L,Yang Y,Lan C,Chen W,Feng H,Hu R

Tue Nov 22 00:00:00 EST 2016

Poly-L-ornithine enhances migration of neural stem/progenitor cells via promoting α-Actinin 4 binding to actin filaments.

Scientific reports

Ge H,Yu A,Chen J,Yuan J,Yin Y,Duanmu W,Tan L,Yang Y,Lan C,Chen W,Feng H,Hu R

Tue Nov 22 00:00:00 EST 2016

Poly-L-ornithine promotes preferred differentiation of neural stem/progenitor cells via ERK signalling pathway.

Scientific reports

Ge H,Tan L,Wu P,Yin Y,Liu X,Meng H,Cui G,Wu N,Lin J,Hu R,Feng H

Tue Oct 27 00:00:00 EDT 2015

Poly-L-ornithine promotes preferred differentiation of neural stem/progenitor cells via ERK signalling pathway.

Scientific reports

Ge H,Tan L,Wu P,Yin Y,Liu X,Meng H,Cui G,Wu N,Lin J,Hu R,Feng H

Tue Oct 27 00:00:00 EDT 2015

Poly-L-ornithine promotes preferred differentiation of neural stem/progenitor cells via ERK signalling pathway.

Scientific reports

Ge H,Tan L,Wu P,Yin Y,Liu X,Meng H,Cui G,Wu N,Lin J,Hu R,Feng H

Tue Oct 27 00:00:00 EDT 2015

Poly-L-ornithine promotes preferred differentiation of neural stem/progenitor cells via ERK signalling pathway.

Scientific reports

Ge H,Tan L,Wu P,Yin Y,Liu X,Meng H,Cui G,Wu N,Lin J,Hu R,Feng H

Tue Oct 27 00:00:00 EDT 2015

Neuropeptide Y has a protective role during murine retrovirus-induced neurological disease.

Journal of virology

Du M,Butchi NB,Woods T,Morgan TW,Peterson KE

Mon Nov 01 00:00:00 EDT 2010

Neuropeptide Y has a protective role during murine retrovirus-induced neurological disease.

Journal of virology

Du M,Butchi NB,Woods T,Morgan TW,Peterson KE

Mon Nov 01 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: basic domain, helix-loop-helix protein, class B, 1; Basic helix loop helix protein class B1 (bHLHB1); basic helix-loop-helix protein 19 (bHLHe19); bHLHb1; bHLHe19; Class B basic helix-loop-helix protein 1; Class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; olig-2; Oligo2; Oligo2 antibody; Oligodendrocyte specific bHLH transcription factor 2; Oligodendrocyte transcription factor 2; oligodendrocyte-specific bHLH transcription factor 2; Protein kinase C-binding protein 2; Protein kinase C-binding protein 2 (PRKCBP2); Protein kinase C-binding protein RACK17

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Gene Aliases: AI604895; BHLHB1; BHLHE19; Olg-2; OLIG2; OLIGO2; PRKCBP2; RACK17; RK17

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UniProt ID: (Human) Q13516, (Mouse) Q9EQW6

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Entrez Gene ID: (Human) 10215, (Mouse) 50913, (Rat) 304103

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Function(s)

DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein homodimerization activity HMG box domain binding transcription factor activity, sequence-specific DNA binding protein binding protein dimerization activity basic helix-loop-helix transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated spinal cord motor neuron differentiation spinal cord oligodendrocyte cell fate specification thalamus development myelination negative regulation of neuron differentiation neuron fate commitment positive regulation of oligodendrocyte differentiation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development nervous system development spinal cord oligodendrocyte cell differentiation oligodendrocyte differentiation

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OLIG2 Polyclonal Antibody

OLIG2 Antibody (13999-1-AP) in IHC (P)

Product Details

13999-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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