Invitrogen

NeuroD1 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

View all (28) NeuroD1 antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-82075

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NEUROD1. Recombinant protein control fragment (Product #RP-100735).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Anitgen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2789236

Product Specific Information

Immunogen sequence: ASFPVHPYSY QSPGLPSPPY GTMDSSHVFH VKPPPHAYSA ALEPFFESPL TDCTSPSFDG PLSPPLSING NFSFKHEPSA EFEKNYAFTM HYPAATLAGA QSHGSIFSGT AAPRCEIPID NIMSFDSHSH HERVMSAQL

Target Information

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; BHF1; bHLHa3; Class A basic helix-loop-helix protein 3; neuro d1; NeuroD; Neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD

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Gene Aliases: BETA2; BHF-1; BHLHA3; MODY6; NEUROD; NEUROD1

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UniProt ID: (Human) Q13562

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Entrez Gene ID: (Human) 4760

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding transcription factor binding sequence-specific DNA binding protein heterodimerization activity E-box binding basic helix-loop-helix transcription factor
Process(es)
pancreatic A cell fate commitment pancreatic PP cell fate commitment transcription from RNA polymerase II promoter nucleocytoplasmic transport nitric oxide mediated signal transduction response to glucose anterior/posterior pattern specification dentate gyrus development cerebellum development neurogenesis signal transduction involved in regulation of gene expression insulin secretion endocrine pancreas development amacrine cell differentiation enteroendocrine cell differentiation response to drug glucose homeostasis positive regulation of apoptotic process positive regulation of cell differentiation positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade embryonic organ morphogenesis neuron development inner ear development regulation of insulin secretion positive regulation of sequence-specific DNA binding transcription factor activity regulation of intestinal epithelial structure maintenance regulation of cell cycle arrest cellular response to glucose stimulus negative regulation of type B pancreatic cell apoptotic process positive regulation of transcription regulatory region DNA binding
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