Product References
Decreased DNA Damage and Improved p53 Specificity of RITA Analogs.
Molecular cancer therapeutics
Zhan Y,Zhou X,Peuget S,Singh M,Peyser BD,Fan Z,Selivanova G
33-7100 was used in Western Blotting to address the question whether RITA analogs NSC777196 and NSC782846 can induce p53-dependent apoptosis without SULT1A1-dependent DNA damage.
Fri Oct 07 00:00:00 EDT 2022
Decreased DNA Damage and Improved p53 Specificity of RITA Analogs.
Molecular cancer therapeutics
Zhan Y,Zhou X,Peuget S,Singh M,Peyser BD,Fan Z,Selivanova G
33-7100 was used in Western Blotting to address the question whether RITA analogs NSC777196 and NSC782846 can induce p53-dependent apoptosis without SULT1A1-dependent DNA damage.
Fri Oct 07 00:00:00 EDT 2022
p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors.
Cancers
Maietta I,Del Peschio F,Buonocore P,Viscusi E,Laudati S,Iannaci G,Minopoli M,Motti ML,De Falco V
33-7100 was used in Immunohistochemistry to demonstrate that p90RSK binds and phosphorylates MDM2 on serine 166 both in vitro and in vivo by kinase assay, immunoblot, and co-immunoprecipitation assay; this phosphorylation increases the stability of MDM2 which in turn binds p53, ubiquitinating it and promoting its degradation by proteasome.
Sun Dec 25 00:00:00 EST 2022
p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors.
Cancers
Maietta I,Del Peschio F,Buonocore P,Viscusi E,Laudati S,Iannaci G,Minopoli M,Motti ML,De Falco V
33-7100 was used in Immunohistochemistry to demonstrate that p90RSK binds and phosphorylates MDM2 on serine 166 both in vitro and in vivo by kinase assay, immunoblot, and co-immunoprecipitation assay; this phosphorylation increases the stability of MDM2 which in turn binds p53, ubiquitinating it and promoting its degradation by proteasome.
Sun Dec 25 00:00:00 EST 2022
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.
The Journal of experimental medicine
Ma S,Yan J,Barr T,Zhang J,Chen Z,Wang LS,Sun JC,Chen J,Caligiuri MA,Yu J
Published figure using MDM2 monoclonal antibody (Product # 33-7100) in Western Blot
Mon Aug 02 00:00:00 EDT 2021
The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors.
International journal of molecular sciences
Timmerman DM,Eleveld TF,Gillis AJM,Friedrichs CC,Hillenius S,Remmers TL,Sriram S,Looijenga LHJ
33-7100 was used in Western Blotting to suggest that TP53 mutations contribute to the cisplatin-resistant phenotype of mediastinal GCTs and, therefore, are a potential candidate for targeted treatment.
Fri Oct 29 00:00:00 EDT 2021
The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors.
International journal of molecular sciences
Timmerman DM,Eleveld TF,Gillis AJM,Friedrichs CC,Hillenius S,Remmers TL,Sriram S,Looijenga LHJ
33-7100 was used in Western Blotting to suggest that TP53 mutations contribute to the cisplatin-resistant phenotype of mediastinal GCTs and, therefore, are a potential candidate for targeted treatment.
Fri Oct 29 00:00:00 EDT 2021
E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration.
Developmental cell
Sladky VC,Knapp K,Soratroi C,Heppke J,Eichin F,Rocamora-Reverte L,Szabo TG,Bongiovanni L,Westendorp B,Moreno E,van Liere EA,Bakker B,Spierings DCJ,Wardenaar R,Pereyra D,Starlinger P,Schultze S,Trauner M,Stojakovic T,Scharnagl H,Fava LL,Foijer F,de Bruin A,Villunger A
33-7100 was used in Western Blotting to provide evidence that PIDDosome is a primary target to manipulate hepatocyte ploidy and proliferation rates in the regenerating liver.
Mon Feb 10 00:00:00 EST 2020
Novel pathogenic alterations in pediatric and adult desmoid-type fibromatosis - A systematic analysis of 204 cases.
Scientific reports
Trautmann M,Rehkämper J,Gevensleben H,Becker J,Wardelmann E,Hartmann W,Grünewald I,Huss S
33-7100 was used in Immunohistochemistry to show that DTF may harbor a broader mutational spectrum beyond CTNNB1 mutations, comprising targetable alterations including the herewith first reported imatinib-sensitive KIT V559D mutation in DTF.
Tue Feb 25 00:00:00 EST 2020
Establishment and Characterization of Histologically and Molecularly Stable Soft-tissue Sarcoma Xenograft Models for Biological Studies and Preclinical Drug Testing.
Molecular cancer therapeutics
Cornillie J,Wozniak A,Li H,Wang Y,Boeckx B,Gebreyohannes YK,Wellens J,Vanleeuw U,Hompes D,Stas M,Sinnaeve F,Wafa H,Lambrechts D,Debiec-Rychter M,Sciot R,Schöffski P
33-7100 was used in Immunohistochemistry to establish and characterize histologically and molecularly stable patient-derived xenograft models from a broad variety of soft-tissue sarcomas subtypes.
Sat Jun 01 00:00:00 EDT 2019
Co-expression of MDM2 and CDK4 in transformed human mesenchymal stem cells causes high-grade sarcoma with a dedifferentiated liposarcoma-like morphology.
Laboratory investigation; a journal of technical methods and pathology
Kim YJ,Kim M,Park HK,Yu DB,Jung K,Song K,Choi YL
33-7100 was used in Immunocytochemistry-immunoflourescence to examine whether MDM2 and/or CDK4 cause well-differentiated liposarcoma (WDLPS)/dedifferentiated liposarcoma (DDLPS).
Sun Sep 01 00:00:00 EDT 2019
FoxO3a as a Positive Prognostic Marker and a Therapeutic Target in Tamoxifen-Resistant Breast Cancer.
Cancers
Pellegrino M,Rizza P,Donà A,Nigro A,Ricci E,Fiorillo M,Perrotta I,Lanzino M,Giordano C,Bonofiglio D,Bruno R,Sotgia F,Lisanti MP,Sisci D,Morelli C
Published figure using MDM2 monoclonal antibody (Product # 33-7100) in Western Blot
Mon Nov 25 00:00:00 EST 2019
FoxO3a as a Positive Prognostic Marker and a Therapeutic Target in Tamoxifen-Resistant Breast Cancer.
Cancers
Pellegrino M,Rizza P,Donà A,Nigro A,Ricci E,Fiorillo M,Perrotta I,Lanzino M,Giordano C,Bonofiglio D,Bruno R,Sotgia F,Lisanti MP,Sisci D,Morelli C
Published figure using MDM2 monoclonal antibody (Product # 33-7100) in Western Blot
Mon Nov 25 00:00:00 EST 2019
A rare case of atypical/anaplastic meningioma with MDM2 amplification.
Rare tumors
Wylleman R,Debiec-Rychter M,Sciot R
Published figure using MDM2 monoclonal antibody (Product # 33-7100) in Immunohistochemistry
Wed Sep 30 00:00:00 EDT 2020
A New Patient-Derived Metastatic Glioblastoma Cell Line: Characterisation and Response to Sodium Selenite Anticancer Agent.
Cancers
Berthier S,Larrouquère L,Champelovier P,Col E,Lefebvre C,Cottet-Rouselle C,Arnaud J,Garrel C,Laporte F,Boutonnat J,Faure P,Hazane-Puch F
33-7100 was used in Immunohistochemistry to establish a new human glioblastoma multiform cell line from the cerebro-spinal fluid of a patient affected by GBM with leptomeningeal metastasis.
Fri Dec 21 00:00:00 EST 2018
RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.
Oncotarget
Gottlieb A,Althoff K,Grunewald L,Thor T,Odersky A,Schulte M,Deubzer HE,Heukamp L,Eggert A,Schramm A,Schulte JH,Künkele A
Published figure using MDM2 monoclonal antibody (Product # 33-7100) in Western Blot
Tue Apr 25 00:00:00 EDT 2017
Association of MDM2 expression with shorter progression-free survival and overall survival in patients with advanced pancreatic cancer treated with gemcitabine-based chemotherapy.
PloS one
Yang SH,Lee JC,Guo JC,Kuo SH,Tien YW,Kuo TC,Cheng AL,Yeh KH
33-7100 was used in Immunohistochemistry to evaluate the prognostic roles of murine double minute 2 (MDM2) and p53 in pancreatic cancer patients treated with gemcitabine-based chemotherapy.
Mon Oct 02 00:00:00 EDT 2017
Association of MDM2 expression with shorter progression-free survival and overall survival in patients with advanced pancreatic cancer treated with gemcitabine-based chemotherapy.
PloS one
Yang SH,Lee JC,Guo JC,Kuo SH,Tien YW,Kuo TC,Cheng AL,Yeh KH
33-7100 was used in Immunohistochemistry to evaluate the prognostic roles of murine double minute 2 (MDM2) and p53 in pancreatic cancer patients treated with gemcitabine-based chemotherapy.
Mon Oct 02 00:00:00 EDT 2017
Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Wang XH,Zhang SF,Bao JT,Liu FY
33-7100 was used in Western Blotting to suggest that the combined treatment of Nutlin-3 plus Oridonin may offer a novel therapeutic strategy for osteosarcoma.
Thu Jun 01 00:00:00 EDT 2017
Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2.
Cell death & disease
Ren Z,Aerts JL,Vandenplas H,Wang JA,Gorbenko O,Chen JP,Giron P,Heirman C,Goyvaerts C,Zacksenhaus E,Minden MD,Stambolic V,Breckpot K,De Grève J
Published figure using MDM2 monoclonal antibody (Product # 33-7100) in Western Blot
Thu Dec 22 00:00:00 EST 2016
Ubiquitin-specific protease 2 decreases p53-dependent apoptosis in cutaneous T-cell lymphoma.
Oncotarget
Wei T,Biskup E,Gjerdrum LM,Niazi O,Ødum N,Gniadecki R
337100 was used in western blot to find that USP2 stabilizes Mdm2 which antagonizes p53 activity
Tue Jul 26 00:00:00 EDT 2016
MDM2 and CDK4 amplifications are rare events in salivary duct carcinomas.
Oncotarget
Grünewald I,Trautmann M,Busch A,Bauer L,Huss S,Schweinshaupt P,Vollbrecht C,Odenthal M,Quaas A,Büttner R,Meyer MF,Beutner D,Hüttenbrink KB,Wardelmann E,Stenner M,Hartmann W
33-7100 was used in Immunohistochemistry to analyse the mutational status, genomic amplification and protein expression in a range of oncogenes in adenoma salivary duct carcinoma.
Tue Nov 15 00:00:00 EST 2016
Prognostic value of HMGA2, CDK4, and JUN amplification in well-differentiated and dedifferentiated liposarcomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Saâda-Bouzid E,Burel-Vandenbos F,Ranchère-Vince D,Birtwisle-Peyrottes I,Chetaille B,Bouvier C,Château MC,Peoc'h M,Battistella M,Bazin A,Gal J,Michiels JF,Coindre JM,Pedeutour F,Bianchini L
33-7100 was used in immunohistochemistry to investigate the frequency and contribution of HMGA2, CDK4, and JUN to dedifferentiated liposarcomas and atypical lipomatous tumors/well-differentiated liposarcomas.
Sun Nov 01 00:00:00 EDT 2015
Myxoid liposarcoma with heterologous components: dedifferentiation or metaplasia? A FISH-documented and CGH-documented case report.
Applied immunohistochemistry & molecular morphology : AIMM
Weingertner N,Neuville A,Chibon F,Ray-Coquard I,Marcellin L,Ghnassia JP
33-7100 was used in immunohistochemistry - paraffin section to characterize a primary myxoid liposarcoma with chondroid and osseous components
Sun Mar 01 00:00:00 EST 2015
Targeting CDH17 suppresses tumor progression in gastric cancer by downregulating Wnt/β-catenin signaling.
PloS one
Qiu HB,Zhang LY,Ren C,Zeng ZL,Wu WJ,Luo HY,Zhou ZW,Xu RH
33-7100 was used in western blot to report proof-of-principle studies targeting CDH7 for treating gastric cancer.
Mon Sep 30 00:00:00 EDT 2013
Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas.
Neuro-oncology
Künkele A,De Preter K,Heukamp L,Thor T,Pajtler KW,Hartmann W,Mittelbronn M,Grotzer MA,Deubzer HE,Speleman F,Schramm A,Eggert A,Schulte JH
33-7100 was used in Western Blotting to suggest that inhibition of the MDM2-p53 interaction with nutlin-3 is a promising therapeutic option for medulloblastomas with functional p53 that should be further evaluated in clinical trials.
Sun Jul 01 00:00:00 EDT 2012
MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype.
The American journal of surgical pathology
Yoshida A,Ushiku T,Motoi T,Beppu Y,Fukayama M,Tsuda H,Shibata T
Thu Mar 01 00:00:00 EST 2012
MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Dujardin F,Binh MB,Bouvier C,Gomez-Brouchet A,Larousserie F,Muret Ad,Louis-Brennetot C,Aurias A,Coindre JM,Guillou L,Pedeutour F,Duval H,Collin C,de Pinieux G
33-7100 was used in immunohistochemistry to examine expression of MDM2-CDK4 in low-grade osteosarcomas and fibrous or fibro-osseous lesions of the bone or paraosseous soft tissue.
Sun May 01 00:00:00 EDT 2011
Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Yoshida A,Ushiku T,Motoi T,Shibata T,Beppu Y,Fukayama M,Tsuda H
33-7100 was used in immunohistochemistry - paraffin section to explore the use of MDM2 and CDK4 for the histological diagnosis of low-grade osteosarcoma
Wed Sep 01 00:00:00 EDT 2010
Well-differentiated liposarcoma with low-grade osteosarcomatous component: an underrecognized variant.
The American journal of surgical pathology
Yoshida A,Ushiku T,Motoi T,Shibata T,Fukayama M,Tsuda H
33-7100 was used in immunohistochemistry - paraffin section to use 9 cases of well-differentiated/dedifferentiated liposarcoma to characterize unappreciated features
Wed Sep 01 00:00:00 EDT 2010
Similarity in genetic alterations between paired well-differentiated and dedifferentiated components of dedifferentiated liposarcoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Horvai AE,DeVries S,Roy R,O'Donnell RJ,Waldman F
33-7100 was used in immunohistochemistry - paraffin section to report genetic changes in dedifferentiated liposarcomas
Sun Nov 01 00:00:00 EDT 2009
Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Weaver J,Goldblum JR,Turner S,Tubbs RR,Wang WL,Lazar AJ,Rubin BP
Thu Jan 01 00:00:00 EST 2009
Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Weaver J,Goldblum JR,Turner S,Tubbs RR,Wang WL,Lazar AJ,Rubin BP
Thu Jan 01 00:00:00 EST 2009
Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Weaver J,Goldblum JR,Turner S,Tubbs RR,Wang WL,Lazar AJ,Rubin BP
Thu Jan 01 00:00:00 EST 2009
Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Weaver J,Goldblum JR,Turner S,Tubbs RR,Wang WL,Lazar AJ,Rubin BP
Thu Jan 01 00:00:00 EST 2009
Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Daugaard S,Christensen LH,Høgdall E
33-7100 was used in immunohistochemistry - paraffin section to identify immunohistochemical markers to aid chondroid tumor diagnosis
Wed Jul 01 00:00:00 EDT 2009
Lipoleiomyosarcoma of the rectosigmoid colon: a unique site for a rare variant of liposarcoma.
American journal of clinical oncology
Nahal A,Meterissian S
33-7100 was used in immunohistochemistry to discuss a rare presentation of a lipoleiomyosarcoma and review the method of pathologic diagnosis
Sat Aug 01 00:00:00 EDT 2009
Immunostaining for peroxisome proliferator gamma distinguishes dedifferentiated liposarcoma from other retroperitoneal sarcomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Horvai AE,Schaefer JT,Nakakura EK,O'Donnell RJ
33-7100 was used in immunohistochemistry - paraffin section to assess if immunostaining for PPAR-gamma distinguishes dedifferentiated liposarcoma from other retroperitoneal sarcomas
Thu May 01 00:00:00 EDT 2008
Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion.
JOP : Journal of the pancreas
Amiot A,Dokmak S,Sauvanet A,Vilgrain V,Bringuier PP,Scoazec JY,Sastre X,Ruszniewski P,Bedossa P,Couvelard A
33-7100 was used in immunohistochemistry to discuss the properties of desmoid tumors
Thu May 08 00:00:00 EDT 2008
Reproducibility of MDM2 and CDK4 staining in soft tissue tumors.
American journal of clinical pathology
Binh MB,Garau XS,Guillou L,Aurias A,Coindre JM
Mon May 01 00:00:00 EDT 2006
alpha-fetoprotein expression in a dedifferentiated liposarcoma.
Virchows Archiv : an international journal of pathology
Bosco M,Allia E,Coindre JM,Odasso C,Pagani A,Pacchioni D
33-7100 was used in immunohistochemistry - paraffin section to present a unique case of relapsing retroperitoneal dedifferentiated liposarcoma with alpha-fetoprotein ectopic production
Sat Apr 01 00:00:00 EST 2006
Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: an alternative pathway to non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Wang YC,Lin RK,Tan YH,Chen JT,Chen CY,Wang YC
Sat Jan 01 00:00:00 EST 2005
MDM2 as a predictor of prostate carcinoma outcome: an analysis of Radiation Therapy Oncology Group Protocol 8610.
Cancer
Khor LY,Desilvio M,Al-Saleem T,Hammond ME,Grignon DJ,Sause W,Pilepich M,Okunieff P,Sandler H,Pollack A
Thu Sep 01 00:00:00 EDT 2005
Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location.
Virchows Archiv : an international journal of pathology
Mentzel T,Toennissen J,Rütten A,Schaller J
33-7100 was used in immunohistochemistry - paraffin section to present the case of a patient with a rare atypical lipomatous tumor with spindle cell features
Tue Mar 01 00:00:00 EST 2005
Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity.
The Journal of pathology
Coindre JM,Hostein I,Maire G,Derré J,Guillou L,Leroux A,Ghnassia JP,Collin F,Pedeutour F,Aurias A
33-7100 was used in immunohistochemistry (frozen) to characterize dedifferentiated liposarcomas with an inflammatory malignant fibrous histiocytoma component.
Thu Jul 01 00:00:00 EDT 2004
Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Coindre JM,Mariani O,Chibon F,Mairal A,De Saint Aubain Somerhausen N,Favre-Guillevin E,Bui NB,Stoeckle E,Hostein I,Aurias A
33-7100 was used in immunohistochemistry (paraffin) to report that most so-called malignant fibrous histiocytomas from the retroperitoneum are dedifferentiated liposarcoma.
Sat Mar 01 00:00:00 EST 2003
