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Product Details
H00005602-M05
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: DPAEVEAPPP QIYDKQLDER EHTIEEWKEL IYKEVMNSEE KTKNGVVKGQ PSPSGAAVNS SESLPPSSSV NDISSMSTDQ TLASDTDSSL EASAGPLGCC R
Target Information
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). MAPK10 is involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: c-Jun N-terminal kinase 3; JNK3 alpha protein kinase; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; Mitogen-activated protein kinase 10; OTTHUMP00000161181; OTTHUMP00000161183; OTTHUMP00000218718; SAPK1b; stress activated protein kinase beta; Stress-activated protein kinase 1b; Stress-activated protein kinase JNK3
Gene Aliases: JNK3; JNK3A; MAPK10; p493F12; p54bSAPK; PRKM10; SAPK1B
UniProt ID: (Human) P53779
Entrez Gene ID: (Human) 5602
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