Invitrogen

Lamin A/C Monoclonal Antibody (JOL3), FITC

Product Details

MA5-46602

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

Assay-dependent

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

JOL3

Immunogen

Recombinant bacterially expressed human lamin A

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2937674

Target Information

Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 70 kDa lamin; lamin A; Lamin A+C mutant; lamin a-c; lamin A/C-like 1; Lamin AC; lamin C; lamin C2; lamin-A/C; mutant 453W; Mutant lamin A/C; Prelamin-A/C; progerin mutant; renal carcinoma antigen NY-REN-32; RP11-54H19.1

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Gene Aliases: CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; PRO1

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UniProt ID: (Human) P02545, (Mouse) P48678

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Entrez Gene ID: (Human) 4000, (Mouse) 16905, (Rat) 60374

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Function(s)

structural molecule activity protein binding protein phosphatase 1 binding

Process(es)

nucleus organization nuclear envelope organization muscle organ development establishment of cell polarity regulation of cell migration establishment or maintenance of microtubule cytoskeleton polarity protein localization to nucleus sterol regulatory element binding protein import into nucleus ventricular cardiac muscle cell development negative regulation of release of cytochrome c from mitochondria positive regulation of cell aging regulation of protein localization to nucleus negative regulation of extrinsic apoptotic signaling pathway mitotic nuclear envelope disassembly mitotic nuclear envelope reassembly spermatogenesis response to mechanical stimulus IRE1-mediated unfolded protein response positive regulation of osteoblast differentiation cellular response to hypoxia negative regulation of adipose tissue development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Lamin A/C Monoclonal Antibody (JOL3), FITC

Product Details

MA5-46602

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

References (0)

Bioinformatics

Performance Guarantee

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