Product References
Genetic instability from a single S phase after whole-genome duplication.
Nature
Gemble S,Wardenaar R,Keuper K,Srivastava N,Nano M,Macé AS,Tijhuis AE,Bernhard SV,Spierings DCJ,Simon A,Goundiam O,Hochegger H,Piel M,Foijer F,Storchová Z,Basto R
MA5-12933 was used in Immunohistochemistry to provide an explanation for the genetic instability landscape that favours tumorigenesis after tetraploidization.
Fri Apr 01 00:00:00 EDT 2022
The splicing regulators TIA1 and TIAL1 are required for the expression of the DNA damage repair machinery during B cell lymphopoiesis.
Cell reports
Osma-Garcia IC,Capitan-Sobrino D,Mouysset M,Aubert Y,Maloudi O,Turner M,Diaz-Muñoz MD
MA5-12933 was used in Flow Cytometry to enable developmental progression.
Tue Dec 20 00:00:00 EST 2022
The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.
Cells
Averbeck NB,Barent C,Jakob B,Syzonenko T,Durante M,Taucher-Scholz G
MA5-12933 was used in Western Blot and Immunocytochemistry to conclude that RNF138 is a regulator of resection that is influenced by DSB complexity and can affect the quality of DSB repair in G1 cells.
Wed Aug 17 00:00:00 EDT 2022
The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.
Cells
Averbeck NB,Barent C,Jakob B,Syzonenko T,Durante M,Taucher-Scholz G
MA5-12933 was used in Western Blot and Immunocytochemistry to conclude that RNF138 is a regulator of resection that is influenced by DSB complexity and can affect the quality of DSB repair in G1 cells.
Wed Aug 17 00:00:00 EDT 2022
VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance.
Signal transduction and targeted therapy
Liu W,Miao C,Zhang S,Liu Y,Niu X,Xi Y,Guo W,Chu J,Lin A,Liu H,Yang X,Chen X,Zhong C,Ma Y,Wang Y,Zhu S,Liu S,Tan W,Lin D,Wu C
Published figure using Ku80 monoclonal antibody (Product # MA5-12933) in Immunoprecipitation
Mon Aug 30 00:00:00 EDT 2021
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.
Nature communications
Guo G,Gao M,Gao X,Zhu B,Huang J,Tu X,Kim W,Zhao F,Zhou Q,Zhu S,Wu Z,Yan Y,Zhang Y,Zeng X,Zhu Q,Yin P,Luo K,Sun J,Deng M,Lou Z
MA5-12933 was used in Western Blot to find that retinoic acid-inducible gene I (RIG-I), a key cytosolic RNA sensor that recognizes RNA virus and initiates the MAVS-IRF3-type I IFN signaling cascade, is recruited to double-stranded breaks (DSBs) and suppresses non-homologous end joining (NHEJ).
Mon Apr 12 00:00:00 EDT 2021
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.
Nature communications
Guo G,Gao M,Gao X,Zhu B,Huang J,Tu X,Kim W,Zhao F,Zhou Q,Zhu S,Wu Z,Yan Y,Zhang Y,Zeng X,Zhu Q,Yin P,Luo K,Sun J,Deng M,Lou Z
MA5-12933 was used in Western Blot to find that retinoic acid-inducible gene I (RIG-I), a key cytosolic RNA sensor that recognizes RNA virus and initiates the MAVS-IRF3-type I IFN signaling cascade, is recruited to double-stranded breaks (DSBs) and suppresses non-homologous end joining (NHEJ).
Mon Apr 12 00:00:00 EDT 2021
Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands.
eLife
Bossaert M,Pipier A,Riou JF,Noirot C,Nguyên LT,Serre RF,Bouchez O,Defrancq E,Calsou P,Britton S,Gomez D
MA5-12933 was used in Western Blot to investigate the cytotoxic activity of topoisomerase 2α.
Mon Jun 28 00:00:00 EDT 2021
Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment.
Cell reports
Shan W,Yuan J,Hu Z,Jiang J,Wang Y,Loo N,Fan L,Tang Z,Zhang T,Xu M,Pan Y,Lu J,Long M,Tanyi JL,Montone KT,Fan Y,Hu X,Zhang Y,Zhang L
MA5-12933 was used in Western Blotting to characterise the recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins in >10,000 tumors.
Tue Jul 14 00:00:00 EDT 2020
LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation.
Cell cycle (Georgetown, Tex.)
Wang X,Liu H,Shi L,Yu X,Gu Y,Sun X
Published figure using Ku80 monoclonal antibody (Product # MA5-12933) in Immunoprecipitation
Mon Sep 09 00:00:00 EDT 2019
LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation.
Cell cycle (Georgetown, Tex.)
Wang X,Liu H,Shi L,Yu X,Gu Y,Sun X
Published figure using Ku80 monoclonal antibody (Product # MA5-12933) in Immunoprecipitation
Mon Sep 09 00:00:00 EDT 2019
LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation.
Cell cycle (Georgetown, Tex.)
Wang X,Liu H,Shi L,Yu X,Gu Y,Sun X
Published figure using Ku80 monoclonal antibody (Product # MA5-12933) in Immunoprecipitation
Mon Sep 09 00:00:00 EDT 2019
Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells.
JCI insight
Wang Y,Xu H,Liu T,Huang M,Butter PP,Li C,Zhang L,Kao GD,Gong Y,Maity A,Koumenis C,Fan Y
MA5-12933 was used in Immunoprecipitation to elucidate the mechanism driving genomic instability and treatment resistance in glioma cancer stem cells.
Thu Feb 08 00:00:00 EST 2018
Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells.
JCI insight
Wang Y,Xu H,Liu T,Huang M,Butter PP,Li C,Zhang L,Kao GD,Gong Y,Maity A,Koumenis C,Fan Y
MA5-12933 was used in Immunoprecipitation to elucidate the mechanism driving genomic instability and treatment resistance in glioma cancer stem cells.
Thu Feb 08 00:00:00 EST 2018
SMARCAD1 Phosphorylation and Ubiquitination Are Required for Resection during DNA Double-Strand Break Repair.
iScience
Chakraborty S,Pandita RK,Hambarde S,Mattoo AR,Charaka V,Ahmed KM,Iyer SP,Hunt CR,Pandita TK
MA5-12933 was used in Chromatin immunoprecipitation to study the mechanistic details of SMARCAD1 coupling to the DNA damage response and repair pathways.
Fri Apr 27 00:00:00 EDT 2018
Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination.
Nature communications
Zan H,Tat C,Qiu Z,Taylor JR,Guerrero JA,Shen T,Casali P
MA512933 was used in western blot to assess the contributions of single-strand annealing factors HR Rad52 and translesion DNA polymerase q to CSR
Wed Feb 08 00:00:00 EST 2017
Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer.
Nature structural & molecular biology
Zhang Y,He Q,Hu Z,Feng Y,Fan L,Tang Z,Yuan J,Shan W,Li C,Hu X,Tanyi JL,Fan Y,Huang Q,Montone K,Dang CV,Zhang L
Published figure using Ku80 monoclonal antibody (Product # MA5-12933) in Immunoprecipitation
Wed Jun 01 00:00:00 EDT 2016
Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer.
Nature structural & molecular biology
Zhang Y,He Q,Hu Z,Feng Y,Fan L,Tang Z,Yuan J,Shan W,Li C,Hu X,Tanyi JL,Fan Y,Huang Q,Montone K,Dang CV,Zhang L
Published figure using Ku80 monoclonal antibody (Product # MA5-12933) in Immunoprecipitation
Wed Jun 01 00:00:00 EDT 2016
The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells.
Cancer medicine
Hirakawa H,Fujisawa H,Masaoka A,Noguchi M,Hirayama R,Takahashi M,Fujimori A,Okayasu R
MA5-12933 was used in western blot to analyze effective tumor control in human lung cancer cells by the combination of heavy-ion irradiation and Hsp90 inhibitor 17AAG
Sun Mar 01 00:00:00 EST 2015
A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines.
Oncotarget
Bouley J,Saad L,Grall R,Schellenbauer A,Biard D,Paget V,Morel-Altmeyer S,Guipaud O,Chambon C,Salles B,Maloum K,Merle-Béral H,Chevillard S,Delic J
MA5-12933 was used in immunoprecipitation and western blot to investigate the role of phospho-Ku70 in DNA repair
Tue Sep 29 00:00:00 EDT 2015
SMCHD1 accumulates at DNA damage sites and facilitates the repair of DNA double-strand breaks.
Journal of cell science
Coker H,Brockdorff N
MA5-12933 was used in immunocytochemistry to study the role of SMCHD1 in DNA double-strand break repair
Thu May 01 00:00:00 EDT 2014
DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1.
Nucleic acids research
Calkins AS,Iglehart JD,Lazaro JB
MA5-12933 was used in immunocytochemistry to study the role of DNA-PK and PARP in the mechanism by which DNA damage inhibits the synthesis of rRNA
Thu Aug 01 00:00:00 EDT 2013
Imatinib radiosensitizes bladder cancer by targeting homologous recombination.
Cancer research
Qiao B,Kerr M,Groselj B,Teo MT,Knowles MA,Bristow RG,Phillips RM,Kiltie AE
MA5-12933 was used in western blot to study the role of homologous recombination in the radiosensitization of bladder cancer cells by imatinib
Fri Mar 01 00:00:00 EST 2013
A noncatalytic function of the ligation complex during nonhomologous end joining.
The Journal of cell biology
Cottarel J,Frit P,Bombarde O,Salles B,Négrel A,Bernard S,Jeggo PA,Lieber MR,Modesti M,Calsou P
MA5-12933 was used in immunoprecipitation and western blot to study the significance of non-catalytic functions of DNA Ligase IV in the ligation complex during non-homologous end-joining
Mon Jan 21 00:00:00 EST 2013
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair.
The Journal of cell biology
Britton S,Coates J,Jackson SP
MA5-12933 was used in immunocytochemistry and western blot to develop a new method to visualize DNA double-strand break complexes
Mon Aug 05 00:00:00 EDT 2013
Characterization of estrogen response element binding proteins as biomarkers of breast cancer behavior.
Clinical biochemistry
Kruer TL,Cummins TD,Powell DW,Wittliff JL
MA5-12933 was used in EMSA to study the prognostic value of estrogen resonse element binding proteins in breast cancer
Fri Nov 01 00:00:00 EDT 2013
Centrosomal localisation of the cancer/testis (CT) antigens NY-ESO-1 and MAGE-C1 is regulated by proteasome activity in tumour cells.
PloS one
Pagotto A,Caballero OL,Volkmar N,Devalle S,Simpson AJ,Lu X,Christianson JC
MA5-12933 was used in immunocytochemistry and western blot to investigate regulation of antigens NY-ESO-1 and MAGE-C1 within cancer cell lines
Tue Sep 30 00:00:00 EDT 2014
Ku80 functions as a tumor suppressor in hepatocellular carcinoma by inducing S-phase arrest through a p53-dependent pathway.
Carcinogenesis
Wei S,Xiong M,Zhan DQ,Liang BY,Wang YY,Gutmann DH,Huang ZY,Chen XP
MA5-12933 was used in western blot to study the role of the p53 pathway in the tumor suppressor activity of Ku80 in hepatocellular carcinoma
Thu Mar 01 00:00:00 EST 2012
A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
Journal of cell science
Bouquet F,Ousset M,Biard D,Fallone F,Dauvillier S,Frit P,Salles B,Muller C
MA5-12933 was used in western blot to study a DNA-dependent stress response involving DNA-PK in hypoxic cells that contributes to cellular adaptation to hypoxia
Wed Jun 01 00:00:00 EDT 2011
Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.
Molecular cancer
Sand-Dejmek J,Adelmant G,Sobhian B,Calkins AS,Marto J,Iglehart DJ,Lazaro JB
MA5-12933 was used in Western Blotting to elucidate the mechanism underlying the effects of DNA-dependent protein kinase on cisplatin sensitivity.
Thu Jun 16 00:00:00 EDT 2011
The effect of DNA-dependent protein kinase on adeno-associated virus replication.
PloS one
Choi YK,Nash K,Byrne BJ,Muzyczka N,Song S
MA5-12933 was used in blocking or activating experiment and western blot to study the role of DNA-dependent protein kinase in adeno-associated virus replication
Mon Dec 20 00:00:00 EST 2010
Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance.
Nucleic acids research
Li S,Kuhne WW,Kulharya A,Hudson FZ,Ha K,Cao Z,Dynan WS
MA5-12933 was used in western blot to investigate the role of p54(nrb) in DNA double-strand break repair in vivo
Sun Nov 01 00:00:00 EDT 2009
Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.
Biochemical and biophysical research communications
Ohno M,Kunimoto M,Nishizuka M,Osada S,Imagawa M
MA5-12933 was used in western blot to investigate the effect of Ku proteins on farnesoid X receptor-mediated gene expression
Fri Dec 18 00:00:00 EST 2009
Down regulation of BRCA2 causes radio-sensitization of human tumor cells in vitro and in vivo.
Cancer science
Yu D,Sekine E,Fujimori A,Ochiya T,Okayasu R
MA5-12933 was used in western blot to investigate the effect of BRCA2 on the radio-sensitization of human tumor cells
Tue Apr 01 00:00:00 EDT 2008
Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.
Experimental cell research
Iwamoto F,Stadler M,Chalupníková K,Oakeley E,Nagamine Y
MA5-12933 was used in western blot to investigate the role of DExH RNA helicase RHAU in the metabolism of mRNA
Tue Apr 01 00:00:00 EDT 2008
DNA-dependent conformational changes in the Ku heterodimer.
Biochemistry
Lehman JA,Hoelz DJ,Turchi JJ
MA5-12933 was used in EMSA to study DNA-induced changes in Ku heterodimer conformation
Tue Apr 15 00:00:00 EDT 2008
Analytical biochemistry of DNA--protein assemblies from crude cell extracts.
Nucleic acids research
Hégarat N,Cardoso GM,Rusconi F,Francois JC,Praseuth D
MA5-12933 was used in western blot to develop an efficient method for the purification of DNA-protein complexes from crude extracts
Wed Aug 15 00:00:00 EDT 2007
Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.
The Journal of biological chemistry
Wu PY,Frit P,Malivert L,Revy P,Biard D,Salles B,Calsou P
MA5-12933 was used in western blot to study the roles of Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends
Fri Nov 02 00:00:00 EDT 2007
Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients.
DNA repair
Howlett NG,Scuric Z,D'Andrea AD,Schiestl RH
MA5-12933 was used in western blot to study the role of impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients
Fri Feb 03 00:00:00 EST 2006
Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway.
Blood
Deriano L,Guipaud O,Merle-Béral H,Binet JL,Ricoul M,Potocki-Veronese G,Favaudon V,Maciorowski Z,Muller C,Salles B,Sabatier L,Delic J
MA5-12933 was used in western blot to study the mechanism by which human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis
Wed Jun 15 00:00:00 EDT 2005
Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma.
Proteomics
Luk JM,Su YC,Lam SC,Lee CK,Hu MY,He QY,Lau GK,Wong FW,Fan ST
MA5-12933 was used in western blot to investigate the Ku70/Ku80 autoantigen in hepatocellular carcinoma
Sun May 01 00:00:00 EDT 2005
The membrane form of the DNA repair protein Ku interacts at the cell surface with metalloproteinase 9.
The EMBO journal
Monferran S,Paupert J,Dauvillier S,Salles B,Muller C
MA5-12933 was used in immunocytochemistry to study the interaction between the membrane form of the DNA repair protein Ku and MMP9
Fri Oct 01 00:00:00 EDT 2004
Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.
The Journal of biological chemistry
Audebert M,Salles B,Calsou P
MA5-12933 was used in western blot to study an alternative pathway for the repair of DNA double-strand breaks that involves poly(ADP-ribose) polymerase-1 and a XRCC1-DNA ligase III complex
Fri Dec 31 00:00:00 EST 2004
Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
Nucleic acids research
Onclercq-Delic R,Calsou P,Delteil C,Salles B,Papadopoulo D,Amor-Guéret M
MA5-12933 was used in western blot to study the potential anti-recombinogenic role of BLM DNA helicase in double-strand break processing
Sat Nov 01 00:00:00 EST 2003
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
Journal of molecular biology
Calsou P,Delteil C,Frit P,Drouet J,Salles B
MA5-12933 was used in western blot to investigate the relationship and assembly of specific proteins during DNA repair process
Fri Feb 07 00:00:00 EST 2003
Evidence implicating Ku antigen as a structural factor in RNA polymerase II-mediated transcription.
Gene
Bertinato J,Tomlinson JJ,Schild-Poulter C,Haché RJ
MA5-12933 was used in western blot to study the potential role of the Ku antigen within the RNA polymerase II holoenzyme
Thu Jan 02 00:00:00 EST 2003
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation.
The Journal of biological chemistry
Udayakumar D,Bladen CL,Hudson FZ,Dynan WS
MA5-12933 was used in western blot to study two biochemically distinct pathways of non-homologous end joining that are differentially regulated by DNA-PK
Fri Oct 24 00:00:00 EDT 2003
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.
Cell
Ma Y,Pannicke U,Schwarz K,Lieber MR
MA5-12933 was used in immunoprecipitation to study the function of an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
Fri Mar 22 00:00:00 EST 2002
The radioprotective effect of the 24 kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit.
Oncogene
Ader I,Muller C,Bonnet J,Favre G,Cohen-Jonathan E,Salles B,Toulas C
MA5-12933 was used in Western Blotting to characterise a novel mechanism of control of DNA repair and radioresistance in human tumour cells.
Thu Sep 19 00:00:00 EDT 2002
Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs.
The Journal of biological chemistry
Ma Y,Lieber MR
MA5-12933 was used in immunoprecipitation to study the ability of inositol hexakisphosphate to bind to Ku but not to DNA-PKcs
Fri Mar 29 00:00:00 EST 2002
Ku entry into DNA inhibits inward DNA transactions in vitro.
The Journal of biological chemistry
Frit P,Li RY,Arzel D,Salles B,Calsou P
MA5-12933 was used in western blot to study the effect of Ku entry into DNA on local DNA processes and the regulatory role of DNA-dependent protein kinase
Fri Nov 17 00:00:00 EST 2000
Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase.
The Journal of biological chemistry
Chen L,Trujillo K,Sung P,Tomkinson AE
MA5-12933 was used in western blot to study the interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase
Fri Aug 25 00:00:00 EDT 2000
Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53.
Molecular cell
Zhang Y,Xiong Y
MA5-12933 was used in immunocytochemistry to study the effect of mutations in exon 2 of human ARF on its nucleolar localization and ability to regulate nuclear export of MDM2 and p53
Sat May 01 00:00:00 EDT 1999
The repressor which binds the -75 GATA motif of the GPB promoter contains Ku70 as the DNA binding subunit.
Nucleic acids research
Camara-Clayette V,Thomas D,Rahuel C,Barbey R,Cartron JP,Bertrand O
MA5-12933 was used in EMSA to study the role of the Ku70 protein in transcriptionally regulating the erythroid glycoprotein B promoter
Thu Apr 01 00:00:00 EST 1999
Ku antigen-DNA conformation determines the activation of DNA-dependent protein kinase and DNA sequence-directed repression of mouse mammary tumor virus transcription.
Molecular and cellular biology
Giffin W,Gong W,Schild-Poulter C,Haché RJ
MA5-12933 was used in EMSA to study the mechanism by which Ku antigen-DNA conformation modulates the repression of MMTV transcription
Tue Jun 01 00:00:00 EDT 1999
Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences.
The Journal of biological chemistry
Galande S,Kohwi-Shigematsu T
MA5-12933 was used in western blot to study the binding of poly(ADP-ribose) polymerase and Ku autoantigen to matrix attachment sequences
Fri Jul 16 00:00:00 EDT 1999
