Product References
Deregulated Transcription and Proteostasis in Adult mapt Knockout Mouse.
International journal of molecular sciences
Andrés-Benito P,Flores Á,Busquet-Areny S,Carmona M,Ausín K,Cartas-Cejudo P,Lachén-Montes M,Del Rio JA,Fernández-Irigoyen J,Santamaría E,Ferrer I
MA5-12808 was used in Western Blotting to reveal a complex altered brain transcriptome and phosphoproteome in tau-KO mice with only mild behavioral alterations.
Fri Mar 31 00:00:00 EDT 2023
Deregulated Transcription and Proteostasis in Adult mapt Knockout Mouse.
International journal of molecular sciences
Andrés-Benito P,Flores Á,Busquet-Areny S,Carmona M,Ausín K,Cartas-Cejudo P,Lachén-Montes M,Del Rio JA,Fernández-Irigoyen J,Santamaría E,Ferrer I
MA5-12808 was used in Western Blotting to reveal a complex altered brain transcriptome and phosphoproteome in tau-KO mice with only mild behavioral alterations.
Fri Mar 31 00:00:00 EDT 2023
The γ-Adducin 1-357 fragment promotes tau pathology.
Frontiers in aging neuroscience
Yu H,Xiong M,Liu C,Xia D,Meng L,Zhang Z
Published figure using Tau monoclonal antibody (Product # MA5-12808) in Western Blot
Tue Oct 03 00:00:00 EDT 2023
The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system.
Nature communications
Saha I,Yuste-Checa P,Da Silva Padilha M,Guo Q,Körner R,Holthusen H,Trinkaus VA,Dudanova I,Fernández-Busnadiego R,Baumeister W,Sanders DW,Gautam S,Diamond MI,Hartl FU,Hipp MS
MA5-12808 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to identify VCP as a core component of the machinery for the removal of neurodegenerative disease aggregates and suggest that its activity can be associated with enhanced aggregate spreading in tauopathies.
Thu Feb 02 00:00:00 EST 2023
Common and Specific Marks of Different Tau Strains Following Intra-Hippocampal Injection of AD, PiD, and GGT Inoculum in hTau Transgenic Mice.
International journal of molecular sciences
Ferrer I,Andrés-Benito P,Carmona M,Del Rio JA
Published figure using Tau monoclonal antibody (Product # MA5-12808) in Western Blot
Wed Dec 14 00:00:00 EST 2022
Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum.
International journal of molecular sciences
Andrés-Benito P,Carmona M,Jordán M,Fernández-Irigoyen J,Santamaría E,Del Rio JA,Ferrer I
MA5-12808 was used in Western Blotting to investigate the importance of host tau in tau seeding and the molecular changes associated with the transformation of host tau into abnormal tau.
Mon Jan 10 00:00:00 EST 2022
Differences in Tau Seeding in Newborn and Adult Wild-Type Mice.
International journal of molecular sciences
Ferrer I,Andrés-Benito P,Garcia-Esparcia P,López-Gonzalez I,Valiente D,Jordán-Pirla M,Carmona M,Sala-Jarque J,Gil V,Del Rio JA
MA5-12808 was used in Immunohistochemistry and Western Blotting to show that (a) differences in tau seeding between newborn and young adults may be related to the ratios between 3Rtau and 4Rtau, and the shift to 4Rtau predominance in adults, together with the immaturity of connections in newborn mice, and (b) intracerebral inoculation of sAD PHFs in newborn mice does not protect from tau seeding following intracerebral inoculation of sAD PHFs in young/adult mice.
Tue Apr 26 00:00:00 EDT 2022
Differences in Tau Seeding in Newborn and Adult Wild-Type Mice.
International journal of molecular sciences
Ferrer I,Andrés-Benito P,Garcia-Esparcia P,López-Gonzalez I,Valiente D,Jordán-Pirla M,Carmona M,Sala-Jarque J,Gil V,Del Rio JA
MA5-12808 was used in Immunohistochemistry and Western Blotting to show that (a) differences in tau seeding between newborn and young adults may be related to the ratios between 3Rtau and 4Rtau, and the shift to 4Rtau predominance in adults, together with the immaturity of connections in newborn mice, and (b) intracerebral inoculation of sAD PHFs in newborn mice does not protect from tau seeding following intracerebral inoculation of sAD PHFs in young/adult mice.
Tue Apr 26 00:00:00 EDT 2022
Protein phosphatase 2A restrains DLK signaling to promote proper Drosophila synaptic development and mammalian cortical neuron survival.
Neurobiology of disease
Hayne M,DiAntonio A
MA5-12808 was used in Western Blotting to demonstrate that inhibition of the DLK pathway is an essential function of Protein phosphatase 2A (PP2A) required for normal Drosophila synaptic terminal development and mammalian cortical neuron survival.
Tue Feb 01 00:00:00 EST 2022
Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease.
Molecular neurodegeneration
Zhang G,Meng L,Wang Z,Peng Q,Chen G,Xiong J,Zhang Z
MA5-12808 was used in Western Blot to examine the presence of islet amyloid polypeptide IAPP in the neurofibrillary tangles of Alzheimer's disease patients. Then test the effect of IAPP on tau aggregation.
Sat Jan 29 00:00:00 EST 2022
Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice.
Environmental health perspectives
Raber J,Perez R,Torres ERS,Krenik D,Boutros S,Patel E,Chlebowski AC,Torres ER,Perveen Z,Penn A,Paulsen DB,Bartlett MG,Jia E,Holden S,Hall R,Morré J,Wong C,Ho E,Choi J,Stevens JF,Noël A,Bobe G,Kisby G
MA5-12808 was used in Dot blot to assess the effects of chronic SHS exposure on behavioral and cognitive function, metabolism, and neuropathology in mice.
Sat May 01 00:00:00 EDT 2021
Retinal ganglion cell loss in an ex vivo mouse model of optic nerve cut is prevented by curcumin treatment.
Cell death discovery
Buccarello L,Dragotto J,Hassanzadeh K,Maccarone R,Corbo M,Feligioni M
Published figure using Tau monoclonal antibody (Product # MA5-12808) in Western Blot
Wed Dec 15 00:00:00 EST 2021
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.
Nature communications
Yuste-Checa P,Trinkaus VA,Riera-Tur I,Imamoglu R,Schaller TF,Wang H,Dudanova I,Hipp MS,Bracher A,Hartl FU
MA5-12808 was used in Western Blot to conclude that upregulation of Clusterin, as observed in AD patients, may enhance Tau seeding and possibly accelerate the spreading of Tau pathology.
Wed Aug 11 00:00:00 EDT 2021
Tau is not necessary for amyloid-β-induced synaptic and memory impairments.
The Journal of clinical investigation
Puzzo D,Argyrousi EK,Staniszewski A,Zhang H,Calcagno E,Zuccarello E,Acquarone E,Fa' M,Li Puma DD,Grassi C,D'Adamio L,Kanaan NM,Fraser PE,Arancio O
MA5-12808 was used in Immunohistochemistry to demonstrated that tau suppression did not protect against Aβ-induced damage of long-term synaptic plasticity and memory, or from amyloid deposition.
Tue Sep 01 00:00:00 EDT 2020
Icariin protects against sodium azide-induced neurotoxicity by activating the PI3K/Akt/GSK-3β signaling pathway.
PeerJ
Zhang Y,Huang N,Lu H,Huang J,Jin H,Shi J,Jin F
Published figure using Tau monoclonal antibody (Product # MA5-12808) in Western Blot
Thu Apr 14 00:00:00 EDT 2022
Icariin protects against sodium azide-induced neurotoxicity by activating the PI3K/Akt/GSK-3β signaling pathway.
PeerJ
Zhang Y,Huang N,Lu H,Huang J,Jin H,Shi J,Jin F
Published figure using Tau monoclonal antibody (Product # MA5-12808) in Western Blot
Thu Apr 14 00:00:00 EDT 2022
Protocol for High-Throughput Screening of Neural Cell or Brain Tissue Protein Using a Dot-Blot Technique with Near-Infrared Imaging.
STAR protocols
Chlebowski AC,Kisby GE
MA5-12808 was used in Protein Assay to provide a detailed protocol for the preparation of brain tissue and neural cell culture lysates for analysis of protein targets by dot blotting.
Fri Sep 18 00:00:00 EDT 2020
Protocol for High-Throughput Screening of Neural Cell or Brain Tissue Protein Using a Dot-Blot Technique with Near-Infrared Imaging.
STAR protocols
Chlebowski AC,Kisby GE
MA5-12808 was used in Protein Assay to provide a detailed protocol for the preparation of brain tissue and neural cell culture lysates for analysis of protein targets by dot blotting.
Fri Sep 18 00:00:00 EDT 2020
Disease-Associated Mutant Tau Prevents Circadian Changes in the Cytoskeleton of Central Pacemaker Neurons.
Frontiers in neuroscience
Cassar M,Law AD,Chow ES,Giebultowicz JM,Kretzschmar D
Published figure using Tau monoclonal antibody (Product # MA5-12808) in Western Blot
Fri Apr 29 00:00:00 EDT 2022
Yeast surface display of full-length human microtubule-associated protein tau.
Biotechnology progress
Wang S,Cho YK
MA5-12808 was used in Immunocytochemistry to show that yeast-displayed tau enables robust measurement of protein interactions and is of particular interest for characterizing conformational change.
Wed Jan 01 00:00:00 EST 2020
NLRP3 inflammasome activation drives tau pathology.
Nature
Ising C,Venegas C,Zhang S,Scheiblich H,Schmidt SV,Vieira-Saecker A,Schwartz S,Albasset S,McManus RM,Tejera D,Griep A,Santarelli F,Brosseron F,Opitz S,Stunden J,Merten M,Kayed R,Golenbock DT,Blum D,Latz E,Buée L,Heneka MT
MA5-12808 was used in Immunohistochemistry to investigate the effect of the NLRP3 inflammasome on tau pathology.
Fri Nov 01 00:00:00 EDT 2019
NLRP3 inflammasome activation drives tau pathology.
Nature
Ising C,Venegas C,Zhang S,Scheiblich H,Schmidt SV,Vieira-Saecker A,Schwartz S,Albasset S,McManus RM,Tejera D,Griep A,Santarelli F,Brosseron F,Opitz S,Stunden J,Merten M,Kayed R,Golenbock DT,Blum D,Latz E,Buée L,Heneka MT
MA5-12808 was used in Immunohistochemistry to investigate the effect of the NLRP3 inflammasome on tau pathology.
Fri Nov 01 00:00:00 EDT 2019
Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease.
Cell reports
Hsieh YC,Guo C,Yalamanchili HK,Abreha M,Al-Ouran R,Li Y,Dammer EB,Lah JJ,Levey AI,Bennett DA,De Jager PL,Seyfried NT,Liu Z,Shulman JM
Published figure using Tau monoclonal antibody (Product # MA5-12808) in Immunoprecipitation
Tue Oct 08 00:00:00 EDT 2019
Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease.
Frontiers in molecular neuroscience
Dai J,Johnson ECB,Dammer EB,Duong DM,Gearing M,Lah JJ,Levey AI,Wingo TS,Seyfried NT
MA5-12808 was used in Western Blotting to reveal alterations in the brain proteome and brain cell types associated with allelic variants in APOE, and suggest further areas for investigation into the upstream mechanisms that drive ApoE-associated risk for AD.
Thu Oct 01 00:00:00 EDT 2020
Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease.
Proteomics
Abreha MH,Dammer EB,Ping L,Zhang T,Duong DM,Gearing M,Lah JJ,Levey AI,Seyfried NT
MA5-12808 was used in Immunoprecipitation to map changes in the Alzheimer's Disease (AD) brain ubiquitylome using an immunoaffinity enrichment approach coupled to mass spectrometry analysis.
Mon Oct 01 00:00:00 EDT 2018
Oxidative Stress Modifies the Levels and Phosphorylation State of Tau Protein in Human Fibroblasts.
Frontiers in neuroscience
Ibáñez-Salazar A,Bañuelos-Hernández B,Rodríguez-Leyva I,Chi-Ahumada E,Monreal-Escalante E,Jiménez-Capdeville ME,Rosales-Mendoza S
Published figure using Tau monoclonal antibody (Product # MA5-12808) in Immunofluorescence
Thu Oct 01 00:00:00 EDT 2020
Oxidative Stress Modifies the Levels and Phosphorylation State of Tau Protein in Human Fibroblasts.
Frontiers in neuroscience
Ibáñez-Salazar A,Bañuelos-Hernández B,Rodríguez-Leyva I,Chi-Ahumada E,Monreal-Escalante E,Jiménez-Capdeville ME,Rosales-Mendoza S
Published figure using Tau monoclonal antibody (Product # MA5-12808) in Immunofluorescence
Thu Oct 01 00:00:00 EDT 2020
Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation.
Nature communications
Choi WH,de Poot SA,Lee JH,Kim JH,Han DH,Kim YK,Finley D,Lee MJ
MA5-12808 was used in western blot to investigate the role of channel gating in mammalian proteasomes
Wed Mar 09 00:00:00 EST 2016
The domestic cat as a natural animal model of Alzheimer's disease.
Acta neuropathologica communications
Chambers JK,Tokuda T,Uchida K,Ishii R,Tatebe H,Takahashi E,Tomiyama T,Une Y,Nakayama H
MA5-12808 was used in western blot to study Alzheimer's disease by use of a domestic cat animal model
Thu Dec 10 00:00:00 EST 2015
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Frontiers in cellular neuroscience
Piedrahita D,Castro-Alvarez JF,Boudreau RL,Villegas-Lanau A,Kosik KS,Gallego-Gomez JC,Cardona-Gómez GP
MA5-12808 was used in western blot to study reduction of hyperphosphorilated Tau by beta-secretase 1's targeting implying autophagy actors in 3xTg-AD mice
Mon Jan 18 00:00:00 EST 2016
Tau reduction prevents disease in a mouse model of Dravet syndrome.
Annals of neurology
Gheyara AL,Ponnusamy R,Djukic B,Craft RJ,Ho K,Guo W,Finucane MM,Sanchez PE,Mucke L
MA5-12808 was used in immunohistochemistry to assess if tau reduction benefits intractable genetic epilepsies
Mon Sep 01 00:00:00 EDT 2014
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.
Frontiers in aging neuroscience
Castro-Alvarez JF,Uribe-Arias SA,Kosik KS,Cardona-Gómez GP
MA5-12808 was used in western blot to use triple transgenic Alzhemier's mice to study short- and long-term CDK5 knockdown and prevention of spatial memory dysfunction and tau pathology
Mon Oct 13 00:00:00 EDT 2014
A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system.
The European journal of neuroscience
Notter T,Panzanelli P,Pfister S,Mircsof D,Fritschy JM
MA5-12808 was used in western blot to identify a method for simultaneous use of both biochemistry and immunohistochemistry in regards to the same tissue
Wed Jan 01 00:00:00 EST 2014
Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.
Age (Dordrecht, Netherlands)
Du LL,Xie JZ,Cheng XS,Li XH,Kong FL,Jiang X,Ma ZW,Wang JZ,Chen C,Zhou XW
MA5-12808 was used in western blot to study the protective effects of pharmacological SIRT1 activation against tau hyperphosphorylation and memory deficits in a rat model of brain insulin resistance
Tue Apr 01 00:00:00 EDT 2014
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Molecular neurodegeneration
Ohia-Nwoko O,Montazari S,Lau YS,Eriksen JL
MA5-12808 was used in immunohistochemistry - paraffin section and western blot to evaluate motor function and tau pathology of P301S tau transgenic mice
Fri Nov 28 00:00:00 EST 2014
Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells.
PloS one
Liu X,Zhou J,Abid MD,Yan H,Huang H,Wan L,Feng Z,Chen J
MA5-12808 was used in western blot to study how induction of Calyculin A in N2a cells can attenuate axonal transport impairment and axonopathy by Berberine
Tue Jan 06 00:00:00 EST 2015
Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease.
Neurobiology of aging
Yu G,Yan T,Feng Y,Liu X,Xia Y,Luo H,Wang JZ,Wang X
MA5-12808 was used in western blot to study the role of CKII-mediated Ser9 phosphorylation in the cytoplasmic retention of SET in Alzheimer's disease
Mon Jul 01 00:00:00 EDT 2013
Nmnat2 attenuates Tau phosphorylation through activation of PP2A.
Journal of Alzheimer's disease : JAD
Cheng XS,Zhao KP,Jiang X,Du LL,Li XH,Ma ZW,Yao J,Luo Y,Duan DX,Wang JZ,Zhou XW
MA5-12808 was used in western blot to study the ability of Nmnat2 overexpression to activate PP2A and reduce levels of tau phosphorylation
Mon Dec 09 00:00:00 EST 2013
Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.
FEBS letters
Cameron A,Giacomozzi B,Joyce J,Gray A,Graham D,Ousson S,Neny M,Beher D,Carlson G,O'Moore J,Shearman M,Hering H
MA5-12808 was used in immunoprecipitation and western blot to study a site-specific rabbit monoclonal antibody that recognozes serine 400 O-GlcNAcylated tau
Fri Nov 15 00:00:00 EST 2013
Overexpression of RCAN1 isoform 4 in mouse neurons leads to a moderate behavioral impairment.
Neurological research
Bhoiwala DL,Koleilat I,Qian J,Beyer B,Hushmendy SF,Mathew A,Bhoiwala DL,Ferland RJ,Crawford DR
MA5-12808 was used in western blot to study the effect of transgenic overexpression of human RCAN1 on cognitive performance in young and adult mice
Tue Jan 01 00:00:00 EST 2013
Glycation exacerbates the neuronal toxicity of β-amyloid.
Cell death & disease
Li XH,Du LL,Cheng XS,Jiang X,Zhang Y,Lv BL,Liu R,Wang JZ,Zhou XW
MA5-12808 was used in western blot to study the increased neuronal toxicity of glycated beta-amyloid
Thu Jun 13 00:00:00 EDT 2013
NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.
Cell death & disease
Tackenberg C,Grinschgl S,Trutzel A,Santuccione AC,Frey MC,Konietzko U,Grimm J,Brandt R,Nitsch RM
MA5-12808 was used in western blot to study the effect of the subunit composition of NMDA receptors on neurodegeneration and synaptic loss induced by beta-amyloid
Thu Apr 25 00:00:00 EDT 2013
Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats.
PloS one
Zussy C,Brureau A,Keller E,Marchal S,Blayo C,Delair B,Ixart G,Maurice T,Givalois L
MA5-12808 was used in western blot to study the ability of a single intracerebroventricular injection of soluble oligomers of a beta-amyloid fragment to induce Alzhiemers's disease pathology in a rat model
Tue Aug 20 00:00:00 EDT 2013
Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response.
Apoptosis : an international journal on programmed cell death
Liu XA,Song J,Jiang Q,Wang Q,Tian Q,Wang JZ
MA5-12808 was used in immunocytochemistry and western blot to study the role of an upregulation of the unfolded protein response in the mechanism by which tau hyperphosphorylation protects against apoptosis induced by ER stress
Mon Oct 01 00:00:00 EDT 2012
AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation.
Neurobiology of aging
Li XH,Lv BL,Xie JZ,Liu J,Zhou XW,Wang JZ
MA5-12808 was used in western blot to study the mechanism by which advanced glycation end-products induce tau hyperphosphorylation and memory impairment
Sun Jul 01 00:00:00 EDT 2012
Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation.
Neuromolecular medicine
Li XH,Xie JZ,Jiang X,Lv BL,Cheng XS,Du LL,Zhang JY,Wang JZ,Zhou XW
MA5-12808 was used in western blot to study the mechanism by which methylglyoxal induces tau hyperphosphorylation
Sat Dec 01 00:00:00 EST 2012
Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains.
FEBS letters
Tian M,Zhu D,Xie W,Shi J
MA5-12808 was used in western blot to investigate the contribution of Ang II to Alzheimer disease.
Fri Oct 19 00:00:00 EDT 2012
Enriched environment prevents cognitive impairment and tau hyperphosphorylation after chronic cerebral hypoperfusion.
Current neurovascular research
Yao ZH,Zhang JJ,Xie XF
MA5-12808 was used in western blot to study the effect of an enriched environment on cognitive impairment and tau hyperphosphorylation in chronic cerebral hypoperfusion
Wed Aug 01 00:00:00 EDT 2012
The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.
The Journal of biological chemistry
Sontag JM,Nunbhakdi-Craig V,White CL,Halpain S,Sontag E
MA5-12808 was used in western blot to investigate interactions between MAP2 and PP2A/Bα in the brain.
Fri Apr 27 00:00:00 EDT 2012
Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease.
Journal of neuroinflammation
Tweedie D,Ferguson RA,Fishman K,Frankola KA,Van Praag H,Holloway HW,Luo W,Li Y,Caracciolo L,Russo I,Barlati S,Ray B,Lahiri DK,Bosetti F,Greig NH,Rosi S
MA5-12808 was used in western blot to study the effects of an inhibitor of TNF-alpha production in animal models of neuroinflammation and Alzheimer's disease
Tue May 29 00:00:00 EDT 2012
A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease.
Toxicological sciences : an official journal of the Society of Toxicology
Li G,Cai F,Yan W,Li C,Wang J
MA5-12808 was used in western blot to study MCLR-induced neurotoxicity using proteomics
Fri Jun 01 00:00:00 EDT 2012
Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration.
Neurobiology of aging
Kulic L,Wollmer MA,Rhein V,Pagani L,Kuehnle K,Cattepoel S,Tracy J,Eckert A,Nitsch RM
MA5-12808 was used in western blot to study the interaction between mitochondrial dysfunction and tau pathology in a novel mouse model
Sat Oct 01 00:00:00 EDT 2011
Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation.
Neurobiology of aging
Hundelt M,Fath T,Selle K,Oesterwind K,Jordan J,Schultz C,Götz J,von Engelhardt J,Monyer H,Lewejohann L,Sachser N,Bakota L,Brandt R
MA5-12808 was used in western blot to study the role of hyperphosphorylation of tau in Alzheimer's disease using a novel transgenic mouse model
Wed Jun 01 00:00:00 EDT 2011
Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues.
Neurobiology of aging
Hall EC,Lee SY,Mairuae N,Simmons Z,Connor JR
MA5-12808 was used in ELISA to test if HFE polymorphisms are associated with alterations in tau phosphorylation in a human neuroblastoma cell line
Mon Aug 01 00:00:00 EDT 2011
Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons.
Journal of neuroscience research
Zhang Z,Zhao R,Qi J,Wen S,Tang Y,Wang D
MA5-12808 was used in western blot to study the inhibition of GSK3-beta by a traditional Chinese medicine and its effects on beta-amyloid toxicity and tau phosphorylation in cortical neurones
Tue Mar 01 00:00:00 EST 2011
Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats.
Journal of Alzheimer's disease : JAD
Wei W,Liu YH,Zhang CE,Wang Q,Wei Z,Mousseau DD,Wang JZ,Tian Q,Liu GP
MA5-12808 was used in western blot to study the role of vitamin B12 in preventing tau phosphorylation and cognition decline in aged rats
Mon Aug 20 00:00:00 EDT 2012
Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells.
Journal of Alzheimer's disease : JAD
Yu G,Li Y,Tian Q,Liu R,Wang Q,Wang JZ,Wang X
MA5-12808 was used in western blot to study the mechanism by which berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation
Mon Sep 19 00:00:00 EDT 2011
Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody.
Amino acids
Yuzwa SA,Yadav AK,Skorobogatko Y,Clark T,Vosseller K,Vocadlo DJ
MA5-12808 was used in western blot to investigate the glycosylation of tau protein
Tue Mar 01 00:00:00 EST 2011
AMPK activation inhibits apoptosis and tau hyperphosphorylation mediated by palmitate in SH-SY5Y cells.
Brain research
Kim J,Park YJ,Jang Y,Kwon YH
MA5-12808 was used in western blot to study the role of AMPK activation in inhibiting palmitate-induded apoptosis and tau hyperphosphorylation in SH-SY5Y cells
Tue Oct 18 00:00:00 EDT 2011
A comparative study of Lrrk2 function in primary neuronal cultures.
Parkinsonism & related disorders
Dächsel JC,Behrouz B,Yue M,Beevers JE,Melrose HL,Farrer MJ
MA5-12808 was used in immunocytochemistry to investigate the role of Lrrk2 in dendritic neuronal arborization
Wed Dec 01 00:00:00 EST 2010
Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.
Journal of Alzheimer's disease : JAD
Liu XA,Liao K,Liu R,Wang HH,Zhang Y,Zhang Q,Wang Q,Li HL,Tian Q,Wang JZ
MA5-12808 was used in western blot to study the mechanism by which tau dephosphorylation facilitates apoptosis
Wed May 05 00:00:00 EDT 2010
LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3β in vivo and in vitro.
Journal of Alzheimer's disease : JAD
Fu ZQ,Yang Y,Song J,Jiang Q,Lin ZC,Wang Q,Zhu LQ,Wang JZ,Tian Q
MA5-12808 was used in western blot to investigate the influence of endoplasmic reticulum stress on tau phosphorylation
Tue Jan 31 00:00:00 EST 2012
Protective effect of isoflavones against homocysteine-mediated neuronal degeneration in SH-SY5Y cells.
Amino acids
Park YJ,Jang Y,Kwon YH
MA5-12808 was used in western blot to study the mechanism for the protective effect of isoflavones on honmocysteine-mediated neuronal degeneration in SH-SY5Y cells
Sun Aug 01 00:00:00 EDT 2010
Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation.
Life sciences
Sul D,Kim HS,Lee D,Joo SS,Hwang KW,Park SY
MA5-12808 was used in western blot to investigate the potential neuroprotective effects of caffeic acid against Abeta-induced toxicity
Fri Feb 27 00:00:00 EST 2009
2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation.
Toxicology
Sul D,Kim HS,Cho EK,Lee M,Kim HS,Jung WW,Hwang KW,Park SY
MA5-12808 was used in western blot to investigate the neurotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
Thu Jan 08 00:00:00 EST 2009
Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain.
Journal of Alzheimer's disease : JAD
Zhang JY,Peng C,Shi H,Wang S,Wang Q,Wang JZ
MA5-12808 was used in western blot to study the mechanism by which inhibition of autophagy promotes proteolysis of tau in rat brain
Fri Mar 27 00:00:00 EDT 2009
Isoflavones prevent endoplasmic reticulum stress-mediated neuronal degeneration by inhibiting tau hyperphosphorylation in SH-SY5Y cells.
Journal of medicinal food
Park YJ,Jang YM,Kwon YH
MA5-12808 was used in western blot to investigate the effect of isoflavone on tau phosphorylation in neurons
Mon Jun 01 00:00:00 EDT 2009
Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation.
Bioscience, biotechnology, and biochemistry
Kim HS,Sul D,Lim JY,Lee D,Joo SS,Hwang KW,Park SY
MA5-12808 was used in western blot to assess the neuroprotective effects of delphinidin against Abeta-induced toxicity
Wed Jul 01 00:00:00 EDT 2009
Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Park SY,Kim HS,Cho EK,Kwon BY,Phark S,Hwang KW,Sul D
MA5-12808 was used in western blot to elucidate the neuroprotective mechanisms by which curcumin protects against Abeta-induced toxicity
Fri Aug 01 00:00:00 EDT 2008
Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.
Journal of cellular and molecular medicine
Liu R,Zhou XW,Tanila H,Bjorkdahl C,Wang JZ,Guan ZZ,Cao Y,Gustafsson JA,Winblad B,Pei JJ
MA5-12808 was used in western blot to determine that Abeta deposition or oestrogen deficiency increases PP2A phosphorylation to compromise tau dephosphorylation and cause neurofibrillary tangle formation in Alzheimer's disease
Tue Jul 22 00:00:00 EDT 2008
Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms.
Neurobiology of aging
Liu GP,Zhang Y,Yao XQ,Zhang CE,Fang J,Wang Q,Wang JZ
MA5-12808 was used in western blot to study the mechanisms by which GSK-3 activation inhibits protein phosphatase-2A
Mon Sep 01 00:00:00 EDT 2008
Three-dimensional neural constructs: a novel platform for neurophysiological investigation.
Journal of neural engineering
Irons HR,Cullen DK,Shapiro NP,Lambert NA,Lee RH,Laplaca MC
MA5-12808 was used in immunocytochemistry to develop an electrophysiologically active 3D neural construct with neurons and astrocytes encased in a bioactive extracellular matrix-based scaffold
Mon Sep 01 00:00:00 EDT 2008
Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A.
Neurochemical research
Liu XA,Zhu LQ,Zhang Q,Shi HR,Wang SH,Wang Q,Wang JZ
MA5-12808 was used in western blot to study the effect of estradiol on PKA-induced tau441 hyperphosphorylation in stably transfected HEK293 cells
Mon Sep 01 00:00:00 EDT 2008
17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner.
Journal of neural transmission (Vienna, Austria : 1996)
Shi HR,Zhu LQ,Wang SH,Liu XA,Tian Q,Zhang Q,Wang Q,Wang JZ
MA5-12808 was used in western blot to study the role of Akt in the attenuation of GSK-3beta activity and tau hyperphosphorylation by 17beta-estradiol
Sun Jun 01 00:00:00 EDT 2008
Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits.
Neuroscience letters
Fukuzaki E,Takuma K,Himeno Y,Yoshida S,Funatsu Y,Kitahara Y,Mizoguchi H,Ibi D,Koike K,Inoue M,Yamada K
MA5-12808 was used in western blot to evaluate if OVX/stress affects levels of Alzheimer's disease-related molecules in the mouse hippocampus
Wed Mar 12 00:00:00 EDT 2008
Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation.
British journal of pharmacology
Selenica ML,Jensen HS,Larsen AK,Pedersen ML,Helboe L,Leist M,Lotharius J
MA5-12808 was used in western blot to evaluate five glycogen synthase kinase-3beta inhibitors and lithium in lowering phosphorylated tau and glycogen synthase kinase-3beta enzyme activity levels in 12-day old postnatal rats
Thu Nov 01 00:00:00 EDT 2007
Effects of tau phosphorylation on proteasome activity.
FEBS letters
Ren QG,Liao XM,Chen XQ,Liu GP,Wang JZ
MA5-12808 was used in western blot to study the effects of tau phosphorylation on proteasome activity
Tue Apr 03 00:00:00 EDT 2007
Caspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons.
Neuroscience
Park SY,Tournell C,Sinjoanu RC,Ferreira A
MA5-12808 was used in western blot to test if sex hormones prevent tau cleavage and Abeta toxicity
Fri Jan 05 00:00:00 EST 2007
Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits.
The American journal of pathology
Schindowski K,Bretteville A,Leroy K,Bégard S,Brion JP,Hamdane M,Buée L
MA5-12808 was used in immunohistochemistry - paraffin section and western blot to characterize a new mouse model of Alzheimer's disease
Tue Aug 01 00:00:00 EDT 2006
The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells.
Journal of molecular medicine (Berlin, Germany)
Esposito G,De Filippis D,Carnuccio R,Izzo AA,Iuvone T
MA5-12808 was used in western blot to investigate the mechanism of tau phosphorylation regulation by cannabidiol in PC12 cells
Wed Mar 01 00:00:00 EST 2006
The involvement of glycogen synthase kinase-3 and protein phosphatase-2A in lactacystin-induced tau accumulation.
FEBS letters
Ren QG,Liao XM,Wang ZF,Qu ZS,Wang JZ
MA5-12808 was used in western blot to study the involvement of GSK-3 and protein phosphatase-2A in lactacystin-induced tau accumulation
Mon May 01 00:00:00 EDT 2006
Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus.
Journal of neural transmission (Vienna, Austria : 1996)
Yoshida S,Maeda M,Kaku S,Ikeya H,Yamada K,Nakaike S
MA5-12808 was used in western blot to assess the effects lithium chloride on cold water stress-induced changes in tau phosphorylation in the mouse hippocampus
Wed Nov 01 00:00:00 EST 2006
EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors.
Cancer research
Hu-Lieskovan S,Zhang J,Wu L,Shimada H,Schofield DE,Triche TJ
MA5-12808 was used in western blot to study whether EWS-FLI1 fusion gene expression is responsible for the primitive neuroectodermal phenotype of Ewing's family tumors
Wed Jun 01 00:00:00 EDT 2005
Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS.
Proceedings of the National Academy of Sciences of the United States of America
Lobsiger CS,Garcia ML,Ward CM,Cleveland DW
MA5-12808 was used in western blot to elucidate how the removal of assembled neurofilaments from axons or misaccumulating neurofilaments in motor neuron cell bodies slows disease in a mouse model of amyotrophic lateral sclerosis
Tue Jul 19 00:00:00 EDT 2005
Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule-binding activity.
FEBS letters
Zhang YJ,Xu YF,Chen XQ,Wang XC,Wang JZ
MA5-12808 was used in western blot to study the potential role of tau nitration in Alzheimer's pathology
Mon Apr 25 00:00:00 EDT 2005
Abnormal group I metabotropic glutamate receptor expression and signaling in the frontal cortex in Pick disease.
Journal of neuropathology and experimental neurology
Dalfó E,Albasanz JL,Rodríguez A,Martín M,Ferrer I
MA5-12808 was used in immunoprecipitation to study abnormal mGluR1 expression and signaling in the frontal cortex in Pick disease
Fri Jul 01 00:00:00 EDT 2005
Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia.
Brain : a journal of neurology
Stanford PM,Shepherd CE,Halliday GM,Brooks WS,Schofield PW,Brodaty H,Martins RN,Kwok JB,Schofield PR
MA5-12808 was used in western blot to study mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia
Tue Apr 01 00:00:00 EST 2003
Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Patzke H,Maddineni U,Ayala R,Morabito M,Volker J,Dikkes P,Ahlijanian MK,Tsai LH
MA5-12808 was used in western blot to study the partial rescue of the Cdk5 adaptor protein p35 -/- phenotype by overexpression of a neronal-specific enolase p25 transgene
Tue Apr 01 00:00:00 EST 2003
Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.
Biochemical and biophysical research communications
Kerokoski P,Suuronen T,Salminen A,Soininen H,Pirttilä T
MA5-12808 was used in western blot to test if calpain cleave the cyclin-dependent kinase 5 activator p35 to a p25 fragment and results in tau hyperphosphorylation.
Fri Nov 15 00:00:00 EST 2002
Rapid detection of protein aggregates in the brains of Alzheimer patients and transgenic mouse models of amyloidosis.
Alzheimer disease and associated disorders
Xu G,Gonzales V,Borchelt DR
MA5-12808 was used in western blot to develop a novel method for the rapid detection of beta-amyloid aggregates in Alzheimer's patients and transgenic mouse models
Wed Dec 04 00:00:00 EST 2002
Hydrogen peroxide induces transient dephosphorylation of tau protein in cultured rat oligodendrocytes.
Neuroscience letters
LoPresti P,Konat GW
MA5-12808 was used in western blot to study the transient dephosphorylation of tau induced by hydrogen peroxide in rat oligodendrocytes
Fri Sep 28 00:00:00 EDT 2001
Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.
The Journal of biological chemistry
Kins S,Crameri A,Evans DR,Hemmings BA,Nitsch RM,Gotz J
MA5-12808 was used in western blot to study the role of protein phosphatase 2A activity in the hyperphosphorylation and compartmentalization of tau in transgenic mice
Fri Oct 12 00:00:00 EDT 2001
