Product References
Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening.
Proceedings of the National Academy of Sciences of the United States of America
Griffin KH,Thorpe SW,Sebastian A,Hum NR,Coonan TP,Sagheb IS,Loots GG,Randall RL,Leach JK
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Tue Sep 26 00:00:00 EDT 2023
STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression.
International journal of molecular sciences
Li N,Wang Y,Wang A,Zhang J,Jia C,Yu C,Song Z,Wang S,Liu L,Yi J,Bao Y,Huang Y,Sun L
12-5981-82 was used in Flow cytometry/Cell sorting to suggest BC as one of the small molecule candidates to stimulate HSPC expansion both in vitro and in vivo when needed in either physiologic or pathologic conditions, but also supports STS1/STS2 as potential therapeutic drug targets for HSPC expansion and hematopoietic injury recovery.
Fri Feb 03 00:00:00 EST 2023
STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression.
International journal of molecular sciences
Li N,Wang Y,Wang A,Zhang J,Jia C,Yu C,Song Z,Wang S,Liu L,Yi J,Bao Y,Huang Y,Sun L
12-5981-82 was used in Flow cytometry/Cell sorting to suggest BC as one of the small molecule candidates to stimulate HSPC expansion both in vitro and in vivo when needed in either physiologic or pathologic conditions, but also supports STS1/STS2 as potential therapeutic drug targets for HSPC expansion and hematopoietic injury recovery.
Fri Feb 03 00:00:00 EST 2023
Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation.
Haematologica
Muto T,Walker CS,Agarwal P,Vick E,Sampson A,Choi K,Niederkorn M,Ishikawa C,Hueneman K,Varney M,Starczynowski DT
12-5981-82 was used in Flow cytometry/Cell sorting to investigate the effects of inflammation on hematopoietic stem and progenitor cells (HSPC) in the context of myelodysplastic syndromes (MDS), particularly the del(5q) subtype.
Sun Oct 01 00:00:00 EDT 2023
Immunostimulatory effects of a subcritical water extract of Ganoderma.
Biomedical reports
Hattori K,Takagi H,Ogata Y,Yamada T,Horiba H,Fukata K,Sakaida T,Yashiro Y,Hasegawa S,Tanaka H
12-5981-82 was used in Flow cytometry/Cell sorting to demonstrate that Ganoderma (SWEG) increased hematopoietic precursor cells, immature B cells, and NK cells in the bone marrow, and T cells in the thymus.
Sun Jan 01 00:00:00 EST 2023
Obesity impairs cardiolipin-dependent mitophagy and therapeutic intercellular mitochondrial transfer ability of mesenchymal stem cells.
Cell death & disease
Sagar S,Faizan MI,Chaudhary N,Singh V,Singh P,Gheware A,Sharma K,Azmi I,Singh VP,Kharya G,Mabalirajan U,Agrawal A,Ahmad T,Sinha Roy S
12-5981-82 was used in Immunocytochemistry to provide the first comprehensive molecular understanding of impaired mitophagy in obese-derived MSCs and highlight the importance of pharmacological modulation of these cells for therapeutic intervention.
Sat May 13 00:00:00 EDT 2023
The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.
Biology open
Ramadan R,Wouters VM,van Neerven SM,de Groot NE,Garcia TM,Muncan V,Franklin OD,Battle M,Carlson KS,Leach J,Sansom OJ,Boulard O,Chamaillard M,Vermeulen L,Medema JP,Huels DJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Dec 15 00:00:00 EST 2022
Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure: Role of PDGF Signaling.
JACC. Basic to translational science
Hamid T,Xu Y,Ismahil MA,Rokosh G,Jinno M,Zhou G,Wang Q,Prabhu SD
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2022
Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells.
International journal of molecular sciences
Kanazawa S,Okada H,Riu D,Mabuchi Y,Akazawa C,Iwata J,Hoshi K,Hikita A
12-5981-82 was used in Flow cytometry/Cell sorting to suggest that a hematopoietic-mesenchymal signal exists, and that the state of the HSCs is important for the stability of MSC properties.
Tue Jul 26 00:00:00 EDT 2022
Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells.
International journal of molecular sciences
Kanazawa S,Okada H,Riu D,Mabuchi Y,Akazawa C,Iwata J,Hoshi K,Hikita A
12-5981-82 was used in Flow cytometry/Cell sorting to suggest that a hematopoietic-mesenchymal signal exists, and that the state of the HSCs is important for the stability of MSC properties.
Tue Jul 26 00:00:00 EDT 2022
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.
Cell stem cell
Vasquez EG,Nasreddin N,Valbuena GN,Mulholland EJ,Belnoue-Davis HL,Eggington HR,Schenck RO,Wouters VM,Wirapati P,Gilroy K,Lannagan TRM,Flanagan DJ,Najumudeen AK,Omwenga S,McCorry AMB,Easton A,Koelzer VH,East JE,Morton D,Trusolino L,Maughan T,Campbell AD,Loughrey MB,Dunne PD,Tsantoulis P,Huels DJ,Tejpar S,Sansom OJ,Leedham SJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Aug 04 00:00:00 EDT 2022
Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types.
iScience
Limbad C,Doi R,McGirr J,Ciotlos S,Perez K,Clayton ZS,Daya R,Seals DR,Campisi J,Melov S
12-5981-82 was used in flow cytometry to show that 25HC represents a potential class of senolytics, which may be useful in combating diseases or physiologies in which cellular senescence is a key driver.
Fri Feb 18 00:00:00 EST 2022
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.
Cell stem cell
Muto T,Guillamot M,Yeung J,Fang J,Bennett J,Nadorp B,Lasry A,Redondo LZ,Choi K,Gong Y,Walker CS,Hueneman K,Bolanos LC,Barreyro L,Lee LH,Greis KD,Vasyliev N,Khodadadi-Jamayran A,Nudler E,Lujambio A,Lowe SW,Aifantis I,Starczynowski DT
12-5981-82 was used in Flow cytometry/Cell sorting to identify signaling states that cooperate with pre-leukemic cells and, notably, the study aimed to uncover the role of the ubiquitin ligase TRAF6 in preventing the transition from a pre-leukemic stage to overt myeloid leukemia by regulating MYC through ubiquitination and acetylation mechanisms.
Thu Feb 03 00:00:00 EST 2022
Nociceptive nerves regulate haematopoietic stem cell mobilization.
Nature
Gao X,Zhang D,Xu C,Li H,Caron KM,Frenette PS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation.
Cell stem cell
Cordero-Espinoza L,Dowbaj AM,Kohler TN,Strauss B,Sarlidou O,Belenguer G,Pacini C,Martins NP,Dobie R,Wilson-Kanamori JR,Butler R,Prior N,Serup P,Jug F,Henderson NC,Hollfelder F,Huch M
12-5981-82 was used in Flow cytometry/Cell sorting to expand the concept of the cellular niche in epithelial tissues, whereby not only soluble factors but also cell-cell contacts are the key regulatory cues involved in the control of cellular behaviors, suggesting a critical role for cell-cell contacts during regeneration.
Thu Nov 04 00:00:00 EDT 2021
Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration.
Cell death and differentiation
Deng CL,Hu CB,Ling ST,Zhao N,Bao LH,Zhou F,Xiong YC,Chen T,Sui BD,Yu XR,Hu CH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Mar 01 00:00:00 EST 2021
Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.
Cell death and differentiation
Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.
Cell death and differentiation
Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.
EMBO reports
Hu Y,Li X,Zhi X,Cong W,Huang B,Chen H,Wang Y,Li Y,Wang L,Fang C,Guo J,Liu Y,Cui J,Cao L,Weng W,Zhou Q,Wang S,Chen X,Su J
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Effects of signaling pathway inhibitors on hematopoietic stem cells.
Molecular medicine reports
Jiang Y,Xu Z,Ma N,Yin L,Hao C,Li J
12-5981 was used in Flow cytometry/Cell sorting to determine the effect of HDACs, mTOR, GSK‚3β and p38MAPK inhibitor combinations on the efficient expansion of HSCs using flow cytometry.
Fri Jan 01 00:00:00 EST 2021
Effects of signaling pathway inhibitors on hematopoietic stem cells.
Molecular medicine reports
Jiang Y,Xu Z,Ma N,Yin L,Hao C,Li J
12-5981 was used in Flow cytometry/Cell sorting to determine the effect of HDACs, mTOR, GSK‚3β and p38MAPK inhibitor combinations on the efficient expansion of HSCs using flow cytometry.
Fri Jan 01 00:00:00 EST 2021
Age-related trabecular bone loss is associated with a decline in serum Galectin-1 level.
BMC musculoskeletal disorders
Xu W,Ni C,Wang Y,Zheng G,Zhang J,Xu Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Tue Apr 27 00:00:00 EDT 2021
The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism.
eLife
Roy A,Tomaz da Silva M,Bhat R,Bohnert KR,Iwawaki T,Kumar A
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Conditionally pathogenic genetic variants of a hematopoietic disease-suppressing enhancer.
Science advances
Soukup AA,Matson DR,Liu P,Johnson KD,Bresnick EH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Dec 10 00:00:00 EST 2021
Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity.
International journal of molecular sciences
Sávio-Silva C,Soinski-Sousa PE,Simplício-Filho A,Bastos RMC,Beyerstedt S,Rangel ÉB
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Feb 04 00:00:00 EST 2021
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
Stem cell reports
Kretzschmar K,Boonekamp KE,Bleijs M,Asra P,Koomen M,Chuva de Sousa Lopes SM,Giovannone B,Clevers H
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Tue Sep 14 00:00:00 EDT 2021
Activation of skeletal muscle-resident glial cells upon nerve injury.
JCI insight
Proietti D,Giordani L,De Bardi M,D'Ercole C,Lozanoska-Ochser B,Amadio S,Volonté C,Marinelli S,Muchir A,Bouché M,Borsellino G,Sacco A,Puri PL,Madaro L
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Apr 08 00:00:00 EDT 2021
MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells.
Nature communications
Wei Q,Pinho S,Dong S,Pierce H,Li H,Nakahara F,Xu J,Xu C,Boulais PE,Zhang D,Maryanovich M,Cuervo AM,Frenette PS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Tue May 04 00:00:00 EDT 2021
Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.
NPJ Regenerative medicine
Ahamad N,Sun Y,Nascimento Da Conceicao V,Xavier Paul Ezhilan CRD,Natarajan M,Singh BB
12-5981-82 was used in Immunohistochemistry (Paraffin), Immunocytochemistry to establish the molecular identity of the calcium channel in MSCs and also show their role in modulating stem cell function.
Wed Oct 20 00:00:00 EDT 2021
Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.
NPJ Regenerative medicine
Ahamad N,Sun Y,Nascimento Da Conceicao V,Xavier Paul Ezhilan CRD,Natarajan M,Singh BB
12-5981-82 was used in Immunohistochemistry (Paraffin), Immunocytochemistry to establish the molecular identity of the calcium channel in MSCs and also show their role in modulating stem cell function.
Wed Oct 20 00:00:00 EDT 2021
The ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways.
BMC biology
Coudert L,Osseni A,Gangloff YG,Schaeffer L,Leblanc P
12-5981-82 was used in Flow Cytometry to show for the first time that Hrs/Hgs is a master regulator that modulates myogenesis at different levels through the control of trafficking, signaling, and degradation pathways.
Fri Jul 30 00:00:00 EDT 2021
Increasing cytosolic Ca2+ levels restore cell proliferation and stem cell potency in aged MSCs.
Stem cell research
Ahamad N,Sun Y,Singh BB
12-5981-82 was used in Cell Culture to suggest that Ca2+ entry is essential for preventing the loss of aged stem cell function and supplementing Ca2+ not only restored their proliferative potential but, allowed them to develop into younger stem cell lineages that could be critical for regenerative medicine.
Fri Oct 01 00:00:00 EDT 2021
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.
Cell reports
Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R
12-5981-82 was used in Flow Cytometry to find that TNF-α-mediated alterations in CML BM stromal niches enhance support of LSC maintenance and growth via CXCL1-CXCR2 signaling and that CXCR2 inhibition effectively depletes CML LSCs.
Tue Jul 13 00:00:00 EDT 2021
Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.
Nature immunology
Muto T,Walker CS,Choi K,Hueneman K,Smith MA,Gul Z,Garcia-Manero G,Ma A,Zheng Y,Starczynowski DT
12-5981 was used in Flow cytometry/Cell sorting to show that chronic inflammation is a determinant for the competitive advantage of myelodysplastic syndrome (MDS) hematopoietic stem and progenitor cells (HSPCs) and for disease progression.
Fri May 01 00:00:00 EDT 2020
STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury.
Nature cell biology
Paris AJ,Hayer KE,Oved JH,Avgousti DC,Toulmin SA,Zepp JA,Zacharias WJ,Katzen JB,Basil MC,Kremp MM,Slamowitz AR,Jayachandran S,Sivakumar A,Dai N,Wang P,Frank DB,Eisenlohr LC,Cantu E,Beers MF,Weitzman MD,Morrisey EE,Worthen GS
12-5981 was used in Flow cytometry/Cell sorting to elucidate repair mechanisms of proliferation and trandifferentiation of type II alveolar pneumocytes (AT2 cells) into type I alveolar pneumocytes (AT1 cells) after acute lung injury.
Thu Oct 01 00:00:00 EDT 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
12-5981-82 was used in Flow Cytometry to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice.
The Journal of clinical investigation
Bosnakovski D,Shams AS,Yuan C,da Silva MT,Ener ET,Baumann CW,Lindsay AJ,Verma M,Asakura A,Lowe DA,Kyba M
12-5981-82 was used in Flow Cytometry to demonstrate a pathophysiological similarity between disease in muscles of iDUX4pA-HSA mice and humans with FSHD, solidifying the value of chronic rare DUX4 expression in mice for modeling pathological mechanisms in FSHD and highlighting the importance FAPs in this disease.
Fri May 01 00:00:00 EDT 2020
Development of an inexpensive Raman-compatible substrate for the construction of a microarray screening platform.
The Analyst
Pastrana-Otero I,Majumdar S,Gilchrist AE,Gorman BL,Harley BAC,Kraft ML
12-5981-82 was used in Flow Cytometry to show that the spectra acquired from individual living cells on functionalized PA gels attached to our custom substrates were of sufficient quality to enable accurate identification of cell phenotypes using PLS-DA models of the cell spectra.
Mon Oct 26 00:00:00 EDT 2020
Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche.
Integrative biology : quantitative biosciences from nano to macro
Gilchrist AE,Harley BAC
12-5981-82 was used in Flow Cytometry to investigate the mechanism of how marrow-derived mesenchymal stromal and progenitor cells impacts hematopoietic stem cells fate decisions.
Fri Jul 10 00:00:00 EDT 2020
Multipotency of mouse trophoblast stem cells.
Stem cell research & therapy
Hou M,Han J,Li G,Kwon MY,Jiang J,Emani S,Taglauer ES,Park JA,Choi EB,Vodnala M,Fong YW,Emani SM,Rosas IO,Perrella MA,Liu X
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Feb 13 00:00:00 EST 2020
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
Nature communications
Wilkes MC,Siva K,Chen J,Varetti G,Youn MY,Chae H,Ek F,Olsson R,Lundbäck T,Dever DP,Nishimura T,Narla A,Glader B,Nakauchi H,Porteus MH,Repellin CE,Gazda HT,Lin S,Serrano M,Flygare J,Sakamoto KM
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Jul 03 00:00:00 EDT 2020
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
Nature communications
Wilkes MC,Siva K,Chen J,Varetti G,Youn MY,Chae H,Ek F,Olsson R,Lundbäck T,Dever DP,Nishimura T,Narla A,Glader B,Nakauchi H,Porteus MH,Repellin CE,Gazda HT,Lin S,Serrano M,Flygare J,Sakamoto KM
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Jul 03 00:00:00 EDT 2020
XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling.
Cell communication and signaling : CCS
Zheng Y,Wang N,Wang S,Yang B,Situ H,Zhong L,Lin Y,Wang Z
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Mar 26 00:00:00 EDT 2020
Use of Busulfan to Condition Mice for Bone Marrow Transplantation.
STAR protocols
Montecino-Rodriguez E,Dorshkind K
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Dec 18 00:00:00 EST 2020
Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.
International journal of molecular sciences
Kroeger C,Roesler R,Wiese S,Hainzl A,Gatzka MV
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Tue May 26 00:00:00 EDT 2020
A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling.
eLife
Geng A,Wu T,Cai C,Song W,Wang J,Yu QC,Zeng YA
12-5981 was used in Flow cytometry/Cell sorting to reveal a novel Wnt-independent role of Rspo1, in which Rspo1 acts as a bona fide GPCR activator eliciting intracellular cAMP signaling.
Tue Aug 04 00:00:00 EDT 2020
A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling.
eLife
Geng A,Wu T,Cai C,Song W,Wang J,Yu QC,Zeng YA
12-5981 was used in Flow cytometry/Cell sorting to reveal a novel Wnt-independent role of Rspo1, in which Rspo1 acts as a bona fide GPCR activator eliciting intracellular cAMP signaling.
Tue Aug 04 00:00:00 EDT 2020
Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages.
Stem cell research & therapy
Liu J,Qiu X,Lv Y,Zheng C,Dong Y,Dou G,Zhu B,Liu A,Wang W,Zhou J,Liu S,Liu S,Gao B,Jin Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Nov 27 00:00:00 EST 2020
Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.
Cell & bioscience
Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Apr 14 00:00:00 EDT 2022
TNFAIP3 Plays a Role in Aging of the Hematopoietic System.
Frontiers in immunology
Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT
12-5981-82 was used in Flow Cytometry to find that the expression of A20 is significantly reduced in aged hematopoietic stem and progenitor cells (HSPC) as compared to young HSPC.
Wed Apr 28 00:00:00 EDT 2021
Nestin-GFP transgene labels skeletal progenitors in the periosteum.
Bone
Tournaire G,Stegen S,Giacomini G,Stockmans I,Moermans K,Carmeliet G,van Gastel N
12-5981-82 was used in Flow Cytometry to show that in adult mice, Nes-GFP cells are present in the periosteum and localize closely to blood vessels, but periosteal Nes-GFP cells express SSC and progenitor markers differently compared to Nes-GFP cells in the bone marrow.
Wed Apr 01 00:00:00 EDT 2020
miR-142 induces accumulation of reactive oxygen species (ROS) by inhibiting pexophagy in aged bone marrow mesenchymal stem cells.
Scientific reports
Houri K,Mori T,Onodera Y,Tsujimoto T,Takehara T,Nakao S,Teramura T,Fukuda K
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Feb 28 00:00:00 EST 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
12-5981 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.
Mon Jul 01 00:00:00 EDT 2019
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Cancer cell
Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH
12-5981-82 was used in Flow cytometry/Cell sorting to investigate the mechanisms of 111 TAM and 141 ML-DS on leukemic transformation.
Mon Aug 12 00:00:00 EDT 2019
Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells.
Cell stem cell
Agarwal P,Isringhausen S,Li H,Paterson AJ,He J,Gomariz Á,Nagasawa T,Nombela-Arrieta C,Bhatia R
12-5981-82 was used in Flow Cytometry to highlight a critical role of niche-specific effects of Cxcl12 expression in maintaining quiescence of TKI-resistant LSC populations.
Thu May 02 00:00:00 EDT 2019
Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures.
Proceedings of the National Academy of Sciences of the United States of America
Boonekamp KE,Kretzschmar K,Wiener DJ,Asra P,Derakhshan S,Puschhof J,López-Iglesias C,Peters PJ,Basak O,Clevers H
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Tue Jul 16 00:00:00 EDT 2019
PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment.
PLoS pathogens
Naipauer J,Rosario S,Gupta S,Premer C,Méndez-Solís O,Schlesinger M,Ponzinibbio V,Jain V,Gay L,Renne R,Chan HL,Morey L,Salyakina D,Abba M,Williams S,Hare JM,Goldschmidt-Clermont PJ,Mesri EA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Sun Dec 01 00:00:00 EST 2019
Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice.
PLoS genetics
Madaro L,Torcinaro A,De Bardi M,Contino FF,Pelizzola M,Diaferia GR,Imeneo G,Bouchè M,Puri PL,De Santa F
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.
Nature communications
Li J,Ayoub A,Xiu Y,Yin X,Sanders JO,Mesfin A,Xing L,Yao Z,Boyce BF
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Wed Jun 26 00:00:00 EDT 2019
Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis.
Science advances
van de Vlekkert D,Demmers J,Nguyen XX,Campos Y,Machado E,Annunziata I,Hu H,Gomero E,Qiu X,Bongiovanni A,Feghali-Bostwick CA,d'Azzo A
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2019
The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression.
Nature communications
Huang J,Zhao L,Fan Y,Liao L,Ma PX,Xiao G,Chen D
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Jun 28 00:00:00 EDT 2019
Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium.
Nature communications
Wang J,Wang D,Chu K,Li W,Zeng YA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Oct 31 00:00:00 EDT 2019
Breast Tumor Cells Highly Resistant to Drugs Are Controlled Only by the Immune Response Induced in an Immunocompetent Mouse Model.
Integrative cancer therapies
Lasso P,Llano Murcia M,Sandoval TA,Urueña C,Barreto A,Fiorentino S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Wed Dec 11 00:00:00 EST 2019
Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq.
iScience
Kwon OJ,Zhang Y,Li Y,Wei X,Zhang L,Chen R,Creighton CJ,Xin L
12-5981 was used in Flow cytometry/Cell sorting to characterise mouse Prostate stromal cells heterogeneity by single-cell RNA-seq.
Fri Mar 29 00:00:00 EDT 2019
Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells.
Cell reports
Chen C,Yu W,Tober J,Gao P,He B,Lee K,Trieu T,Blobel GA,Speck NA,Tan K
12-5981 was used in Flow cytometry/Cell sorting to find that chromosomal compartments and topologically associating domains (TADs) are largely conserved between fetal and adult HSCs.
Tue Dec 17 00:00:00 EST 2019
Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS.
PloS one
Rando A,de la Torre M,Martinez-Muriana A,Zaragoza P,Musaro A,Hernández S,Navarro X,Toivonen JM,Osta R
12-5981 was used in Flow cytometry/Cell sorting to study the effect of known stem cell mobilising agents and antimetabolite 5-fluorouracil in the SOD1G93A model of amyotrophic lateral sclerosis.
Fri Nov 01 00:00:00 EDT 2019
Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle.
Nature medicine
Wang G,Biswas AK,Ma W,Kandpal M,Coker C,Grandgenett PM,Hollingsworth MA,Jain R,Tanji K,Lόpez-Pintado S,Borczuk A,Hebert D,Jenkitkasemwong S,Hojyo S,Davuluri RV,Knutson MD,Fukada T,Acharyya S
12-5981 was used in Magnetic cell separation to identify the metal-ion transporter ZRT- and IRT-like protein 14 as a critical mediator of cancer-induced cachexia.
Fri Jun 01 00:00:00 EDT 2018
Quiescent Tissue Stem Cells Evade Immune Surveillance.
Immunity
Agudo J,Park ES,Rose SA,Alibo E,Sweeney R,Dhainaut M,Kobayashi KS,Sachidanandam R,Baccarini A,Merad M,Brown BD
12-5981 was used in Flow cytometry/Cell sorting to identify a link between stem cell quiescence, antigen presentation, and immune evasion.
Tue Feb 20 00:00:00 EST 2018
Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.
Immunity
Burrack KS,Huggins MA,Taras E,Dougherty P,Henzler CM,Yang R,Alter S,Jeng EK,Wong HC,Felices M,Cichocki F,Miller JS,Hart GT,Johnson AJ,Jameson SC,Hamilton SE
12-5981-82 was used in Flow Cytometry to identify a regulatory role for cytokine-stimulated NK cells in the prevention of a pathogenic immune response.
Tue Apr 17 00:00:00 EDT 2018
MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice.
Human molecular genetics
Gallot YS,Straughn AR,Bohnert KR,Xiong G,Hindi SM,Kumar A
12-5981-82 was used in Flow cytometry/Cell sorting to demonstrate that MyD88-mediated signaling in satellite cells is essential for the regeneration of injured myofibers in dystrophic muscle of mdx mice.
Mon Oct 01 00:00:00 EDT 2018
PDGF is a potent initiator of bone formation in a tissue engineered model of pathological ossification.
Journal of tissue engineering and regenerative medicine
Davies OG,Grover LM,Lewis MP,Liu Y
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Tracking of Adipose-Derived Mesenchymal Stromal/Stem Cells in a Model of Cisplatin-Induced Acute Kidney Injury: Comparison of Bioluminescence Imaging versus qRT-PCR.
International journal of molecular sciences
Schubert R,Sann J,Frueh JT,Ullrich E,Geiger H,Baer PC
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Wed Aug 29 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles.
Scientific reports
Lee D,Taniguchi N,Sato K,Choijookhuu N,Hishikawa Y,Kataoka H,Morinaga H,Lotz M,Chosa E
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Jun 25 00:00:00 EDT 2018
Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.
Nature communications
Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Jun 22 00:00:00 EDT 2018
RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.
The Journal of biological chemistry
Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Jun 15 00:00:00 EDT 2018
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.
Epigenetics & chromatin
Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM
12-5981 was used in Flow cytometry/Cell sorting to demonstrate that megakaryopoietic profiles are established early in haematopoiesis and are present in the majority of the haematopoietic progenitor population.
Mon May 28 00:00:00 EDT 2018
Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization.
Cell reports
Ruiz-Estevez M,Staats J,Paatela E,Munson D,Katoku-Kikyo N,Yuan C,Asakura Y,Hostager R,Kobayashi H,Asakura A,Kikyo N
12-5981-82 was used in Magnetic cell separation to study the role of Fkbp5 in myogenesis.
Tue Nov 27 00:00:00 EST 2018
Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.
Cell reports
Barros-Silva JD,Linn DE,Steiner I,Guo G,Ali A,Pakula H,Ashton G,Peset I,Brown M,Clarke NW,Bronson RT,Yuan GC,Orkin SH,Li Z,Baena E
12-5981 was used in Flow cytometry/Cell sorting to analyse the molecular heterogeneity in basal and luminal prostate compartments.
Tue Dec 18 00:00:00 EST 2018
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.
Nature communications
Guarnerio J,Mendez LM,Asada N,Menon AV,Fung J,Berry K,Frenette PS,Ito K,Pandolfi PP
12-5981 was used in Flow cytometry/Cell sorting to show Pml in mesenchymal stem cells regulate pro-inflammatory cytokines which may sustain leukemic cells.
Thu Jan 04 00:00:00 EST 2018
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.
Nature medicine
Hahm E,Wei C,Fernandez I,Li J,Tardi NJ,Tracy M,Wadhwani S,Cao Y,Peev V,Zloza A,Lusciks J,Hayek SS,O'Connor C,Bitzer M,Gupta V,Sever S,Sykes DB,Scadden DT,Reiser J
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2017
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Immunity
Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY
12-5981 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.
Tue Nov 21 00:00:00 EST 2017
The transcriptional regulator Aire binds to and activates super-enhancers.
Nature immunology
Bansal K,Yoshida H,Benoist C,Mathis D
12-5981 was used in Flow cytometry/Cell sorting to demonstrate the interaction between AIRE and partner proteins and long chromatin regions containing many super-enhancers.
Wed Mar 01 00:00:00 EST 2017
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Nature immunology
Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT
12-5981 was used in Flow cytometry/Cell sorting to examine the significance of ubiquitin signalling in coordinating RNA processing by Toll-like receptor pathways during an immune response and in premalignant haematologic diseases.
Wed Feb 01 00:00:00 EST 2017
Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Cell stem cell
Schneider RK,Mullally A,Dugourd A,Peisker F,Hoogenboezem R,Van Strien PMH,Bindels EM,Heckl D,Büsche G,Fleck D,Müller-Newen G,Wongboonsin J,Ventura Ferreira M,Puelles VG,Saez-Rodriguez J,Ebert BL,Humphreys BD,Kramann R
12-5981 was used in Flow cytometry/Cell sorting to study the cellular origin of bone marrow fibrosis.
Thu Jun 01 00:00:00 EDT 2017
FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.
The Journal of clinical investigation
Li H,Liu P,Xu S,Li Y,Dekker JD,Li B,Fan Y,Zhang Z,Hong Y,Yang G,Tang T,Ren Y,Tucker HO,Yao Z,Guo X
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Apr 03 00:00:00 EDT 2017
GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.
The Journal of clinical investigation
Géraud C,Koch PS,Zierow J,Klapproth K,Busch K,Olsavszky V,Leibing T,Demory A,Ulbrich F,Diett M,Singh S,Sticht C,Breitkopf-Heinlein K,Richter K,Karppinen SM,Pihlajaniemi T,Arnold B,Rodewald HR,Augustin HG,Schledzewski K,Goerdt S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.
PLoS medicine
Xu J,Guardado J,Hoffman R,Xu H,Namas R,Vodovotz Y,Xu L,Ramadan M,Brown J,Turnquist HR,Billiar TR
12-5981 was used in Flow cytometry/Cell sorting to suggest that IL33 may initiate early detrimental type 2 immune responses after trauma through ILC2 regulation of neutrophil IL5 production.
Sat Jul 01 00:00:00 EDT 2017
Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical.
Oxidative medicine and cellular longevity
Zhang J,Xue X,Han X,Li Y,Lu L,Li D,Fan S
12-5981 was used in Flow cytometry/Cell sorting to examine whether consumption of hydrogen-rich water could ameliorate hematopoietic stem cell injury in mice with total body irradiation.
Thu Mar 16 00:00:00 EDT 2017
Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo.
Development (Cambridge, England)
Pievani A,Sacchetti B,Corsi A,Rambaldi B,Donsante S,Scagliotti V,Vergani P,Remoli C,Biondi A,Robey PG,Riminucci M,Serafini M
12-5981 was used in Flow cytometry/Cell sorting to show that human umbilical cord blood-borne fibroblasts are able to recapitulate the conditions by which the bone marrow microenvironment is formed and establish complete hematopoietic stem cell niches.
Wed Mar 15 00:00:00 EDT 2017
A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing.
Stem cell reports
Astuti Y,Kramer AC,Blake AL,Blazar BR,Tolar J,Taisto ME,Lund TC
12598182 was used in flow cytometry to report that ergosterol increases hematopoietic cell homing in zebrafish and mice
Tue Jan 10 00:00:00 EST 2017
Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.
Nature communications
Tao L,Xiang D,Xie Y,Bronson RT,Li Z
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.
Nature communications
Shirai CL,White BS,Tripathi M,Tapia R,Ley JN,Ndonwi M,Kim S,Shao J,Carver A,Saez B,Fulton RS,Fronick C,O'Laughlin M,Lagisetti C,Webb TR,Graubert TA,Walter MJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Jan 09 00:00:00 EST 2017
Microgrooved-surface topography enhances cellular division and proliferation of mouse bone marrow-derived mesenchymal stem cells.
PloS one
Chaudhary JK,Rath PC
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Oct 19 00:00:00 EDT 2017
Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.
PloS one
Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Sep 18 00:00:00 EDT 2017
The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration.
eLife
Xiong G,Hindi SM,Mann AK,Gallot YS,Bohnert KR,Cavener DR,Whittemore SR,Kumar A
12-5981 was used in Flow cytometry/Cell sorting to investigate the mechanism of UPR regulation during regenerative myogenesis.
Thu Mar 23 00:00:00 EDT 2017
Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation.
Scientific reports
Rouaud T,Siami N,Dupas T,Gervier P,Gardahaut MF,Auda-Boucher G,Thiriet C
12-5981 was used in Flow cytometry/Cell sorting to study how innate immune system secretions promotes myogenic differentiation.
Mon Mar 13 00:00:00 EDT 2017
Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation.
Scientific reports
Rouaud T,Siami N,Dupas T,Gervier P,Gardahaut MF,Auda-Boucher G,Thiriet C
12-5981 was used in Flow cytometry/Cell sorting to study how innate immune system secretions promotes myogenic differentiation.
Mon Mar 13 00:00:00 EDT 2017
lncRNA requirements for mouse acute myeloid leukemia and normal differentiation.
eLife
Delás MJ,Sabin LR,Dolzhenko E,Knott SR,Munera Maravilla E,Jackson BT,Wild SA,Kovacevic T,Stork EM,Zhou M,Erard N,Lee E,Kelley DR,Roth M,Barbosa IA,Zuber J,Rinn JL,Smith AD,Hannon GJ
12-5981 was used in Flow cytometry/Cell sorting to assess lncRNA function via an in vivo RNAi screen in a model of acute myeloid leukemia.
Wed Sep 06 00:00:00 EDT 2017
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation.
Nature cell biology
Welte T,Kim IS,Tian L,Gao X,Wang H,Li J,Holdman XB,Herschkowitz JI,Pond A,Xie G,Kurley S,Nguyen T,Liao L,Dobrolecki LE,Pang L,Mo Q,Edwards DP,Huang S,Xin L,Xu J,Li Y,Lewis MT,Wang T,Westbrook TF,Rosen JM,Zhang XH
12598182 was used in flow cytometry to describe the role of mTOR signalling in recruiting pro-tumorigenic myeloid-derived suppressor cells.
Wed Jun 01 00:00:00 EDT 2016
Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes.
Stem cells international
Bruna F,Contador D,Conget P,Erranz B,Sossa CL,Arango-Rodríguez ML
12-5981 was used in Flow cytometry/Cell sorting to suggest, the treatment with adult''s BM-MSCs or their acd-MSCs in cutaneous wound promotes a better tissue repair/regeneration.
Wed Jun 01 00:00:00 EDT 2016
Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity.
Experimental cell research
Hettmer S,Lin MM,Tchessalova D,Tortorici SJ,Castiglioni A,Desai T,Mao J,McMahon AP,Wagers AJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.
Pain reports
Cabañero D,Irie T,Celorrio M,Trousdale C,Owens DM,Virley D,Albrecht PJ,Caterina MJ,Rice FL,Morón JA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
Laminin regulates PDGFRβ(+) cell stemness and muscle development.
Nature communications
Yao Y,Norris EH,Mason CE,Strickland S
12-5981 was used in Flow cytometry/Cell sorting to show that laminin has a critical role in the control of PDGFRBeta(+) cell stemness and that PDGFRBeta(+) may be a drug target for treatment of muscular dystrophy.
Tue May 03 00:00:00 EDT 2016
Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.
Nature communications
Seki T,Hosaka K,Lim S,Fischer C,Honek J,Yang Y,Andersson P,Nakamura M,Näslund E,Ylä-Herttuala S,Sun M,Iwamoto H,Li X,Liu Y,Samani NJ,Cao Y
12-5981 was used in Flow cytometry/Cell sorting to investigate PDGF-CC regulation of angiogenesis-dependent thermogenesis in beige fat.
Fri Aug 05 00:00:00 EDT 2016
miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia.
Nature communications
Jiang X,Hu C,Arnovitz S,Bugno J,Yu M,Zuo Z,Chen P,Huang H,Ulrich B,Gurbuxani S,Weng H,Strong J,Wang Y,Li Y,Salat J,Li S,Elkahloun AG,Yang Y,Neilly MB,Larson RA,Le Beau MM,Herold T,Bohlander SK,Liu PP,Zhang J,Li Z,He C,Jin J,Hong S,Chen J
12-5981 was used in Flow cytometry/Cell sorting to investigate the anti-tumourigenic role of miR-22, showing that it has an anti-tumour role in acute myeloid leukaemia.
Tue Apr 26 00:00:00 EDT 2016
The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.
PloS one
Braun J,Meixner A,Brachner A,Foisner R
12-5981 was used in Flow cytometry/Cell sorting to test whether ANKLE1 may contribute to Holliday junction resolution during DNA repair in mice.
Fri Aug 12 00:00:00 EDT 2016
Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells.
PloS one
Schibler J,Tomanek-Chalkley AM,Reedy JL,Zhan F,Spitz DR,Schultz MK,Goel A
12-5981 was used in Flow cytometry/Cell sorting to a novel strategy of oxidative stress-induced cytotoxic killing of MM cells.
Thu Jul 06 00:00:00 EDT 2017
KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.
Nature medicine
Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
A microfluidic device for epigenomic profiling using 100 cells.
Nature methods
Cao Z,Chen C,He B,Tan K,Lu C
12-5981 was used in Flow cytometry/Cell sorting to demonstrate the effectiveness of a microfluidics-based ChIP-Seq protocol to uncover several novel enhancers in hematopoietic stem and progenitor cells.
Thu Oct 01 00:00:00 EDT 2015
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity.
Nature cell biology
Jeffery E,Church CD,Holtrup B,Colman L,Rodeheffer MS
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Cis-regulatory mechanisms governing stem and progenitor cell transitions.
Science advances
Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors.
Development (Cambridge, England)
Karamitros D,Patmanidi AL,Kotantaki P,Potocnik AJ,Bähr-Ivacevic T,Benes V,Lygerou Z,Kioussis D,Taraviras S
12-5981 was used in Flow cytometry/Cell sorting to investigate the role of geminin in hematopoiesis.
Thu Jan 01 00:00:00 EST 2015
Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during Pneumocystis Lung Infection in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Prigge JR,Hoyt TR,Dobrinen E,Capecchi MR,Schmidt EE,Meissner N
12-5981 was used in Flow cytometry/Cell sorting to highlight how distal fungal infections can have profound systemic effects that impair hematopoiesis.
Tue Dec 01 00:00:00 EST 2015
Spred1, a Suppressor of the Ras-ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells.
Journal of immunology (Baltimore, Md. : 1950)
Suzuki M,Morita R,Hirata Y,Shichita T,Yoshimura A
12-5981 was used in Flow cytometry/Cell sorting to demonstrate that Spred1, a negative regulator of the Ras-ERK pathway, plays an important role in the proliferation and apoptosis of ILC2s and in cytokine secretion from ILC2s.
Sat Aug 01 00:00:00 EDT 2015
Generation of embryonic stem cells from mouse adipose-tissue derived cells via somatic cell nuclear transfer.
Cell cycle (Georgetown, Tex.)
Qin Y,Qin J,Zhou C,Li J,Gao WQ
12-5981 was used in Flow cytometry/Cell sorting to demonstrates that ESCs can be generated from the adipose tissue by somatic cell nuclear transfer (SCNT) and suggests that ADCs can be a new donor-cell type for potential therapeutic cloning.
Tue Jan 26 00:00:00 EST 2016
Cellular and molecular characterization of human cardiac stem cells reveals key features essential for their function and safety.
Stem cells and development
Vahdat S,Mousavi SA,Omrani G,Gholampour M,Sotoodehnejadnematalahi F,Ghazizadeh Z,Gharechahi J,Baharvand H,Salekdeh GH,Aghdami N
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Jun 15 00:00:00 EDT 2015
Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.
Stem cells and development
Samant MD,Jackson CM,Felix CL,Jones AJ,Goodrich DW,Foster BA,Huss WJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri May 15 00:00:00 EDT 2015
Limited miR-17-92 overexpression drives hematologic malignancies.
Leukemia research
Danielson LS,Reavie L,Coussens M,Davalos V,Castillo-Martin M,Guijarro MV,Coffre M,Cordon-Cardo C,Aifantis I,Ibrahim S,Liu C,Koralov SB,Hernando E
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2015
Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model.
Journal of translational medicine
Jiang C,Hu X,Wang L,Cheng H,Lin Y,Pang Y,Yuan W,Cheng T,Wang J
12-5981 was used in Flow cytometry/Cell sorting to conclude that primitive hematopoietic cells in bone marrow enter proliferation earlier than leukemic cells after chemotherapy, and gradually lose their regenerative capacity partly by senescence due to accelerated cycling.
Fri Jul 17 00:00:00 EDT 2015
Type 2 Fibroblast Growth Factor Receptor Signaling Preserves Stemness and Prevents Differentiation of Prostate Stem Cells from the Basal Compartment.
The Journal of biological chemistry
Huang Y,Hamana T,Liu J,Wang C,An L,You P,Chang JYF,Xu J,Jin C,Zhang Z,McKeehan WL,Wang F
12-5981 was used in Flow cytometry/Cell sorting to indicate that FGFR2 signaling is critical for preserving stemness and preventing differentiation of Prostate stem cells (P-SCs).
Fri Jul 17 00:00:00 EDT 2015
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
Nature medicine
Bruns I,Lucas D,Pinho S,Ahmed J,Lambert MP,Kunisaki Y,Scheiermann C,Schiff L,Poncz M,Bergman A,Frenette PS
12-5981 was used in Flow cytometry/Cell sorting to indicate that a terminally differentiated cell type derived from HSCs contributes to the HSC niche, directly regulating HSC behavior.
Sat Nov 01 00:00:00 EDT 2014
Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue.
Circulation
Li X,Zhu M,Penfold ME,Koenen RR,Thiemann A,Heyll K,Akhtar S,Koyadan S,Wu Z,Gremse F,Kiessling F,van Zandvoort M,Schall TJ,Weber C,Schober A
12-5981 was used in Flow cytometry/Cell sorting to determine the role of the chemokine receptor, CXCR7, in atherosclerosis and vascular remodelling.
Tue Mar 18 00:00:00 EDT 2014
Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair.
Circulation research
Furtado MB,Costa MW,Pranoto EA,Salimova E,Pinto AR,Lam NT,Park A,Snider P,Chandran A,Harvey RP,Boyd R,Conway SJ,Pearson J,Kaye DM,Rosenthal NA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Apr 25 00:00:00 EDT 2014
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.
The Journal of clinical investigation
Li J,Razumilava N,Gores GJ,Walters S,Mizuochi T,Mourya R,Bessho K,Wang YH,Glaser SS,Shivakumar P,Bezerra JA
12-5981 was used in Flow cytometry/Cell sorting to demonstrate the role of the Th2-promoting cytokine, IL-33, in cholangiocyte proliferation.
Tue Jul 01 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
Overexpressing sonic hedgehog peptide restores periosteal bone formation in a murine bone allograft transplantation model.
Molecular therapy : the journal of the American Society of Gene Therapy
Huang C,Tang M,Yehling E,Zhang X
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Sat Feb 01 00:00:00 EST 2014
Ebf2 is a selective marker of brown and beige adipogenic precursor cells.
Proceedings of the National Academy of Sciences of the United States of America
Wang W,Kissig M,Rajakumari S,Huang L,Lim HW,Won KJ,Seale P
12-5981 was used in Flow cytometry/Cell sorting to study Ebf2 specifically marking and regulating the molecular profile of brown preadipose cells.
Tue Oct 07 00:00:00 EDT 2014
Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells.
Journal of biomedical science
Cheng CC,Lee YH,Lin SP,Huangfu WC,Liu IH
12-5981 was used in Flow cytometry/Cell sorting to inhibit the enzymatic activity of cell-autonomous HPSE1 in BM-MSCs to clarify the physiological role of HPSE1 in BM-MSCs.
Thu Mar 13 00:00:00 EDT 2014
Recruitment of bone marrow-derived cells to periodontal tissue defects.
Frontiers in cell and developmental biology
Kimura Y,Komaki M,Iwasaki K,Sata M,Izumi Y,Morita I
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Nov 03 00:00:00 EST 2014
Evidence for Transfer of Membranes from Mesenchymal Stem Cells to HL-1 Cardiac Cells.
Stem cells international
Boomsma RA,Geenen DL
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Wed Oct 08 00:00:00 EDT 2014
Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis.
Experimental animals
Akitsu A,Kakuta S,Saijo S,Iwakura Y
12-5981 was used in Flow cytometry/Cell sorting to explore the relationship between IL-17A-producing cells and Treg cells in immune homeostasis of the colon.
Wed Oct 22 00:00:00 EDT 2014
Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.
PloS one
Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu May 28 00:00:00 EDT 2015
Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.
Cancer cell international
Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML
12-5981 was used in Flow cytometry/Cell sorting to study the affect of transforming growth factor-beta1 as an epithelial-to-mesenchymal transition inducer, and hence identify a role in early cancer cell metastasis.
Mon Mar 03 00:00:00 EST 2014
Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.
Cancer cell international
Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML
12-5981 was used in Flow cytometry/Cell sorting to study the affect of transforming growth factor-beta1 as an epithelial-to-mesenchymal transition inducer, and hence identify a role in early cancer cell metastasis.
Mon Mar 03 00:00:00 EST 2014
BMP-non-responsive Sca1+ CD73+ CD44+ mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation.
PloS one
Madhu V,Li CJ,Dighe AS,Balian G,Cui Q
12-5981 was used in Flow cytometry/Cell sorting to study how combined action of VEGF and BMP on MSCs enhances osteoblastic differentiation of MSCs and increases their bone forming ability.
Fri Nov 20 00:00:00 EST 2015
Histological characterization and quantification of cellular events following neural and fibroblast(-like) stem cell grafting in healthy and demyelinated CNS tissue.
Methods in molecular biology (Clifton, N.J.)
Praet J,Santermans E,Reekmans K,de Vocht N,Le Blon D,Hoornaert C,Daans J,Goossens H,Berneman Z,Hens N,Van der Linden A,Ponsaerts P
12-5981-82 was used in Flow cytometry/Cell sorting to provide protocols to isolate eGFP(+) neural and fibroblast (-like) stem cells from embryonic mouse tissue, determine cell viability, and induce reproducible demyelination in the CNS of mice by means of cuprizone administration.
Fri May 22 00:00:00 EDT 2015
Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells.
Nature communications
Kwon OJ,Valdez JM,Zhang L,Zhang B,Wei X,Su Q,Ittmann MM,Creighton CJ,Xin L
12-5981 was used in Flow cytometry/Cell sorting to study a pro-metastatic function of Notch signalling during prostate cancer progression.
Tue Jul 22 00:00:00 EDT 2014
Clock gene Bmal1 is dispensable for intrinsic properties of murine hematopoietic stem cells.
Journal of negative results in biomedicine
Ieyasu A,Tajima Y,Shimba S,Nakauchi H,Yamazaki S
12-5981 was used in Flow cytometry/Cell sorting to investigate the necessity of Bmal1 for haematopoietic stem cell functions.
Sat Mar 08 00:00:00 EST 2014
Arteriolar niches maintain haematopoietic stem cell quiescence.
Nature
Kunisaki Y,Bruns I,Scheiermann C,Ahmed J,Pinho S,Zhang D,Mizoguchi T,Wei Q,Lucas D,Ito K,Mar JC,Bergman A,Frenette PS
12-5981 was used in Immunofluorescence on wholemounted tissues to investigate the spatial localisation of quiescent haematopoietic stem cells in bone marrow, showing that arteriolar niches maintain quiescence.
Thu Oct 31 00:00:00 EDT 2013
CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology
Akhtar S,Gremse F,Kiessling F,Weber C,Schober A
12-5981 was used in Flow cytometry/Cell sorting to investigate the role of CXCL12 in the treatment of unstable atherosclerotic lesions.
Mon Apr 01 00:00:00 EDT 2013
Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors.
European journal of immunology
Baik S,Jenkinson EJ,Lane PJ,Anderson G,Jenkinson WE
12-5981 was used in Flow cytometry/Cell sorting to reveal an unexpected overlap in the phenotypic properties of bipotent TECs with their lineage-restricted counterparts.
Fri Mar 01 00:00:00 EST 2013
Lgr4 is a key regulator of prostate development and prostate stem cell differentiation.
Stem cells (Dayton, Ohio)
Luo W,Rodriguez M,Valdez JM,Zhu X,Tan K,Li D,Siwko S,Xin L,Liu M
12-5981 was used in Flow cytometry/Cell sorting to investigate mechanisms modulating prostate cell fate determination, showing that Lgr4 is a key regulator of development.
Fri Nov 01 00:00:00 EDT 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2013
A non-redundant function of cyclin E1 in hematopoietic stem cells.
Cell cycle (Georgetown, Tex.)
Campaner S,Viale A,De Fazio S,Doni M,De Franco F,D'Artista L,Sardella D,Pelicci PG,Amati B
12-5981 was used in Flow cytometry/Cell sorting to support a role for cyclin E1 in controlling the exit from quiescence in hematopoietic stem cells.
Sun Dec 01 00:00:00 EST 2013
MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse.
RNA biology
Feuermann Y,Kang K,Gavrilova O,Haetscher N,Jang SJ,Yoo KH,Jiang C,Gonzalez FJ,Robinson GW,Hennighausen L
12-5981 was used in Flow cytometry/Cell sorting to investigate the contributions of two microRNAs to the development of brown adipose tissue in vivo using mouse genetics.
Sun Dec 01 00:00:00 EST 2013
Interferon gamma and T cells inhibit osteogenesis induced by allogeneic mesenchymal stromal cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Dighe AS,Yang S,Madhu V,Balian G,Cui Q
12-5981 was used in Flow cytometry/Cell sorting to investigate whether MSCs can be used for bone repair, showing that interferon gamma and T cells inhibit osteogenesis induced by allogeneic MSCs.
Fri Feb 01 00:00:00 EST 2013
Suppression of cytochrome p450 reductase enhances long-term hematopoietic stem cell repopulation efficiency in mice.
PloS one
Zhang Y,Dong F,Zhang N,Cheng H,Pang Y,Wang X,Xu J,Ding X,Cheng T,Gu J,Yuan W
12-5981 was used in Flow cytometry/Cell sorting to examine the effects of low cytochrome P450 reductase expression on haematopoietic stem cell function.
Tue Apr 29 00:00:00 EDT 2014
p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses.
The Journal of clinical investigation
Wang Y,Sharpless N,Chang S
12-5981 was used in Flow cytometry/Cell sorting to provide experimental evidence that p16(INK4a) exerts protective functions in proliferative cells bearing dysfunctional telomeres.
Tue Oct 01 00:00:00 EDT 2013
Fetal skeletal muscle progenitors have regenerative capacity after intramuscular engraftment in dystrophin deficient mice.
PloS one
Sakai H,Sato T,Sakurai H,Yamamoto T,Hanaoka K,Montarras D,Sehara-Fujisawa A
12-5981 was used in Flow cytometry/Cell sorting to demonstrate the potential of muscle progenitors for muscle repair and cell therapy after degenerative muscle disease.
Tue Dec 24 00:00:00 EST 2013
Mechanisms of adhesion and subsequent actions of a haematopoietic stem cell line, HPC-7, in the injured murine intestinal microcirculation in vivo.
PloS one
Kavanagh DP,Yemm AI,Zhao Y,Frampton J,Kalia N
12-5981 was used in Flow cytometry/Cell sorting to study the mechanisms of haematopoietic stem cell adhesion to gut and muscle and the relationship between adhesion and leukocyte recruitment.
Tue Sep 24 00:00:00 EDT 2013
Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.
Cancer cell
Xu K,Usary J,Kousis PC,Prat A,Wang DY,Adams JR,Wang W,Loch AJ,Deng T,Zhao W,Cardiff RD,Yoon K,Gaiano N,Ling V,Beyene J,Zacksenhaus E,Gridley T,Leong WL,Guidos CJ,Perou CM,Egan SE
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Tue May 15 00:00:00 EDT 2012
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Blood
Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu May 10 00:00:00 EDT 2012
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
12-5981 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.
Thu Feb 09 00:00:00 EST 2012
Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.
The Journal of clinical investigation
Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Mon Oct 01 00:00:00 EDT 2012
Molecular imaging of bone marrow mononuclear cell survival and homing in murine peripheral artery disease.
JACC. Cardiovascular imaging
van der Bogt KE,Hellingman AA,Lijkwan MA,Bos EJ,de Vries MR,van Rappard JR,Fischbein MP,Quax PH,Robbins RC,Hamming JF,Wu JC
12-5981 was used in Flow cytometry/Cell sorting to assess the kinetics of transplanted MNCs in PAD using in vivo molecular imaging.
Sun Jan 01 00:00:00 EST 2012
CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion.
The EMBO journal
Gu P,Min JN,Wang Y,Huang C,Peng T,Chai W,Chang S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Wed May 16 00:00:00 EDT 2012
CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion.
The EMBO journal
Gu P,Min JN,Wang Y,Huang C,Peng T,Chai W,Chang S
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Wed May 16 00:00:00 EDT 2012
Induction of cardiac myogenic lineage development differs between mesenchymal and satellite cells and is accelerated by bone morphogenetic protein-4.
Journal of molecular and cellular cardiology
Grajales L,García J,Geenen DL
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2012
The mouse mammary microenvironment redirects mesoderm-derived bone marrow cells to a mammary epithelial progenitor cell fate.
Stem cells and development
Boulanger CA,Bruno RD,Rosu-Myles M,Smith GH
12-5981 was used in Flow cytometry/Cell sorting to show that signals from the mammary microenvironment are capable of redirecting mesoderm-derived adult progenitor cells to produce MEC progeny.
Tue Apr 10 00:00:00 EDT 2012
Leptin differentially regulate STAT3 activation in ob/ob mouse adipose mesenchymal stem cells.
Nutrition & metabolism
Zhou Z,Neupane M,Zhou HR,Wu D,Chang CC,Moustaid-Moussa N,Claycombe KJ
12-5981 was used in Flow cytometry/Cell sorting to demonstrate that leptin increases adipose stem cell number and differentially activates Signal Transducer and Activator of Transcription 3 protein resulting in up-regulation of MCP-1 gene expression.
Wed Dec 05 00:00:00 EST 2012
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Nature immunology
Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D
12-5981 was used in Flow cytometry/Cell sorting to demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after viral replication.
Tue Nov 01 00:00:00 EDT 2011
Essential roles for Pot1b in HSC self-renewal and survival.
Blood
Wang Y,Shen MF,Chang S
12-5981 was used in Flow cytometry/Cell sorting to investigate why bone marrow failure occurs following Pot1b deletion.
Thu Dec 01 00:00:00 EST 2011
Essential roles for Pot1b in HSC self-renewal and survival.
Blood
Wang Y,Shen MF,Chang S
12-5981 was used in Flow cytometry/Cell sorting to investigate why bone marrow failure occurs following Pot1b deletion.
Thu Dec 01 00:00:00 EST 2011
Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair.
Cell stem cell
Loffredo FS,Steinhauser ML,Gannon J,Lee RT
12-5981 was used in Flow cytometry/Cell sorting to stimulate endogenous cardiomyocyte progenitors and promote cardiac repair as part of bone marrow-derived cell therapy.
Fri Apr 08 00:00:00 EDT 2011
Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat β-thalassemia.
Molecular therapy : the journal of the American Society of Gene Therapy
Ronen K,Negre O,Roth S,Colomb C,Malani N,Denaro M,Brady T,Fusil F,Gillet-Legrand B,Hehir K,Beuzard Y,Leboulch P,Down JD,Payen E,Bushman FD
12-5981 was used in Flow cytometry/Cell sorting to study integration sites of a lentiviral vector encoding β-globin during treatment of β-thalassemia, showing that integration occurred multiple times and clonal populations with integration near growth-control genes were not enriched.
Fri Jul 01 00:00:00 EDT 2011
Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling.
Journal of immunology (Baltimore, Md. : 1950)
MacNamara KC,Oduro K,Martin O,Jones DD,McLaughlin M,Choi K,Borjesson DL,Winslow GM
12-5981 was used in Flow cytometry/Cell sorting to provide evidence that IFN-γ acts to control infection by directly promoting myeloid cell differentiation.
Sat Jan 15 00:00:00 EST 2011
CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells.
Stem cells and development
Qiu Q,Hernandez JC,Dean AM,Rao PH,Darlington GJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Adipose-derived stem cells promote lymphangiogenesis in response to VEGF-C stimulation or TGF-β1 inhibition.
Future oncology (London, England)
Yan A,Avraham T,Zampell JC,Haviv YS,Weitman E,Mehrara BJ
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
A high omega-3 fatty acid diet has different effects on early and late stage myeloid progenitors.
Lipids
Varney ME,Buchanan JT,Dementieva Y,Hardman WE,Sollars VE
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Sat Jan 01 00:00:00 EST 2011
Functional myogenic engraftment from mouse iPS cells.
Stem cell reviews and reports
Darabi R,Pan W,Bosnakovski D,Baik J,Kyba M,Perlingeiro RC
12-5981 was used in Flow cytometry/Cell sorting to study the use of induced pluripotent stem cells in the treatment of muscle disorders.
Tue Nov 01 00:00:00 EDT 2011
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.
The Journal of experimental medicine
Morita Y,Ema H,Nakauchi H
12-5981 was used in Immunofluorescence to highlight the complexity and hierarchy of reconstitution capability among HSCs in mice.
Mon Jun 07 00:00:00 EDT 2010
Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after myocardial infarction.
Circulation. Cardiovascular imaging
Swijnenburg RJ,Govaert JA,van der Bogt KE,Pearl JI,Huang M,Stein W,Hoyt G,Vogel H,Contag CH,Robbins RC,Wu JC
12-5981 was used in Flow cytometry/Cell sorting to show in general, there is poor long-term engraftment and bone marrow mononuclear cells tend to adopt inflammatory cell phenotypes.
Fri Jan 01 00:00:00 EST 2010
Delayed enrichment of mesenchymal cells promotes cardiac lineage and calcium transient development.
Journal of molecular and cellular cardiology
Grajales L,García J,Banach K,Geenen DL
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2010
Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells.
Cell stem cell
Le Grand F,Jones AE,Seale V,Scimè A,Rudnicki MA
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Fri Jun 05 00:00:00 EDT 2009
Type I interferon modulates monocyte recruitment and maturation in chronic inflammation.
The American journal of pathology
Lee PY,Li Y,Kumagai Y,Xu Y,Weinstein JS,Kellner ES,Nacionales DC,Butfiloski EJ,van Rooijen N,Akira S,Sobel ES,Satoh M,Reeves WH
12-5981 was used in Flow cytometry/Cell sorting to define the mechanisms underlying the sustained influx of monocytes observable during chronic inflammation.
Sun Nov 01 00:00:00 EDT 2009
Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice.
BMC biotechnology
Bergwerf I,De Vocht N,Tambuyzer B,Verschueren J,Reekmans K,Daans J,Ibrahimi A,Van Tendeloo V,Chatterjee S,Goossens H,Jorens PG,Baekelandt V,Ysebaert D,Van Marck E,Berneman ZN,Linden AV,Ponsaerts P
Published figure using Ly-6A/E (Sca-1) monoclonal antibody (Product # 12-5981-82) in Flow Cytometry
Wed Jan 07 00:00:00 EST 2009
A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1.
Cell research
Sheng H,Wang Y,Jin Y,Zhang Q,Zhang Y,Wang L,Shen B,Yin S,Liu W,Cui L,Li N
12-5981 was used in Flow cytometry/Cell sorting to investigate the role that IFNγ plays in mesenchymal stem cell mediated suppression of T cell proliferation.
Fri Aug 01 00:00:00 EDT 2008
Runx proteins are involved in regulation of CD122, Ly49 family and IFN-gamma expression during NK cell differentiation.
International immunology
Ohno S,Sato T,Kohu K,Takeda K,Okumura K,Satake M,Habu S
12-5981 was used in Flow cytometry/Cell sorting to investigate the role of Runx family proteins in NK cells, showing that they are involved in regulation of CD122, Ly49 family and IFN-gamma expression during differentiation.
Tue Jan 01 00:00:00 EST 2008
Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.
PloS one
Kalaitzidis D,Neel BG
12-5981 was used in Flow cytometry/Cell sorting to develop a method to study intracellular signaling in murine HSC/progenitor cell (HPC)-enriched populations, showing agonist and temporal differences in responses of HSC/HPC.
Tue Feb 10 00:00:00 EST 2009
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.
The Journal of experimental medicine
Besseyrias V,Fiorini E,Strobl LJ,Zimber-Strobl U,Dumortier A,Koch U,Arcangeli ML,Ezine S,Macdonald HR,Radtke F
12-5981 was used in Flow cytometry/Cell sorting to study the Notch-Delta interactions that promote T cell development.
Mon Feb 19 00:00:00 EST 2007
Beta-catenin is dispensable for hematopoiesis and lymphopoiesis.
The Journal of experimental medicine
Cobas M,Wilson A,Ernst B,Mancini SJ,MacDonald HR,Kemler R,Radtke F
12-5981 was used in Flow cytometry/Cell sorting to investigate an essential role for beta-catenin during hematopoiesis and lymphopoiesis.
Mon Jan 19 00:00:00 EST 2004
Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes.
The Journal of biological chemistry
Matsuura K,Nagai T,Nishigaki N,Oyama T,Nishi J,Wada H,Sano M,Toko H,Akazawa H,Sato T,Nakaya H,Kasanuki H,Komuro I
12-5981 was used in Flow cytometry/Cell sorting to demonstrate that Sca-1-positive cells in adult hearts have some of the features of stem cells, and may contribute to their regeneration following injury.
Fri Mar 19 00:00:00 EST 2004
