Product References
Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development.
Neuron
Su Y,Wang X,Yang Y,Chen L,Xia W,Hoi KK,Li H,Wang Q,Yu G,Chen X,Wang S,Wang Y,Xiao L,Verkhratsky A,Fancy SPJ,Yi C,Niu J
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate a correlation between the developmental formation of astrocytic endfeet on vessels and the termination of OPC perivascular migration.
Wed Jan 18 00:00:00 EST 2023
Single Prolonged Stress Decreases the Level of Adult Hippocampal Neurogenesis in C57BL/6, but Not in House Mice.
Current issues in molecular biology
Kurilova E,Sidorova M,Tuchina O
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to model PTSD in long-inbred C57BL/6 and wild-derived (house) female mice.
Fri Jan 06 00:00:00 EST 2023
Recurrent Desmoid Fibromatosis of the Thyroid Gland: A Diagnostic Challenge.
Journal of the ASEAN Federation of Endocrine Societies
Singh BK,Chumber S,Rathore YS,Agarwal S,Rastogi S,Surabhi V
MA5-14520 was used in Immunohistochemistry to show that the case is being reported for its rarity and the discussion of its differential diagnoses.
Thu Jun 01 00:00:00 EDT 2023
Enriched Environment Induces Sex-Specific Changes in the Adult Neurogenesis, Cytokine and miRNA Expression in Rat Hippocampus.
Biomedicines
Vinogradova A,Sysova M,Smirnova P,Sidorova M,Turkin A,Kurilova E,Tuchina O
MA5-14520 was used in Immunohistochemistry to study the behavior and hippocampal neurogenesis in adult male and female Wistar rats that were housed in an enriched environment (EE) for two months. Both EE males and females performed better than control animals in a Barnes maze, meaning that EE enhances spatial memory.
Tue May 02 00:00:00 EDT 2023
High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice.
Communications biology
Hases L,Stepanauskaite L,Birgersson M,Brusselaers N,Schuppe-Koistinen I,Archer A,Engstrand L,Williams C
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to report clear host sex differences along with remarkably sex-dependent responses to high-fat diet.
Mon Jan 09 00:00:00 EST 2023
Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability.
Nature communications
Luo Z,Xin D,Liao Y,Berry K,Ogurek S,Zhang F,Zhang L,Zhao C,Rao R,Dong X,Li H,Yu J,Lin Y,Huang G,Xu L,Xin M,Nishinakamura R,Yu J,Kool M,Pfister SM,Roussel MF,Zhou W,Weiss WA,Andreassen P,Lu QR
MA5-14520 was used in Immunocytochemistry to demonstrate that CTDNEP1 is a tumor suppressor in highly aggressive MYC-driven medulloblastomas by controlling MYC activity and mitotic fidelity, pointing to a CTDNEP1-dependent targetable therapeutic vulnerability.
Fri Feb 10 00:00:00 EST 2023
An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1.
British journal of cancer
Aftab F,Rodriguez-Fuguet A,Silva L,Kobayashi IS,Sun J,Politi K,Levantini E,Zhang W,Kobayashi SS,Zhang WC
MA5-14520 was used in Immunohistochemistry-immunofluorescence to investigate the inhibitory effects of AICAR on MUC1 activity in EGFR-mutant lung cancer cells.
Mon May 01 00:00:00 EDT 2023
TET2 and TET3 loss disrupts small intestine differentiation and homeostasis.
Nature communications
Ansari I,Solé-Boldo L,Ridnik M,Gutekunst J,Gilliam O,Korshko M,Liwinski T,Jickeli B,Weinberg-Corem N,Shoshkes-Carmel M,Pikarsky E,Elinav E,Lyko F,Bergman Y
MA5-14520 was used in Immunohistochemistry to show that ablation of TET2/3 in intestinal epithelial cells results in a murine phenotype characterized by a severe homeostasis imbalance in the small intestine.
Thu Jul 06 00:00:00 EDT 2023
Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation.
Nature communications
Freitas-Andrade M,Comin CH,Van Dyken P,Ouellette J,Raman-Nair J,Blakeley N,Liu QY,Leclerc S,Pan Y,Liu Z,Carrier M,Thakur K,Savard A,Rurak GM,Tremblay MÈ,Salmaso N,da F Costa L,Coppola G,Lacoste B
MA5-14520 was used in Immunohistochemistry-immunofluorescence to identify astroglial Hmgb1 as an important player in postnatal gliovascular maturation.
Wed Aug 16 00:00:00 EDT 2023
Step-dose IL-7 treatment promotes systemic expansion of T cells and alters immune cell landscape in blood and lymph nodes.
iScience
Pandit H,Valentin A,Angel M,Deleage C,Bergamaschi C,Bear J,Sowder R,Felber BK,Pavlakis GN
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to study treatment of T cells and immune cell landscape in blood and lymph nodes.
Fri Feb 17 00:00:00 EST 2023
Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.
Science advances
Nguyen DD,Kim E,Le NT,Ding X,Jaiswal RK,Kostlan RJ,Nguyen TNT,Shiva O,Le MT,Chai W
MA5-14520 was used in Immunohistochemistry to identify STN1 deficiency as a risk factor for CRC and implicates the previously unknown STN1-BER axis in protecting colon tissues from oxidative damage, therefore providing insights into the CRC tumor-suppressing mechanism.
Wed May 10 00:00:00 EDT 2023
Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer.
Nature cancer
Perelli L,Carbone F,Zhang L,Huang JK,Le C,Khan H,Citron F,Del Poggetto E,Gutschner T,Tomihara H,Soeung M,Minelli R,Srinivasan S,Peoples M,Lam TNA,Lundgren S,Xia R,Zhu C,Mohamed AMT,Zhang J,Sircar K,Sgambato A,Gao J,Jonasch E,Draetta GF,Futreal A,Bakouny Z,Van Allen EM,Choueiri T,Signoretti S,Msaouel P,Litchfield K,Turajlic S,Wang L,Chen YB,Di Natale RG,Hakimi AA,Giuliani V,Heffernan TP,Viale A,Bristow CA,Tannir NM,Carugo A,Genovese G
MA5-14520 was used in Immunohistochemistry to provide critical knowledge on drivers of renal cell carcinoma progression and defines the primary role of interferon signaling in constraining the propagation of aneuploid clones in cancer evolution.
Sat Jul 01 00:00:00 EDT 2023
Suspended hydrogel culture as a method to scale up intestinal organoids.
Scientific reports
Co JY,Klein JA,Kang S,Homan KA
MA5-14520 was used in Immunohistochemistry-immunofluorescence to demonstrate the compatibility of this method with multiple culture formats, and provide examples of suspended BME hydrogel organoids in downstream applications: implementation in a medium-throughput drug screen and generation of Transwell monolayers for barrier evaluation.
Tue Jun 27 00:00:00 EDT 2023
IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury.
Inflammation and regeneration
Wang J,Xu L,Peng D,Zhu Y,Gu Z,Yao Y,Li H,Cao X,Fu CY,Zheng M,Song X,Ding Y,Shen Y,Zhong J,Chen YY,Hu J,Wang LL
MA5-14520 was used in Immunohistochemistry to identify INF-γ as a critical mediator of CD8+ T-cell-NSC cross talk and a potential node for therapeutic intervention in spinal cord injury.
Mon Feb 13 00:00:00 EST 2023
Rhamnazin Enhanced Anti-Tumor Efficacy of Anti-PD-1 Therapy for Lung Cancer in Mice through Inhibition of PD-L1 Expression.
The Tohoku journal of experimental medicine
Wang SS,Liu Y,Zhang XT,Yu DQ
MA5-14520 was used in Flow cytometry/Cell sorting to suggest that rhamnazin enhances antitumor effect of anti-PD-1 therapy for lung cancer in mice via inhibition of PD-L1 expression.
Sat May 20 00:00:00 EDT 2023
Murine neonatal cardiac B cells promote cardiomyocyte proliferation and heart regeneration.
NPJ Regenerative medicine
Tan Y,Duan X,Wang B,Liu X,Zhan Z
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to find that the neonatal mice with B cell depletion showed markedly reduced cardiomyocyte proliferation, leading to cardiac dysfunction, fibrosis scar formation, and the complete failure of heart regeneration after apical resection.
Sat Feb 11 00:00:00 EST 2023
Lithium Chloride Exerts Anti-Inflammatory and Neuroprotective Effects by Inhibiting Microglial Activation in LPS-Induced Retinal Injury.
Investigative ophthalmology & visual science
Wu N,Luo Q,Huang Y,Wan L,Hou X,Jiang Z,Li Y,Qiu J,Chen P,Yu K,Zhuang J,Yang Y
MA5-14520 was used in Immunohistochemistry-immunofluorescence to demonstrate that LiCl exerts anti-inflammatory and neuroprotective effects by inhibiting microglial activation via the PI3K/Akt/NF-κB pathway in LPS-induced retinal injury.
Wed Mar 01 00:00:00 EST 2023
Anti-angiogenic and anti-proliferative activity of ziziphus leaf extract as a novel potential therapeutic agent for reducing hepatic injury in experimental hamster schistosomiasis.
PLoS neglected tropical diseases
Alghamdi T,Salem DA,El-Refaei MF
MA5-14520 was used in Immunohistochemistry (Paraffin) to evaluate the therapeutic potential of Ziziphus spina-christi leaf extract (ZLE) as an anti-angiogenic, and anti-proliferative agent in hamsters infected with S. mansoni.
Thu Jun 01 00:00:00 EDT 2023
Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis.
Cell death & disease
Zhou Y,Cui G,Xu H,Chun J,Yang D,Zhang Z,Yang L,Wang J,Wan M,Calvisi DF,Lin S,Chen X,Wang H
MA5-14520 was used in Immunohistochemistry to demonstrate that loss of TP53 cooperates with c-MET to drive hepatocarcinogenesis in vivo.
Thu Jul 27 00:00:00 EDT 2023
Hypoxia-inducible factor 1A inhibition overcomes castration resistance of prostate tumors.
EMBO molecular medicine
Terzic J,Abu El Maaty MA,Lutzing R,Vincent A,El Bizri R,Jung M,Keime C,Metzger D
MA5-14520 was used in Immunohistochemistry to demonstrate that HIF1A in prostatic tumor cells is a critical factor that enables their survival after ADT, and identify it as a target for CRPC management.
Wed Jun 07 00:00:00 EDT 2023
Transcriptional and epigenetic decoding of the microglial aging process.
Nature aging
Li X,Li Y,Jin Y,Zhang Y,Wu J,Xu Z,Huang Y,Cai L,Gao S,Liu T,Zeng F,Wang Y,Wang W,Yuan TF,Tian H,Shu Y,Guo F,Lu W,Mao Y,Mei X,Rao Y,Peng B
MA5-14520 was used in Immunohistochemistry to map the transcriptional and epigenetic profiles of microglia from 3- to 24-month-old mice.
Sun Oct 01 00:00:00 EDT 2023
Dual Targeting of EGFR and MTOR Pathways Inhibits Glioblastoma Growth by Modulating the Tumor Microenvironment.
Cells
Sidorov M,Dighe P,Woo RWL,Rodriguez-Brotons A,Chen M,Ice RJ,Vaquero E,Jian D,Desprez PY,Nosrati M,Galvez L,Leng L,Dickinson L,Kashani-Sabet M,McAllister SD,Soroceanu L
MA5-14520 was used in Immunohistochemistry to demonstrate that pharmacological co-targeting of EGFR and MTOR using clinically available drugs represents an effective treatment paradigm for EGFR-driven GBMs, acting both by inhibiting tumor cell growth and modulating the immune tumor microenvironment.
Wed Feb 08 00:00:00 EST 2023
Decellularization of xenografted tumors provides cell-specific in vitro 3D environment.
Frontiers in oncology
Iazzolino G,Mendibil U,Arnaiz B,Ruiz-de-Angulo A,Azkargorta M,Uribe KB,Khatami N,Elortza F,Olalde B,Gomez-Vallejo V,Llop J,Abarrategi A
MA5-14520 was used in Immuno-assay to serve as a proof-of-concept for further potential generation of patient-specific in vitro research models.
Tue Mar 28 00:00:00 EDT 2023
CD36 deficiency inhibits proliferation by cell cycle control in skeletal muscle cells.
Frontiers in physiology
Sun J,Su Y,Xu Y,Qin D,He Q,Qiu H,Zhuo J,Li W
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that CD36 was involved in skeletal muscle cell proliferation by cell cycle control, and these findings might facilitate the treatment of obesity-related muscle wasting.
Sat Sep 17 00:00:00 EDT 2022
Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Meyer Zu Reckendorf S,Moser D,Blechschmidt A,Joga VN,Sinske D,Hegler J,Deininger S,Catanese A,Vettorazzi S,Antoniadis G,Boeckers T,Knöll B
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to highlight a dual TSG function with PTEN loss impairing physiological neuron function but furthermore underscoring the positive effects of PTEN ablation in axon regeneration also for the PNS.SIGNIFICANCE STATEMENT Tumor suppressor genes (TSGs) restrict cell proliferation and growth.
Wed Mar 23 00:00:00 EDT 2022
In Vitro and Ectopic In Vivo Studies toward the Utilization of Rapidly Isolated Human Nasal Chondrocytes for Single-Stage Arthroscopic Cartilage Regeneration Therapy.
International journal of molecular sciences
Lehoczky G,Trofin RE,Vallmajo-Martin Q,Chawla S,Pelttari K,Mumme M,Haug M,Egloff C,Jakob M,Ehrbar M,Martin I,Barbero A
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to determine the feasibility for a single-stage application of NCs for cartilage regeneration under minimally invasive settings.
Tue Jun 21 00:00:00 EDT 2022
ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis.
Nature
Zhang T,Yin C,Fedorov A,Qiao L,Bao H,Beknazarov N,Wang S,Gautam A,Williams RM,Crawford JC,Peri S,Studitsky V,Beg AA,Thomas PG,Walkley C,Xu Y,Poptsova M,Herbert A,Balachandran S
MA5-14520 was used in Immunocytochemistry-immunofluorescence to demonstrate that ADAR1 represses endogenous Z-RNAs and identifies ZBP1-mediated necroptosis as a new determinant of tumour immunogenicity masked by ADAR1.
Wed Jun 01 00:00:00 EDT 2022
Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy.
Cell reports
Tholen S,Patel R,Agas A,Kovary KM,Rabiee A,Nicholls HT,Bielczyk-Maczyńska E,Yang W,Kraemer FB,Teruel MN
MA5-14520 was used in Immunohistochemistry to investigate how disrupting circadian glucocorticoid oscillations in mice, akin to stress from jet lag or work-life imbalances, leads to a metabolic state characterized by elevated insulin, low glucose and fatty acids, and adipose tissue expansion, revealing a protective response to chronic stress on metabolic health.
Tue Jun 28 00:00:00 EDT 2022
CPSF1 positively regulates NSDHL by alternative polyadenylation and promotes gastric cancer progression.
American journal of cancer research
Kang W,Yang Y,Chen C,Yu C
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that CPSF1 promotes GC progression, at least in part, by enhancing NSDHL and offered new insights into therapeutic targets for GC.
Thu Nov 17 00:00:00 EST 2022
CPSF1 positively regulates NSDHL by alternative polyadenylation and promotes gastric cancer progression.
American journal of cancer research
Kang W,Yang Y,Chen C,Yu C
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that CPSF1 promotes GC progression, at least in part, by enhancing NSDHL and offered new insights into therapeutic targets for GC.
Thu Nov 17 00:00:00 EST 2022
CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2.
Cancer research
Li H,Wang Y,Lin K,Venkadakrishnan VB,Bakht M,Shi W,Meng C,Zhang J,Tremble K,Liang X,Song JH,Feng X,Van V,Deng P,Burks JK,Aparicio A,Keyomarsi K,Chen J,Lu Y,Beltran H,Zhao D
MA5-14520 was used in Immunohistochemistry-immunofluorescence to demonstrate that CHD1 plays an important role in modulating Aurora kinases and drug sensitivities, providing new insights into biomarker-driven therapies targeting Aurora kinases for future clinical studies.
Fri Sep 02 00:00:00 EDT 2022
Expression and Prognostic Value of Melanoma-Associated Antigen D2 in Gliomas.
Brain sciences
Yan J,Li S,Lenahan C,Chen H,Wen J,Huang Q,Jiang Q,Guo F,Deng T,Mo L
MA5-14520 was used in Immunohistochemistry to investigate the mechanism and function of melanoma-associated antigen D2 in glioma.
Tue Jul 26 00:00:00 EDT 2022
DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma.
JCI insight
Olsen TK,Dyberg C,Embaie BT,Alchahin A,Milosevic J,Ding J,Otte J,Tümmler C,Hed Myrberg I,Westerhout EM,Koster J,Versteeg R,Ding HF,Kogner P,Johnsen JI,Sykes DB,Baryawno N
MA5-14520 was used in Immunohistochemistry to show that DHODH inhibition combined with temozolomide has therapeutic potential in neuroblastoma, and we propose this combination for clinical testing.
Tue Aug 09 00:00:00 EDT 2022
Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types.
eLife
Shekhar K,Whitney IE,Butrus S,Peng YR,Sanes JR
MA5-14520 was used in Immunohistochemistry to study how newly born (postmitotic) mouse retinal ganglion cell (RGC) precursors diversify into ~45 discrete types.
Tue Feb 22 00:00:00 EST 2022
Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression.
Science advances
Abu El Maaty MA,Terzic J,Keime C,Rovito D,Lutzing R,Yanushko D,Parisotto M,Grelet E,Namer IJ,Lindner V,Laverny G,Metzger D
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to characterize prostatic intraepithelial neoplasia (PIN) progression and demonstrate that HIF1A is a target for PCa prevention and that TGM2 is a promising prognostic biomarker of early relapse after prostatectomy.
Fri Jul 22 00:00:00 EDT 2022
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia.
Science immunology
Lindholm HT,Parmar N,Drurey C,Campillo Poveda M,Vornewald PM,Ostrop J,Díez-Sanchez A,Maizels RM,Oudhoff MJ
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that IL-13 induces the bone morphogenetic protein (BMP) pathway, which acts in a negative feedback loop on immune type 2-driven tuft cell hyperplasia.
Fri May 13 00:00:00 EDT 2022
Development of an implantable three-dimensional model of a functional pathogenic multispecies biofilm to study infected wounds.
Scientific reports
Cárdenas-Calderón C,Veloso-Giménez V,González T,Wozniak A,García P,Martín SS,Varas JF,Carrasco-Wong I,Vera M,Egaña JT
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to study functional biofilms in physiological conditions in vitro, and their potential effects in health and regeneration in vivo.
Sat Dec 17 00:00:00 EST 2022
Towards an In Vitro 3D Model for Photosynthetic Cancer Treatment: A Study of Microalgae and Tumor Cell Interactions.
International journal of molecular sciences
Holmes C,Varas J,San Martín S,Egaña JT
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to present a 3D photosynthetic tumor model composed of human melanoma cells and the microalgae Chlamydomonas reinhardtii, both seeded into a collagen scaffold, which allows for the simultaneous study of both cell types.
Fri Nov 04 00:00:00 EDT 2022
InfectionCMA: A Cell MicroArray Approach for Efficient Biomarker Screening in In Vitro Infection Assays.
Pathogens (Basel, Switzerland)
Magalhães AC,Ricardo S,Moreira AC,Nunes M,Tavares M,Pinto RJ,Gomes MS,Pereira L
MA5-14520 was used in Immunocytochemistry to demonstrate that the chip-like organization of the InfectionCMA has several advantages, allowing side-by-side comparisons between diverse cell lines, infection time points, and biomarker expression and cytolocalization evaluation in the same slide.
Thu Mar 03 00:00:00 EST 2022
Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure.
Nature communications
Katz LS,Brill G,Zhang P,Kumar A,Baumel-Alterzon S,Honig LB,Gómez-Banoy N,Karakose E,Tanase M,Doridot L,Alvarsson A,Davenport B,Wang P,Lambertini L,Stanley SA,Homann D,Stewart AF,Lo JC,Herman MA,Garcia-Ocaña A,Scott DK
MA5-14520 was used in Immunocytochemistry-immunoflourescence to investigate if carbohydrate response-element binding protein, whether adaptive or maladaptive, is an important determinant of β-cell fate and a potential target for the preservation of β-cell mass in diabetes.
Sat Jul 30 00:00:00 EDT 2022
Npas3 regulates stemness maintenance of radial glial cells and neuronal migration in the developing mouse cerebral cortex.
Frontiers in cellular neuroscience
Liu JW,Li H,Zhang Y
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that Npas3 knockdown profoundly impaired neuronal radial migration and changed the laminar cell fate of the cells detained in the deep cortical layers.
Wed Nov 02 00:00:00 EDT 2022
Targeted depletion of uterine glandular Foxa2 induces embryonic diapause in mice.
eLife
Matsuo M,Yuan J,Kim YS,Dewar A,Fujita H,Dey SK,Sun X
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that dormant blastocysts are recovered from these mice on day 8 of pregnancy with persistent expression of uterine Msx1, a gene critical to maintaining the uterine quiescent state, suggesting that these mice enter embryonic diapause.
Thu Jul 21 00:00:00 EDT 2022
The Diagnostic Potential of SHOX2 and RASSF1A DNA Methylation in Early Lung Adenocarcinoma.
Frontiers in oncology
Gao H,Yang J,He L,Wang W,Liu Y,Hu Y,Ge M,Ding J,Ye Q
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to conclude that the combined promoter methylation assay for SHOX2 and RASSF1A can be used for screening and diagnosis of early LUAD, with good sensitivity and specificity.
Sat Jul 16 00:00:00 EDT 2022
Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study.
Gastroenterology
Shoda T,Collins MH,Rochman M,Wen T,Caldwell JM,Mack LE,Osswald GA,Besse JA,Haberman Y,Aceves SS,Arva NC,Capocelli KE,Chehade M,Davis CM,Dellon ES,Falk GW,Gonsalves N,Gupta SK,Hirano I,Khoury P,Klion A,Menard-Katcher C,Leung J,Mukkada VA,Putnam PE,Spergel JM,Wechsler JB,Yang GY,Furuta GT,Denson LA,Rothenberg ME
MA5-14520 was used in Immunohistochemistry to establish EoC as a distinct disease compared with other EGIDs and IBD, thereby providing a basis for improving diagnosis and treatment.
Sun May 01 00:00:00 EDT 2022
Effect of Collagen Matrix on Doxorubicin Distribution and Cancer Cells' Response to Treatment in 3D Tumor Model.
Cancers
Druzhkova I,Nikonova E,Ignatova N,Koryakina I,Zyuzin M,Mozherov A,Kozlov D,Krylov D,Kuznetsova D,Lisitsa U,Shcheslavskiy V,Shirshin EA,Zagaynova E,Shirmanova M
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to explore distribution of doxorubicin (DOX) and its effects on cancer cells' metabolism in the presence of collagen with different structures in 3D models.
Tue Nov 08 00:00:00 EST 2022
Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier.
eLife
Tran NL,Ferreira LM,Alvarez-Moya B,Buttiglione V,Ferrini B,Zordan P,Monestiroli A,Fagioli C,Bezzecchi E,Scotti GM,Esposito A,Leone R,Gnasso C,Brendolan A,Guidotti LG,Sitia G
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that the continuous infusion of therapeutic doses of interferon-alpha (IFNα) controls CRC invasion by acting on hepatic endothelial cells (HECs).
Tue Oct 25 00:00:00 EDT 2022
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Cell
Gangoso E,Southgate B,Bradley L,Rus S,Galvez-Cancino F,McGivern N,Güç E,Kapourani CA,Byron A,Ferguson KM,Alfazema N,Morrison G,Grant V,Blin C,Sou I,Marques-Torrejon MA,Conde L,Parrinello S,Herrero J,Beck S,Brandner S,Brennan PM,Bertone P,Pollard JW,Quezada SA,Sproul D,Frame MC,Serrels A,Pollard SM
MA5-14520 was used in Immunohistochemistry, Immunocytochemistry to conclude that epigenetic immunoediting may drive an acquired immune evasion program in the most aggressive mesenchymal GBM subtype by reshaping the tumor immune microenvironment.
Thu Apr 29 00:00:00 EDT 2021
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Cell
Gangoso E,Southgate B,Bradley L,Rus S,Galvez-Cancino F,McGivern N,Güç E,Kapourani CA,Byron A,Ferguson KM,Alfazema N,Morrison G,Grant V,Blin C,Sou I,Marques-Torrejon MA,Conde L,Parrinello S,Herrero J,Beck S,Brandner S,Brennan PM,Bertone P,Pollard JW,Quezada SA,Sproul D,Frame MC,Serrels A,Pollard SM
MA5-14520 was used in Immunohistochemistry, Immunocytochemistry to conclude that epigenetic immunoediting may drive an acquired immune evasion program in the most aggressive mesenchymal GBM subtype by reshaping the tumor immune microenvironment.
Thu Apr 29 00:00:00 EDT 2021
Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin.
Nature genetics
Kameneva P,Artemov AV,Kastriti ME,Faure L,Olsen TK,Otte J,Erickson A,Semsch B,Andersson ER,Ratz M,Frisén J,Tischler AS,de Krijger RR,Bouderlique T,Akkuratova N,Vorontsova M,Gusev O,Fried K,Sundström E,Mei S,Kogner P,Baryawno N,Kharchenko PV,Adameyko I
MA5-14520 was used in Immunohistochemistry to examine the transcriptional states of neural crest- and mesoderm-derived lineages differentiating into adrenal glands, kidneys, endothelium and hematopoietic tissue between post-conception weeks 6 and 14 of human development.
Sat May 01 00:00:00 EDT 2021
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.
Cell stem cell
Breunig M,Merkle J,Wagner M,Melzer MK,Barth TFE,Engleitner T,Krumm J,Wiedenmann S,Cohrs CM,Perkhofer L,Jain G,Krüger J,Hermann PC,Schmid M,Madácsy T,Varga Á,Griger J,Azoitei N,Müller M,Wessely O,Robey PG,Heller S,Dantes Z,Reichert M,Günes C,Bolenz C,Kuhn F,Maléth J,Speier S,Liebau S,Sipos B,Kuster B,Seufferlein T,Rad R,Meier M,Hohwieler M,Kleger A
MA5-14520 was used in Immunohistochemistry to show that PDLOs enable in vitro and in vivo studies of pancreatic plasticity, dysplasia, and cancer formation from a genetically defined background.
Thu Jun 03 00:00:00 EDT 2021
BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis.
The EMBO journal
Vara-Pérez M,Rossi M,Van den Haute C,Maes H,Sassano ML,Venkataramani V,Michalke B,Romano E,Rillaerts K,Garg AD,Schepkens C,Bosisio FM,Wouters J,Oliveira AI,Vangheluwe P,Annaert W,Swinnen JV,Colet JM,van den Oord JJ,Fendt SM,Mazzone M,Agostinis P
MA5-14520 was used in Immunohistochemistry to unravel an unexpected role of BNIP3 as upstream regulator of the pro-tumorigenic HIF-1α glycolytic program in melanoma cells.
Mon May 17 00:00:00 EDT 2021
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection.
PLoS pathogens
Parmar N,Burrows K,Vornewald PM,Lindholm HT,Zwiggelaar RT,Díez-Sánchez A,Martín-Alonso M,Fosslie M,Vallance BA,Dahl JA,Zaph C,Oudhoff MJ
MA5-14520 was used in Immunohistochemistry to show intestinal-epithelial epigenetic regulation by LSD1 as a critical element in host protection from infection.
Mon Mar 01 00:00:00 EST 2021
EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis.
Development (Cambridge, England)
Reehorst CM,Nightingale R,Luk IY,Jenkins L,Koentgen F,Williams DS,Darido C,Tan F,Anderton H,Chopin M,Schoffer K,Eissmann MF,Buchert M,Mouradov D,Sieber OM,Ernst M,Dhillon AS,Mariadason JM
MA5-14520 was used in Immunohistochemistry to investigate the role of Ets homologous factor in development and epithelial homeostasis.
Tue Jun 15 00:00:00 EDT 2021
Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis.
Molecular cancer therapeutics
Wang Y,Pandey RN,Roychoudhury K,Milewski D,Kalin TV,Szabo S,Pressey JG,Hegde RS
MA5-14520 was used in Functional Assay to investigate molecular and cellular mechanisms through which EYA3 might promote Ewing sarcoma tumor growth and to determine whether the EYA3 tyrosine phosphatase activity represents a viable therapeutic target.
Sat May 01 00:00:00 EDT 2021
Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis.
Molecular cancer therapeutics
Wang Y,Pandey RN,Roychoudhury K,Milewski D,Kalin TV,Szabo S,Pressey JG,Hegde RS
MA5-14520 was used in Functional Assay to investigate molecular and cellular mechanisms through which EYA3 might promote Ewing sarcoma tumor growth and to determine whether the EYA3 tyrosine phosphatase activity represents a viable therapeutic target.
Sat May 01 00:00:00 EDT 2021
Knockdown of lncRNA CCAT1 Inhibits the Progression of Colorectal Cancer via hsa-miR-4679 Mediating the Downregulation of GNG10.
Journal of immunology research
Wang N,Li J,He J,Jing YG,Zhao WD,Yu WJ,Wang J
MA5-14520 was used in Western Blot, Immunohistochemistry to reveal that lncRNA CCAT1 facilitated colorectal cancer progression via the hsa-miR-4679/GNG10 axis and provided new potential therapeutic targets for colorectal cancer.
Fri Feb 24 00:00:00 EST 2023
Knockdown of lncRNA CCAT1 Inhibits the Progression of Colorectal Cancer via hsa-miR-4679 Mediating the Downregulation of GNG10.
Journal of immunology research
Wang N,Li J,He J,Jing YG,Zhao WD,Yu WJ,Wang J
MA5-14520 was used in Western Blot, Immunohistochemistry to reveal that lncRNA CCAT1 facilitated colorectal cancer progression via the hsa-miR-4679/GNG10 axis and provided new potential therapeutic targets for colorectal cancer.
Fri Feb 24 00:00:00 EST 2023
Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling.
OncoTargets and therapy
Xu R,Zeng M,Wu Y,Wang S,Zhang B,Zhang J,Kan Y,Li B,Cao B,Zheng X,Feng W
MA5-14520 was used in Western Blot to investigate the intervention and mechanism of 50% acetone extract of C. officinalis leaves (SZYY) on melanoma xenografts.
Sat Apr 23 00:00:00 EDT 2022
Evidence and manipulation of O-GlcNAcylation in granulosa cells of bovine antral follicles†.
Biology of reproduction
Maucieri AM,Townson DH
MA5-14520 was used in Immunocytochemistry to determine O-GlcNAcylation in GCs and its effects on GC proliferation.
Thu Apr 01 00:00:00 EDT 2021
Exosomes derived from retinoblastoma cells enhance tumour deterioration by infiltrating the microenvironment.
Oncology reports
Chen S,Chen X,Qiu J,Chen P,Han X,Wu Y,Zhuang J,Yang M,Wu C,Wu N,Yang Y,Ge J,Yu K,Zhuang J
MA5-14520 was used in Immunocytochemistry to reveal the role of exosomes (EXOs) from retinoblastoma cells in tumour development.
Fri Jan 01 00:00:00 EST 2021
Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo.
The Prostate
Thulin MH,Määttä J,Linder A,Sterbova S,Ohlsson C,Damber JE,Widmark A,Persson E
MA5-14520 was used in Immunohistochemistry to suggest STAT3 as a candidate for molecular targeted therapies of skeletal metastatic disease.
Tue Jun 01 00:00:00 EDT 2021
Sexual dimorphisms in brain gene expression in the growth-restricted guinea pig can be modulated with intra-placental therapy.
Pediatric research
Wilson RL,Stephens KK,Lampe K,Jones HN
MA5-14520 was used in Immunohistochemistry (Paraffin) to study morphology and messenger RNA expression in fetal growth-restricted tissues at midpregnancy in fetal guinea pigs.
Sat May 01 00:00:00 EDT 2021
Histological and Immunohistochemical Characterization of Vomeronasal Organ Aging in Mice.
Animals : an open access journal from MDPI
Mechin V,Pageat P,Teruel E,Asproni P
MA5-14520 was used in Immunohistochemistry to study the role of ageing in neuronal degeneration using histological and immunohistological analysis in mice.
Thu Apr 22 00:00:00 EDT 2021
STRADA-mutant human cortical organoids model megalencephaly and exhibit delayed neuronal differentiation.
Developmental neurobiology
Dang LT,Vaid S,Lin G,Swaminathan P,Safran J,Loughman A,Lee M,Glenn T,Majolo F,Crino PB,Parent JM
MA5-14520 was used in Immunocytochemistry-immunoflourescence to study the effect of mechanistic target of rapamycin hyperactivity on early stages of cortical development.
Thu Jul 01 00:00:00 EDT 2021
Insulin-like growth factor 1 promotes the extension of Tracheal Epithelium in an in Vitro Tracheal organ culture model.
Auris, nasus, larynx
Kishimoto I,Ohnishi H,Yamahara K,Nakagawa T,Yamashita M,Omori K,Yamamoto N
MA5-14520 was used in Immunohistochemistry to demonstrate that topical insulin-like growth factor 1 treatment promoted the extension of tracheal epithelium, suggesting the potential utility of insulin-like growth factor 1 in aiding rapid tracheal epithelialization in patients requiring tracheal reconstruction using tissue-engineered tracheas.
Tue Jun 01 00:00:00 EDT 2021
Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction.
iScience
Low JL,Du W,Gocha T,Oguz G,Zhang X,Chen MW,Masirevic S,Yim DGR,Tan IBH,Ramasamy A,Fan H,DasGupta R
MA5-14520 was used in Immunohistochemistry (Paraffin) to to report a molecular docking-based approach to identify small molecules that can target the β-catenin (β-cat)-TCF4 protein-protein interaction (PPI), a key effector complex for nuclear Wnt signaling activity.
Fri Jun 25 00:00:00 EDT 2021
DNA Hypermethylation Induced by L-Methionine Leads to Oligodendroglial and Myelin Deficits and Schizophrenia-Like Behaviors in Adolescent Mice.
Frontiers in neuroscience
Chen X,Huang NX,Cheng YJ,Cai QY,Tian YP,Chen XS,Xiao L
MA5-14520 was used in Immunohistochemistry to provide new insights into the possibility that precise modulation of DNA methylation status in oligodendroglia could be beneficial for the white matter pathology in schizophrenia.
Sat May 08 00:00:00 EDT 2021
Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer.
Cell reports
Yang Y,Leonard M,Luo Z,Yeo S,Bick G,Hao M,Cai C,Charif M,Wang J,Guan JL,Lower EE,Zhang X
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to support a functional cooperation between MED1 and HER2 co-amplified genes in HER2+ mammary tumorigenesis with potential use as therapeutic targets for the treatment of HER2+ breast cancers.
Tue Mar 09 00:00:00 EST 2021
Rapid Prototyping of Multilayer Microphysiological Systems.
ACS biomaterials science & engineering
Hosic S,Bindas AJ,Puzan ML,Lake W,Soucy JR,Zhou F,Koppes RA,Breault DT,Murthy SK,Koppes AN
MA5-14520 was used in Immunocytochemistry to present a compelling fabrication technique for developing organs-on-chips of various geometries to study multicellular tissues.
Mon Jul 12 00:00:00 EDT 2021
Immunohistochemical evaluation of hepatic progenitor cells in different types of feline liver diseases.
The Journal of veterinary medical science
Abou Monsef Y,Kutsal O
MA5-14520 was used in Immunohistochemistry to indicate the major role played by hepatic progenitor cells in regeneration of the feline liver.
Fri Apr 09 00:00:00 EDT 2021
The SWI/SNF-Related, Matrix Associated, Actin-Dependent Regulator of Chromatin A4 Core Complex Represses Respiratory Syncytial Virus-Induced Syncytia Formation and Subepithelial Myofibroblast Transition.
Frontiers in immunology
Xu X,Qiao D,Dong C,Mann M,Garofalo RP,Keles S,Brasier AR
MA5-14520 was used in Immunocytochemistry-immunoflourescence to examine the epigenetic role of the SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin A4 in the epithelial response to RSV infection.
Thu Sep 16 00:00:00 EDT 2021
Expression of Grainyhead-like 2 in the Process of Ductal Development of Mouse Mammary Gland.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Matsuoka S,Suzuki H,Kato C,Kamikawa-Tokai M,Kamikawa A,Okamatsu-Ogura Y,Kimura K
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that Grhl2 expressed in the luminal epithelial and myoepithelial cells from the early phase of ductal development, controlling the expression of cell adhesion molecules to establish functional ducts.
Tue Jun 01 00:00:00 EDT 2021
Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease.
Cells
Zhang JQJ,Saravanabavan S,Rangan GK
MA5-14520 was used in Immunohistochemistry to conclude that despite short-term effects on reducing renal cell proliferation, chronic progression was not altered by reducing ATM in vivo.
Wed Mar 03 00:00:00 EST 2021
miR-224 aggravates cancer-associated fibroblast-induced progression of non-small cell lung cancer by modulating a positive loop of the SIRT3/AMPK/mTOR/HIF-1α axis.
Aging
Zhang J,Han L,Yu J,Li H,Li Q
MA5-14520 was used in Immunohistochemistry to show that both Sirt1 overexpression and HIF-1α inhibition repressed miR-224 levels and miR-224-mediated promotive effects in NSCLC.
Sun Apr 04 00:00:00 EDT 2021
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage.
Nature communications
Martín-Alonso M,Iqbal S,Vornewald PM,Lindholm HT,Damen MJ,Martínez F,Hoel S,Díez-Sánchez A,Altelaar M,Katajisto P,Arroyo AG,Oudhoff MJ
MA5-14520 was used in Immunohistochemistry-immunofluorescence to identify an important signaling axis that establishes a role for smooth muscle cells as modulators of intestinal epithelial regeneration and the intestinal stem cell niche.
Thu Nov 18 00:00:00 EST 2021
TNFα promotes oral cancer growth, pain, and Schwann cell activation.
Scientific reports
Salvo E,Tu NH,Scheff NN,Dubeykovskaya ZA,Chavan SA,Aouizerat BE,Ye Y
MA5-14520 was used in Immunocytochemistry to suggest that TNFα promotes cancer proliferation, progression, and nociception at least partially by activating Schwann cells. Inhibiting TNFα or Schwann cell activation might serve as therapeutic approaches for the treatment of oral cancer and associated pain.
Tue Jan 19 00:00:00 EST 2021
Generation and functional characterization of murine mammary organoids.
STAR protocols
Yip HYK,Papa A
MA5-14520 was used in Immunohistochemistry to describe step-by-step experimental procedures for the successful establishment of murine mammary organoid lines isolated from mammary glands or mammary tumors driven by mutations in components of the PI3K pathway.
Fri Sep 17 00:00:00 EDT 2021
Role of Adiponectin-Notch pathway in cognitive dysfunction associated with depression and in the therapeutic effect of physical exercise.
Aging cell
You J,Sun L,Wang J,Sun F,Wang W,Wang D,Fan X,Liu D,Xu Z,Qiu C,Chen J,Yan H,Liu B
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that Adiponectin-Notch pathway is involved in the pathogenesis of cognitive dysfunction associated with depression, but also contributes to the therapeutic effect of physical exercise.
Tue Jun 01 00:00:00 EDT 2021
Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance.
Science advances
Ma W,Gil HJ,Liu X,Diebold LP,Morgan MA,Oxendine-Burns MJ,Gao P,Chandel NS,Oliver G
MA5-14520 was used in Immunohistochemistry to indicate that by sensing the LEC differentiation status and microenvironmental metabolic conditions, mitochondrial complex III regulates the critical Prox1-Vegfr3 feedback loop and, therefore, LEC fate specification and maintenance.
Thu Apr 01 00:00:00 EDT 2021
Selenoprotein DIO2 Is a Regulator of Mitochondrial Function, Morphology and UPRmt in Human Cardiomyocytes.
International journal of molecular sciences
Bomer N,Pavez-Giani MG,Deiman FE,Linders AN,Hoes MF,Baierl CLJ,Oberdorf-Maass SU,de Boer RA,Silljé HHW,Berezikov E,Simonides WS,Westenbrink BD,van der Meer P
MA5-14520 was used in Immunocytochemistry to suggest a key position of human DIO2 as a regulator of mitochondrial function in human cardiomyocytes.
Tue Nov 02 00:00:00 EDT 2021
Following cytotoxic nanoconjugates from injection to halting the cell cycle machinery and its therapeutic implications in oral cancer.
BMC cancer
Abdel Hamid HM,Darwish ZE,Elsheikh SM,Mourad GM,Donia HM,Afifi MM
MA5-14520 was used in Immunohistochemistry to indicate that the cellular biological events do not predict the outcome seen in our in vivo model.
Wed Feb 17 00:00:00 EST 2021
Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice.
Kidney360
Ranea-Robles P,Portman K,Bender A,Lee K,He JC,Mulholland DJ,Argmann C,Houten SM
MA5-14520 was used in Immunohistochemistry to assess the role of androgens in the kidney phenotype of Ehhadh KO mice.
Wed Sep 01 00:00:00 EDT 2021
Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis.
Cell reports
Yucer N,Ahdoot R,Workman MJ,Laperle AH,Recouvreux MS,Kurowski K,Naboulsi DJ,Liang V,Qu Y,Plummer JT,Gayther SA,Orsulic S,Karlan BY,Svendsen CN
MA5-14520 was used in Immunocytochemistry to generate induced pluripotent stem cells (iPSCs) from healthy individuals and young ovarian cancer patients with germline pathogenic BRCA1 mutations (BRCA1mut).
Tue Dec 28 00:00:00 EST 2021
Integrin α10-Antibodies Reduce Glioblastoma Tumor Growth and Cell Migration.
Cancers
Masoumi KC,Huang X,Sime W,Mirkov A,Munksgaard Thorén M,Massoumi R,Lundgren-Åkerlund E
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that function-blocking antibody targeting integrin α10β1 is a promising therapeutic strategy for the treatment of glioblastoma.
Tue Mar 09 00:00:00 EST 2021
High-Grade B-Cell Lymphoma (HGBL) with MYC and BCL2 and/or BCL6 Rearrangements Is Predominantly BCL6-Rearranged and BCL6-Expressing in Taiwan.
Cancers
Tsai CC,Su YC,Bamodu OA,Chen BJ,Tsai WC,Cheng WH,Lee CH,Hsieh SM,Liu ML,Fang CL,Lin HT,Chen CL,Yeh CT,Lee WH,Ho CL,Lai SW,Tzeng HE,Hsieh YY,Chang CL,Zheng YM,Liu HW,Yen Y,Whang-Peng J,Chao TY
MA5-14520 was used in Immunohistochemistry to investigate the epidemiological and clinical peculiarities of BCL2 and BCL6 rearrangement in patients with high grade B-cell lymphoma (HGBL) from Taiwan, compared with data from Western countries.
Wed Mar 31 00:00:00 EDT 2021
Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas.
Frontiers in endocrinology
Yong HJ,Xie G,Liu C,Wang W,Naji A,Irianto J,Wang YJ
MA5-14520 was used in Immunohistochemistry-immunofluorescence to test the hypothesis that single-cell RNA-seq enables in-depth exploration of the rare NEUROG3+ cells directly in humans.
Tue Feb 15 00:00:00 EST 2022
Loss of retinoic acid receptor-related receptor alpha (Rorα) promotes the progression of UV-induced cSCC.
Cell death & disease
Zhang G,Yan G,Fu Z,Wu Y,Wu F,Zheng Z,Fang S,Gao Y,Bao X,Liu Y,Wang X,Zhu S
MA5-14520 was used in Immunohistochemistry to show that Rorα would serve as a potential novel target for cSCC, which will facilitate the treatment of cSCC in the future.
Thu Mar 04 00:00:00 EST 2021
Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes.
Theranostics
Hsu SC,Chen CL,Cheng ML,Chu CY,Changou CA,Yu YL,Yeh SD,Kuo TC,Kuo CC,Chuu CP,Li CF,Wang LH,Chen HW,Yen Y,Ann DK,Wang HJ,Kung HJ
MA5-14520 was used in Immunohistochemistry to demonstrate the underlying mechanisms by which arginine starvation-induced cell death and to develop a dietary arginine-restriction xenograft model to study the in vivo effects.
Wed Jul 28 00:00:00 EDT 2021
A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis.
Cell reports
Tan SH,Phuah P,Tan LT,Yada S,Goh J,Tomaz LB,Chua M,Wong E,Lee B,Barker N
MA5-14520 was used in Immunohistochemistry to study relevance of diphtheria toxin receptors in intestinal epithelial integrity and turnover in vivo.
Tue Jan 26 00:00:00 EST 2021
SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer.
Nature communications
Wang X,Zhang H,Sapio R,Yang J,Wong J,Zhang X,Guo JY,Pine S,Van Remmen H,Li H,White E,Liu C,Kiledjian M,Pestov DG,Steven Zheng XF
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to describe the generation of an inducible Sod1 knockout in KRAS-driven NSCLC mouse model.
Thu Apr 15 00:00:00 EDT 2021
AQP5 enriches for stem cells and cancer origins in the distal stomach.
Nature
Tan SH,Swathi Y,Tan S,Goh J,Seishima R,Murakami K,Oshima M,Tsuji T,Phuah P,Tan LT,Wong E,Fatehullah A,Sheng T,Ho SWT,Grabsch HI,Srivastava S,Teh M,Denil SLIJ,Mustafah S,Tan P,Shabbir A,So J,Yeoh KG,Barker N
MA5-14520 was used in Immunohistochemistry-immunofluorescence to show that stem cells within the AQP5+ compartment are a source of WNT-driven, invasive gastric cancer in vivo, using newly generated Aqp5-creERT2 mouse models.
Sat Feb 01 00:00:00 EST 2020
Single-Cell Transcriptome Atlas of Murine Endothelial Cells.
Cell
Kalucka J,de Rooij LPMH,Goveia J,Rohlenova K,Dumas SJ,Meta E,Conchinha NV,Taverna F,Teuwen LA,Veys K,García-Caballero M,Khan S,Geldhof V,Sokol L,Chen R,Treps L,Borri M,de Zeeuw P,Dubois C,Karakach TK,Falkenberg KD,Parys M,Yin X,Vinckier S,Du Y,Fenton RA,Schoonjans L,Dewerchin M,Eelen G,Thienpont B,Lin L,Bolund L,Li X,Luo Y,Carmeliet P
MA5-14520 was used in Immunohistochemistry (Paraffin) to create a detailed atlas of >32,000 single-endothelial cell transcriptomes.
Thu Feb 20 00:00:00 EST 2020
MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype.
Cancer discovery
Sodir NM,Kortlever RM,Barthet VJA,Campos T,Pellegrinet L,Kupczak S,Anastasiou P,Swigart LB,Soucek L,Arends MJ,Littlewood TD,Evan GI
MA5-14520 was used in Immunohistochemistry to demonstrate that this Myc-driven PDAC switch is completely and immediately reversible: Myc deactivation/inhibition triggers meticulous disassembly of advanced PDAC tumor and stroma and concomitant death of tumor cells.
Wed Apr 01 00:00:00 EDT 2020
Oncogenic Mutations in Armadillo Repeats 5 and 6 of β-Catenin Reduce Binding to APC, Increasing Signaling and Transcription of Target Genes.
Gastroenterology
Liu P,Liang B,Liu M,Lebbink JHG,Li S,Qian M,Lavrijsen M,Peppelenbosch MP,Chen X,Smits R
MA5-14520 was used in Immunohistochemistry to investigate the mechanisms by which these substitutions increase signaling and the effects on liver carcinogenesis in mice.
Sun Mar 01 00:00:00 EST 2020
An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion.
Nature immunology
Hatzioannou A,Banos A,Sakelaropoulos T,Fedonidis C,Vidali MS,Köhne M,Händler K,Boon L,Henriques A,Koliaraki V,Georgiadis P,Zoidakis J,Termentzi A,Beyer M,Chavakis T,Boumpas D,Tsirigos A,Verginis P
MA5-14520 was used in Immunohistochemistry to identify a cell-intrinsic role of the alarmin interleukin (IL)-33 in the functional stability of Treg cells.
Wed Jan 01 00:00:00 EST 2020
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer.
The Journal of experimental medicine
Recouvreux MV,Moldenhauer MR,Galenkamp KMO,Jung M,James B,Zhang Y,Lowy A,Bagchi A,Commisso C
MA5-14520 was used in Immunohistochemistry to show that nutrient stress caused by glutamine deprivation leads to the induction of epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) cells.
Mon Sep 07 00:00:00 EDT 2020
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease.
Autophagy
Yazdankhah M,Shang P,Ghosh S,Bhutto IA,Stepicheva N,Grebe R,Hose S,Weiss J,Luo T,Mishra S,Riazuddin SA,Ghosh A,Handa JT,Lutty GA,Zigler JS,Sinha D
MA5-14520 was used in Immunohistochemistry to demonstrate in vivo that gefitinib (EGFR inhibitor) can rescue the PFV phenotype in Nuc1 and may serve as a novel therapy for PFV disease by modulating the EGFR-MTORC1-autophagy pathway.
Mon Jun 01 00:00:00 EDT 2020
Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation and cardiac repair.
Cell proliferation
Lan C,Cao N,Chen C,Qu S,Fan C,Luo H,Zeng A,Yu C,Xue Y,Ren H,Li L,Wang H,Jose PA,Xu Z,Zeng C
MA5-14520 was used in Western Blotting to uncover a role of circulating progesterone withdrawal as a novel mechanism for the postnatal loss of mammalian cardiac regenerative potential.
Sun Nov 01 00:00:00 EDT 2020
Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice.
Glia
Barca-Mayo O,Boender AJ,Armirotti A,De Pietri Tonelli D
MA5-14520 was used in Immunohistochemistry (Frozen) to study how astrocyte-specific deletion of clock gene Bmal1 contributes to metabolic dysfunction and early death.
Mon Jun 01 00:00:00 EDT 2020
Immune Modulation to Improve Survival of Viral Pneumonia in Mice.
American journal of respiratory cell and molecular biology
Wali S,Flores JR,Jaramillo AM,Goldblatt DL,Pantaleón García J,Tuvim MJ,Dickey BF,Evans SE
MA5-14520 was used in Flow Cytometry to validate strategies for immune modulation in a preclinical model of viral pneumonia and determine their mechanisms.
Tue Dec 01 00:00:00 EST 2020
RAB6 GTPase regulates mammary secretory function by controlling the activation of STAT5.
Development (Cambridge, England)
Cayre S,Faraldo MM,Bardin S,Miserey-Lenkei S,Deugnier MA,Goud B
MA5-14520 was used in Immunohistochemistry-immunofluorescence to reveal a crucial role for RAB6A/A' in the lactogenic function of the mammary gland and suggest that the trafficking pathways controlled by RAB6A/A' depend on cell-type specialization and tissue context.
Thu Oct 08 00:00:00 EDT 2020
UDP-glucuronosyltransferase polymorphisms affect diethylnitrosamine-induced carcinogenesis in humanized transgenic mice.
Cancer science
Landerer S,Kalthoff S,Paulusch S,Strassburg CP
MA5-14520 was used in Immunohistochemistry to examine the direct effect of common UGT1A polymorphisms (SNPs) on HCC development and outcome in a diethylnitrosamine (DEN)-induced mouse model.
Sun Nov 01 00:00:00 EDT 2020
Targeting Fatty Acid Oxidation to Promote Anoikis and Inhibit Ovarian Cancer Progression.
Molecular cancer research : MCR
Sawyer BT,Qamar L,Yamamoto TM,McMellen A,Watson ZL,Richer JK,Behbakht K,Schlaepfer IR,Bitler BG
MA5-14520 was used in Immunohistochemistry-immunofluorescence to examine the contribution of fatty acid oxidation in supporting anoikis resistance using HGSOC cell lines.
Wed Jul 01 00:00:00 EDT 2020
The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage.
Glycobiology
Punch PR,Irons EE,Manhardt CT,Marathe H,Lau JTY
MA5-14520 was used in Immunohistochemistry to investigate the contribution of ST6GAL1 to susceptibility to total body irradiation in vivo.
Mon Jul 20 00:00:00 EDT 2020
Mammalian Target of Rapamycin Complex 2 Signaling Is Required for Liver Regeneration in a Cholestatic Liver Injury Murine Model.
The American journal of pathology
Zhou Y,Xu M,Liu P,Liang B,Qian M,Wang H,Song X,Nyshadham P,Che L,Calvisi DF,Li F,Lin S,Chen X
MA5-14520 was used in Immunohistochemistry to indicate that mTORC2 signaling effectively regulates liver regeneration by inducing oval cell proliferation.
Wed Jul 01 00:00:00 EDT 2020
The secretome of human dental pulp stem cells protects myoblasts from hypoxia‑induced injury via the Wnt/β‑catenin pathway.
International journal of molecular medicine
Zhang W,Yu L,Han X,Pan J,Deng J,Zhu L,Lu Y,Huang W,Liu S,Li Q,Liu Y
MA5-14520 was used in Immunocytochemistry-immunoflourescence to demonstrate that C2C12 myoblast coculture with human dental pulp stem cells (hDPSCs) attenuated CoCl2-induced hypoxic injury compared with C2C12 alone.
Fri May 01 00:00:00 EDT 2020
Dynamic shifts in chromatin states differentially mark the proliferative basal cells and terminally differentiated cells of the developing epidermis.
Epigenetics
Shue YT,Lee KT,Walters BW,Ong HB,Silvaraju S,Lam WJ,Lim CY
MA5-14520 was used in Immunohistochemistry-immunofluorescence to investigate the dynamics of 13 key histone marks in epidermal cells at three distinct stages of embryonic skin development and identified significant changes that corresponded with the maturation of the proliferative basal epidermal cells and terminally differentiated cells in the stratified layers.
Tue Sep 01 00:00:00 EDT 2020
Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors.
Translational oncology
Wang Y,Wozniak A,Wellens J,Gebreyohannes YK,Guillén MJ,Avilés PM,Debiec-Rychter M,Sciot R,Schöffski P
MA5-14520 was used in Immunohistochemistry to evaluate a tubulin inhibitor, plocabulin, in patient-derived xenograft (PDX) models of GIST, a disease generally considered to be resistant to cytotoxic agents.
Sun Nov 01 00:00:00 EDT 2020
Loss of Setd4 delays radiation-induced thymic lymphoma in mice.
DNA repair
Feng X,Lu H,Yue J,Schneider N,Liu J,Denzin LK,Chan CS,De S,Shen Z
MA5-14520 was used in Immunohistochemistry to report that conditional Setd4 deletion in adult mice significantly extended the survival of radiation-induced T-lymphoma.
Sat Feb 01 00:00:00 EST 2020
Silencing of long‑chain non‑coding RNA GAS5 in osteoarthritic chondrocytes is mediated by targeting the miR‑34a/Bcl‑2 axis.
Molecular medicine reports
Ji Q,Qiao X,Liu Y,Wang D,Yan J
MA5-14520 was used in Western Blot to indicate that GAS5 participated in the development of OA by regulating the biological behavior of chondrocytes via the miR‚34a/Bcl‚2 axis.
Sun Mar 01 00:00:00 EST 2020
Optic vesicle morphogenesis requires primary cilia.
Developmental biology
Fiore L,Takata N,Acosta S,Ma W,Pandit T,Oxendine M,Oliver G
MA5-14520 was used in Immunohistochemistry to investigate the role of primary cilia during the morphogenetic movements required for the formation of the eye.
Mon Jun 15 00:00:00 EDT 2020
Long non-coding RNA RFPL3S is a novel prognostic biomarker in lung cancer.
Oncology letters
Liu Z,Ning Z,Lu H,Cao T,Zhou F,Ye X,Chen C
MA5-14520 was used in Immunohistochemistry-immunofluorescence to investigate the expression pattern of RFPL3 antisense (RFPL3S) and its associations with clinicopathological characteristics in patients with lung cancer.
Sat Aug 01 00:00:00 EDT 2020
A Novel Approach to Deliver Therapeutic Extracellular Vesicles Directly into the Mouse Kidney via Its Arterial Blood Supply.
Cells
Ullah M,Liu DD,Rai S,Razavi M,Choi J,Wang J,Concepcion W,Thakor AS
MA5-14520 was used in Immunohistochemistry-immunofluorescence to develop in mice a reproducible microsurgical technique for the delivery of therapeutics directly into each kidney, via its arterial blood supply.
Fri Apr 10 00:00:00 EDT 2020
Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors.
Cell reports
Kogot-Levin A,Hinden L,Riahi Y,Israeli T,Tirosh B,Cerasi E,Mizrachi EB,Tam J,Mosenzon O,Leibowitz G
MA5-14520 was used in Immunocytochemistry-immunoflourescence to study mTORC1 in the context of the pathogenesis of diabetic nephropathy.
Tue Jul 28 00:00:00 EDT 2020
Nutrient-Driven O-GlcNAcylation Controls DNA Damage Repair Signaling and Stem/Progenitor Cell Homeostasis.
Cell reports
Na HJ,Akan I,Abramowitz LK,Hanover JA
MA5-14520 was used in Immunocytochemistry to reveal a conserved mechanistic link among O-GlcNAc cycling, stem cell self-renewal, and DDR with profound implications for stem-cell-derived diseases including cancer.
Tue May 12 00:00:00 EDT 2020
Suppression of Metastatic Melanoma Growth in Lung by Modulated Electro-Hyperthermia Monitored by a Minimally Invasive Heat Stress Testing Approach in Mice.
Cancers
Thomas MJ,Major E,Benedek A,Horváth I,Máthé D,Bergmann R,Szász AM,Krenács T,Benyó Z
MA5-14520 was used in Immunohistochemistry to evaluate the potential of mEHT, inducing local hyperthermia, in the treatment of pulmonary metastatic melanoma.
Mon Dec 21 00:00:00 EST 2020
AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma.
Nature communications
Yao CD,Haensel D,Gaddam S,Patel T,Atwood SX,Sarin KY,Whitson RJ,McKellar S,Shankar G,Aasi S,Rieger K,Oro AE
MA5-14520 was used in Immunohistochemistry to identify three prognostic surface markers (LYPD3, TACSTD2, and LY6D) which correlate with nuclear myocardin-related transcription factor(nMRTF) and resistance to Smoothened(SMO) inhibitors, using single-cell RNA-sequencing of patient tumours.
Thu Oct 08 00:00:00 EDT 2020
IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models.
PloS one
Gasilina A,Premnauth G,Gurjar P,Biesiada J,Hegde S,Milewski D,Ma G,Kalin TV,Merino E,Meller J,Seibel W,Cancelas JA,Vinnedge LP,Nassar NN
MA5-14520 was used in Immunohistochemistry to report the synthesis and preliminary characterization of IODVA1, a potent small molecule that is active in xenograft mouse models of Ras-driven lung and breast cancers.
Mon Jul 20 00:00:00 EDT 2020
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science advances
Zwiggelaar RT,Lindholm HT,Fosslie M,Terndrup Pedersen M,Ohta Y,Díez-Sánchez A,Martín-Alonso M,Ostrop J,Matano M,Parmar N,Kvaløy E,Spanjers RR,Nazmi K,Rye M,Drabløs F,Arrowsmith C,Arne Dahl J,Jensen KB,Sato T,Oudhoff MJ
MA5-14520 was used in Immunohistochemistry to identify regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures.
Tue Sep 01 00:00:00 EDT 2020
Novel CD11b+Gr-1+Sca-1+ myeloid cells drive mortality in bacterial infection.
Science advances
Park MY,Kim HS,Lee HY,Zabel BA,Bae YS
MA5-14520 was used in Flow Cytometry to find a previously unidentified pathogenic CD11b+Gr-1+ myeloid cell population that expresses stem cell antigen-1 (Sca-1) induced upon experimental infection with Staphylococcus aureus.
Wed Jan 01 00:00:00 EST 2020
Long-term PM2.5 exposure increases the risk of non-small cell lung cancer (NSCLC) progression by enhancing interleukin-17a (IL-17a)-regulated proliferation and metastasis.
Aging
Chao X,Yi L,Lan LL,Wei HY,Wei D
MA5-14520 was used in Immunohistochemistry to explore the role of PM2.5 in the etiology of NSCLC.
Thu Jun 18 00:00:00 EDT 2020
A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation.
Frontiers in cell and developmental biology
Ostrop J,Zwiggelaar RT,Terndrup Pedersen M,Gerbe F,Bösl K,Lindholm HT,Díez-Sánchez A,Parmar N,Radetzki S,von Kries JP,Jay P,Jensen KB,Arrowsmith C,Oudhoff MJ
MA5-14520 was used in Immunocytochemistry to develop a semi-automated organoid screening method, to be applied to a library of highly specific chemical probes to identify epigenetic regulators of intestinal epithelial biology.
Sat Feb 13 00:00:00 EST 2021
Evidence for a non-stochastic two-field hypothesis for persistent skin cancer risk.
Scientific reports
Konger RL,Ren L,Sahu RP,Derr-Yellin E,Kim YL
MA5-14520 was used in Immunohistochemistry (Paraffin) to challenge current models that suggest that persistence of cancer risk in the absence of continued carcinogen exposures is simply a function of stochastically arranged, long-lived but dormant epithelial clonal stem cells mutants.
Thu Nov 05 00:00:00 EST 2020
Oncogene-dependent function of BRG1 in hepatocarcinogenesis.
Cell death & disease
Wang P,Song X,Cao D,Cui K,Wang J,Utpatel K,Shang R,Wang H,Che L,Evert M,Zhao K,Calvisi DF,Chen X
MA5-14520 was used in Immunohistochemistry to propose BRG1 can be both oncogenic and tumor suppressive depending on the oncogenic stimuli during hepatocarcinogenesis.
Tue Feb 04 00:00:00 EST 2020
Secondary ossification center induces and protects growth plate structure.
eLife
Xie M,Gol'din P,Herdina AN,Estefa J,Medvedeva EV,Li L,Newton PT,Kotova S,Shavkuta B,Saxena A,Shumate LT,Metscher BD,Großschmidt K,Nishimori S,Akovantseva A,Usanova AP,Kurenkova AD,Kumar A,Arregui IL,Tafforeau P,Fried K,Carlström M,Simon A,Gasser C,Kronenberg HM,Bastepe M,Cooper KL,Timashev P,Sanchez S,Adameyko I,Eriksson A,Chagin AS
MA5-14520 was used in Immunohistochemistry to understand the role of the secondary ossification center (SOC).
Fri Oct 16 00:00:00 EDT 2020
High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner.
Scientific reports
Hases L,Archer A,Indukuri R,Birgersson M,Savva C,Korach-André M,Williams C
MA5-14520 was used in Immunohistochemistry to demonstrate how HFD and estrogens modulate the colon microenvironment in a sex- and ER-specific manner.
Wed Sep 30 00:00:00 EDT 2020
Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module.
Cell reports
Di Magno L,Manni S,Di Pastena F,Coni S,Macone A,Cairoli S,Sambucci M,Infante P,Moretti M,Petroni M,Nicoletti C,Capalbo C,De Smaele E,Di Marcotullio L,Giannini G,Battistini L,Goffredo BM,Iorio E,Agostinelli E,Maroder M,Canettieri G
MA5-14520 was used in Immunohistochemistry to show here that at clinically relevant concentrations, phenformin elicits a significant therapeutic effect through a redox-dependent but complex I-independent mechanism.
Tue Feb 11 00:00:00 EST 2020
Positive Effects of Preventive Nutrition Supplement on Anticancer Radiotherapy in Lung Cancer Bearing Mice.
Cancers
Liu YM,Wu TH,Chiu YH,Wang H,Li TL,Hsia S,Chan YL,Wu CJ
MA5-14520 was used in Immunocytochemistry to demonstrate that the prescription of the TNuF total nutrition formula before and after cancer diagnosis attains similar benefits in testing subjects with typical anticancer RT.
Fri Aug 28 00:00:00 EDT 2020
Yolk-sac-derived macrophages progressively expand in the mouse kidney with age.
eLife
Ide S,Yahara Y,Kobayashi Y,Strausser SA,Ide K,Watwe A,Xu-Vanpala S,Privratsky JR,Crowley SD,Shinohara ML,Alman BA,Souma T
MA5-14520 was used in Immunocytochemistry-immunoflourescence to find that yolk-sac-derived macrophages progressively expand in number with age and become a major contributor to the renal macrophage population in older mice.
Fri Apr 17 00:00:00 EDT 2020
Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models.
International journal of molecular sciences
Krenacs T,Meggyeshazi N,Forika G,Kiss E,Hamar P,Szekely T,Vancsik T
MA5-14520 was used in Immunohistochemistry-immunofluorescence to review the mEHT-related damage mechanisms published in tumor models.
Sat Aug 29 00:00:00 EDT 2020
Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro.
Nanomaterials (Basel, Switzerland)
Elena Sima L,Bonciu A,Baciu M,Anghel I,Dumitrescu LN,Rusen L,Dinca V
MA5-14520 was used in Immunocytochemistry-immunoflourescence to show parallel micro line anisotropic surfaces are able to guide cell growth only for the steep surfaces, while the curved ones reduce the initial response and show the lowest osteogenic response.
Wed Dec 09 00:00:00 EST 2020
Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.
Nature protocols
Uroda T,Chillón I,Annibale P,Teulon JM,Pessey O,Karuppasamy M,Pellequer JL,Marcia M
MA5-14520 was used in Flow Cytometry to present a protocol that integrates non-denaturing lncRNA purification with in-solution hydrodynamic analysis and single-particle atomic force microscopy (AFM) imaging to produce highly homogeneous lncRNA preparations and visualize their 3D topology at ~15-Å resolution.
Mon Jun 01 00:00:00 EDT 2020
GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism.
Cancer cell
Mondragón L,Mhaidly R,De Donatis GM,Tosolini M,Dao P,Martin AR,Pons C,Chiche J,Jacquin M,Imbert V,Proïcs E,Boyer L,Doye A,Luciano F,Neels JG,Coutant F,Fabien N,Sormani L,Rubio-Patiño C,Bossowski JP,Muller F,Marchetti S,Villa E,Peyron JF,Gaulard P,Lemonnier F,Asnafi V,Genestier L,Benhida R,Fournié JJ,Passeron T,Ricci JE,Verhoeyen E
MA5-14520 was used in Immunohistochemistry (Paraffin) to suggest the therapeutic potential of targeting NF-κB signaling in AITL and provide a model for future AITL therapeutic investigations.
Mon Sep 16 00:00:00 EDT 2019
Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.
Cancer cell
Zhang L,He X,Liu X,Zhang F,Huang LF,Potter AS,Xu L,Zhou W,Zheng T,Luo Z,Berry KP,Pribnow A,Smith SM,Fuller C,Jones BV,Fouladi M,Drissi R,Yang ZJ,Gustafson WC,Remke M,Pomeroy SL,Girard EJ,Olson JM,Morrissy AS,Vladoiu MC,Zhang J,Tian W,Xin M,Taylor MD,Potter SS,Roussel MF,Weiss WA,Lu QR
MA5-14520 was used in Immunohistochemistry to show that glial lineage-associated OLIG2+ progenitors are tumor-initiating cells during medulloblastoma tumorigenesis and relapse.
Mon Sep 16 00:00:00 EDT 2019
Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells.
Gastroenterology
Cook L,Stahl M,Han X,Nazli A,MacDonald KN,Wong MQ,Tsai K,Dizzell S,Jacobson K,Bressler B,Kaushic C,Vallance BA,Steiner TS,Levings MK
MA5-14520 was used in Flow cytometry/Cell sorting to develop methods to isolate and expand human type 1 Treg cells and define their functions.
Sun Dec 01 00:00:00 EST 2019
Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network.
Cancer research
Román M,López I,Guruceaga E,Baraibar I,Ecay M,Collantes M,Nadal E,Vallejo A,Cadenas S,Miguel ME,Jang JH,Martin-Uriz PS,Castro-Labrador L,Vilas-Zornoza A,Lara-Astiaso D,Ponz-Sarvise M,Rolfo C,Santos ES,Raez LE,Taverna S,Behrens C,Weder W,Wistuba II,Vicent S,Gil-Bazo I
MA5-14520 was used in Immunohistochemistry to highlight the prognostic significance of the transcriptional regulator Id1 in KRAS-mutant lung adenocarcinoma and provide mechanistic insight into how it controls tumor growth and metastasis.
Fri Feb 01 00:00:00 EST 2019
Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells.
Genes & development
Rajakulendran N,Rowland KJ,Selvadurai HJ,Ahmadi M,Park NI,Naumenko S,Dolma S,Ward RJ,So M,Lee L,MacLeod G,Pasiliao C,Brandon C,Clarke ID,Cusimano MD,Bernstein M,Batada N,Angers S,Dirks PB
MA5-14520 was used in Immunohistochemistry to report context-specific actions of Wnt/βcatenin signaling in directing cellular fate specification and renewal.
Wed May 01 00:00:00 EDT 2019
RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.
Cell death and differentiation
Anderton H,Bandala-Sanchez E,Simpson DS,Rickard JA,Ng AP,Di Rago L,Hall C,Vince JE,Silke J,Liccardi G,Feltham R
MA5-14520 was used in Immunohistochemistry-immunofluorescence to show that genetic deletion of Ripk1 licenses TRADD to complex with FADD-caspase-8 and activates caspase-8 during development.
Wed May 01 00:00:00 EDT 2019
Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis.
Arteriosclerosis, thrombosis, and vascular biology
Li Y,Xu Y,Jadhav K,Zhu Y,Yin L,Zhang Y
MA5-14520 was used in Immunohistochemistry to showed that FOXA3 directly bound to the promoter of the Apoa1 gene to regulate its transcription.
Thu Aug 01 00:00:00 EDT 2019
Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.
Breast cancer research : BCR
Kennedy SP,Han JZR,Portman N,Nobis M,Hastings JF,Murphy KJ,Latham SL,Cadell AL,Miladinovic D,Marriott GR,O'Donnell YEI,Shearer RF,Williams JT,Munoz AG,Cox TR,Watkins DN,Saunders DN,Timpson P,Lim E,Kolch W,Croucher DR
MA5-14520 was used in Immunohistochemistry to show the inactivation of ERBB3/PI3K by these therapeutic antibodies is insufficient to inhibit the growth of ERBB2-amplified breast cancer cells.
Thu Mar 21 00:00:00 EDT 2019
Astrocyte-to-astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation.
Glia
Li J,Khankan RR,Caneda C,Godoy MI,Haney MS,Krawczyk MC,Bassik MC,Sloan SA,Zhang Y
MA5-14520 was used in Immunocytochemistry to identify molecular markers of astrocyte maturation and established an in vitro assay for studying the mechanisms of astrocyte maturation.
Thu Aug 01 00:00:00 EDT 2019
TEA Domain Transcription Factor 4 Is the Major Mediator of Yes-Associated Protein Oncogenic Activity in Mouse and Human Hepatoblastoma.
The American journal of pathology
Zhang J,Liu P,Tao J,Wang P,Zhang Y,Song X,Che L,Sumazin P,Ribback S,Kiss A,Schaff Z,Cigliano A,Dombrowski F,Cossu C,Pascale RM,Calvisi DF,Monga SP,Chen X
MA5-14520 was used in Immunohistochemistry to study TEA domain-mediated transcriptional activity in yes-associated protein driven hepatoblastoma development.
Wed May 01 00:00:00 EDT 2019
Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea.
Toxicological sciences : an official journal of the Society of Toxicology
Peters MF,Landry T,Pin C,Maratea K,Dick C,Wagoner MP,Choy AL,Barthlow H,Snow D,Stevens Z,Armento A,Scott CW,Ayehunie S
MA5-14520 was used in Immunohistochemistry to show drug-induced diarrhea can be predicted by analyzing human 3D gastrointestinal microtissue barrier.
Fri Mar 01 00:00:00 EST 2019
Developmental changes in interkinetic nuclear migration dynamics with respect to cell-cycle progression in the mouse cerebral cortex ventricular zone.
The Journal of comparative neurology
Fousse J,Gautier E,Patti D,Dehay C
MA5-14520 was used in Immunohistochemistry to examine the relationship between interkinetic nuclear migration and cell-cycle progression of apical progenitors in the ventricular zone at different stages of mouse cerebral corticogenesis.
Mon Jul 01 00:00:00 EDT 2019
Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model.
Cancers
Linder B,Weirauch U,Ewe A,Uhmann A,Seifert V,Mittelbronn M,Harter PN,Aigner A,Kögel D
MA5-14520 was used in Immunohistochemistry to present data showing that the therapeutic application of siRNAs, formulated in nanoscale lipopolyplexes (LPP) based on polyethylenimine (PEI) and the phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), represents a promising new approach to target Stat3 in glioma.
Fri Mar 08 00:00:00 EST 2019
Prolonged elevated levels of c-kit+ progenitor cells after a myocardial infarction by beta 2 adrenergic receptor priming.
Journal of cellular physiology
Finan A,Demion M,Sicard P,Guisiano M,Bideaux P,Monceaux K,Thireau J,Richard S
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that ß2-AR stimulation may improve the cardiac repair process by supporting an endogenous progenitor cell response but is not sufficient to improve the cardiac function.
Thu Aug 01 00:00:00 EDT 2019
Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratification.
Nature communications
Czarnewski P,Parigi SM,Sorini C,Diaz OE,Das S,Gagliani N,Villablanca EJ
MA5-14520 was used in Immunohistochemistry to demonstrate that cross-species comparison enables stratification of patients undistinguishable by other molecular approaches.
Fri Jun 28 00:00:00 EDT 2019
Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma.
eLife
Thomson BR,Carota IA,Souma T,Soman S,Vestweber D,Quaggin SE
MA5-14520 was used in Immunohistochemistry to describe a novel approach to enhance canal formation in human and mice by deleting a single allele of the gene encoding the phosphatase PTPRB during development.
Thu Oct 17 00:00:00 EDT 2019
Improved Oxygen Supply to Multicellular Spheroids Using A Gas-permeable Plate and Embedded Hydrogel Beads.
Cells
Mihara H,Kugawa M,Sayo K,Tao F,Shinohara M,Nishikawa M,Sakai Y,Akama T,Kojima N
MA5-14520 was used in Immunocytochemistry to indicate that the combination of gas-permeable culture equipment and embedded hydrogel beads improves culture 3D spheroids produced from primary or PDX-expanded tumor cells.
Fri May 31 00:00:00 EDT 2019
Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity.
Cell metabolism
Kumar S,Sharife H,Kreisel T,Mogilevsky M,Bar-Lev L,Grunewald M,Aizenshtein E,Karni R,Paldor I,Shlomi T,Keshet E
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to reveal a previously unappreciated graded metabolic zonation directly impacting the acquisition of multiple aggressive tumor traits.
Tue Jul 02 00:00:00 EDT 2019
Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer.
Journal of medicinal chemistry
de Moura Sperotto ND,Deves Roth C,Rodrigues-Junior VS,Ev Neves C,Reisdorfer Paula F,da Silva Dadda A,Bergo P,Freitas de Freitas T,Souza Macchi F,Moura S,Duarte de Souza AP,Campos MM,Valim Bizarro C,Santos DS,Basso LA,Machado P
MA5-14520 was used in Immunohistochemistry to evaluate novel pyrimidine-2,4-diones as inhibitors of human thymidine phosphorylase (hTP) activity.
Thu Feb 14 00:00:00 EST 2019
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.
Nature communications
Bufalieri F,Infante P,Bernardi F,Caimano M,Romania P,Moretti M,Lospinoso Severini L,Talbot J,Melaiu O,Tanori M,Di Magno L,Bellavia D,Capalbo C,Puget S,De Smaele E,Canettieri G,Guardavaccaro D,Busino L,Peschiaroli A,Pazzaglia S,Giannini G,Melino G,Locatelli F,Gulino A,Ayrault O,Fruci D,Di Marcotullio L
MA5-14520 was used in Immunohistochemistry to demonstrate the role of ERAP1 in the Hh signalling pathway and to show its effect in cancer and possible uses for therapeutic treatment.
Wed Jul 24 00:00:00 EDT 2019
Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics.
Theranostics
Timmermand OV,Elgqvist J,Beattie KA,Örbom A,Larsson E,Eriksson SE,Thorek DLJ,Beattie BJ,Tran TA,Ulmert D,Strand SE
MA5-14520 was used in Immunohistochemistry to assessed the efficacy of hu11B6 labeled with a low LET beta-emitter, Lutetium-177 (177Lu) and investigated whether similar tumor killing and AR-enhancement is produced.
Thu Jun 25 00:00:00 EDT 2020
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.
Nature communications
Sang Y,Li Y,Zhang Y,Alvarez AA,Yu B,Zhang W,Hu B,Cheng SY,Feng H
MA5-14520 was used in Immunohistochemistry to suggest targeting CDK5/TRIM59 signaling axis as a putative strategy for treating glioblastoma.
Thu Sep 05 00:00:00 EDT 2019
The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.
Nature communications
Wang Y,Pandey RN,York AJ,Mallela J,Nichols WC,Hu YC,Molkentin JD,Wikenheiser-Brokamp KA,Hegde RS
MA5-14520 was used in Immunohistochemistry-immunofluorescence to establish EYA3 as a disease-modifying target whose function in the pathophysiology of pulmonary arterial hypertension can be targeted by available inhibitors.
Thu Sep 12 00:00:00 EDT 2019
Liver-specific Sirtuin6 ablation impairs liver regeneration after 2/3 partial hepatectomy.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Liu Q,Pu S,Chen L,Shen J,Cheng S,Kuang J,Li H,Wu T,Li R,Jiang W,Zou M,Zhang Z,Li Y,Li J,He J
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that Sirt6 LKO impaired liver regeneration via delayed cell cycle and impaired m-TOR and Akt activity.
Mon Jul 01 00:00:00 EDT 2019
The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats.
Scientific reports
Maejima Y,Yokota S,Horita S,Shimomura K
MA5-14520 was used in Immunohistochemistry-immunofluorescence to suggest that undeveloped properties of VTA GABA neurons in juvenile rats can promote higher EI regardless of high or less palatable feeding, and contribute to growth promotion.
Wed Aug 14 00:00:00 EDT 2019
Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice.
JCI insight
Rogers RG,Fournier M,Sanchez L,Ibrahim AG,Aminzadeh MA,Lewis MI,Marbán E
MA5-14520 was used in Immunohistochemistry to demonstrate regenerative responses of cardiac and skeletal muscle tissue to intravenous cardiosphere-derived cells and exosomes in mdx mice.
Thu Apr 04 00:00:00 EDT 2019
Disruption of Cancer Metabolic SREBP1/miR-142-5p Suppresses Epithelial-Mesenchymal Transition and Stemness in Esophageal Carcinoma.
Cells
Huang CM,Huang CS,Hsu TN,Huang MS,Fong IH,Lee WH,Liu SC
MA5-14520 was used in Immunohistochemistry to investigate the therapeutic potential of SREBP1 and associated signaling in esophageal cancer.
Wed Dec 18 00:00:00 EST 2019
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors.
Scientific reports
Petroni M,Sahùn Roncero M,Ramponi V,Fabretti F,Nicolis Di Robilant V,Moretti M,Alfano V,Corsi A,De Panfilis S,Giubettini M,Di Giulio S,Capalbo C,Belardinilli F,Coppa A,Sardina F,Colicchia V,Pedretti F,Infante P,Cardinali B,Tessitore A,Canettieri G,De Smaele E,Giannini G
MA5-14520 was used in Immunohistochemistry to validate a new culture method to grow postnatal granule cell progenitors as hedgehog-dependent neurospheres with prolonged self-renewal and ability to differentiate into granule cells, under appropriate conditions.
Mon Dec 23 00:00:00 EST 2019
Combination of laser and human adipose-derived stem cells in repair of rabbit anal sphincter injury: a new therapeutic approach.
Stem cell research & therapy
Sarveazad A,Babahajian A,Yari A,Rayner CK,Mokhtare M,Babaei-Ghazani A,Agah S,Mahjoubi B,Shamseddin J,Yousefifard M
MA5-14520 was used in Immunohistochemistry to indicate that co-application of laser and hADSC therapy immediately after anal sphincter damage could improve subsequent sphincter function.
Mon Dec 02 00:00:00 EST 2019
The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma.
Cancer cell
Momcilovic M,Bailey ST,Lee JT,Fishbein MC,Braas D,Go J,Graeber TG,Parlati F,Demo S,Li R,Walser TC,Gricowski M,Shuman R,Ibarra J,Fridman D,Phelps ME,Badran K,St John M,Bernthal NM,Federman N,Yanagawa J,Dubinett SM,Sadeghi S,Christofk HR,Shackelford DB
MA5-14520 was used in Immunohistochemistry to perform in vivo metabolic profiling and molecular analysis of lung squamous cell carcinoma (SCC) to identify metabolic nodes to therapeutically target.
Mon May 14 00:00:00 EDT 2018
Therapeutic Targeting of Sunitinib-Induced AR Phosphorylation in Renal Cell Carcinoma.
Cancer research
Adelaiye-Ogala R,Damayanti NP,Orillion AR,Arisa S,Chintala S,Titus MA,Kao C,Pili R
MA5-14520 was used in Immunohistochemistry-immunofluorescence to show the potential role of androgen receptor as a target for therapeutic interventions, in combination with receptor tyrosine kinase inhibitor, to overcome drug resistance in renal cell carcinoma.
Fri Jun 01 00:00:00 EDT 2018
Necessity and Sufficiency of Ldb1 in the Generation, Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.
Frontiers in molecular neuroscience
Xiao D,Jin K,Xiang M
MA5-14520 was used in Immunohistochemistry to study the role of Ldb1 in retinal development.
Wed Sep 30 00:00:00 EDT 2020
HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation.
Molecular cancer therapeutics
Efimova EV,Ricco N,Labay E,Mauceri HJ,Flor AC,Ramamurthy A,Sutton HG,Weichselbaum RR,Kron SJ
MA5-14520 was used in Immunohistochemistry-immunofluorescence to report that pitavastatin and other lipophilic statins are potent inhibitors of DSB repair in breast and melanoma models both in vitro and in vivo.
Thu Feb 01 00:00:00 EST 2018
A new genetically engineered mouse model of choroid plexus carcinoma.
Biochemical and biophysical research communications
El Nagar S,Zindy F,Moens C,Martin L,Plassard D,Roussel MF,Lamonerie T,Billon N
MA5-14520 was used in Immunocytochemistry to generate a novel mouse model of choroid plexus carcinoma (CPC) to elucidate the mechanism of CPC formation and develop successful therapies.
Mon Feb 05 00:00:00 EST 2018
Luteinizing hormone compromises the in vivo anti-tumor effect of cisplatin on human epithelial ovarian cancer cells.
Oncology letters
Huang Y,Zhou Y,Xia L,Tang J,Wen H,Zhang M
MA5-14520 was used in Immunohistochemistry to study the effect of cisplatin and/or lutenizing hormone on platinum resistance in ovarian cancer.
Thu Mar 01 00:00:00 EST 2018
Divergent Innate and Epithelial Functions of the RNA-Binding Protein HuR in Intestinal Inflammation.
Frontiers in immunology
Christodoulou-Vafeiadou E,Ioakeimidis F,Andreadou M,Giagkas G,Stamatakis G,Reczko M,Samiotaki M,Papanastasiou AD,Karakasiliotis I,Kontoyiannis DL
MA5-14520 was used in Immunohistochemistry to demonstrate that epithelial and myeloid HuR affect different cellular dynamics in the intestine that need to be carefully considered for its pharmacological exploitation and points toward potential windows for harnessing HuR functions in intestinal inflammation.
Wed Oct 02 00:00:00 EDT 2019
Development of a murine intravesical orthotopic human bladder cancer (mio-hBC) model.
American journal of clinical and experimental urology
Raven PA,D'Costa NM,Moskalev I,Tan Z,Frees S,Chavez-Munoz C,So AI
MA5-14520 was used in Immunohistochemistry on paraffin embedded tissues to develop a murine intravesical orthotopic human bladder cancer (mio-hBC) model for the establishment of superficial urothelial cell carcinomas.
Thu Oct 01 00:00:00 EDT 2020
UXT is required for spermatogenesis in mice.
PloS one
Schafler ED,Thomas PA,Ha S,Wang Y,Bermudez-Hernandez K,Tang Z,Fenyö D,Vigodner M,Logan SK
MA5-14520 was used in Immunohistochemistry-immunofluorescence to reveal ubiquitous expressed transcript is required for spermatogenesis as it regulates distinct transcriptional programs in spermatogonial stem cells and differentiating spermatogonia.
Fri Jul 27 00:00:00 EDT 2018
DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.
Scientific reports
Tögel L,Nightingale R,Wu R,Chüeh AC,Al-Obaidi S,Luk I,Dávalos-Salas M,Chionh F,Murone C,Buchanan DD,Chatterton Z,Sieber OM,Arango D,Tebbutt NC,Williams D,Dhillon AS,Mariadason JM
MA5-14520 was used in Immunohistochemistry to show that DUSP5 plays a limited role in regulating ERK signalling associated with the growth of colorectal tumours.
Mon Jan 29 00:00:00 EST 2018
Effects of Amyloid-β Peptide on the Biology of Human Neural Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Bernabeu-Zornoza A,Coronel R,Lachgar M,Palmer C,Liste I
MA5-14520 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to describe the preparation of different forms (monomeric, oligomeric and fibrillary) of Aβ peptide and subsequent cell treatment, followed by the analysis of the effects on toxicity, cell proliferation and cell fate specification of hNS1 cells.
Mon Jul 22 00:00:00 EDT 2019
Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulating adipose stromal interleukin 6 production in mice.
The Journal of biological chemistry
Sun X,Gupta K,Wu B,Zhang D,Yuan B,Zhang X,Chiang HC,Zhang C,Curiel TJ,Bendeck MP,Hursting S,Hu Y,Li R
MA5-14520 was used in Immunohistochemistry to demonstrate the importance of host Discoidin domain receptor 1 (DDR1) in the promotion of mammary tumour growth in mice, and reveal its regulatory role in the expression of IL-6 by adipose cells.
Fri Feb 23 00:00:00 EST 2018
Autoreactive, Low-Affinity T Cells Preferentially Drive Differentiation of Short-Lived Memory B Cells at the Expense of Germinal Center Maintenance.
Cell reports
Jain RW,Parham KA,Tesfagiorgis Y,Craig HC,Romanchik E,Kerfoot SM
MA5-14520 was used in Flow cytometry/Cell sorting to characterise germinal centre kinetics and B cell fate choices in a response to the autoantigen myelin oligodendrocyte glycoprotein (MOG).
Tue Dec 18 00:00:00 EST 2018
Low-dose statin treatment increases prostate cancer aggressiveness.
Oncotarget
Caro-Maldonado A,Camacho L,Zabala-Letona A,Torrano V,Fernández-Ruiz S,Zamacola-Bascaran K,Arreal L,Valcárcel-Jiménez L,Martín-Martín N,Flores JM,Cortazar AR,Zúñiga-García P,Arruabarrena-Aristorena A,Guillaumond F,Cabrera D,Falcón-Perez JM,Aransay AM,Gomez-Muñoz A,Olivan M,Morote J,Carracedo A
MA5-14520 was used in Immunohistochemistry on paraffin embedded tissues to reveal a prostate cancer experimental system where statins exhibit an undesirable effect, and warrant further research to address the relevance and implications of this observation in human prostate cancer.
Fri Jan 05 00:00:00 EST 2018
WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.
Cell death & disease
Abu-Remaileh M,Khalaileh A,Pikarsky E,Aqeilan RI
MA5-14520 was used in Immunohistochemistry (Paraffin) to to study the effect of specific targeted deletion of Wwox on liver biology and hepatocellular carcinoma.
Tue May 01 00:00:00 EDT 2018
Kctd13 deletion reduces synaptic transmission via increased RhoA.
Nature
Escamilla CO,Filonova I,Walker AK,Xuan ZX,Holehonnur R,Espinosa F,Liu S,Thyme SB,López-García IA,Mendoza DB,Usui N,Ellegood J,Eisch AJ,Konopka G,Lerch JP,Schier AF,Speed HE,Powell CM
MA5-14520 was used in Immunohistochemistry to determine the function of KCTD13 in the mammalian brain.
Thu Nov 09 00:00:00 EST 2017
Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.
Nucleic acids research
Schuhwerk H,Bruhn C,Siniuk K,Min W,Erener S,Grigaravicius P,Krüger A,Ferrari E,Zubel T,Lazaro D,Monajembashi S,Kiesow K,Kroll T,Bürkle A,Mangerich A,Hottiger M,Wang ZQ
MA5-14520 was used in Immunocytochemistry to investigate the mechanism of the PARP1 responses to genotoxic stress.
Thu Nov 02 00:00:00 EDT 2017
Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology
de Jong RJ,Paulin N,Lemnitzer P,Viola JR,Winter C,Ferraro B,Grommes J,Weber C,Reutelingsperger C,Drechsler M,Soehnlein O
MA514520 was used in immunohistochemistry - paraffin section to examine the role of the proresolving protein annexin A1 in healing after wire injury
Wed Feb 01 00:00:00 EST 2017
In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents.
Journal of medicinal chemistry
Cui MT,Jiang L,Goto M,Hsu PL,Li L,Zhang Q,Wei L,Yuan SJ,Hamel E,Morris-Natschke SL,Lee KH,Xie L
MA5-14520 was used in Immunohistochemistry to reveal a class of tubulin-binding tumor-vascular disrupting agents that target established blood vessels in tumors.
Thu Jul 13 00:00:00 EDT 2017
Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.
The Journal of investigative dermatology
Anderton H,Rickard JA,Varigos GA,Lalaoui N,Silke J
MA5-14520 was used in Immunohistochemistry-immunofluorescence to determine the role of inhibitor of apoptosis proteins (IAPs) in skin homeostasis.
Wed Nov 01 00:00:00 EDT 2017
Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma.
Cell cycle (Georgetown, Tex.)
Che L,Pilo MG,Cigliano A,Latte G,Simile MM,Ribback S,Dombrowski F,Evert M,Chen X,Calvisi DF
MA514520 was used in immunohistochemistry - paraffin section to test if de novo lipogenesis is required for liver carcinogenesis
Sun Mar 19 00:00:00 EDT 2017
Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling.
Human molecular genetics
Li J,Lu D,Liu H,Williams BO,Overbeek PA,Lee B,Zheng L,Yang T
MA5-14520 was used in Immunohistochemistry on paraffin embedded tissues to establish that STAT3 inhibition may be a potential treatment of SCLT1-associated cystic kidney.
Tue Aug 01 00:00:00 EDT 2017
FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.
Molecular and cellular biology
Yamauchi T,Nishiyama M,Moroishi T,Kawamura A,Nakayama KI
MA514520 was used in immunohistochemistry - paraffin section to confirm that FBXL5 contributes to regulation of neural stem-progenitor cells proliferation during mammalian brain development
Sat Apr 15 00:00:00 EDT 2017
Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response.
Radiology and oncology
Savarin M,Kamensek U,Cemazar M,Heller R,Sersa G
MA5-14520 was used in Immunohistochemistry on paraffin embedded tissues to determine the effect of gene transfer of plasmid encoding shRNA for silencing endoglin on radiosensitisation of melanoma B16F10 tumours.
Wed Mar 01 00:00:00 EST 2017
Stabilization of HIF-1α and HIF-2α, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model.
PloS one
Malchenko S,Sredni ST,Bi Y,Margaryan NV,Boyineni J,Mohanam I,Tomita T,Davuluri RV,Soares MB
MA514520 was used in immunohistochemistry - paraffin section to assess mechanisms of tumorigenesis in the mouse model of CNS primitive neuroectodermal tumors
Thu Aug 17 00:00:00 EDT 2017
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.
Scientific reports
Coni S,Mancuso AB,Di Magno L,Sdruscia G,Manni S,Serrao SM,Rotili D,Spiombi E,Bufalieri F,Petroni M,Kusio-Kobialka M,De Smaele E,Ferretti E,Capalbo C,Mai A,Niewiadomski P,Screpanti I,Di Marcotullio L,Canettieri G
MA514520 was used in immunohistochemistry - paraffin section to analyze the contributions of developmental Hedgehog signaling effectors HDAC1 and HDAC2 in SHH Medulloblastoma
Thu Mar 09 00:00:00 EST 2017
Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma.
Nature communications
Ju HQ,Ying H,Tian T,Ling J,Fu J,Lu Y,Wu M,Yang L,Achreja A,Chen G,Zhuang Z,Wang H,Nagrath D,Yao J,Hung MC,DePinho RA,Huang P,Xu RH,Chiao PJ
MA514520 was used in immunohistochemistry - paraffin section to determine the contribution of NOX4 to the development of pancreatic ductal adenocarcinoma
Fri Feb 24 00:00:00 EST 2017
An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.
Nature communications
Vallejo A,Perurena N,Guruceaga E,Mazur PK,Martinez-Canarias S,Zandueta C,Valencia K,Arricibita A,Gwinn D,Sayles LC,Chuang CH,Guembe L,Bailey P,Chang DK,Biankin A,Ponz-Sarvise M,Andersen JB,Khatri P,Bozec A,Sweet-Cordero EA,Sage J,Lecanda F,Vicent S
MA514520 was used in immunohistochemistry to report FOSL1 as a common transcriptional signature across mutant KRAS cancers of distinct tissue origin
Tue Feb 21 00:00:00 EST 2017
Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.
Oncotarget
Lázaro S,Pérez-Crespo M,Enguita AB,Hernández P,Martínez-Palacio J,Oteo M,Sage J,Paramio JM,Santos M
MA5-14520 was used in Immunohistochemistry (Paraffin) to to investigate the role of two Rb family proteins in lung tumorigenesis.
Tue Jan 17 00:00:00 EST 2017
Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly.
Scientific reports
Sgourdou P,Mishra-Gorur K,Saotome I,Henagariu O,Tuysuz B,Campos C,Ishigame K,Giannikou K,Quon JL,Sestan N,Caglayan AO,Gunel M,Louvi A
MA514520 was used in immunohistochemistry to reveal critical and diverse functions of WD repeat domain 62 in neocortical development
Wed Mar 08 00:00:00 EST 2017
Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype.
Oncotarget
Hopkinson BM,Klitgaard MC,Petersen OW,Villadsen R,Rønnov-Jessen L,Kim J
MA514520 was used in immunocytochemistry to discuss estrogen receptor regulation and function in normal breast and breast cancer
Tue Feb 07 00:00:00 EST 2017
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
Nature communications
Zhang X,Chiang HC,Wang Y,Zhang C,Smith S,Zhao X,Nair SJ,Michalek J,Jatoi I,Lautner M,Oliver B,Wang H,Petit A,Soler T,Brunet J,Mateo F,Angel Pujana M,Poggi E,Chaldekas K,Isaacs C,Peshkin BN,Ochoa O,Chedin F,Theoharis C,Sun LZ,Curiel TJ,Elledge R,Jin VX,Hu Y,Li R
MA5-14520 was used in Immunohistochemistry to show pausing of RNA polymerase II contributes to BRCA1-associated R-loop accumulation and breast cancer development.
Mon Jun 26 00:00:00 EDT 2017
Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice.
Oncoimmunology
Mikyskova R,Indrova M,Stepanek I,Kanchev I,Bieblova J,Vosahlikova S,Moserova I,Truxova I,Fucikova J,Bartunkova J,Spisek R,Sedlacek R,Reinis M
MA5-14520 was used in Immunohistochemistry to demonstrate that dendritic cell based vaccines represent a tool for the treatment of human prostate cancer.
Tue Jan 12 00:00:00 EST 2021
DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.
Cell
Herrtwich L,Nanda I,Evangelou K,Nikolova T,Horn V,Erny D,Stefanowski J,Rogell L,Klein C,Gharun K,Follo M,Seidl M,Kremer B,Münke N,Senges J,Fliegauf M,Aschman T,Pfeifer D,Sarrazin S,Sieweke MH,Wagner D,Dierks C,Haaf T,Ness T,Zaiss MM,Voll RE,Deshmukh SD,Prinz M,Goldmann T,Hölscher C,Hauser AE,Lopez-Contreras AJ,Grün D,Gorgoulis V,Diefenbach A,Henneke P,Triantafyllopoulou A
MA514520 was used in immunohistochemistry - frozen section to describe how TLR2 signaling promotes macrophage polyploidy
Thu Nov 17 00:00:00 EST 2016
IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment.
EMBO molecular medicine
Catarinella M,Monestiroli A,Escobar G,Fiocchi A,Tran NL,Aiolfi R,Marra P,Esposito A,Cipriani F,Aldrighetti L,Iannacone M,Naldini L,Guidotti LG,Sitia G
MA5-14520 was used in immunohistochemistry - paraffin section to study cessation of colorectal cancer colonization of the liver by acting on the hepatic microenvironment by IFN-alpha gene/cell therapy
Mon Feb 01 00:00:00 EST 2016
Activation of the Lin28/let-7 Axis by Loss of ESE3/EHF Promotes a Tumorigenic and Stem-like Phenotype in Prostate Cancer.
Cancer research
Albino D,Civenni G,Dallavalle C,Roos M,Jahns H,Curti L,Rossi S,Pinton S,D'Ambrosio G,Sessa F,Hall J,Catapano CV,Carbone GM
MA5-14520 was used in immunohistochemistry to report that control by ESE3/EHF over the Lin28/let-7 axis is a critical barrier to malignant transformation in cancer stem-like cells
Wed Jun 15 00:00:00 EDT 2016
Vaccine Induction of Lymph Node-Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques.
Journal of immunology (Baltimore, Md. : 1950)
Vargas-Inchaustegui DA,Demers A,Shaw JM,Kang G,Ball D,Tuero I,Musich T,Mohanram V,Demberg T,Karpova TS,Li Q,Robert-Guroff M
MA5-14520 was used in immunohistochemistry - paraffin section to study lymph node-resident simian immunodeficiency virus env-specific T follicular helper cells due to vaccine induction in Rhesus Macaques
Mon Feb 15 00:00:00 EST 2016
Generation of Homogenous Three-Dimensional Pancreatic Cancer Cell Spheroids Using an Improved Hanging Drop Technique.
Tissue engineering. Part C, Methods
Ware MJ,Colbert K,Keshishian V,Ho J,Corr SJ,Curley SA,Godin B
MA5-14520 was used in immunohistochemistry - paraffin section to study the generation of homogenous three-dimensional pancreatic cancer cell spheroids and their improved hanging drop technique
Fri Apr 01 00:00:00 EDT 2016
Attempt towards a novel classification of triple-negative breast cancer using immunohistochemical markers.
Oncology letters
Liu YX,Wang KR,Xing H,Zhai XJ,Wang LP,Wang W
MA5-14520 was used in immunohistochemistry - paraffin section to classify triple-negative breast cancer into subtypes
Mon Aug 01 00:00:00 EDT 2016
High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22.
Scientific reports
Gulhane M,Murray L,Lourie R,Tong H,Sheng YH,Wang R,Kang A,Schreiber V,Wong KY,Magor G,Denman S,Begun J,Florin TH,Perkins A,Cuív PÓ,McGuckin MA,Hasnain SZ
MA5-14520 was used in western blot to assess the induction of colonic epithelial cell stress and inflammation reversed by IL-22 due to high fat diets
Tue Jun 28 00:00:00 EDT 2016
Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome.
Scientific reports
Dubail J,Vasudevan D,Wang LW,Earp SE,Jenkins MW,Haltiwanger RS,Apte SS
MA5-14520 was used in immunohistochemistry - paraffin section describe a role for ADAMTS9 in ocular morphogenesis
Fri Sep 30 00:00:00 EDT 2016
Immunogenomics reveal molecular circuits of diclofenac induced liver injury in mice.
Oncotarget
Lee EH,Oh JH,Selvaraj S,Park SM,Choi MS,Spanel R,Yoon S,Borlak J
MA5-14520 was used in immunohistochemistry - paraffin section to determine the induction of liver injury in mice due to molecular circuits of diclofenac revealed by immunogenomics
Tue Mar 22 00:00:00 EDT 2016
Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus.
Oncotarget
Mehta FF,Son J,Hewitt SC,Jang E,Lydon JP,Korach KS,Chung SH
MA5-14520 was used in Western Blotting to describe the regulation and function in the cervix of of progesterone receptor in the mouse vagina and uterus.
Tue Apr 05 00:00:00 EDT 2016
Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus.
Oncotarget
Mehta FF,Son J,Hewitt SC,Jang E,Lydon JP,Korach KS,Chung SH
MA5-14520 was used in Western Blotting to describe the regulation and function in the cervix of of progesterone receptor in the mouse vagina and uterus.
Tue Apr 05 00:00:00 EDT 2016
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.
Nature medicine
Wang P,Alvarez-Perez JC,Felsenfeld DP,Liu H,Sivendran S,Bender A,Kumar A,Sanchez R,Scott DK,Garcia-Ocaña A,Stewart AF
MA5-14520 was used in immunocytochemistry and immunohistochemistry to identify analogs of harmine as a new class of human beta cell mitogenic compounds and identify the pathways they activate.
Wed Apr 01 00:00:00 EDT 2015
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.
Nature medicine
Wang P,Alvarez-Perez JC,Felsenfeld DP,Liu H,Sivendran S,Bender A,Kumar A,Sanchez R,Scott DK,Garcia-Ocaña A,Stewart AF
MA5-14520 was used in immunocytochemistry and immunohistochemistry to identify analogs of harmine as a new class of human beta cell mitogenic compounds and identify the pathways they activate.
Wed Apr 01 00:00:00 EDT 2015
Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.
Nature medicine
Adachi T,Kobayashi T,Sugihara E,Yamada T,Ikuta K,Pittaluga S,Saya H,Amagai M,Nagao K
MA5-14520 was used in immunohistochemistry to research skin-resident memory T cell homeostasis and lymphoma mediated by hair follicle-derived IL-7 and IL-15
Sun Nov 01 00:00:00 EDT 2015
p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.
Nature
Zuo W,Zhang T,Wu DZ,Guan SP,Liew AA,Yamamoto Y,Wang X,Lim SJ,Vincent M,Lessard M,Crum CP,Xian W,McKeon F
MA5-14520 was used in immunohistochemistry to investigate how DASC(p63/Krt5) regulates regeneration of tissue after influenza-induced lung damage.
Thu Jan 29 00:00:00 EST 2015
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Nature immunology
Finkin S,Yuan D,Stein I,Taniguchi K,Weber A,Unger K,Browning JL,Goossens N,Nakagawa S,Gunasekaran G,Schwartz ME,Kobayashi M,Kumada H,Berger M,Pappo O,Rajewsky K,Hoshida Y,Karin M,Heikenwalder M,Ben-Neriah Y,Pikarsky E
MA5-14520 was used in immunohistochemistry - paraffin section to study hepatocellular carcinoma and ectopic lymphoid structures function as microniches for tumor progenitor cells
Tue Dec 01 00:00:00 EST 2015
Vessel maturation schedule determines vulnerability to neuronal injuries of prematurity.
The Journal of clinical investigation
Licht T,Dor-Wollman T,Ben-Zvi A,Rothe G,Keshet E
MA5-14520 was used in immunohistochemistry - paraffin section to evaluate an animal model for periventricular leukomalacia
Mon Mar 02 00:00:00 EST 2015
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.
The Journal of clinical investigation
Mu X,Español-Suñer R,Mederacke I,Affò S,Manco R,Sempoux C,Lemaigre FP,Adili A,Yuan D,Weber A,Unger K,Heikenwälder M,Leclercq IA,Schwabe RF
MA5-14520 was used in immunohistochemistry - paraffin section to elucidate the origin of hepatocellular carcinoma.
Thu Oct 01 00:00:00 EDT 2015
Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation.
Diabetes
Zhang P,Kumar A,Katz LS,Li L,Paulynice M,Herman MA,Scott DK
MA5-14520 was used in immunocytochemistry to study the relationship between ChREBPbeta and glucose in beta cells
Tue Dec 01 00:00:00 EST 2015
Meningeal Infiltration of the Spinal Cord by Non-Classically Activated B Cells is Associated with Chronic Disease Course in a Spontaneous B Cell-Dependent Model of CNS Autoimmune Disease.
Frontiers in immunology
Dang AK,Tesfagiorgis Y,Jain RW,Craig HC,Kerfoot SM
MA5-14520 was used in Immunohistochemistry on paraffin embedded tissues to characterise B cell infiltration of the spinal cord in a B cell-dependent spontaneous model of CNS autoimmunity, showing meningeal infiltration of the spinal cord by non-classically activated B cells.
Wed Oct 07 00:00:00 EDT 2015
Unipotent, Atoh1+ progenitors maintain the Merkel cell population in embryonic and adult mice.
The Journal of cell biology
Wright MC,Reed-Geaghan EG,Bolock AM,Fujiyama T,Hoshino M,Maricich SM
MA5-14520 was used in immunohistochemistry - frozen section to characterize the Merkel cell population in embryonic and adult mice as unipotent, Atoh1+ progenitors
Mon Feb 02 00:00:00 EST 2015
KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice.
PLoS pathogens
Sin SH,Kim Y,Eason A,Dittmer DP
MA5-14520 was used in immunohistochemistry - paraffin section to study lymphoma in mice driven by Myc cooperating with the KSHV latency locus
Tue Sep 01 00:00:00 EDT 2015
Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region.
Neurobiology of disease
Liu W,Zhou H,Liu L,Zhao C,Deng Y,Chen L,Wu L,Mandrycky N,McNabb CT,Peng Y,Fuchs PN,Lu J,Sheen V,Qiu M,Mao M,Lu QR
MA5-14520 was used in immunohistochemistry - frozen section to study a gene called Olig2, found in the Down syndrome critical region, shows disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2
Fri May 01 00:00:00 EDT 2015
Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas?
Journal of gastroenterology
Hijioka S,Hosoda W,Mizuno N,Hara K,Imaoka H,Bhatia V,Mekky MA,Tajika M,Tanaka T,Ishihara M,Yogi T,Tsutumi H,Fujiyoshi T,Sato T,Hieda N,Yoshida T,Okuno N,Shimizu Y,Yatabe Y,Niwa Y,Yamao K
MA5-14520 was used in immunohistochemistry to determine if pancreatic neuroendocrine carcinomas are accurately characterized by the WHO 2010 classification of pancreatic neuroendocrine neoplasms
Fri May 01 00:00:00 EDT 2015
Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI.
Nanomedicine : nanotechnology, biology, and medicine
Bechet D,Auger F,Couleaud P,Marty E,Ravasi L,Durieux N,Bonnet C,Plénat F,Frochot C,Mordon S,Tillement O,Vanderesse R,Lux F,Perriat P,Guillemin F,Barberi-Heyob M
MA5-14520 was used in immunohistochemistry to provide in vivo proof of principle for the use of closed-head iPDT guided by real-time MRI using targeted ultra small nanoplatforms
Wed Apr 01 00:00:00 EDT 2015
IKKβ Regulates VEGF Expression and Is a Potential Therapeutic Target for Ovarian Cancer as an Antiangiogenic Treatment.
Molecular cancer therapeutics
Kinose Y,Sawada K,Makino H,Ogura T,Mizuno T,Suzuki N,Fujikawa T,Morii E,Nakamura K,Sawada I,Toda A,Hashimoto K,Isobe A,Mabuchi S,Ohta T,Itai A,Morishige K,Kurachi H,Kimura T
MA5-14520 was used in immunohistochemistry - paraffin section to study the role of IKKbeta during ovarian cancer angiogenesis
Wed Apr 01 00:00:00 EDT 2015
Combination strategy targeting VEGF and HGF/c-met in human renal cell carcinoma models.
Molecular cancer therapeutics
Ciamporcero E,Miles KM,Adelaiye R,Ramakrishnan S,Shen L,Ku S,Pizzimenti S,Sennino B,Barrera G,Pili R
MA5-14520 was used in immunohistochemistry to determine the effects of targeting the VEGF and c-met pathways in clear cell renal cell carcinoma models.
Thu Jan 01 00:00:00 EST 2015
Retrospective analysis of metastatic behaviour of breast cancer subtypes.
Breast cancer research and treatment
Savci-Heijink CD,Halfwerk H,Hooijer GK,Horlings HM,Wesseling J,van de Vijver MJ
MA5-14520 was used in immunohistochemistry - paraffin section to analyze breast cancer subtypes and retrospective analysis of metastatic behaviour
Wed Apr 01 00:00:00 EDT 2015
The effect of pomegranate fruit extract on testosterone-induced BPH in rats.
The Prostate
Ammar AE,Esmat A,Hassona MD,Tadros MG,Abdel-Naim AB,Guns ES
MA5-14520 was used in immunohistochemistry - paraffin section to study the effect of Pomegranate Fruit Extract (PFE) in a testosterone-induced benign prostatic hyperplasia model
Fri May 01 00:00:00 EDT 2015
Abnormal proliferation and spontaneous differentiation of myoblasts from a symptomatic female carrier of X-linked Emery-Dreifuss muscular dystrophy.
Neuromuscular disorders : NMD
Meinke P,Schneiderat P,Srsen V,Korfali N,Lê Thành P,Cowan GJ,Cavanagh DR,Wehnert M,Schirmer EC,Walter MC
MA5-14520 was used in immunocytochemistry to use of a myoblasts from a symptomatic female carrier of X-linnked Emery-Dreifuss muscular dystrophy to study abnormal proliferation and spontaneous differentiation
Sun Feb 01 00:00:00 EST 2015
Primary intraosseous hybrid nerve sheath tumor of femur: a hitherto undescribed occurrence in bone with secondary aneurysmal bone cyst formation resulting in pathological fracture.
Pathology, research and practice
Chow LT
MA5-14520 was used in immunohistochemistry to characterize first case of primary intraosseous hybrid nerve sheath tumor
Fri May 01 00:00:00 EDT 2015
Missense Mutations in Exons 18-24 of EGFR in Hepatocellular Carcinoma Tissues.
BioMed research international
Panvichian R,Tantiwetrueangdet A,Sornmayura P,Leelaudomlipi S
MA5-14520 was used in immunohistochemistry - paraffin section to characterize hepatocellular carcinoma tissues and missense mutations in exons 18-24 of EGFR
Tue Jul 19 00:00:00 EDT 2016
A challenging case of ocular melanoma.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Costache M,Dumitru AV,Pătraşcu OM,Popa-Cherecheanu DA,Bădilă P,Miu JC,Procop A,Popa M,Tampa MŞ,Sajin M,Simionescu O,Cîrstoiu MM
MA5-14520 was used in immunohistochemistry to present a case of highly aggressive ocular melanoma
Tue May 10 00:00:00 EDT 2016
P16(INK 4a) and Ki-67 expression in human papilloma virus-related head and neck mucosal lesions.
Investigacion clinica
Gültekin SE,Sengüven B,Klussmann JP,Dienes HP
MA5-14520 was used in immunohistochemistry - paraffin section to determine the potential role of p16(INK 4a) and Ki-67 expression in human papilloma virus-related lesions
Sun Mar 01 00:00:00 EST 2015
Site-specific programming of the host epithelial transcriptome by the gut microbiota.
Genome biology
Sommer F,Nookaew I,Sommer N,Fogelstrand P,Bäckhed F
MA5-14520 was used in immunohistochemistry - frozen section to examine microbiota-induced transcriptional responses in specific fractions of intestinal epithelial cells.
Sat Mar 28 00:00:00 EDT 2015
Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.
PLoS genetics
Evason KJ,Francisco MT,Juric V,Balakrishnan S,Lopez Pazmino Mdel P,Gordan JD,Kakar S,Spitsbergen J,Goga A,Stainier DY
MA5-14520 was used in immunohistochemistry - paraffin section to assess beta-catenin-driven liver tumorigenesis in zebrafish by indentifying chemical inhibitors
Wed Jul 01 00:00:00 EDT 2015
In vivo imaging of cell proliferation for a dynamic, whole body, analysis of undesired drug effects.
Toxicological sciences : an official journal of the Society of Toxicology
Rizzi N,Manni I,Vantaggiato C,Delledonne GA,Gentileschi MP,Maggi A,Piaggio G,Ciana P
MA5-14520 was used in immunohistochemistry - paraffin section to image cell proliferation in vivo in a non-invasive fashion to investigate undesired drug effects
Mon Jun 01 00:00:00 EDT 2015
miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability.
Cell reports
Parchem RJ,Moore N,Fish JL,Parchem JG,Braga TT,Shenoy A,Oldham MC,Rubenstein JL,Schneider RA,Blelloch R
MA5-14520 was used in immunohistochemistry - frozen section to characterize the timing of neural tube closure, embryonic viability, and neural differentiation by the required miR-302
Tue Aug 04 00:00:00 EDT 2015
Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers.
PloS one
Dodbiba L,Teichman J,Fleet A,Thai H,Starmans MH,Navab R,Chen Z,Girgis H,Eng L,Espin-Garcia O,Shen X,Bandarchi B,Schwock J,Tsao MS,El-Zimaity H,Der SD,Xu W,Bristow RG,Darling GE,Boutros PC,Ailles LE,Liu G
MA5-14520 was used in immunohistochemistry - paraffin section to use of xenograft models from patients to evaluate pharmacologic therapies for esophageal/gastro-esophageal junction cancers
Sun Mar 27 00:00:00 EDT 2016
Castration-resistant Lgr5(+) cells are long-lived stem cells required for prostatic regeneration.
Stem cell reports
Wang BE,Wang X,Long JE,Eastham-Anderson J,Firestein R,Junttila MR
MA5-14520 was used in immunocytochemistry to identify G-protein-coupled receptor 5 (Lgr5) expression in prostate epithelial progenitor cells
Tue May 12 00:00:00 EDT 2015
Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies.
Oncotarget
Jäger W,Xue H,Hayashi T,Janssen C,Awrey S,Wyatt AW,Anderson S,Moskalev I,Haegert A,Alshalalfa M,Erho N,Davicioni E,Fazli L,Li E,Collins C,Wang Y,Black PC
MA5-14520 was used in immunohistochemistry - paraffin section to develop and characterize patient-derived primary xenografts to a model of muscle invasive bladder cancer.
Fri Aug 28 00:00:00 EDT 2015
A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells.
PloS one
Malchenko S,Sredni ST,Hashimoto H,Kasai A,Nagayasu K,Xie J,Margaryan NV,Seiriki K,Lulla RR,Seftor RE,Pachman LM,Meltzer HY,Hendrix MJ,Soares MB
MA5-14520 was used in immunohistochemistry - paraffin section to describe a mouse model to study primitive neuroectodermal tumors
Sun Mar 27 00:00:00 EDT 2016
Oral squamous cell carcinoma associated with proliferative verrucous leukoplakia compared with conventional squamous cell carcinoma--a clinical, histologic and immunohistochemical study.
Oral surgery, oral medicine, oral pathology and oral radiology
Akrish S,Ben-Izhak O,Sabo E,Rachmiel A
MA5-14520 was used in immunohistochemistry - paraffin section to compare the features of patients with proliferative verrucous leukoplakia and those with conventional squamous cell carcinoma
Sun Mar 01 00:00:00 EST 2015
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.
Nature genetics
Mirzaa G,Parry DA,Fry AE,Giamanco KA,Schwartzentruber J,Vanstone M,Logan CV,Roberts N,Johnson CA,Singh S,Kholmanskikh SS,Adams C,Hodge RD,Hevner RF,Bonthron DT,Braun KPJ,Faivre L,Rivière JB,St-Onge J,Gripp KW,Mancini GM,Pang K,Sweeney E,van Esch H,Verbeek N,Wieczorek D,Steinraths M,Majewski J,Boycot KM,Pilz DT,Ross ME,Dobyns WB,Sheridan EG
MA5-14520 was used in immunohistochemistry - frozen section to discover how de novo mutations of CCND2 lead to cyclin D2 stabilization and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
Thu May 01 00:00:00 EDT 2014
Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes.
Gastroenterology
Li A,Morton JP,Ma Y,Karim SA,Zhou Y,Faller WJ,Woodham EF,Morris HT,Stevenson RP,Juin A,Jamieson NB,MacKay CJ,Carter CR,Leung HY,Yamashiro S,Blyth K,Sansom OJ,Machesky LM
MA5-14520 was used in immunohistochemistry to evaluate the prognostic value of fascin in pancreatic cancer
Thu May 01 00:00:00 EDT 2014
AMPKα1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression.
Journal of hepatology
Merlen G,Gentric G,Celton-Morizur S,Foretz M,Guidotti JE,Fauveau V,Leclerc J,Viollet B,Desdouets C
MA5-14520 was used in immunohistochemistry to study the role of cyclin D2 in the energy balance-independent modulation of hepatocyte proliferation by AMPK-alpha1
Wed Jan 01 00:00:00 EST 2014
MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.
The Journal of clinical investigation
Grzmil M,Huber RM,Hess D,Frank S,Hynx D,Moncayo G,Klein D,Merlo A,Hemmings BA
MA5-14520 was used in immunohistochemistry and western blot to study the mechanism by which the MNK1 pathway maintains protein synthetic activity in glioma cells treated with rapamycin analogs
Sat Feb 01 00:00:00 EST 2014
Constructs of electrospun PLGA, compressed collagen and minced urothelium for minimally manipulated autologous bladder tissue expansion.
Biomaterials
Ajalloueian F,Zeiai S,Fossum M,Hilborn JG
MA5-14520 was used in immunohistochemistry to develop a system for the expansion of autologous bladder tissue based on the use of electrospun PLGA, compressed collagen and minced urothelium
Tue Jul 01 00:00:00 EDT 2014
The kidney is the principal organ mediating klotho effects.
Journal of the American Society of Nephrology : JASN
Lindberg K,Amin R,Moe OW,Hu MC,Erben RG,Östman Wernerson A,Lanske B,Olauson H,Larsson TE
MA5-14520 was used in immunohistochemistry - paraffin section report the kidney is the principal contributor of circulating Klotho and regulates anti-aging traits
Wed Oct 01 00:00:00 EDT 2014
Contrasting responses of non-small cell lung cancer to antiangiogenic therapies depend on histological subtype.
EMBO molecular medicine
Larrayoz M,Pio R,Pajares MJ,Zudaire I,Ajona D,Casanovas O,Montuenga LM,Agorreta J
MA5-14520 was used in immunohistochemistry to study the response of different histological sub-types of non-small cell lung cancer to anti-angiogenic therapy
Tue Apr 01 00:00:00 EDT 2014
Mesenchymal stem cells from human fat engineered to secrete BMP4 are nononcogenic, suppress brain cancer, and prolong survival.
Clinical cancer research : an official journal of the American Association for Cancer Research
Li Q,Wijesekera O,Salas SJ,Wang JY,Zhu M,Aprhys C,Chaichana KL,Chesler DA,Zhang H,Smith CL,Guerrero-Cazares H,Levchenko A,Quinones-Hinojosa A
MA5-14520 was used in immunohistochemistry to evaluate the therapeutic potential of engineered mesenchymal stem cells from human fat for glioblastoma
Thu May 01 00:00:00 EDT 2014
MYC synergizes with activated BRAFV600E in mouse lung tumor development by suppressing senescence.
Cancer research
Tabor V,Bocci M,Alikhani N,Kuiper R,Larsson LG
MA5-14520 was used in immunocytochemistry to examine the role of MYC during tumor development in vivo
Fri Aug 15 00:00:00 EDT 2014
FGFR1-WNT-TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma.
Cancer research
Carstens JL,Shahi P,Van Tsang S,Smith B,Creighton CJ,Zhang Y,Seamans A,Seethammagari M,Vedula I,Levitt JM,Ittmann MM,Rowley DR,Spencer DM
MA5-14520 was used in immunohistochemistry to use transgenic murine models to esablish the key role of the FGR1-Wnt-TGF-beta signaling axis in prostate cancer reactive stroma
Wed Jan 15 00:00:00 EST 2014
Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites.
Cancer research
Hoos A,Protsyuk D,Borsig L
MA5-14520 was used in immunohistochemistry to study the role of PSGL-1 in the recruitment of monocytes to sites of metastasis
Sat Feb 01 00:00:00 EST 2014
Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth.
Cancer research
Barceló C,Paco N,Morell M,Alvarez-Moya B,Bota-Rabassedas N,Jaumot M,Vilardell F,Capella G,Agell N
MA5-14520 was used in immunohistochemistry to study the role of serine 181 phosphorylation in the ocogenic properties of KRAS
Sat Feb 15 00:00:00 EST 2014
Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer.
Cancer research
Yeo EJ,Cassetta L,Qian BZ,Lewkowich I,Li JF,Stefater JA,Smith AN,Wiechmann LS,Wang Y,Pollard JW,Lang RA
MA5-14520 was used in immunohistochemistry to study the angiogenic switch and metastatic progression of breast cancer and the role of myeloid cell WNT7b
Sun Jun 01 00:00:00 EDT 2014
A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.
Genes & development
Okada N,Lin CP,Ribeiro MC,Biton A,Lai G,He X,Bu P,Vogel H,Jablons DM,Keller AC,Wilkinson JE,He B,Speed TP,He L
MA5-14520 was used in immunohistochemistry to study the role of a p53-miRNA-34 positive-feedback loop in tumor suppression in lung cancer
Sat Mar 01 00:00:00 EST 2014
ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes.
Genes & development
Boxer LD,Barajas B,Tao S,Zhang J,Khavari PA
MA5-14520 was used in immunohistochemistry to characterize the transcription factor ZNF750.
Mon Sep 15 00:00:00 EDT 2014
Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome.
Journal of pineal research
Corrales A,Vidal R,García S,Vidal V,Martínez P,García E,Flórez J,Sanchez-Barceló EJ,Martínez-Cué C,Rueda N
MA5-14520 was used in immunohistochemistry to study the role of increased neurogenesis and normalization of electrophysiology in the therapeutic effects of melatonin in a murine model of Down syndrome
Wed Jan 01 00:00:00 EST 2014
Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegradable microparticles promotes cardiac repair in a rat myocardial infarction model through activation of endogenous regeneration.
Journal of controlled release : official journal of the Controlled Release Society
Formiga FR,Pelacho B,Garbayo E,Imbuluzqueta I,Díaz-Herráez P,Abizanda G,Gavira JJ,Simón-Yarza T,Albiasu E,Tamayo E,Prósper F,Blanco-Prieto MJ
MA5-14520 was used in immunohistochemistry to characterize endogenous regeneration induced by fibroblast growth factor-1 and neuregulin-1
Fri Jan 10 00:00:00 EST 2014
SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.
Haematologica
Simonetti G,Bertilaccio MT,Rodriguez TV,Apollonio B,Dagklis A,Rocchi M,Innocenzi A,Casola S,Winkler TH,Nitschke L,Ponzoni M,Caligaris-Cappio F,Ghia P
MA5-14520 was used in immunohistochemistry to study the increased incidence of B-cell lymphoproliferative disorders in Siglecg (-/-) mice
Fri Aug 01 00:00:00 EDT 2014
Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors.
Endoscopy
Hasegawa T,Yamao K,Hijioka S,Bhatia V,Mizuno N,Hara K,Imaoka H,Niwa Y,Tajika M,Kondo S,Tanaka T,Shimizu Y,Kinoshita T,Kohsaki T,Nishimori I,Iwasaki S,Saibara T,Hosoda W,Yatabe Y
MA5-14520 was used in immunohistochemistry to study the malignancy risk of pancreatic neuroendocrine tumors based on the Ki67 index of endoscopic ultrasound-guided fine-needle aspiration samples
Wed Jan 01 00:00:00 EST 2014
G0-G1 transition and the restriction point in pancreatic β-cells in vivo.
Diabetes
Hija A,Salpeter S,Klochendler A,Grimsby J,Brandeis M,Glaser B,Dor Y
MA5-14520 was used in immunohistochemistry to study the cell-cycle kinetics of the pancreatic beta-cell and the restriction point at the Go-G1 transition
Sat Feb 01 00:00:00 EST 2014
Contribution of mesenchymal proliferation in tooth root morphogenesis.
Journal of dental research
Sohn WJ,Choi MA,Yamamoto H,Lee S,Lee Y,Jung JK,Jin MU,An CH,Jung HS,Suh JY,Shin HI,Kim JY
MA5-14520 was used in immunohistochemistry to study the role of mesenchymal proliferation in the morphogenesis of the tooth root
Wed Jan 01 00:00:00 EST 2014
The kinetics of ER fusion protein activation in vivo.
Oncogene
Wilson CH,Gamper I,Perfetto A,Auw J,Littlewood TD,Evan GI
MA5-14520 was used in immunohistochemistry to determine the best route of delivery of 4-hydroxytamoxifen for the in vivo activation of estrogen receptor fusion proteins
Thu Oct 02 00:00:00 EDT 2014
Differentiation and histogenesis of syringomatous tumour of the nipple and low-grade adenosquamous carcinoma: evidence for a common origin.
Histopathology
Boecker W,Stenman G,Loening T,Andersson MK,Sinn HP,Barth P,Oberhellmann F,Bos I,Berg T,Marusic Z,Samoilova V,Buchwalow I
MA5-14520 was used in immunohistochemistry to study the potential common origin of syringomatous tumor of the nipple and low-grade adenosquamous carcinoma of the breast
Tue Jul 01 00:00:00 EDT 2014
Temsirolimus combined with cisplatin or bevacizumab is active in osteosarcoma models.
International journal of cancer
Fleuren ED,Versleijen-Jonkers YM,Roeffen MH,Franssen GM,Flucke UE,Houghton PJ,Oyen WJ,Boerman OC,van der Graaf WT
MA5-14520 was used in immunohistochemistry to study the efficacy of combination therapy with the mTOR inhibitor temsirolimus plus either cisplatin or bevacizumab in xenograft models of osteosarcoma
Mon Dec 15 00:00:00 EST 2014
Protease-activated receptor-1 drives pancreatic cancer progression and chemoresistance.
International journal of cancer
Queiroz KC,Shi K,Duitman J,Aberson HL,Wilmink JW,van Noesel CJ,Richel DJ,Spek CA
MA5-14520 was used in immunohistochemistry to study pancreatic cancer and the role of PAR-1 in progression and chemoresistance
Sat Nov 15 00:00:00 EST 2014
Tumor vascularization is critical for oncolytic vaccinia virus treatment of peritoneal carcinomatosis.
International journal of cancer
Ottolino-Perry K,Tang N,Head R,Ng C,Arulanandam R,Angarita FA,Acuna SA,Chen Y,Bell J,Dacosta RS,McCart JA
MA5-14520 was used in immunohistochemistry to study the effects of an oncolytic vaccina virus against peritoneal carcinomatosis and the key role of a diseminated tumor vasculature for therapeutic efficacy
Sat Feb 01 00:00:00 EST 2014
High stress hormone levels accelerate the onset of memory deficits in male Huntington's disease mice.
Neurobiology of disease
Mo C,Pang TY,Ransome MI,Hill RA,Renoir T,Hannan AJ
MA5-14520 was used in immunohistochemistry to study the mechanisms underlying the accelerated development of memory impairment in male Huntington's disease mice in response to elevated stress hormone levels
Mon Sep 01 00:00:00 EDT 2014
Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Li K,Nicaise C,Sannie D,Hala TJ,Javed E,Parker JL,Putatunda R,Regan KA,Suain V,Brion JP,Rhoderick F,Wright MC,Poulsen DJ,Lepore AC
MA5-14520 was used in immunohistochemistry to study the deleterious effects of astrocyte GLT1 overexpression on cervical contusion spinal cord injury-induced neuronal damage and respiratory impairment
Wed May 28 00:00:00 EDT 2014
Characterization of ectopic colonies that form in widespread areas of the nervous system with neural stem cell transplants into the site of a severe spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Steward O,Sharp KG,Yee KM,Hatch MN,Bonner JF
MA5-14520 was used in immunohistochemistry - frozen section to characterize the incidence, distribution, and cellular composition of the ectopic colonies arising from transplanted fetal neuronal stem cells in the nervous system
Wed Oct 15 00:00:00 EDT 2014
Adipogenic differentiation is impaired in replicative senescent human subcutaneous adipose-derived stromal/progenitor cells.
The journals of gerontology. Series A, Biological sciences and medical sciences
Mitterberger MC,Lechner S,Mattesich M,Zwerschke W
MA5-14520 was used in immunocytochemistry to study the reduced adipogenic differentiation potential of human subcutaneous adipose-derived stromal/progenitor cells that have entered replicative senescence following prolonged culture
Wed Jan 01 00:00:00 EST 2014
Culture dimensionality influences the resistance of glioblastoma stem-like cells to multikinase inhibitors.
Molecular cancer therapeutics
Fernandez-Fuente G,Mollinedo P,Grande L,Vazquez-Barquero A,Fernandez-Luna JL
MA5-14520 was used in immunocytochemistry to study the sensitivity of glioblastoma stem-like cells to multi-kinase inhbitors and the effect of 2-D versus 3-D culture
Sun Jun 01 00:00:00 EDT 2014
WFDC1 is a key modulator of inflammatory and wound repair responses.
The American journal of pathology
Ressler SJ,Dang TD,Wu SM,Tse DY,Gilbert BE,Vyakarnam A,Yang F,Schauer IG,Barron DA,Rowley DR
MA5-14520 was used in immunohistochemistry to investigate the role of WDC1 during infection and wound healing using wdc1-null mice
Sat Nov 01 00:00:00 EDT 2014
Prolactin-induced prostate tumorigenesis links sustained Stat5 signaling with the amplification of basal/stem cells and emergence of putative luminal progenitors.
The American journal of pathology
Sackmann-Sala L,Chiche A,Mosquera-Garrote N,Boutillon F,Cordier C,Pourmir I,Pascual-Mathey L,Kessal K,Pigat N,Camparo P,Goffin V
MA5-14520 was used in immunohistochemistry - paraffin section to study the role of prolactin and STAT5 during early prostate tumorigenesis
Sat Nov 01 00:00:00 EDT 2014
RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland.
Disease models & mechanisms
McDonald L,Ferrari N,Terry A,Bell M,Mohammed ZM,Orange C,Jenkins A,Muller WJ,Gusterson BA,Neil JC,Edwards J,Morris JS,Cameron ER,Blyth K
MA5-14520 was used in immunohistochemistry to study the association of high levels of RUNX2 expression with ER/PR/HER2-negative breast cancers and the role of elevated RUNX2 in promoting mammary epithelial neoplastic changes
Thu May 01 00:00:00 EDT 2014
n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice.
Frontiers in aging neuroscience
Cutuli D,De Bartolo P,Caporali P,Laricchiuta D,Foti F,Ronci M,Rossi C,Neri C,Spalletta G,Caltagirone C,Farioli-Vecchioli S,Petrosini L
MA5-14520 was used in immunohistochemistry to examine the positive neuroprotective effects from omega-3 polyunsaturated acid supplementation
Tue Sep 09 00:00:00 EDT 2014
CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy.
Laboratory investigation; a journal of technical methods and pathology
Duitman J,Borensztajn KS,Pulskens WP,Leemans JC,Florquin S,Spek CA
MA5-14520 was used in immunohistochemistry to study chronic obstructive nephropathy and the role of C/EBP-delta in modulating tubular damage and interstitial fibrosis
Wed Jan 01 00:00:00 EST 2014
Activation of cutaneous immune responses in complex regional pain syndrome.
The journal of pain
Birklein F,Drummond PD,Li W,Schlereth T,Albrecht N,Finch PM,Dawson LF,Clark JD,Kingery WS
MA5-14520 was used in immunohistochemistry to study cell proliferation and the cellular source of inflammatory mediators in complex regional pain syndrome using a rat fracture model
Thu May 01 00:00:00 EDT 2014
Degeneration, regeneration, and cicatrization after fat grafting: dynamic total tissue remodeling during the first 3 months.
Plastic and reconstructive surgery
Kato H,Mineda K,Eto H,Doi K,Kuno S,Kinoshita K,Kanayama K,Yoshimura K
MA5-14520 was used in immunohistochemistry to study the dynamics of fat remodeling following surgical grafting
Sat Mar 01 00:00:00 EST 2014
Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex.
Cerebral cortex (New York, N.Y. : 1991)
Bando Y,Hirano T,Tagawa Y
MA5-14520 was used in immunohistochemistry to study impaired cerebral cortical migration of neurones in developing mice following knockdown of various KCNK potassium channels
Tue Apr 01 00:00:00 EDT 2014
GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast.
Hormones & cancer
Scaling AL,Prossnitz ER,Hathaway HJ
MA5-14520 was used in immunohistochemistry to study estrogen-induced breast epithelial cell proliferation in normal and malignant breast tissue and the involvement of GPER
Sun Jun 01 00:00:00 EDT 2014
A disintegrin and metalloproteinase 12 (ADAM12) localizes to invasive trophoblast, promotes cell invasion and directs column outgrowth in early placental development.
Molecular human reproduction
Aghababaei M,Perdu S,Irvine K,Beristain AG
MA5-14520 was used in immunohistochemistry to study the role of trophoblast-localized ADAM12 in early placental development
Sat Mar 01 00:00:00 EST 2014
Diverse roles for Wnt7a in ventral midbrain neurogenesis and dopaminergic axon morphogenesis.
Stem cells and development
Fernando CV,Kele J,Bye CR,Niclis JC,Alsanie W,Blakely BD,Stenman J,Turner BJ,Parish CL
MA5-14520 was used in immunohistochemistry to study ventral midbrain neurogenesis and the growth of dopaminergic axons, and the modulatory roles played by the secreted glycoprotein Wnt7a
Mon Sep 01 00:00:00 EDT 2014
Ex vivo culture of primary human colonic tissue for studying transcriptional responses to 1α,25(OH)2 and 25(OH) vitamin D.
Physiological genomics
Mapes B,Chase M,Hong E,Ludvik A,Ceryes K,Huang Y,Kupfer SS
MA5-14520 was used in immunohistochemistry to study the transcriptional responses to vitamin D using an ex vivo primary human colon tissue model system
Tue Apr 15 00:00:00 EDT 2014
Histone deacetylase expression in white matter oligodendrocytes after stroke.
Neurochemistry international
Kassis H,Chopp M,Liu XS,Shehadah A,Roberts C,Zhang ZG
MA5-14520 was used in immunohistochemistry to measure the expression of individual HDACs in the oligodendrocyte lineage during stroke-induced oligodendrogenesis
Sat Nov 01 00:00:00 EDT 2014
Distribution pattern of the Ki67 labelling index in breast cancer and its implications for choosing cut-off values.
Breast (Edinburgh, Scotland)
Cserni G,Vörös A,Liepniece-Karele I,Bianchi S,Vezzosi V,Grabau D,Sapino A,Castellano I,Regitnig P,Foschini MP,Zolota V,Varga Z,Figueiredo P,Decker T,Focke C,Kulka J,Kaya H,Reiner-Concin A,Amendoeira I,Callagy G,Caffrey E,Wesseling J,Wells C
MA5-14520 was used in immunohistochemistry to study Ki labelling index in breast cancer samples with respect to the appropriateness of cut-off values used to diagnose tumors with low and high proliferative capacity
Sun Jun 01 00:00:00 EDT 2014
Therapeutic expression of hairpins targeting apolipoprotein B100 induces phenotypic and transcriptome changes in murine liver.
Gene therapy
Maczuga P,Verheij J,van der Loos C,van Logtenstein R,Hooijer G,Martier R,Borel F,Lubelski J,Koornneef A,Blits B,van Deventer S,Petry H,Konstantinova P
MA5-14520 was used in immunohistochemistry to study the effects of short hairpin-mediated knockdown of hepatic ApoB100 and the associated phentypic and gene expression changes
Wed Jan 01 00:00:00 EST 2014
P53-participated cellular and molecular responses to irradiation are cell differentiation-determined in murine intestinal epithelium.
Archives of biochemistry and biophysics
Wang F,Cheng J,Liu D,Sun H,Zhao J,Wang J,Chen J,Su Y,Zou Z
MA5-14520 was used in immunohistochemistry to study the effect of differentiation status on the responses of murine epithelial cells to irradiation
Wed Jan 15 00:00:00 EST 2014
Cells of renin lineage take on a podocyte phenotype in aging nephropathy.
American journal of physiology. Renal physiology
Pippin JW,Glenn ST,Krofft RD,Rusiniak ME,Alpers CE,Hudkins K,Duffield JS,Gross KW,Shankland SJ
MA5-14520 was used in immunohistochemistry to study podocyte depletion in aging nephropathy and the ability of renin lineage cells to adopt a podocyte phenotype
Thu May 15 00:00:00 EDT 2014
μ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche.
Addiction biology
Contet C,Kim A,Le D,Iyengar SK,Kotzebue RW,Yuan CJ,Kieffer BL,Mandyam CD
MA5-14520 was used in immunohistochemistry to study the role of the mu-opioid receptor in the effects of chronic ethanol consumption on dentate gyrus neuroplasticity
Mon Sep 01 00:00:00 EDT 2014
The small GTPase Rheb is required for spermatogenesis but not oogenesis.
Reproduction (Cambridge, England)
Baker MD,Ezzati M,Aloisio GM,Tarnawa ED,Cuevas I,Nakada Y,Castrillon DH
MA5-14520 was used in immunohistochemistry to use conditional knockout mice to study the spermatogenic role of the Rhab small GTPase and its lack of corresponding involvement in oogenesis
Thu May 01 00:00:00 EDT 2014
High-risk human papillomavirus load and biomarkers in cervical intraepithelial neoplasia and cancer.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Chang MS,Oh S,Jung EJ,Park JH,Jeon HW,Lee TS,Kim JH,Choi E,Byeon SJ,Park IA
MA5-14520 was used in immunohistochemistry to study the relationships between high risk HPV load, the expression of various biomarkers, and cervical intraepithelial neoplasia and cancer
Thu May 01 00:00:00 EDT 2014
MET expression is associated with disease-specific survival in breast cancer patients in the neoadjuvant setting.
Pathology, research and practice
Koh YW,Lee HJ,Ahn JH,Lee JW,Gong G
MA5-14520 was used in immunohistochemistry to study the prognostic value of MET expression in breast cancer patienrs receiving neoadjuvant chemotherapy
Fri Aug 01 00:00:00 EDT 2014
Immunohistochemical distribution of cell cycle proteins p27, p57, cyclin D3, PCNA and Ki67 in normal and diabetic human placentas.
Journal of molecular histology
Unek G,Ozmen A,Mendilcioglu I,Simsek M,Korgun ET
MA5-14520 was used in immunohistochemistry to examine human placentas from control and diabetic subjects for the immunohistochemical localization of a number of cell cycle related proteins
Sat Feb 01 00:00:00 EST 2014
CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways.
Developmental biology
Saba R,Wu Q,Saga Y
MA5-14520 was used in immunohistochemistry to study the suppression of STRA8-dependent and -independent pathways in the mechanism by which CYP26B1 promotes the differentiation of male germ cells
Thu May 15 00:00:00 EDT 2014
NANOS2 promotes male germ cell development independent of meiosis suppression.
Developmental biology
Saba R,Kato Y,Saga Y
MA5-14520 was used in immunohistochemistry to study the mechanism underlying the role in male germ cell development of the NANOS2 RNA-binding protein
Wed Jan 01 00:00:00 EST 2014
Birthdating of myenteric neuron subtypes in the small intestine of the mouse.
The Journal of comparative neurology
Bergner AJ,Stamp LA,Gonsalvez DG,Allison MB,Olson DP,Myers MG,Anderson CR,Young HM
MA5-14520 was used in immunohistochemistry to determine when murine small intestine myenteric neuron subtypes are born
Sat Feb 15 00:00:00 EST 2014
The expression of cell cycle related proteins PCNA, Ki67, p27 and p57 in normal and preeclamptic human placentas.
Tissue & cell
Unek G,Ozmen A,Mendilcioglu I,Simsek M,Korgun ET
MA5-14520 was used in immunohistochemistry to examine human placentas from normal and preeclampsic pregnancies for the expression of PCNA, Ki67 and p57
Sun Jun 01 00:00:00 EDT 2014
Bronchiolar remodeling in adult mice following neonatal exposure to hyperoxia: relation to growth.
Anatomical record (Hoboken, N.J. : 2007)
O'Reilly M,Hansbro PM,Horvat JC,Beckett EL,Harding R,Sozo F
MA5-14520 was used in immunohistochemistry - paraffin section to study hyperoxia in neonatal bronchioles
Tue Apr 01 00:00:00 EDT 2014
Immunolocalization of cell cycle proteins (p57, p27, cyclin D3, PCNA and Ki67) in intrauterine growth retardation (IUGR) and normal human term placentas.
Acta histochemica
Unek G,Ozmen A,Ozekinci M,Sakinci M,Korgun ET
MA5-14520 was used in immunohistochemistry to perform a comparative study of intrauterine growth retardation and normal human term placentas in respect of the expression and localization of p57, p27, cyclin D3, PCNA and Ki67
Tue Apr 01 00:00:00 EDT 2014
Solitary tumours associated with Jaagsiekte retrovirus in sheep are heterogeneous and contain cells expressing markers identifying progenitor cells in lung repair.
Journal of comparative pathology
De las Heras M,de Martino A,Borobia M,Ortín A,Álvarez R,Borderías L,Giménez-Más JA
MA5-14520 was used in immunohistochemistry to study the heterogeneity and the presence of lung repair progenitor cells in Jaagsiekte retrovirus-associated solitary tumors in sheep
Tue Nov 18 00:00:00 EST 2014
Non-viral FoxM1 gene delivery to hepatocytes enhances liver repopulation.
Cell death & disease
Xiang D,Liu CC,Wang MJ,Li JX,Chen F,Yao H,Yu B,Lu L,Borjigin U,Chen YX,Zhong L,Wangensteen KJ,He ZY,Wang X,Hu YP
MA5-14520 was used in immunocytochemistry to study the enhanced proliferative and liver repopulation capacity of hepatocytes following transposon vector delivery of the FoxM1 gene
Thu May 22 00:00:00 EDT 2014
Renal tubular Notch signaling triggers a prosenescent state after acute kidney injury.
American journal of physiology. Renal physiology
Sörensen-Zender I,Rong S,Susnik N,Zender S,Pennekamp P,Melk A,Haller H,Schmitt R
MA5-14520 was used in immunohistochemistry to study the promotion of a pro-senescent state by tubular epithelial Notch signaling following kidney ischemia-reperfusion injury
Tue Apr 15 00:00:00 EDT 2014
Effects of siRNA on RET/PTC3 junction oncogene in papillary thyroid carcinoma: from molecular and cellular studies to preclinical investigations.
PloS one
Ali HM,Urbinati G,Chapuis H,Desmaele D,Bertrand JR,Couvreur P,Massaad-Massade L
MA5-14520 was used in immunohistochemistry to study the therapeutic effects against papillary thyroid carcinoma of siRNA-mediated knockdown of RET/PTC3 junction oncogene in cellular and murine models
Fri Jun 19 00:00:00 EDT 2015
Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma.
PLoS genetics
Kikuchi K,Hettmer S,Aslam MI,Michalek JE,Laub W,Wilky BA,Loeb DM,Rubin BP,Wagers AJ,Keller C
MA5-14520 was used in immunocytochemistry to investigate regulation of the Pax3:Foxo1a locus in cancer cells
Wed Jan 01 00:00:00 EST 2014
Nlrp3 prevents early renal interstitial edema and vascular permeability in unilateral ureteral obstruction.
PloS one
Pulskens WP,Butter LM,Teske GJ,Claessen N,Dessing MC,Flavell RA,Sutterwala FS,Florquin S,Leemans JC
MA5-14520 was used in immunohistochemistry to study the non-canonical role of the Nlrp3 inflammasome in protecting against renal interstitial edema and increased vascular permeability following unilateral ureteral obstruction
Sun Sep 21 00:00:00 EDT 2014
Influence of oxygen tension on dopaminergic differentiation of human fetal stem cells of midbrain and forebrain origin.
PloS one
Krabbe C,Bak ST,Jensen P,von Linstow C,Martínez Serrano A,Hansen C,Meyer M
MA5-14520 was used in immunocytochemistry to study human fetal midbrain and forebrain stem cells and the effect of oxygen tension on their dopaminergic differentiation
Tue Jun 23 00:00:00 EDT 2015
Characterization of the 9L gliosarcoma implanted in the Fischer rat: an orthotopic model for a grade IV brain tumor.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Bouchet A,Bidart M,Miladi I,Le Clec'h C,Serduc R,Coutton C,Regnard P,Khalil E,Dufort S,Lemasson B,Laissue J,Pelletier L,Le Duc G
MA5-14520 was used in immunohistochemistry to study an orthotopic model of grade IV brain tumor based on Fischer rats implanted in the right caudate nucleus of the brain with the 9L gliosarcoma
Tue Jul 01 00:00:00 EDT 2014
Novel epigenetic target therapy for prostate cancer: a preclinical study.
PloS one
Naldi I,Taranta M,Gherardini L,Pelosi G,Viglione F,Grimaldi S,Pani L,Cinti C
MA5-14520 was used in immunohistochemistry - frozen section to research a preclinical study on a novel epigenetic target therapy for prostate cancer
Tue Jan 20 00:00:00 EST 2015
Spdef deletion rescues the crypt cell proliferation defect in conditional Gata6 null mouse small intestine.
BMC molecular biology
Aronson BE,Stapleton KA,Vissers LA,Stokhuijzen E,Bruijnzeel H,Krasinski SD
MA5-14520 was used in immunohistochemistry to study the role of Spdef as a downstream effector of Gata6 and its role in modulating intestinal crypt cell proliferation
Tue Jan 28 00:00:00 EST 2014
CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling.
Oncotarget
Wang T,Guo S,Liu Z,Wu L,Li M,Yang J,Chen R,Liu X,Xu H,Cai S,Chen H,Li W,Xu S,Wang L,Hu Z,Zhuang Q,Wang L,Wu K,Liu J,Ye Z,Ji JY,Wang C,Chen K
MA5-14520 was used in immunohistochemistry - paraffin section to investigate the anti-tumor effect of CAMK2N1 on prostate cancer progression
Sat Nov 15 00:00:00 EST 2014
DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells.
Aging
Laos M,Anttonen T,Kirjavainen A,af Hällström T,Laiho M,Pirvola U
MA5-14520 was used in immunohistochemistry - paraffin section to study how proliferative restrictions of supporting cells are linked with DNA damage signaling
Sun Jun 01 00:00:00 EDT 2014
Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration.
Cell stem cell
Metcalfe C,Kljavin NM,Ybarra R,de Sauvage FJ
MA5-14520 was used in immunohistochemistry - paraffin section to study the role of Lgr5-positive stem cells during radiation-induced intestinal regeneration
Thu Feb 06 00:00:00 EST 2014
Neural crest-derived mesenchymal cells require Wnt signaling for their development and drive invagination of the telencephalic midline.
PloS one
Choe Y,Zarbalis KS,Pleasure SJ
MA5-14520 was used in western blot to study the role of Wnt signaling in the development of neural crest-derived mesenchymal cells and in the formation of cranial mesenchymal structures
Tue Jan 13 00:00:00 EST 2015
Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer.
Cell & bioscience
Kido T,Schubert S,Hatakeyama S,Ohyama C,Schmidtke J,Lau YF
MA5-14520 was used in immunohistochemistry to use a murine transgenic model to study the role of the Y-chromosome locatated human TSPY proto-oncogene in prostate cancer oncogenesis
Mon Feb 17 00:00:00 EST 2014
Comparative characterization of stroma cells and ductal epithelium in chronic pancreatitis and pancreatic ductal adenocarcinoma.
PloS one
Helm O,Mennrich R,Petrick D,Goebel L,Freitag-Wolf S,Röder C,Kalthoff H,Röcken C,Sipos B,Kabelitz D,Schäfer H,Oberg HH,Wesch D,Sebens S
MA5-14520 was used in immunohistochemistry - paraffin section to characterize stroma cells and ductal epithelium comparing chronic pancreatitis and pancreatic ductal adenocarcinoma
Fri Jun 12 00:00:00 EDT 2015
Molecular analysis of the KIT gene in gastrointestinal stromal tumors with novel mutations.
Applied immunohistochemistry & molecular morphology : AIMM
Calibasi G,Baskin Y,Alyuruk H,Cavas L,Oztop I,Sagol O,Atila K,Ellidokuz H,Yilmaz U
MA5-14520 was used in immunohistochemistry to study the clinicopathology of gastrointestinal stromal tumors with novel KIT mutations
Wed Jan 01 00:00:00 EST 2014
Conditioned medium from hypoxic bone marrow-derived mesenchymal stem cells enhances wound healing in mice.
PloS one
Chen L,Xu Y,Zhao J,Zhang Z,Yang R,Xie J,Liu X,Qi S
MA5-14520 was used in immunohistochemistry to study the improved murine skin wound healing observed following treatment with conditioned medium obtained from hypoxic cultures of bone marrow-derived mesenchymal stem cells
Thu Jan 22 00:00:00 EST 2015
Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers.
PloS one
Schleifman EB,Desai R,Spoerke JM,Xiao Y,Wong C,Abbas I,O'Brien C,Patel R,Sumiyoshi T,Fu L,Tam RN,Koeppen H,Wilson TR,Raja R,Hampton GM,Lackner MR
MA5-14520 was used in immunohistochemistry to analyze matched primary and metastatic tissue from ER-positive breast cancer patients for the expression of a panel of biomarkers
Mon Oct 13 00:00:00 EDT 2014
Immune status, strain background, and anatomic site of inoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas.
PloS one
Sundberg JP,Stearns TM,Joh J,Proctor M,Ingle A,Silva KA,Dadras SS,Jenson AB,Ghim SJ
MA5-14520 was used in immunohistochemistry - paraffin section to analyze mouse papillomavirus (MmuPV1) induction of endophytic trichoblastomas and exophytic papillomas for strain background, immune status, and anatomic site of inoculation
Tue Jul 28 00:00:00 EDT 2015
Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion.
The Journal of biological chemistry
Zhang H,von Gise A,Liu Q,Hu T,Tian X,He L,Pu W,Huang X,He L,Cai CL,Camargo FD,Pu WT,Zhou B
MA5-14520 was used in immunohistochemistry to study atrioventricular endothelial-to-mesenchymal transition and the role of Yap1
Fri Jul 04 00:00:00 EDT 2014
Tis21 is required for adult neurogenesis in the subventricular zone and for olfactory behavior regulating cyclins, BMP4, Hes1/5 and Ids.
Frontiers in cellular neuroscience
Farioli-Vecchioli S,Ceccarelli M,Saraulli D,Micheli L,Cannas S,D'Alessandro F,Scardigli R,Leonardi L,Cinà I,Costanzi M,Mattera A,Cestari V,Tirone F
MA5-14520 was used in immunohistochemistry to study the role of Tis21 in adult subventricular neurogenesis and olfactory performance
Fri Apr 18 00:00:00 EDT 2014
Enhanced Wnt/β-catenin and Notch signalling in the activated canine hepatic progenitor cell niche.
BMC veterinary research
Schotanus BA,Kruitwagen HS,van den Ingh TS,van Wolferen ME,Rothuizen J,Penning LC,Spee B
MA5-14520 was used in immunohistochemistry - paraffin section to study canine hepatic progenitor cell niche activation by enhanced Wnt/beta-catenin and Notch signaling
Wed Dec 31 00:00:00 EST 2014
GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.
Nature
Atwood SX,Li M,Lee A,Tang JY,Oro AE
MA5-14520 was used in immunohistochemistry to study the modulation of basal cell carcinoma growth by atypical PKC iota/lambda-mediated activation of the GLI transcription factor
Thu Feb 28 00:00:00 EST 2013
A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.
Cancer cell
Pribluda A,Elyada E,Wiener Z,Hamza H,Goldstein RE,Biton M,Burstain I,Morgenstern Y,Brachya G,Billauer H,Biton S,Snir-Alkalay I,Vucic D,Schlereth K,Mernberger M,Stiewe T,Oren M,Alitalo K,Pikarsky E,Ben-Neriah Y
MA5-14520 was used in immunohistochemistry to study the senescence-associated inflammatory response and how it can switch from being cancer inhibitory to a cancer promoting
Mon Aug 12 00:00:00 EDT 2013
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.
Nature immunology
Huang LR,Wohlleber D,Reisinger F,Jenne CN,Cheng RL,Abdullah Z,Schildberg FA,Odenthal M,Dienes HP,van Rooijen N,Schmitt E,Garbi N,Croft M,Kurts C,Kubes P,Protzer U,Heikenwalder M,Knolle PA
MA5-14520 was used in immunohistochemistry to study the local expansion of CD8-positice T-cells in intrahepatic myeloid-cell aggregates and the implications for chronic hepatic viral infection immunotherapy
Sat Jun 01 00:00:00 EDT 2013
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation.
Nature neuroscience
Bardehle S,Krüger M,Buggenthin F,Schwausch J,Ninkovic J,Clevers H,Snippert HJ,Theis FJ,Meyer-Luehmann M,Bechmann I,Dimou L,Götz M
MA5-14520 was used in immunocytochemistry and immunohistochemistry to use in vivo two-photon laser-scanning microscopy to study the proliferation of juxtavascular astrocytes in response to injury in the adult murine brain
Wed May 01 00:00:00 EDT 2013
Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.
Cell stem cell
Wang S,Bates J,Li X,Schanz S,Chandler-Militello D,Levine C,Maherali N,Studer L,Hochedlinger K,Windrem M,Goldman SA
MA5-14520 was used in immunohistochemistry to study the myelination and rescue of a murine model of congenital hypomyelination using oligidendrocyte precursor cells derived from human induced pluripotent stem cells
Thu Feb 07 00:00:00 EST 2013
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.
Cell stem cell
Takubo K,Nagamatsu G,Kobayashi CI,Nakamura-Ishizu A,Kobayashi H,Ikeda E,Goda N,Rahimi Y,Johnson RS,Soga T,Hirao A,Suematsu M,Suda T
MA5-14520 was used in immunocytochemistry to study the modulation of hematopoietic stem cell quiescence by a Pdk-regulated glycolytic cell cycle check point
Thu Jan 03 00:00:00 EST 2013
Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.
Cell stem cell
Schepers K,Pietras EM,Reynaud D,Flach J,Binnewies M,Garg T,Wagers AJ,Hsiao EC,Passegué E
MA5-14520 was used in immunohistochemistry to study the remodeling of the endosteal bone marrow niche into a self-renewing leukemic niche by myeloproliferative neoplasia
Thu Sep 05 00:00:00 EDT 2013
Lithium rescues synaptic plasticity and memory in Down syndrome mice.
The Journal of clinical investigation
Contestabile A,Greco B,Ghezzi D,Tucci V,Benfenati F,Gasparini L
MA5-14520 was used in immunohistochemistry to study the molecular and cellular mechanisms underlying the beneficial effects of lithium on synaptic plasticity and memory in a murine model of Down syndrome
Tue Jan 01 00:00:00 EST 2013
The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus.
Neuron
Li G,Fang L,Fernández G,Pleasure SJ
MA5-14520 was used in immunohistochemistry to investigate the embryonic origin of long-lived adult neural stem cells of the dentate gyrus
Wed May 22 00:00:00 EDT 2013
Enhanced liver progenitor cell survival and differentiation in vivo by spheroid implantation in a vascularized tissue engineering chamber.
Biomaterials
Yap KK,Dingle AM,Palmer JA,Dhillon RS,Lokmic Z,Penington AJ,Yeoh GC,Morrison WA,Mitchell GM
MA5-14520 was used in immunohistochemistry to develop a novel vascularized tissue engineering chamber in combination with liver progenitor cell spheroids that results in enhanced cell survival
Wed May 01 00:00:00 EDT 2013
Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models.
Clinical cancer research : an official journal of the American Association for Cancer Research
Flanigan SA,Pitts TM,Newton TP,Kulikowski GN,Tan AC,McManus MC,Spreafico A,Kachaeva MI,Selby HM,Tentler JJ,Eckhardt SG,Leong S
MA5-14520 was used in immunohistochemistry to study the synergistic therapeutic effects in colorectal cancer of combined pharmacological inhibition of MEK and IGR1R/IR
Fri Nov 15 00:00:00 EST 2013
Serial diffusion MRI to monitor and model treatment response of the targeted nanotherapy CRLX101.
Clinical cancer research : an official journal of the American Association for Cancer Research
Ng TS,Wert D,Sohi H,Procissi D,Colcher D,Raubitschek AA,Jacobs RE
MA5-14520 was used in immunohistochemistry to study the use of serial diffusion MRI to monitor the response to a cyclodextrin polymer nanoparticle containing a DNA topoisomerase I inhibitor in a murine lymphoma model
Wed May 01 00:00:00 EDT 2013
Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Radhakrishnan P,Bryant VC,Blowers EC,Rajule RN,Gautam N,Anwar MM,Mohr AM,Grandgenett PM,Bunt SK,Arnst JL,Lele SM,Alnouti Y,Hollingsworth MA,Natarajan A
MA5-14520 was used in immunohistochemistry to study the therapeutic activity and molecular mechanism of a quinoxaline urea-based IKKbeta inhibitor in pancreatic cancer
Mon Apr 15 00:00:00 EDT 2013
Dynamics of senescent cell formation and retention revealed by p14ARF induction in the epidermis.
Cancer research
Tokarsky-Amiel R,Azazmeh N,Helman A,Stein Y,Hassan A,Maly A,Ben-Porath I
MA5-14520 was used in immunohistochemistry to study the role of p14ARF in cellular senescence using a conditional transgenic murine model
Wed May 01 00:00:00 EDT 2013
Acquired expression of NFATc1 downregulates E-cadherin and promotes cancer cell invasion.
Cancer research
Oikawa T,Nakamura A,Onishi N,Yamada T,Matsuo K,Saya H
MA5-14520 was used in immunohistochemistry to study the role of E-cadherin downregulation in the mechanism by which acquired expression of NFATc1 promotes the invasiveness of human carcinoma cells
Thu Aug 15 00:00:00 EDT 2013
PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition.
Cancer research
Metcalfe C,Alicke B,Crow A,Lamoureux M,Dijkgraaf GJ,Peale F,Gould SE,de Sauvage FJ
MA5-14520 was used in immunohistochemistry to study the anti-tumor effects of Hedgehog pathway inhibition in medulloblastoma and the effects of PTEN loss
Sun Dec 01 00:00:00 EST 2013
FGFR1 is essential for prostate cancer progression and metastasis.
Cancer research
Yang F,Zhang Y,Ressler SJ,Ittmann MM,Ayala GE,Dang TD,Wang F,Rowley DR
MA5-14520 was used in immunohistochemistry to study the progression and metastasis of prostate cancer and the essential role played by FGFR1 signaling
Sat Jun 15 00:00:00 EDT 2013
State-dependent signaling by Cav1.2 regulates hair follicle stem cell function.
Genes & development
Yucel G,Altindag B,Gomez-Ospina N,Rana A,Panagiotakos G,Lara MF,Dolmetsch R,Oro AE
MA5-14520 was used in immunohistochemistry to study the mechanism by which Cav1.2 modulates the function of hair follicle stem cells
Sat Jun 01 00:00:00 EDT 2013
Hepatic regeneration and functional recovery following partial liver resection in an experimental model of hepatic steatosis treated with omega-3 fatty acids.
The British journal of surgery
Marsman HA,de Graaf W,Heger M,van Golen RF,Ten Kate FJ,Bennink R,van Gulik TM
MA5-14520 was used in immunohistochemistry to study the beneficial effects of omega-3 fatty acids on liver regeneration in a rat model of hepatic steatosis
Mon Apr 01 00:00:00 EDT 2013
Fibrin-based scaffold incorporating VEGF- and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice.
Acta biomaterialia
Losi P,Briganti E,Errico C,Lisella A,Sanguinetti E,Chiellini F,Soldani G
MA5-14520 was used in immunohistochemistry to study the stimulation of murine diabetic wound healing by a fibrin-based scaffold incorporating nanoparticles containing VEGF and bFGF
Thu Aug 01 00:00:00 EDT 2013
Systemic regulation of the age-related decline of pancreatic β-cell replication.
Diabetes
Salpeter SJ,Khalaileh A,Weinberg-Corem N,Ziv O,Glaser B,Dor Y
MA5-14520 was used in immunohistochemistry to study the age-related decline in the replicative capacity of panceatic beta-cells and the potential involvement of systemic factors
Thu Aug 01 00:00:00 EDT 2013
eIF4F suppression in breast cancer affects maintenance and progression.
Oncogene
Nasr Z,Robert F,Porco JA,Muller WJ,Pelletier J
MA5-14520 was used in immunohistochemistry to study the role and therapeutic potential of the mTOR-eIF4F axis in breast cancer
Thu Feb 14 00:00:00 EST 2013
Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis.
Oncogene
Akbay EA,Peña CG,Ruder D,Michel JA,Nakada Y,Pathak S,Multani AS,Chang S,Castrillon DH
MA5-14520 was used in immunohistochemistry to study the roles of p53 and Pot1a in endometrial carcinogenesis
Thu Apr 25 00:00:00 EDT 2013
Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer.
Breast cancer research : BCR
Wang S,Huang J,Lyu H,Cai B,Yang X,Li F,Tan J,Edgerton SM,Thor AD,Lee CK,Liu B
MA5-14520 was used in immunohistochemistry to study the enhanced anti-tumor effects in models of erbB2-expressing breast cancer of a combination of paclitaxel plus an anti-erbB3 antibody
Thu Sep 11 00:00:00 EDT 2014
K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Boecker W,Stenman G,Loening T,Andersson MK,Bankfalvi A,von Holstein S,Heegaard S,Lange A,Berg T,Samoilova V,Tiemann K,Buchwalow I
MA5-14520 was used in immunohistochemistry to study myoepithelial differentiation in salivary gland-like breast tumors and the involvement of cells expressing K5 and K14 keratins
Thu Aug 01 00:00:00 EDT 2013
Cyclin D1 is required for proliferation of Olig2-expressing progenitor cells in the injured cerebral cortex.
Glia
Nobs L,Nestel S,Kulik A,Nitsch C,Atanasoski S
MA5-14520 was used in immunohistochemistry to study the role of cyclin D1 and Cdk4 in the cerebral cortical injury-induced proliferation of Olig2-positive oligodendrocyte progenitors in a murine model
Sun Sep 01 00:00:00 EDT 2013
Is Ki-67 expression prognostic for local relapse in early-stage breast cancer patients treated with breast conservation therapy (BCT)?
International journal of radiation oncology, biology, physics
Hafeez F,Neboori HJ,Harigopal M,Wu H,Haffty BG,Yang Q,Schiff D,Moran MS
MA5-14520 was used in immunohistochemistry to study whether Ki67 expression is of prognostic value in breast cancer patients undergoing breast conservation therapy
Tue Oct 01 00:00:00 EDT 2013
Histology-driven data mining of lipid signatures from multiple imaging mass spectrometry analyses: application to human colorectal cancer liver metastasis biopsies.
Analytical chemistry
Thomas A,Patterson NH,Marcinkiewicz MM,Lazaris A,Metrakos P,Chaurand P
MA5-14520 was used in immunohistochemistry to study the use of imaging mass spectrometry data mining to identify lipid signatures of relevance to human colorectal cancer liver metastasis
Tue Mar 05 00:00:00 EST 2013
Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma.
The Journal of investigative dermatology
Liu W,Luo Y,Dunn JH,Norris DA,Dinarello CA,Fujita M
MA5-14520 was used in immunohistochemistry to study the mechanisms underlying the role of ASC in human melanoma tumorigenesis
Fri Feb 01 00:00:00 EST 2013
An in vivo screen of secreted proteins identifies adiponectin as a regulator of murine cutaneous wound healing.
The Journal of investigative dermatology
Salathia NS,Shi J,Zhang J,Glynne RJ
MA5-14520 was used in immunohistochemistry to study the ability of adiponectin to promote cutaneous wound healing in mice
Fri Mar 01 00:00:00 EST 2013
Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome.
Antioxidants & redox signaling
Villegas LR,Kluck D,Field C,Oberley-Deegan RE,Woods C,Yeager ME,El Kasmi KC,Savani RC,Bowler RP,Nozik-Grayck E
MA5-14520 was used in immunohistochemistry to study the protective effects of a pharmacological SOD mimetic against the effects of chronic hypoxia on pulmonary hypertension, vascular changes and inflammatory responses
Fri May 10 00:00:00 EDT 2013
Combination therapy of cilengitide with belotecan against experimental glioblastoma.
International journal of cancer
Kim YH,Lee JK,Kim B,DeWitt JP,Lee JE,Han JH,Kim SK,Oh CW,Kim CY
MA5-14520 was used in immunohistochemistry to study the efficacy of combination therapy with cilengitide plus belotecan against murine xenografts of human glioblastoma
Thu Aug 01 00:00:00 EDT 2013
Targeting 5-HT(1A) receptors in astrocytes to protect dopaminergic neurons in Parkinsonian models.
Neurobiology of disease
Miyazaki I,Asanuma M,Murakami S,Takeshima M,Torigoe N,Kitamura Y,Miyoshi K
MA5-14520 was used in immunocytochemistry to study the protection of dopaminergic neurons in models of Parkinson's disease by agonist-mediated activation of astrocyte 5-HT(1A) receptors and the role of increased metallothionein expression
Fri Nov 01 00:00:00 EDT 2013
Proliferation and cell cycle dynamics in the developing stellate ganglion.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gonsalvez DG,Cane KN,Landman KA,Enomoto H,Young HM,Anderson CR
MA5-14520 was used in immunohistochemistry to study cellular proliferation in the murine embryonic stellate ganglion
Wed Apr 03 00:00:00 EDT 2013
MEN1 intragenic deletions may represent the most prevalent somatic event in sporadic primary hyperparathyroidism.
European journal of endocrinology
Alvelos MI,Vinagre J,Fonseca E,Barbosa E,Teixeira-Gomes J,Sobrinho-Simões M,Soares P
MA5-14520 was used in immunohistochemistry to study the role of intragenic deletions of MEN1 in sporadic primary hyperparathyroidism
Fri Feb 01 00:00:00 EST 2013
Characterization of WWOX inactivation in murine mammary gland development.
Journal of cellular physiology
Abdeen SK,Salah Z,Khawaled S,Aqeilan RI
MA5-14520 was used in immunohistochemistry to study the role of WWOX in normal breast development and tumorigenesis in a conditional knockout mouse model
Mon Jul 01 00:00:00 EDT 2013
In vitro and in vivo activity of cabozantinib (XL184), an inhibitor of RET, MET, and VEGFR2, in a model of medullary thyroid cancer.
Thyroid : official journal of the American Thyroid Association
Bentzien F,Zuzow M,Heald N,Gibson A,Shi Y,Goon L,Yu P,Engst S,Zhang W,Huang D,Zhao L,Vysotskaia V,Chu F,Bautista R,Cancilla B,Lamb P,Joly AH,Yakes FM
MA5-14520 was used in immunohistochemistry to study the biochemical activity of cabozantiinib against disease-associated RET mutants and its growth inhibitory activity in medullary thyroid cancer models
Sun Dec 01 00:00:00 EST 2013
Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Maruyama T,Jiang M,Hsu W
MA5-14520 was used in immunohistochemistry to study the molecular mechanisms underlying the modulation of skeletal development by Gpr177
Wed May 01 00:00:00 EDT 2013
Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas.
The American journal of surgical pathology
Deyrup AT,Chibon F,Guillou L,Lagarde P,Coindre JM,Weiss SW
MA5-14520 was used in immunohistochemistry to report on a distinct group of liposarcomas termed fibrosarcoma-like lipomatous neoplasm
Sun Sep 01 00:00:00 EDT 2013
Combined targeting of mTOR and AKT is an effective strategy for basal-like breast cancer in patient-derived xenograft models.
Molecular cancer therapeutics
Xu S,Li S,Guo Z,Luo J,Ellis MJ,Ma CX
MA5-14520 was used in immunohistochemistry to use patient-derived xenograft models to study the efficacy of combined inhibition of mTOR and Akt in basal-like breast cancer
Thu Aug 01 00:00:00 EDT 2013
miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression.
The American journal of pathology
Ohyagi-Hara C,Sawada K,Kamiura S,Tomita Y,Isobe A,Hashimoto K,Kinose Y,Mabuchi S,Hisamatsu T,Takahashi T,Kumasawa K,Nagata S,Morishige K,Lengyel E,Kurachi H,Kimura T
MA5-14520 was used in immunohistochemistry to study the role of reduced integrin ?5 expression in the mechanism by which miR-92a inhibits the peritoneal dissemination of ovarian cancer cells
Wed May 01 00:00:00 EDT 2013
The regulation of SOX7 and its tumor suppressive role in breast cancer.
The American journal of pathology
Stovall DB,Wan M,Miller LD,Cao P,Maglic D,Zhang Q,Stampfer MR,Liu W,Xu J,Sui G
MA5-14520 was used in immunohistochemistry to study the regulation of the SOX7 tumor suppressor in breast cancer
Fri Nov 01 00:00:00 EDT 2013
Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer.
The American journal of pathology
Zhu S,Mott RT,Fry EA,Taneja P,Kulik G,Sui G,Inoue K
MA5-14520 was used in immunohistochemistry to study the significance in breast cancer of Dmp1 loss coupled with cyclin D1 overexpression
Tue Oct 01 00:00:00 EDT 2013
Expression of Lewis X is associated with poor prognosis in triple-negative breast cancer.
American journal of clinical pathology
Koh YW,Lee HJ,Ahn JH,Lee JW,Gong G
MA5-14520 was used in immunohistochemistry to study the prognostic value of Lewis X expression in triple-negative breast cancer
Sat Jun 01 00:00:00 EDT 2013
The oxysterol receptors LXRα and LXRβ suppress proliferation in the colon.
Molecular carcinogenesis
Vedin LL,Gustafsson JÅ,Steffensen KR
MA5-14520 was used in immunohistochemistry to study the role of oxysterol receptors LXRalpha and LXRbeta in suppressing proliferation in the colon
Fri Nov 01 00:00:00 EDT 2013
Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory.
Neurobiology of aging
Pristerà A,Saraulli D,Farioli-Vecchioli S,Strimpakos G,Costanzi M,di Certo MG,Cannas S,Ciotti MT,Tirone F,Mattei E,Cestari V,Canu N
MA5-14520 was used in immunocytochemistry and immunohistochemistry to study the effects of a pathogenic tau fragment on hippocampal neurogenesis, behaviour and learning
Fri Nov 01 00:00:00 EDT 2013
Diet-induced obesity increases tumor growth and promotes anaplastic change in thyroid cancer in a mouse model.
Endocrinology
Kim WG,Park JW,Willingham MC,Cheng SY
MA5-14520 was used in immunohistochemistry to study the molecular mechanisms underlying the promotion of anaplastic change and tumor growth in a murine model of thyroid cancer by a high-fat diet
Thu Aug 01 00:00:00 EDT 2013
An integrated computational/experimental model of lymphoma growth.
PLoS computational biology
Frieboes HB,Smith BR,Chuang YL,Ito K,Roettgers AM,Gambhir SS,Cristini V
MA5-14520 was used in immunohistochemistry to develop an in silico model of the growth of non-Hodgkin's lymphoma
Fri Nov 08 00:00:00 EST 2013
Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.
Carcinogenesis
You X,Liu F,Zhang T,Li Y,Ye L,Zhang X
MA5-14520 was used in immunohistochemistry to study the abnormal lipogenesis and induction of hepatoma cell proliferation by HBV X-protein and the role of the Rab18 oncogene
Mon Jul 01 00:00:00 EDT 2013
Nuclear karyopherin-α2 expression in primary lesions and metastatic lymph nodes was associated with poor prognosis and progression in gastric cancer.
Carcinogenesis
Altan B,Yokobori T,Mochiki E,Ohno T,Ogata K,Ogawa A,Yanai M,Kobayashi T,Luvsandagva B,Asao T,Kuwano H
MA5-14520 was used in immunohistochemistry to study the prognostic and predictive value of the immunohistochemical expression of KPNA2 in primary lesions and metastatic lymph nodes of patients with gastric cancer
Tue Oct 01 00:00:00 EDT 2013
MEK inhibition increases lapatinib sensitivity via modulation of FOXM1.
Current medicinal chemistry
Gayle SS,Castellino RC,Buss MC,Nahta R
MA5-14520 was used in immunohistochemistry to study the role of FOXM1 in the mechanism by which MEK inhibition increases sensitivity to lapatinib
Fri Nov 08 00:00:00 EST 2013
Impaired basal and running-induced hippocampal neurogenesis coincides with reduced Akt signaling in adult R6/1 HD mice.
Molecular and cellular neurosciences
Ransome MI,Hannan AJ
MA5-14520 was used in immunohistochemistry to study the significance of reduced Akt levels in the decreased levels of basal and running-induced neurogenesis observed in the hippocampus of a murine model of Huntington's disease
Wed May 01 00:00:00 EDT 2013
Is survivin expression prognostic or predictive in malignant pleural mesothelioma?
Virchows Archiv : an international journal of pathology
Hmeljak J,Erčulj N,Dolžan V,Pižem J,Kern I,Kovač V,Cemažar M,Cör A
MA5-14520 was used in immunohistochemistry to study the prognostic and predictive value of survivin expression in malignant pleural mesothelioma
Fri Mar 01 00:00:00 EST 2013
Microvessel proliferation by co-expression of endothelial nestin and Ki-67 is associated with a basal-like phenotype and aggressive features in breast cancer.
Breast (Edinburgh, Scotland)
Krüger K,Stefansson IM,Collett K,Arnes JB,Aas T,Akslen LA
MA5-14520 was used in immunohistochemistry to study the association of endothelial nestin and Ki-67 coexpression with microvessel proliferation and aggressive breast cancer
Sat Jun 01 00:00:00 EDT 2013
Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling.
Biology of reproduction
Defalco T,Saraswathula A,Briot A,Iruela-Arispe ML,Capel B
MA5-14520 was used in immunohistochemistry to show the mechanism for the effect of testosterone on mouse fetal Leydig cell progenitors
Mon Apr 01 00:00:00 EDT 2013
Enhanced oxygen supply improves islet viability in a new bioartificial pancreas.
Cell transplantation
Barkai U,Weir GC,Colton CK,Ludwig B,Bornstein SR,Brendel MD,Neufeld T,Bremer C,Leon A,Evron Y,Yavriyants K,Azarov D,Zimermann B,Maimon S,Shabtay N,Balyura M,Rozenshtein T,Vardi P,Bloch K,de Vos P,Rotem A
MA5-14520 was used in immunohistochemistry to study the function of an implantable bioartificial pancreas and the requirement for an enhanced supply of oxygen
Tue Apr 08 00:00:00 EDT 2014
SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein.
Oncology reports
Kuo SJ,Lin HY,Chien SY,Chen DR
MA5-14520 was used in immunohistochemistry to study the role of reduced Bcl-2 levels in the mechanism by which SIRT1 inhibition suppresses the growth of breast cancer
Mon Jul 01 00:00:00 EDT 2013
Methyl donor deficiency affects small-intestinal differentiation and barrier function in rats.
The British journal of nutrition
Bressenot A,Pooya S,Bossenmeyer-Pourie C,Gauchotte G,Germain A,Chevaux JB,Coste F,Vignaud JM,Guéant JL,Peyrin-Biroulet L
MA5-14520 was used in immunohistochemistry to study the effects on rat small-intestinal enterocyte differentiation and barrier function of a diet deficient in methyl donors
Thu Feb 28 00:00:00 EST 2013
Podocyte repopulation by renal progenitor cells following glucocorticoids treatment in experimental FSGS.
American journal of physiology. Renal physiology
Zhang J,Pippin JW,Krofft RD,Naito S,Liu ZH,Shankland SJ
MA5-14520 was used in immunocytochemistry to study the effect of glucocorticoid therapy on the repopulation of podocytes by renal progenitor cells in a murine model of focal segmental glomerulosclerosis
Sat Jun 01 00:00:00 EDT 2013
Donor cornea transfer from Optisol GS to organ culture storage: a two-step procedure to increase donor tissue lifespan.
Acta ophthalmologica
Haug K,Azqueta A,Johnsen-Soriano S,Shahdadfar A,Drolsum LK,Moe MC,Røger MT,Romero FJ,Collins AR,Nicolaissen B
MA5-14520 was used in immunohistochemistry to study the effect of transfer from Optisol-GS to organ culture storage of the lifespan of donor corneas
Wed May 01 00:00:00 EDT 2013
VEGF expression and microvascular responses to severe transient hypoxia in the fetal sheep brain.
Pediatric research
Baburamani AA,Castillo-Melendez M,Walker DW
MA5-14520 was used in immunohistochemistry to study the effects of severe transient cerebral hypoxia on VEGF expression and microvascular changes in a fetal sheep model
Fri Mar 01 00:00:00 EST 2013
LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.
Investigational new drugs
Yan SB,Peek VL,Ajamie R,Buchanan SG,Graff JR,Heidler SA,Hui YH,Huss KL,Konicek BW,Manro JR,Shih C,Stewart JA,Stewart TR,Stout SL,Uhlik MT,Um SL,Wang Y,Wu W,Yan L,Yang WJ,Zhong B,Walgren RA
MA5-14520 was used in immunohistochemistry to study the anti-tumor activity in murine xenograft models of a novel bioavailable kinase inhibitor displaying activity against multiple receptor tyrosine kinases
Thu Aug 01 00:00:00 EDT 2013
Signature patterns of human papillomavirus type 16 in invasive anal carcinoma.
Human pathology
Valmary-Degano S,Jacquin E,Prétet JL,Monnien F,Girardo B,Arbez-Gindre F,Joly M,Bosset JF,Kantelip B,Mougin C
MA5-14520 was used in immunohistochemistry to study HPV16 infection in patients with invasive anal carcinoma
Sat Jun 01 00:00:00 EDT 2013
Lack of high-dose radiation mediated prostate cancer promotion and low-dose radiation adaptive response in the TRAMP mouse model.
Radiation research
Lawrence MD,Ormsby RJ,Blyth BJ,Bezak E,England G,Newman MR,Tilley WD,Sykes PJ
MA5-14520 was used in immunohistochemistry to study the lack of effect of either low-dose or high-dose radiation on prostate cancer growth in the TRAMP mouse model
Tue Oct 01 00:00:00 EDT 2013
Contribution of DOG1 expression to the diagnosis of gastrointestinal stromal tumors.
Pathology, research and practice
Kara T,Serinsoz E,Arpaci RB,Gubur O,Orekici G,Ata A,Colak T,Arican A
MA5-14520 was used in immunohistochemistry to study the diagnostic value of the immunohistochemical expression of DOG1 in gastrointestinal stromal tumors
Mon Jul 01 00:00:00 EDT 2013
The PPARγ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model.
Cancer chemotherapy and pharmacology
Grommes C,Karlo JC,Caprariello A,Blankenship D,Dechant A,Landreth GE
MA5-14520 was used in immunohistochemistry to study the ability of pioglitazone to penetrate the murine blood-brain barrier and inhibit the growth of human glioma xenografts
Mon Apr 01 00:00:00 EDT 2013
Suppression of cytochrome P450 reductase expression promotes astrocytosis in subventricular zone of adult mice.
Neuroscience letters
Yao Y,Liu S,Wang Y,Yuan W,Ding X,Cheng T,Shen Q,Gu J
MA5-14520 was used in immunohistochemistry to study the role of NADPH cytochrome P450 in preventing subventricular zone astrocytosis in adult mice
Mon Aug 26 00:00:00 EDT 2013
A cell population that strongly expresses the CB1 cannabinoid receptor in the ependyma of the rat spinal cord.
The Journal of comparative neurology
Garcia-Ovejero D,Arevalo-Martin A,Paniagua-Torija B,Sierra-Palomares Y,Molina-Holgado E
MA5-14520 was used in immunohistochemistry to study the expression of CB1 cannabinoid receptor in the ependyma of the rat spinal cord
Tue Jan 01 00:00:00 EST 2013
Transcription factor Sox11 is essential for both embryonic and adult neurogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists
Wang Y,Lin L,Lai H,Parada LF,Lei L
MA5-14520 was used in immunohistochemistry to study the neurogenic role of Sox11 in both embryonic and adult mice
Sat Jun 01 00:00:00 EDT 2013
The effects of ulipristal on Bax/Bcl-2, cytochrome c, Ki-67 and cyclooxygenase-2 expression in a rat model with surgically induced endometriosis.
European journal of obstetrics, gynecology, and reproductive biology
Huniadi CA,Pop OL,Antal TA,Stamatian F
MA5-14520 was used in immunohistochemistry to use a rat model of endometriosis to study the effects of ulipristal on endometrial histology and the expression of Bax/Bcl-2, cytochrome c, Ki-67 and COX-2
Mon Jul 01 00:00:00 EDT 2013
Complementary expression and repulsive signaling suggest that EphB2 and ephrin-B1 are possibly involved in epithelial boundary formation at the squamocolumnar junction in the rodent stomach.
Histochemistry and cell biology
Ogawa K,Saeki N,Igura Y,Hayashi Y
MA5-14520 was used in immunohistochemistry to study the potential involvement of EphB2 and ephrin-B1 in the formation of the epithelial boundary at the squamocolumnar junction
Sun Dec 01 00:00:00 EST 2013
FDG PET in the evaluation of phaeochromocytoma: a correlative study with MIBG scintigraphy and Ki-67 proliferative index.
Clinical imaging
Lin M,Wong V,Yap J,Jin R,Leong P,Campbell P
MA5-14520 was used in immunohistochemistry to study whether flurodeoxyglucose PET, MIBG scintigraphy and Ki-67 proliferation index correlate in patients with phaeochromocytoma
Wed Aug 06 00:00:00 EDT 2014
Slow turning lateral vessel bioreactor improves embryoid body formation and cardiogenic differentiation of mouse embryonic stem cells.
Cellular reprogramming
Rungarunlert S,Klincumhom N,Tharasanit T,Techakumphu M,Pirity MK,Dinnyes A
MA5-14520 was used in immunohistochemistry to study the increased formation of embroid bodies and cardiomyocytic differentiation of murine embryonic stem cells cultured in a slow turning lateral vessel bioreactor
Tue Oct 01 00:00:00 EDT 2013
Local insulin application on the carotid artery inhibits neointima formation.
Canadian journal of physiology and pharmacology
Chiang S,Breen DM,Guo J,Mori Y,Giacca A
MA5-14520 was used in immunohistochemistry to study the inhibition of neointima formation by local insulin administration to the carotid artery following balloon-mediated injury
Sun Dec 01 00:00:00 EST 2013
Adenovirus-mediated interferon-γ gene therapy induced human pancreatic carcinoma Capan-2 cell apoptosis in vitro and in vivo.
Anatomical record (Hoboken, N.J. : 2007)
Xie FJ,Zhao P,Zhang YP,Liu FY,Nie XL,Zhu YH,Yu XM,Zheng QQ,Mao WM,Lu HY,Wei H,Huang W
MA5-14520 was used in immunohistochemistry to study the ability of adenoviral delivery of IFN-gamma to inhibit the growth of a human pancreatic carcinoma cell line via the induction of apoptosis
Mon Apr 01 00:00:00 EDT 2013
Role of Langerhans cells, Ki-67 protein and apoptosis in acquired cholesteatoma: prospective clinical study.
The Journal of laryngology and otology
Akdogan V,Yilmaz I,Canpolat T,Ozluoglu LN
MA5-14520 was used in immunohistochemistry to study the role of Langerhans cells in the pathogenesis of acquired cholesteatoma
Fri Mar 01 00:00:00 EST 2013
Expression of matrix metalloproteinase-13 and Ki-67 in nonmelanoma skin cancer in xeroderma pigmentosum and non-xeroderma pigmentosum.
The American Journal of dermatopathology
El-Hawary AK,Yassin E,Khater A,Abdelgaber S
MA5-14520 was used in immunohistochemistry to study the pathological significance of MMP13 and Ki-67 expression in basal cell carcinomas and squamous cell carcinomas in xeroderma pigmentosum patients
Fri Feb 01 00:00:00 EST 2013
Insulinoma diagnosed as drug-refractory epilepsy in an adolescent boy: a case report.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Horváth E,Gozar H,Chira L,Dunca I,Kiss E,Pávai Z
MA5-14520 was used in immunohistochemistry to report on a case of pediatric insulinoma
Wed Jul 02 00:00:00 EDT 2014
Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.
PLoS genetics
Esnault C,Cornelis G,Heidmann O,Heidmann T
MA5-14520 was used in immunohistochemistry to study the evolutionary fates of the envV gene captured from the endogenous retrovirus type V provirus to play a role in placentation in ancestral primates
Fri Mar 01 00:00:00 EST 2013
Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors.
PloS one
Yumoto T,Nakadate K,Nakamura Y,Sugitani Y,Sugitani-Yoshida R,Ueda S,Sakakibara S
MA5-14520 was used in immunohistochemistry to study the role of the novel mitotic spindle protein radmis in neural progenitor cell division
Mon Jul 07 00:00:00 EDT 2014
Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases.
BMC neuroscience
Smardencas A,Rizkalla K,Kim HA,Massalas J,O'Leary C,Ehrlich ME,Schütz G,Lawrence AJ,Drago J
MA5-14520 was used in immunohistochemistry to study murine models in order to identify the cell-types being generated from dividing progenitors in neurodegenerative basal ganglia diseases
Thu Oct 03 00:00:00 EDT 2013
Effects of steroid hormones on differentiated glandular epithelial and stromal cells in a three dimensional cell culture model of the canine endometrium.
BMC veterinary research
Bartel C,Tichy A,Schoenkypl S,Aurich C,Walter I
MA5-14520 was used in immunohistochemistry to study the effects of steroid hormones on estrogen and progesterone receptor expression and cell proliferation in a 3-dimensional cell culture model of dog endometrium
Wed Apr 24 00:00:00 EDT 2013
Glycyrrhizic acid suppresses the development of precancerous lesions via regulating the hyperproliferation, inflammation, angiogenesis and apoptosis in the colon of Wistar rats.
PloS one
Khan R,Khan AQ,Lateef A,Rehman MU,Tahir M,Ali F,Hamiza OO,Sultana S
MA5-14520 was used in immunohistochemistry to the study the mechanisms by which glycyrrhizic acid suppresses the formation of precancerous lesions in the rat colon
Mon Aug 26 00:00:00 EDT 2013
Specimen quality evaluation in Canadian biobanks participating in the COEUR repository.
Biopreservation and biobanking
Le Page C,Köbel M,de Ladurantaye M,Rahimi K,Madore J,Babinszky S,Bachvarov DR,Bachvarova M,Beauchamp MC,Cass CE,Chadwick D,Colleen C,Damaraju S,Dufour J,Gotlieb WH,Kalloger SE,Portelance L,McAlpine JN,Matte I,Piché A,Shaw P,Roehrl MH,Vanderhyden BC,Watson PH,Huntsman DG,Provencher DM,Mes-Masson AM
MA5-14520 was used in immunohistochemistry to study the quality of biological samples held in Canadian biobanks forming part of the COEUR repository
Mon Apr 01 00:00:00 EDT 2013
Multiple delivery of siRNA against endoglin into murine mammary adenocarcinoma prevents angiogenesis and delays tumor growth.
PloS one
Dolinsek T,Markelc B,Sersa G,Coer A,Stimac M,Lavrencak J,Brozic A,Kranjc S,Cemazar M
MA5-14520 was used in Immunohistochemistry to demonstrate that silencing of endoglin is a promising antiangiogenic therapy of tumors that could not be used as single treatment, but as an adjunct to the established cytotoxic treatment approaches.
Fri Aug 16 00:00:00 EDT 2013
The microenvironment of human neuroblastoma supports the activation of tumor-associated T lymphocytes.
Oncoimmunology
Carlson LM,De Geer A,Sveinbjørnsson B,Orrego A,Martinsson T,Kogner P,Levitskaya J
MA5-14520 was used in immunohistochemistry to study the ability of the human neuroblastoma microenvironment to support tumor-associated T-cell activation
Fri Mar 01 00:00:00 EST 2013
A husband and a wife with simultaneous presentation of glioblastoma multiforme: a case report.
Case reports in oncology
Roviello G,Petrioli R,Cerase A,Marsili S,Miracco C,Rubino G,Tini P
MA5-14520 was used in immunohistochemistry to report on a case of husband and wife presenting simultaneously with glioblastoma multiforme
Wed Dec 18 00:00:00 EST 2013
APC/C-Cdh1 coordinates neurogenesis and cortical size during development.
Nature communications
Delgado-Esteban M,García-Higuera I,Maestre C,Moreno S,Almeida A
MA5-14520 was used in immunohistochemistry to study the modulation of cortical neurogenesis and size by APC/C-Cdh1
Tue Oct 07 00:00:00 EDT 2014
Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells.
PloS one
Osawa Y,Hoshi M,Yasuda I,Saibara T,Moriwaki H,Kozawa O
MA5-14520 was used in immunohistochemistry to study the role of TIMP1 production by hepatic stellate cells in the mechanism by which TNF-alpha promotes liver fibrosis in a murine model of cholestasis
Tue Jan 13 00:00:00 EST 2015
Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA).
Asian Pacific journal of cancer prevention : APJCP
Saad N,Esa NM,Ithnin H
MA5-14520 was used in immunohistochemistry to study the ability of phytic acid from rice bran to reduce the expression of beta-catenin and COX-2 and to inhibit colon cancer proliferation in a rat carcinogen-induced model
Tue Oct 14 00:00:00 EDT 2014
Inhibition of tumor angiogenesis and tumor growth by the DSL domain of human Delta-like 1 targeted to vascular endothelial cells.
Neoplasia (New York, N.Y.)
Zhao XC,Dou GR,Wang L,Liang L,Tian DM,Cao XL,Qin HY,Wang CM,Zhang P,Han H
MA5-14520 was used in immunohistochemistry to study the ability of a vascular endothelial cell-targeted construct containing the DSl domain of Delta-like 1 to inhibit the angiogenesis and growth of tumor cells
Mon Jul 01 00:00:00 EDT 2013
Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.
Acta neuropathologica communications
Navis AC,Niclou SP,Fack F,Stieber D,van Lith S,Verrijp K,Wright A,Stauber J,Tops B,Otte-Holler I,Wevers RA,van Rooij A,Pusch S,von Deimling A,Tigchelaar W,van Noorden CJ,Wesseling P,Leenders WP
MA5-14520 was used in immunohistochemistry - paraffin section to characterize E478 xenografts at the genetic, histologic, and metabolic level
Wed May 29 00:00:00 EDT 2013
Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis.
PloS one
Maruyama EO,Yu HM,Jiang M,Fu J,Hsu W
MA5-14520 was used in immunohistochemistry to study the role of Gpr177 in mammary organogenesis and Wnt-driven tumorigenesis
Wed Aug 28 00:00:00 EDT 2013
Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc(-/+) mice.
BMC cancer
Karim BO,Rhee KJ,Liu G,Zheng D,Huso DL
MA5-14520 was used in immunohistochemistry to study the potential of silibin and Cdk4 inhibition for the chemoprevention of colorectal cancer
Wed Mar 27 00:00:00 EDT 2013
Role of fibrinogen in acute ischemic kidney injury.
American journal of physiology. Renal physiology
Sörensen-Zender I,Rong S,Susnik N,Lange J,Gueler F,Degen JL,Melk A,Haller H,Schmitt R
MA5-14520 was used in immunohistochemistry to study renal ischemia-reperfusion injury and the roles of fibrinogen
Sun Sep 01 00:00:00 EDT 2013
Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2.
PloS one
Navis AC,Bourgonje A,Wesseling P,Wright A,Hendriks W,Verrijp K,van der Laak JA,Heerschap A,Leenders WP
MA5-14520 was used in immunohistochemistry to study the therapeutic efficacy of a tyrosine kinase inhibitor active against both c-MET and VEGFR2 in a xenoraft model of human glioblastoma
Tue Sep 03 00:00:00 EDT 2013
CoupTFI interacts with retinoic acid signaling during cortical development.
PloS one
Harrison-Uy SJ,Siegenthaler JA,Faedo A,Rubenstein JL,Pleasure SJ
MA5-14520 was used in immunohistochemistry to study the modulation of cortical development by interactions between CoupTF I and retinoic acid signaling pathways
Tue Dec 03 00:00:00 EST 2013
Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.
PloS one
El-Zaatari M,Kao JY,Tessier A,Bai L,Hayes MM,Fontaine C,Eaton KA,Merchant JL
MA5-14520 was used in immunohistochemistry - frozen section to determine the contribution of Hedgehog signaling to gastric transformation
Tue Sep 10 00:00:00 EDT 2013
Chemoprevention of lung squamous cell carcinoma by ginseng.
Cancer prevention research (Philadelphia, Pa.)
Pan J,Zhang Q,Li K,Liu Q,Wang Y,You M
MA5-14520 was used in immunohistochemistry to study the chemopreventative activity of ginseng in a murine model of squamous cell carcinoma of the lung
Sat Jun 01 00:00:00 EDT 2013
The anti-erbB3 antibody MM-121/SAR256212 in combination with trastuzumab exerts potent antitumor activity against trastuzumab-resistant breast cancer cells.
Molecular cancer
Huang J,Wang S,Lyu H,Cai B,Yang X,Wang J,Liu B
MA5-14520 was used in immunohistochemistry to study the potent anti-cancer activity against erbB2-positive trastuzumab-resistant breast cancer of a combination of trastuzumab plus an anti-erbB3 antibody
Mon Nov 11 00:00:00 EST 2013
Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia.
PloS one
Yang X,La Rosa FG,Genova EE,Huber K,Schaack J,Degregori J,Serkova NJ,Li Y,Su LJ,Kessler E,Flaig TW
MA5-14520 was used in immunohistochemistry to study the formation of soft tissue sarcoma and bladder urothelial hyperplasia following simultaneous Kras activation/p53 inactivation in a murine model
Mon Jun 16 00:00:00 EDT 2014
A novel model of adenine-induced tubulointerstitial nephropathy in mice.
BMC nephrology
Jia T,Olauson H,Lindberg K,Amin R,Edvardsson K,Lindholm B,Andersson G,Wernerson A,Sabbagh Y,Schiavi S,Larsson TE
MA5-14520 was used in immunohistochemistry to describe a novel adenine-based model of murine renal failure
Thu May 30 00:00:00 EDT 2013
Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis.
BMC cancer
Tsofack SP,Meunier L,Sanchez L,Madore J,Provencher D,Mes-Masson AM,Lebel M
MA5-14520 was used in immunohistochemistry to study the prognostic value of the immunohistochemical expresson of RPS4X in patients with serous epithelial ovarian cancer
Sat Jun 22 00:00:00 EDT 2013
Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.
PLoS genetics
Schaffer AE,Taylor BL,Benthuysen JR,Liu J,Thorel F,Yuan W,Jiao Y,Kaestner KH,Herrera PL,Magnuson MA,May CL,Sander M
MA5-14520 was used in immunohistochemistry to study the central role of the Nkx6.1 transcription factor in the specification and maintenance of pancreatic beta-cells
Thu May 30 00:00:00 EDT 2013
Label retention identifies a multipotent mesenchymal stem cell-like population in the postnatal thymus.
PloS one
Osada M,Singh VJ,Wu K,Sant'Angelo DB,Pezzano M
MA5-14520 was used in immunohistochemistry to study a postnatal thymus population of multipotent mesenchymal stem-like cells
Tue Sep 30 00:00:00 EDT 2014
Aldara activates TLR7-independent immune defence.
Nature communications
Walter A,Schäfer M,Cecconi V,Matter C,Urosevic-Maiwald M,Belloni B,Schönewolf N,Dummer R,Bloch W,Werner S,Beer HD,Knuth A,van den Broek M
MA5-14520 was used in immunohistochemistry to study the ability of Aldara to induce inflammatory immune responses independently of TLR7 activation
Thu Jun 20 00:00:00 EDT 2013
Uterine deletion of Gp130 or Stat3 shows implantation failure with increased estrogenic responses.
Molecular endocrinology (Baltimore, Md.)
Sun X,Bartos A,Whitsett JA,Dey SK
MA5-14520 was used in immunohistochemistry - frozen section to elucidate the role of Gp130 and STAT3 in the uterus during implantation
Sun Sep 01 00:00:00 EDT 2013
Tumor stress-induced phosphoprotein1 (STIP1) as a prognostic biomarker in ovarian cancer.
PloS one
Chao A,Lai CH,Tsai CL,Hsueh S,Hsueh C,Lin CY,Chou HH,Lin YJ,Chen HW,Chang TC,Wang TH
MA5-14520 was used in immunocytochemistry to study the prognostic value of the immunohistochemical expression of STIP1 in ovarian cancer
Fri Aug 23 00:00:00 EDT 2013
Tissue engineered skin substitutes created by laser-assisted bioprinting form skin-like structures in the dorsal skin fold chamber in mice.
PloS one
Michael S,Sorg H,Peck CT,Koch L,Deiwick A,Chichkov B,Vogt PM,Reimers K
MA5-14520 was used in immunohistochemistry to study the use of laser-assisted bioprinting to produce tissue engineered skin substitutes capable of forming skin-like structures
Tue Aug 27 00:00:00 EDT 2013
Dmp1α inhibits HER2/neu-induced mammary tumorigenesis.
PloS one
Fry EA,Taneja P,Maglic D,Zhu S,Sui G,Inoue K
MA5-14520 was used in immunohistochemistry to study the mechanism by which Dmp1-alpha blocks HER2-driven mammary tumorigenesis
Thu Sep 04 00:00:00 EDT 2014
Biological and demographic profile of meningiomas in a cohort of Egyptian patients: impact on tumor recurrence.
TheScientificWorldJournal
Abdelzaher E,El Deeb NM,Gowil AG,Yehya A
MA5-14520 was used in immunohistochemistry to study the relationship between meningioma biological and demographic profiles and disease recurrence in Egyptian patients
Mon Jun 16 00:00:00 EDT 2014
TLR2 mediates Helicobacter pylori-induced tolerogenic immune response in mice.
PloS one
Sun X,Zhang M,El-Zataari M,Owyang SY,Eaton KA,Liu M,Chang YM,Zou W,Kao JY
MA5-14520 was used in immunohistochemistry - paraffin section to assess the role of TLR2 in mediating H. pylori tolerogenic programming of dendritic cells.
Mon Jun 16 00:00:00 EDT 2014
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
Circulation
Zhao L,Chen CN,Hajji N,Oliver E,Cotroneo E,Wharton J,Wang D,Li M,McKinsey TA,Stenmark KR,Wilkins MR
MA5-14520 was used in immunohistochemistry to study the therapeutic potential of HDAC inhibition in models of pulmonary hypertension
Tue Jul 24 00:00:00 EDT 2012
Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Fischer E,Chaitanya K,Wüest T,Wadle A,Scott AM,van den Broek M,Schibli R,Bauer S,Renner C
MA5-14520 was used in immunohistochemistry to study the anti-tumor activity of radioimmunoconjugates of two rapidly internalizing antibodies recognizing FAP
Thu Nov 15 00:00:00 EST 2012
Highly specific targeting of the TMPRSS2/ERG fusion gene using liposomal nanovectors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Shao L,Tekedereli I,Wang J,Yuca E,Tsang S,Sood A,Lopez-Berestein G,Ozpolat B,Ittmann M
MA5-14520 was used in immunohistochemistry to study the use of liposomal nanovectors for the specific targeting of siRNAs against the TMPRSS2-ERG fusion gene
Sat Dec 15 00:00:00 EST 2012
Targeting fibroblast growth factor receptor signaling inhibits prostate cancer progression.
Clinical cancer research : an official journal of the American Association for Cancer Research
Feng S,Shao L,Yu W,Gavine P,Ittmann M
MA5-14520 was used in immunohistochemistry to study the inhibition of prostate cancer progression by pharmacological blockade of FGF receptors
Sun Jul 15 00:00:00 EDT 2012
A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Shan W,Akinfenwa PY,Savannah KB,Kolomeyevskaya N,Laucirica R,Thomas DG,Odunsi K,Creighton CJ,Lev DC,Anderson ML
MA5-14520 was used in immunohistochemistry to study the ability of a small-molecule inhibitor targeting the mitotic spindle checkpoint to inhibit uterine leiomyosarcoma growth
Fri Jun 15 00:00:00 EDT 2012
Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury.
Autophagy
Liu S,Hartleben B,Kretz O,Wiech T,Igarashi P,Mizushima N,Walz G,Huber TB
MA5-14520 was used in immunohistochemistry to study the role of kidney tubular cell autophagy in the maintenance of kidney function under conditions of stress
Tue May 01 00:00:00 EDT 2012
Identification of a molecular signature underlying inhibition of mammary carcinoma growth by dietary N-3 fatty acids.
Cancer research
Jiang W,Zhu Z,McGinley JN,El Bayoumy K,Manni A,Thompson HJ
MA5-14520 was used in immunohistochemistry to study the molecular changes associated with the dietary n-3 fatty acid-induced inhibition of mammary carcinoma growth
Wed Aug 01 00:00:00 EDT 2012
Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues.
Journal of the National Cancer Institute
Neumeister VM,Anagnostou V,Siddiqui S,England AM,Zarrella ER,Vassilakopoulou M,Parisi F,Kluger Y,Hicks DG,Rimm DL
MA5-14520 was used in immunohistochemistry and western blot to study the effect of the period of pre-analysis cold ischemia on the antigenicity of a number of breast cancer proteins
Wed Dec 05 00:00:00 EST 2012
Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in vitro and in vivo.
Journal of controlled release : official journal of the Controlled Release Society
Xia W,Wang P,Lin C,Li Z,Gao X,Wang G,Zhao X
MA5-14520 was used in immunohistochemistry to study the inhibition of HepG2 growth by knockdown of telomerase reverse transcriptase by siRNA delivered via a biodegradeable PEI-based carrier system
Fri Feb 10 00:00:00 EST 2012
Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas.
European journal of cancer (Oxford, England : 1990)
Asmane I,Watkin E,Alberti L,Duc A,Marec-Berard P,Ray-Coquard I,Cassier P,Decouvelaere AV,Ranchère D,Kurtz JE,Bergerat JP,Blay JY
MA5-14520 was used in immunohistochemistry to study exclusive nuclear IGF-R1 staining as a biomarker predictive of good response to IGF-1R monoclonal antibody therapy in sarcoma patients
Thu Nov 01 00:00:00 EDT 2012
Promoting role of cholecystokinin 2 receptor (CCK2R) in gastrointestinal stromal tumour pathogenesis.
The Journal of pathology
Quattrone A,Dewaele B,Wozniak A,Bauters M,Vanspauwen V,Floris G,Schöffski P,Chibon F,Coindre JM,Sciot R,Debiec-Rychter M
MA5-14520 was used in immunohistochemistry to study the role of the cholecytokinin-2 receptor in promoting gastrointestinal stromal tumor tumorigenicity
Sat Dec 01 00:00:00 EST 2012
Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals.
Cancer letters
Lühr I,Friedl A,Overath T,Tholey A,Kunze T,Hilpert F,Sebens S,Arnold N,Rösel F,Oberg HH,Maass N,Mundhenke C,Jonat W,Bauer M
MA5-14520 was used in immunocytochemistry to study the mechanisms by which mammary fibroblasts regulate normal and tumorigenic breast epithelial cell morphogenesis
Fri Dec 28 00:00:00 EST 2012
Functional consequences of human airway smooth muscle phenotype plasticity.
British journal of pharmacology
Dekkers BG,Bos IS,Zaagsma J,Meurs H
MA5-14520 was used in immunocytochemistry to study the phenotypic plasticity of human airway smooth muscle cells and the significance for remodeling in asthma
Tue May 01 00:00:00 EDT 2012
Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase.
British journal of cancer
Hiyoshi H,Abdelhady S,Segerström L,Sveinbjörnsson B,Nuriya M,Lundgren TK,Desfrere L,Miyakawa A,Yasui M,Kogner P,Johnsen JI,Andäng M,Uhlén P
MA5-14520 was used in immunohistochemistry to study the role of the ouabain/Na,K-ATPase in regulating the growth of neuroblastoma cells
Tue May 22 00:00:00 EDT 2012
WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma.
British journal of cancer
Rogers HA,Sousa S,Salto C,Arenas E,Coyle B,Grundy RG
MA5-14520 was used in immunohistochemistry to study the role of Wnt/beta-catenin pathway activity in the pathogenesis of medulloblastoma using a myc-immortalized cerebellar progenitor cell model
Tue Sep 25 00:00:00 EDT 2012
Antitumor effects of cis-urocanic acid on experimental urothelial cell carcinoma of the bladder.
The Journal of urology
Arentsen HC,Jansen CF,Hulsbergen-van de Kaa CA,Laihia JK,Pylkkänen L,Leino L,Oosterwijk E,Witjes JA
MA5-14520 was used in immunohistochemistry to study the anti-tumor effects of cis-urocanic acid on experimental urothelial cell carcinoma of the bladder.
Sun Apr 01 00:00:00 EDT 2012
Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1.
The Journal of investigative dermatology
Li J,Jiang TX,Hughes MW,Wu P,Yu J,Widelitz RB,Fan G,Chuong CM
MA5-14520 was used in immunohistochemistry to study the role of reduced stem cell activation in alopecia induced by deletion of DNA methyltransferase-1
Sat Dec 01 00:00:00 EST 2012
Overexpression of cathepsin S induces chronic atopic dermatitis in mice.
The Journal of investigative dermatology
Kim N,Bae KB,Kim MO,Yu DH,Kim HJ,Yuh HS,Ji YR,Park SJ,Kim S,Son KH,Park SJ,Yoon D,Lee DS,Lee S,Lee HS,Kim TY,Ryoo ZY
MA5-14520 was used in immunohistochemistry to study the development of chronic atopic dermatitis in transgenic mice overexpressing cathepsin S
Sun Apr 01 00:00:00 EDT 2012
IL-12 and IL-23 affect photocarcinogenesis differently.
The Journal of investigative dermatology
Jantschitsch C,Weichenthal M,Proksch E,Schwarz T,Schwarz A
MA5-14520 was used in immunohistochemistry to investigate the effect of IL-23 and IL-12 on UVR-induced tumorigenesis
Tue May 01 00:00:00 EDT 2012
Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy.
PLoS pathogens
Zeng M,Southern PJ,Reilly CS,Beilman GJ,Chipman JG,Schacker TW,Haase AT
MA5-14520 was used in immunohistochemistry to test if damage to the lymphoid tissue fibroblastic reticular cell network contributes to naive T cell loss during HIV-1 infection
Sun Jan 01 00:00:00 EST 2012
Mice lacking epidermal PPARγ exhibit a marked augmentation in photocarcinogenesis associated with increased UVB-induced apoptosis, inflammation and barrier dysfunction.
International journal of cancer
Sahu RP,DaSilva SC,Rashid B,Martel KC,Jernigan D,Mehta SR,Mohamed DR,Rezania S,Bradish JR,Armstrong AB,Warren S,Konger RL
MA5-14520 was used in immunohistochemistry to study the mechanisms underlying increased photocarcinogenesis in mice lacking epidermal PPAR gamma
Mon Oct 01 00:00:00 EDT 2012
An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells.
International journal of cancer
Houben R,Adam C,Baeurle A,Hesbacher S,Grimm J,Angermeyer S,Henzel K,Hauser S,Elling R,Bröcker EB,Gaubatz S,Becker JC,Schrama D
MA5-14520 was used in immunohistochemistry to investigate the mechanism for the growth of Merkel cell carcinoma cells
Wed Feb 15 00:00:00 EST 2012
Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.
Development (Cambridge, England)
VanDussen KL,Carulli AJ,Keeley TM,Patel SR,Puthoff BJ,Magness ST,Tran IT,Maillard I,Siebel C,Kolterud Å,Grosse AS,Gumucio DL,Ernst SA,Tsai YH,Dempsey PJ,Samuelson LC
MA5-14520 was used in immunohistochemistry to study the role of Notch in intestinal crypt base columnar stem cell proliferation and differentiation
Wed Feb 01 00:00:00 EST 2012
Collective action of hematopoietic cell subsets mediates anti-IL10R1 and CpG tumor immunity.
Cancer immunology, immunotherapy : CII
Chou MY,Austin CD,Kim JM
MA5-14520 was used in immunohistochemistry to investigate the role of hematopoietic-derived cells in anti-IL10R1 and CpG tumor immunity
Sun Jul 01 00:00:00 EDT 2012
The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.
The American journal of surgical pathology
Lee CH,Mariño-Enriquez A,Ou W,Zhu M,Ali RH,Chiang S,Amant F,Gilks CB,van de Rijn M,Oliva E,Debiec-Rychter M,Dal Cin P,Fletcher JA,Nucci MR
MA5-14520 was used in immunohistochemistry to report on the clinical and pathological features of 13 cases of YWHAE-FAM22 endometrial stromal sarcoma
Tue May 01 00:00:00 EDT 2012
Chemotherapy-associated changes of histopathological features of Mycobacterium ulcerans lesions in a Buruli ulcer mouse model.
Antimicrobial agents and chemotherapy
Ruf MT,Schütte D,Chauffour A,Jarlier V,Ji B,Pluschke G
MA5-14520 was used in immunohistochemistry to investigate the effect of chemotherapy on the infection lesions of M. ulcerans in a mouse model
Wed Feb 01 00:00:00 EST 2012
Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Schmidt-Strassburger U,Schips TG,Maier HJ,Kloiber K,Mannella F,Braunstein KE,Holzmann K,Ushmorov A,Liebau S,Boeckers TM,Wirth T
MA5-14520 was used in immunohistochemistry to study the mechanism by which transgenic expression of constitutively active FoxO3 leads to enhanced apoptosis and loss of forebrain neural progenitors in mice
Sat Dec 01 00:00:00 EST 2012
YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor.
The American journal of pathology
Zhi X,Zhao D,Zhou Z,Liu R,Chen C
MA5-14520 was used in immunohistochemistry to study the role of the KLF5 transcription factor in the mechanism by which YAP promotes the proliferation and survival of breast cells
Fri Jun 01 00:00:00 EDT 2012
Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia.
The American journal of pathology
Syu LJ,El-Zaatari M,Eaton KA,Liu Z,Tetarbe M,Keeley TM,Pero J,Ferris J,Wilbert D,Kaatz A,Zheng X,Qiao X,Grachtchouk M,Gumucio DL,Merchant JL,Samuelson LC,Dlugosz AA
MA5-14520 was used in immunohistochemistry to study the induction of inflammation, metaplasia and displasia following transgenic expression of IFN-gamma in the murine stomach
Sat Dec 01 00:00:00 EST 2012
Blockage of lysophosphatidic acid signaling improves spinal cord injury outcomes.
The American journal of pathology
Goldshmit Y,Matteo R,Sztal T,Ellett F,Frisca F,Moreno K,Crombie D,Lieschke GJ,Currie PD,Sabbadini RA,Pébay A
MA5-14520 was used in immunohistochemistry to study the beneficial effects of an anti-lysophasphatidic acid antibody in models of spinal cord injury
Sat Sep 01 00:00:00 EDT 2012
Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor α.
The American journal of pathology
Joshi A,Wang H,Jiang G,Douglas W,Chan JS,Korach KS,Ellenson LH
MA5-14520 was used in immunohistochemistry and western blot to study endometrial tumorigenesis in heterozygous Pten (+/-) mice and the relationship with estrogen signaling
Fri Jun 01 00:00:00 EDT 2012
Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27.
The American journal of pathology
Wan M,Huang W,Kute TE,Miller LD,Zhang Q,Hatcher H,Wang J,Stovall DB,Russell GB,Cao PD,Deng Z,Wang W,Zhang Q,Lei M,Torti SV,Akman SA,Sui G
MA5-14520 was used in immunohistochemistry to study the role of p27 in the oncogenic activity of Yin Yang-1 in breast cancer
Tue May 01 00:00:00 EDT 2012
Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.
Journal of molecular medicine (Berlin, Germany)
Yang SB,Lee HY,Young DM,Tien AC,Rowson-Baldwin A,Shu YY,Jan YN,Jan LY
MA5-14520 was used in immunohistochemistry to study the mechanisms underlying the induction of glucose intolerance in mice by rapamycin
Tue May 01 00:00:00 EDT 2012
Targeting colorectal cancer stem cells with inducible caspase-9.
Apoptosis : an international journal on programmed cell death
Kemper K,Rodermond H,Colak S,Grandela C,Medema JP
MA5-14520 was used in immunohistochemistry to investigate the influence of dimerization of inducible caspase-9 in colorectal cancer stem cells
Tue May 01 00:00:00 EDT 2012
Nanostructured porous silicon micropatterns as a tool for substrate-conditioned cell research.
Nanoscale research letters
Punzón-Quijorna E,Sánchez-Vaquero V,Muñoz-Noval A,Pérez-Roldán MJ,Martín-Palma RJ,Rossi F,Climent-Font A,Manso-Silván M,Ruiz JP,Torres-Costa V
MA5-14520 was used in immunocytochemistry to study nanostructured porous silicon micropatterns as a tool for substrate-conditioned cell research
Mon Jul 16 00:00:00 EDT 2012
Association of aberrations in one-carbon metabolism with molecular phenotype and grade of breast cancer.
Molecular carcinogenesis
Naushad SM,Pavani A,Rupasree Y,Divyya S,Deepti S,Digumarti RR,Gottumukkala SR,Prayaga A,Kutala VK
MA5-14520 was used in immunohistochemistry to investigate one-carbon metabolism dysfunction in breast cancer progression
Mon Oct 01 00:00:00 EDT 2012
The adult pituitary shows stem/progenitor cell activation in response to injury and is capable of regeneration.
Endocrinology
Fu Q,Gremeaux L,Luque RM,Liekens D,Chen J,Buch T,Waisman A,Kineman R,Vankelecom H
MA5-14520 was used in immunocytochemistry and immunohistochemistry to study the ability of stem/progenitor cells to promote regeneration of the adult pituitary following injury
Sun Jul 01 00:00:00 EDT 2012
Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia.
American journal of physiology. Gastrointestinal and liver physiology
Veniaminova NA,Hayes MM,Varney JM,Merchant JL
MA5-14520 was used in immunohistochemistry to study the increase in the number of antral G cells and antrum gastrin expression in response to conditional ablation of menin
Sat Sep 15 00:00:00 EDT 2012
Failure of delayed intravenous administration of bone marrow stromal cells after traumatic brain injury.
Journal of neurotrauma
Bonilla C,Zurita M,Otero L,Aguayo C,Rico MA,Rodríguez A,Vaquero J
MA5-14520 was used in immunohistochemistry to study the effect of injection of bone marrow stromal cells on tramautic brain injury following the establishment of neurological deficits
Fri Jan 20 00:00:00 EST 2012
Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors.
Translational oncology
Zhang W,Haines BB,Efferson C,Zhu J,Ware C,Kunii K,Tammam J,Angagaw M,Hinton MC,Keilhack H,Paweletz CP,Zhang T,Winter C,Sathyanarayanan S,Cheng J,Zawel L,Fawell S,Gilliland G,Majumder PK
MA5-14520 was used in immunohistochemistry to study Akt-indepenedent mTOR activation in a model of PTEN-deficient prostate cancer and the therapeutic potential of combining both mTOR and Akt inhibitors
Sat Dec 01 00:00:00 EST 2012
Cell signaling pathways associated with a reduction in mammary cancer burden by dietary common bean (Phaseolus vulgaris L.).
Carcinogenesis
Thompson MD,Mensack MM,Jiang W,Zhu Z,Lewis MR,McGinley JN,Brick MA,Thompson HJ
MA5-14520 was used in immunohistochemistry to investigate the mechanism of bean food-induced breast cancer inhibition
Sun Jan 01 00:00:00 EST 2012
KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer.
Breast cancer research and treatment
Anbalagan M,Carrier L,Glodowski S,Hangauer D,Shan B,Rowan BG
MA5-14520 was used in immunohistochemistry to study the synergistic effects against estrogen receptor-alpha-positive breast cancer of a peptidomimetic Src kinase inhibitor and tamoxifen
Sun Apr 01 00:00:00 EDT 2012
Insights antifibrotic mechanism of methyl palmitate: impact on nuclear factor kappa B and proinflammatory cytokines.
Toxicology and applied pharmacology
Mantawy EM,Tadros MG,Awad AS,Hassan DA,El-Demerdash E
MA5-14520 was used in immunohistochemistry to study the antifibrotic mechanism of methyl palmitate
Sun Jan 01 00:00:00 EST 2012
Regenerative capacity of the adult pituitary: multiple mechanisms of lactotrope restoration after transgenic ablation.
Stem cells and development
Fu Q,Vankelecom H
MA5-14520 was used in immunohistochemistry to study the mechanisms underlying lactotrope repair in transgenically ablated adult murine pituitary
Mon Dec 10 00:00:00 EST 2012
Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.
Stem cells and development
Jagielska A,Norman AL,Whyte G,Vliet KJ,Guck J,Franklin RJ
MA5-14520 was used in immunocytochemistry to study the modulation of the properties of oligodendrocyte progenitors by the mechanical properties of their growth substrate
Thu Nov 01 00:00:00 EDT 2012
HOXB9 expression promoting tumor cell proliferation and angiogenesis is associated with clinical outcomes in breast cancer patients.
Annals of surgical oncology
Seki H,Hayashida T,Jinno H,Hirose S,Sakata M,Takahashi M,Maheswaran S,Mukai M,Kitagawa Y
MA5-14520 was used in immunohistochemistry to study the prognostic value of HOXB9 expression in breast cancer
Fri Jun 01 00:00:00 EDT 2012
Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats.
Toxicology letters
Camacho L,Latendresse JR,Muskhelishvili L,Patton R,Bowyer JF,Thomas M,Doerge DR
MA5-14520 was used in immunohistochemistry to study the effect of acrylamide exposure on reproductive tissues and hypothalamic-pituitary-testes axis
Fri Jun 01 00:00:00 EDT 2012
Susceptibility loci affecting ERBB2/neu-induced mammary tumorigenesis in mice.
Genes, chromosomes & cancer
Quan L,Dittmar A,Zhou Y,Hutson A,Stassen AP,Demant P
MA5-14520 was used in immunohistochemistry to identify susceptibility loci that affect ERBB2/neu-induced mammary tumorigenesis in mice
Sun Jul 01 00:00:00 EDT 2012
Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice.
Biology of reproduction
Mork L,Maatouk DM,McMahon JA,Guo JJ,Zhang P,McMahon AP,Capel B
MA5-14520 was used in immunohistochemistry to study the time course of granulosa cell specification in the murine ovary
Wed Feb 01 00:00:00 EST 2012
Bimodal effect of retinoic acid on melanocyte differentiation identified by time-dependent analysis.
Pigment cell & melanoma research
Inoue Y,Hasegawa S,Yamada T,Date Y,Mizutani H,Nakata S,Matsunaga K,Akamatsu H
MA5-14520 was used in immunocytochemistry to study the effects of retinoic acid on melanocytes at each stage of differentiation
Tue May 01 00:00:00 EDT 2012
Fates of murine pluripotent stem cell-derived neural progenitors following transplantation into mouse cochleae.
Cell transplantation
Nishimura K,Nakagawa T,Sakamoto T,Ito J
MA5-14520 was used in immunocytochemistry to study the tumorigenic risk associated with the cochleal transplantaion of neural progenitors derived from mouse pluripotent stem cells
Tue Jun 25 00:00:00 EDT 2013
PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis.
American journal of physiology. Renal physiology
Lan R,Geng H,Polichnowski AJ,Singha PK,Saikumar P,McEwen DG,Griffin KA,Koesters R,Weinberg JM,Bidani AK,Kriz W,Venkatachalam MA
MA5-14520 was used in immunohistochemistry to investigate the involvement of PTEN in fibrosis after renal repair
Tue May 01 00:00:00 EDT 2012
De novo expression of podocyte proteins in parietal epithelial cells in experimental aging nephropathy.
American journal of physiology. Renal physiology
Zhang J,Hansen KM,Pippin JW,Chang AM,Taniguchi Y,Krofft RD,Pickering SG,Liu ZH,Abrass CK,Shankland SJ
MA5-14520 was used in immunohistochemistry to study the expression of podocyte-specific proteins by parietal epithelial cells during experimental aging nephropathy
Thu Mar 01 00:00:00 EST 2012
Carbidopa enhances antitumoral activity of bicalutamide on the androgen receptor-axis in castration-resistant prostate tumors.
The Prostate
Thomas C,Wafa LA,Lamoureux F,Cheng H,Fazli L,Gleave ME,Rennie PS
MA5-14520 was used in immunohistochemistry to study the effect of carbidopa on the antitumoral activity of bicalutamide in the androgen receptor-axis in castration-resistant prostate tumors
Fri Jun 01 00:00:00 EDT 2012
The effects of intrauterine growth restriction and antenatal glucocorticoids on ovine fetal lung development.
Pediatric research
Sutherland AE,Crossley KJ,Allison BJ,Jenkin G,Wallace EM,Miller SL
MA5-14520 was used in immunohistochemistry to study fetal lung development in sheep and the effects of intrauterine growth restriction and glucocorticoid administration
Fri Jun 01 00:00:00 EDT 2012
Activation of neural progenitor cells in human eyes with proliferative vitreoretinopathy.
Experimental eye research
Johnsen EO,Frøen RC,Albert R,Omdal BK,Sarang Z,Berta A,Nicolaissen B,Petrovski G,Moe MC
MA5-14520 was used in immunohistochemistry to study whether neural stem/progenitor cells can be activated in human eyes suffering proliferative vitreoretinopathy
Tue May 01 00:00:00 EDT 2012
Increased adult hippocampal neurogenesis and abnormal migration of adult-born granule neurons is associated with hippocampal-specific cognitive deficits in phospholipase C-β1 knockout mice.
Hippocampus
Manning EE,Ransome MI,Burrows EL,Hannan AJ
MA5-14520 was used in immunohistochemistry to study the cellular mechanisms linking PLC-beta1 knockout to schizophrenia-like behavior
Wed Feb 01 00:00:00 EST 2012
Effect of staged ovariectomy on measures of mammary growth and development in prepubertal dairy heifers.
Animal : an international journal of animal bioscience
Velayudhan BT,Huderson BP,McGilliard ML,Jiang H,Ellis SE,Akers RM
MA5-14520 was used in immunohistochemistry to study the effect of staged ovariectomy on mammary growth and development in prepubertal dairy heifers
Fri Jun 01 00:00:00 EDT 2012
Compton scattering by internal shields based on melanin-containing mushrooms provides protection of gastrointestinal tract from ionizing radiation.
Cancer biotherapy & radiopharmaceuticals
Revskaya E,Chu P,Howell RC,Schweitzer AD,Bryan RA,Harris M,Gerfen G,Jiang Z,Jandl T,Kim K,Ting LM,Sellers RS,Dadachova E,Casadevall A
MA5-14520 was used in immunohistochemistry to study the ability of oral administration of mushrooms containing melanin to protect the gut against ionizing radiation
Thu Nov 01 00:00:00 EDT 2012
Intermediate progenitors are increased by lengthening of the cell cycle through calcium signaling and p53 expression in human neural progenitors.
Molecular biology of the cell
García-García E,Pino-Barrio MJ,López-Medina L,Martínez-Serrano A
MA5-14520 was used in immunocytochemistry to study the role of Ca(2+) signaling and p53 activation in the generation of intermediate progenitors from human neural progenitor cells
Sun Apr 01 00:00:00 EDT 2012
Somatotroph pituitary adenoma with acromegaly and autosomal dominant polycystic kidney disease: SSTR5 polymorphism and PKD1 mutation.
Pituitary
Syro LV,Sundsbak JL,Scheithauer BW,Toledo RA,Camargo M,Heyer CM,Sekiya T,Uribe H,Escobar JI,Vasquez M,Rotondo F,Toledo SP,Kovacs K,Horvath E,Babovic-Vuksanovic D,Harris PC
MA5-14520 was used in immunohistochemistry to report on a case of somatotroph pituitary adenoma presenting with acromegaly and autosomal dominant polycystic kidney disease
Sat Sep 01 00:00:00 EDT 2012
BCL10 down-regulation in peripheral T-cell lymphomas.
Human pathology
Rossi M,Agostinelli C,Righi S,Sabattini E,Bacci F,Gazzola A,Pileri SA,Piccaluga PP
MA5-14520 was used in immunohistochemistry to study the down-regulation of BCL10 in peripheral T-cell lymphomas
Sat Dec 01 00:00:00 EST 2012
Wnt signaling regulates intermediate precursor production in the postnatal dentate gyrus by regulating CXCR4 expression.
Developmental neuroscience
Choe Y,Pleasure SJ
MA5-14520 was used in immunohistochemistry to study the role of CXCR4 in the mechanism by which Wnt modulates the production of intermediate precursors in the dentate gyrus of neonates
Thu Sep 19 00:00:00 EDT 2013
Evaluation of apoptosis along with BCL-2 and Ki-67 expression in patients with intestinal metaplasia.
Pathology, research and practice
Erkan G,Gonul II,Kandilci U,Dursun A
MA5-14520 was used in immunohistochemistry to study BCL-2 and Ki-67 expression and apoptotic status in patients with intestinal metaplasia
Wed Feb 15 00:00:00 EST 2012
Expression and activation of EphA4 in the human brain after traumatic injury.
Journal of neuropathology and experimental neurology
Frugier T,Conquest A,McLean C,Currie P,Moses D,Goldshmit Y
MA5-14520 was used in immunocytochemistry to study the effect of traumatic brain injury on EphA4 expression and activation in humans
Thu Mar 01 00:00:00 EST 2012
Testis development requires the repression of Wnt4 by Fgf signaling.
Developmental biology
Jameson SA,Lin YT,Capel B
MA5-14520 was used in immunohistochemistry to study the role of Wnt repression in testicular development and the role played by Fgf signaling pathways
Mon Oct 01 00:00:00 EDT 2012
Comparative morphological and immunohistochemical study of human meningioma after intracranial transplantation into nude mice.
Journal of neuroscience methods
Friedrich S,Schwabe K,Klein R,Krusche CA,Krauss JK,Nakamura M
MA5-14520 was used in immunohistochemistry to study the morphology and immunohistochemistry of human meningioma after intracranial transplantation into nude mice
Fri Mar 30 00:00:00 EDT 2012
Mapping differentiation kinetics in the mouse retina reveals an extensive period of cell cycle protein expression in post-mitotic newborn neurons.
Developmental dynamics : an official publication of the American Association of Anatomists
Pacal M,Bremner R
MA5-14520 was used in immunohistochemistry to develop a high resolution map of the kinetics of differentiation of murine retinal newborn neurons
Mon Oct 01 00:00:00 EDT 2012
Electrospun small-diameter polyurethane vascular grafts: ingrowth and differentiation of vascular-specific host cells.
Artificial organs
Bergmeister H,Grasl C,Walter I,Plasenzotti R,Stoiber M,Schreiber C,Losert U,Weigel G,Schima H
MA5-14520 was used in immunohistochemistry to study the performance of small diameter microspun vascular grafts made of polyurethane in a rat model
Sun Jan 01 00:00:00 EST 2012
Quantitative assessment of liver function after ischemia-reperfusion injury and partial hepatectomy in rats.
The Journal of surgical research
de Graaf W,Heger M,Spruijt O,Maas A,de Bruin K,Hoekstra R,Bennink RJ,van Gulik TM
MA5-14520 was used in immunohistochemistry to measure liver function following ischemia-reperfusion injury and partial hepatectomy in rats
Sun Jan 01 00:00:00 EST 2012
Increased FDG uptake in breast cancer is associated with prognostic factors.
Annals of nuclear medicine
Sanli Y,Kuyumcu S,Ozkan ZG,Işik G,Karanlik H,Guzelbey B,Turkmen C,Ozel S,Yavuz E,Mudun A
MA5-14520 was used in immunohistochemistry to study the relationship between FDG uptake and prognostic factors in breast cancer
Tue May 01 00:00:00 EDT 2012
Late embryonic and postnatal development of interstitial cells of cajal in mouse esophagus: distribution, proliferation and kit dependence.
Cells, tissues, organs
He X,Yang WC,Wen XY,Tang D,Xiao L,Han J,Yu B,Zhang W,Mei F
MA5-14520 was used in immunohistochemistry to study the development of murine esophageal interstitial cells of cajal through the late embryonic and early post-natal stages
Thu Jan 17 00:00:00 EST 2013
Primary pure squamous cell carcinoma of the thyroid: report and histogenic consideration of a case involving a BRAF mutation.
Pathology international
Ko YS,Hwang TS,Han HS,Lim SD,Kim WS,Oh SY
MA5-14520 was used in immunohistochemistry to study a case of primary squamous cell carcinoma of the thyroid
Sun Jan 01 00:00:00 EST 2012
Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review.
Sao Paulo medical journal = Revista paulista de medicina
Alvarenga CA,Lopes JM,Vinagre J,Paravidino PI,Alvarenga M,Prando A,Castilho LN,Soares P,Billis A
MA5-14520 was used in immunohistochemistry to report on a case of paraganglioma of seminal vesicle and chromophobe renal cell carcinoma
Thu Oct 04 00:00:00 EDT 2012
Honey as a substitute for formalin?
Biotechnic & histochemistry : official publication of the Biological Stain Commission
Ozkan N,Salva E,Cakalağaoğlu F,Tüzüner B
MA5-14520 was used in immunohistochemistry to evaluate honey as an alternative to formalin in histopathological examination
Wed Feb 01 00:00:00 EST 2012
Rgs19 regulates mouse palatal fusion by modulating cell proliferation and apoptosis in the MEE.
Mechanisms of development
Sohn WJ,Ji YR,Kim HS,Gwon GJ,Chae YM,An CH,Park HD,Jung HS,Ryoo ZY,Lee S,Kim JY
MA5-14520 was used in immunohistochemistry to study the mechanism by which Rgs19 regulates mouse palatal fusion
Wed Jun 12 00:00:00 EDT 2013
Combination hyperbaric oxygen and temozolomide therapy in C6 rat glioma model.
Acta cirurgica brasileira
Dagıstan Y,Karaca I,Bozkurt ER,Ozar E,Yagmurlu K,Toklu A,Bilir A
MA5-14520 was used in immunohistochemistry to study the effects of hyperbaric oxygen and temozolomide in a rat rat model of glioma
Fri Jun 01 00:00:00 EDT 2012
No harmful effect of mycophenolate mofetil on liver regeneration: an experimental study.
Transplantation proceedings
Demiray M,Kucuk HF,Yildirim M,Barisik NO
MA5-14520 was used in immunohistochemistry to study the effects of mycophenolate mofetil on liver regeneration following partial hepatectomy
Thu Jan 03 00:00:00 EST 2013
Cauda equina paraganglioma with ependymoma-like histology: a case report.
Turkish neurosurgery
Midi A,Yener AN,Sav A,Cubuk R
MA5-14520 was used in immunohistochemistry to report on a case of cauda equina paraganglioma
Thu Nov 29 00:00:00 EST 2012
Early changes in carcinogenesis of colorectal adenomas.
The West Indian medical journal
Toru S,Bilezikçi B
MA5-14520 was used in immunohistochemistry to study early changes and high risk factors in carcinogenesis of colorectal adenomas
Sun Jan 01 00:00:00 EST 2012
Oxidative stress gradient in a medium during human corneal organ culture.
Molecular vision
Johnsen-Soriano S,Haug K,Arnal E,Peris-Martinez C,Moe MC,Romero FJ,Nicolaissen B
MA5-14520 was used in immunohistochemistry to study the establishment of an oxidative stress gradient in storage vials during corneal organ culture
Tue Nov 13 00:00:00 EST 2012
MSP58 knockdown inhibits the proliferation of esophageal squamous cell carcinoma in vitro and in vivo.
Asian Pacific journal of cancer prevention : APJCP
Xu CS,Zheng JY,Zhang HL,Zhao HD,Zhang J,Wu GQ,Wu L,Wang Q,Wang WZ,Zhang J
MA5-14520 was used in immunohistochemistry to study the inhibition of esophageal squamous cell carcinoma proliferation by shRNA-mediated knockdown of MSP58
Mon Jun 03 00:00:00 EDT 2013
Knockdown of ubiquitin ligases in glioblastoma cancer stem cells leads to cell death and differentiation.
Journal of biomolecular screening
Low J,Blosser W,Dowless M,Ricci-Vitiani L,Pallini R,de Maria R,Stancato L
MA5-14520 was used in immunocytochemistry to study the induction of glioblastoma cancer stem cell death and differentiation following shRNA knockdown of ubiquitin ligases
Wed Feb 01 00:00:00 EST 2012
Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review.
Diagnostic pathology
Yin WH,Li J,Chan JK
MA5-14520 was used in immunohistochemistry to report on a case of sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression
Thu Apr 12 00:00:00 EDT 2012
Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18.
The Journal of biological chemistry
Du Y,Kong G,You X,Zhang S,Zhang T,Gao Y,Ye L,Zhang X
MA5-14520 was used in immunohistochemistry to study the increase in HULC mediated by hepatitis B virus X protein and its role in hepatoma cell proliferation
Fri Jul 27 00:00:00 EDT 2012
Pigmented paraganglioma of the kidney: a case report.
Diagnostic pathology
Zhao L,Luo J,Zhang H,Da J
MA5-14520 was used in immunohistochemistry to report on a case of pigmented paraganglioma of the kidney
Thu Jun 28 00:00:00 EDT 2012
Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia.
PloS one
Saqui-Salces M,Covés-Datson E,Veniaminova NA,Waghray M,Syu LJ,Dlugosz AA,Merchant JL
MA5-14520 was used in immunohistochemistry to study the mechanisms underlying the inhibition of gastrin expression by inflammation and Gli2 in an animal model of antral hyperplasia
Fri Apr 05 00:00:00 EDT 2013
Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival.
PloS one
Cawthorn TR,Moreno JC,Dharsee M,Tran-Thanh D,Ackloo S,Zhu PH,Sardana G,Chen J,Kupchak P,Jacks LM,Miller NA,Youngson BJ,Iakovlev V,Guidos CJ,Vallis KA,Evans KR,McCready D,Leong WL,Done SJ
MA5-14520 was used in immunohistochemistry to identify prognostic biomarkers in breast cancer patients using proteomoc analysis
Fri Jun 29 00:00:00 EDT 2012
Early onset of endothelial cell proliferation in coronary thrombi of patients with an acute myocardial infarction: implications for plaque healing.
Journal of thrombosis and haemostasis : JTH
Li X,Kramer MC,VAN DER Loos CM,Ploegmakers HJ,DE Boer OJ,Koch KT,Tijssen JG,DE Winter RJ,VAN DER Wal AC
MA5-14520 was used in immunohistochemistry to study neovascularization and the timing of endothelial cell proliferation in coronary thrombi following acute myocardial infarction
Thu Mar 01 00:00:00 EST 2012
Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments.
BMC cancer
Nguyen L,Fifis T,Malcontenti-Wilson C,Chan LS,Costa PN,Nikfarjam M,Muralidharan V,Christophi C
MA5-14520 was used in immunohistochemistry to characterize the inherent differences in the microenvironment of the tumor periphery that contribute to OXi4503 treatment resistance
Thu Nov 15 00:00:00 EST 2012
The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors.
PloS one
Méndez-Gómez HR,Vicario-Abejón C
MA5-14520 was used in immunohistochemistry to study the role of the Gsx2 transcription factor in modulating neural stem cell self-renewal and differentiation
Tue May 08 00:00:00 EDT 2012
Overexpression of miR-30b in the developing mouse mammary gland causes a lactation defect and delays involution.
PloS one
Le Guillou S,Sdassi N,Laubier J,Passet B,Vilotte M,Castille J,Laloë D,Polyte J,Bouet S,Jaffrézic F,Cribiu EP,Vilotte JL,Le Provost F
MA5-14520 was used in immunohistochemistry to study the defective lactation and delayed involution observed in the developing mammary gland of mice transgenically overexpressing miRNA-30b
Thu Mar 28 00:00:00 EDT 2013
Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature.
Case reports in oncology
Masago K,Hosada W,Sasaki E,Murakami Y,Sugano M,Nagasaka T,Yamada M,Yatabe Y
MA5-14520 was used in immunohistochemistry to report on a patient with large pulmonary meningothelial-like nodules
Tue May 01 00:00:00 EDT 2012
Differential function of NBS1 and ATR in neurogenesis.
DNA repair
Zhou Z,Bruhn C,Wang ZQ
MA5-14520 was used in immunohistochemistry to study the different neurogenic roles of NBS1 and ATR
Wed Feb 01 00:00:00 EST 2012
Reduced proliferation in the adult mouse subventricular zone increases survival of olfactory bulb interneurons.
PloS one
Sui Y,Horne MK,Stanić D
MA5-14520 was used in immunohistochemistry to test if survival of adult-born cells is regulated by the rate of precursor proliferation in the subependymal zone
Fri Jun 29 00:00:00 EDT 2012
The prognostic value of Skp2 expression in Egyptian diffuse large B-cell lymphoma.
Applied immunohistochemistry & molecular morphology : AIMM
Abdou AG,Asaad NY,Abd El-Wahed MM,Samaka RM,Allah MS
MA5-14520 was used in immunohistochemistry to study Skp2 expression and its prognostic value in Egyptian diffuse large B-cell lymphoma
Sun Jan 01 00:00:00 EST 2012
Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood.
Scientific reports
Anttonen T,Kirjavainen A,Belevich I,Laos M,Richardson WD,Jokitalo E,Brakebusch C,Pirvola U
MA5-14520 was used in immunohistochemistry to study the effects of Cdc42 ablation on auditory supporting cells and adult wound healing
Fri Jun 14 00:00:00 EDT 2013
A crucial role of bone morphogenetic protein signaling in the wound healing response in acute liver injury induced by carbon tetrachloride.
International journal of hepatology
Oumi N,Taniguchi KA,Kanai AM,Yasunaga M,Nakanishi T,Sato K
MA5-14520 was used in immunohistochemistry to study the role of BMP signaling in wound repair in a rat model of acute hepatic injury
Thu Aug 23 00:00:00 EDT 2012
Characterization of the Tumor-Microenvironment in Patient-Derived Cervix Xenografts (OCICx).
Cancers
Chaudary N,Pintilie M,Schwock J,Dhani N,Clarke B,Milosevic M,Fyles A,Hill RP
MA5-14520 was used in immunohistochemistry to discuss how the microenvironmental properties of primary tumors are recapitulated in xenograft models
Wed Aug 29 00:00:00 EDT 2012
COP1 is a tumour suppressor that causes degradation of ETS transcription factors.
Nature
Vitari AC,Leong KG,Newton K,Yee C,O'Rourke K,Liu J,Phu L,Vij R,Ferrando R,Couto SS,Mohan S,Pandita A,Hongo JA,Arnott D,Wertz IE,Gao WQ,French DM,Dixit VM
MA5-14520 was used in immunohistochemistry to investigate post-translational regulation of ETS family and their roles in prostatic tumorgenesis
Sun May 15 00:00:00 EDT 2011
Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan.
Gastroenterology
Emmink BL,Van Houdt WJ,Vries RG,Hoogwater FJ,Govaert KM,Verheem A,Nijkamp MW,Steller EJ,Jimenez CR,Clevers H,Borel Rinkes IH,Kranenburg O
MA5-14520 was used in immunohistochemistry to investigate the association of tumor-initiating potential with irinotecan resistance in human colorectal cancer cells
Fri Jul 01 00:00:00 EDT 2011
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.
Nature immunology
Ramirez-Carrozzi V,Sambandam A,Luis E,Lin Z,Jeet S,Lesch J,Hackney J,Kim J,Zhou M,Lai J,Modrusan Z,Sai T,Lee W,Xu M,Caplazi P,Diehl L,de Voss J,Balazs M,Gonzalez L,Singh H,Ouyang W,Pappu R
MA5-14520 was used in immunohistochemistry to investigate the effect of IL-17C on the non-specific immune response of epithelial cells
Wed Oct 12 00:00:00 EDT 2011
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations.
The Journal of clinical investigation
Grachtchouk M,Pero J,Yang SH,Ermilov AN,Michael LE,Wang A,Wilbert D,Patel RM,Ferris J,Diener J,Allen M,Lim S,Syu LJ,Verhaegen M,Dlugosz AA
MA5-14520 was used in immunohistochemistry to investigate the origin of basal cell carcinomas
Sun May 01 00:00:00 EDT 2011
Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis.
Kidney international
Sörensen I,Susnik N,Inhester T,Degen JL,Melk A,Haller H,Schmitt R
MA5-14520 was used in immunohistochemistry to investigate the role of fibrinogen in renal fibrosis
Tue Nov 01 00:00:00 EDT 2011
Predicting IGF-1R therapy response in bone sarcomas: immuno-SPECT imaging with radiolabeled R1507.
Clinical cancer research : an official journal of the American Association for Cancer Research
Fleuren ED,Versleijen-Jonkers YM,van de Luijtgaarden AC,Molkenboer-Kuenen JD,Heskamp S,Roeffen MH,van Laarhoven HW,Houghton PJ,Oyen WJ,Boerman OC,van der Graaf WT
MA5-14520 was used in immunohistochemistry to develop a novel non-invasive method to help predict the response of bone sarcomas to IGF-1R therapy
Thu Dec 15 00:00:00 EST 2011
Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells.
Cancer research
Damelin M,Geles KG,Follettie MT,Yuan P,Baxter M,Golas J,DiJoseph JF,Karnoub M,Huang S,Diesl V,Behrens C,Choe SE,Rios C,Gruzas J,Sridharan L,Dougher M,Kunz A,Hamann PR,Evans D,Armellino D,Khandke K,Marquette K,Tchistiakova L,Boghaert ER,Abraham RT,Wistuba II,Zhou BB
MA5-14520 was used in immunohistochemistry to investigate the heterogeneity and hierarchy in non-small cell lung cancer cells
Wed Jun 15 00:00:00 EDT 2011
Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.
Cancer research
Meyer DS,Brinkhaus H,Müller U,Müller M,Cardiff RD,Bentires-Alj M
MA5-14520 was used in immunohistochemistry to elucidate the contribution of PIK3CA H1047R to breast cancer pathogenesis.
Fri Jul 01 00:00:00 EDT 2011
Autophagy-deficient mice develop multiple liver tumors.
Genes & development
Takamura A,Komatsu M,Hara T,Sakamoto A,Kishi C,Waguri S,Eishi Y,Hino O,Tanaka K,Mizushima N
MA5-14520 was used in western blot to study the development of liver tumors in autophagy-deficient mice
Fri Apr 15 00:00:00 EDT 2011
Validation of MdmX as a therapeutic target for reactivating p53 in tumors.
Genes & development
Garcia D,Warr MR,Martins CP,Brown Swigart L,Passegué E,Evan GI
MA5-14520 was used in immunohistochemistry to study MdmX as a therapeutic target for reactivating p53 in tumors
Mon Aug 15 00:00:00 EDT 2011
Endogenous Myc maintains the tumor microenvironment.
Genes & development
Sodir NM,Swigart LB,Karnezis AN,Hanahan D,Evan GI,Soucek L
MA5-14520 was used in immunohistochemistry to investigate the involvement of endogenous Myc in tumor microenvironment maintenance
Sun May 01 00:00:00 EDT 2011
Laser microdissection for the assessment of the clonal relationship between chronic lymphocytic leukemia/small lymphocytic lymphoma and proliferating B cells within lymph node pseudofollicles.
Leukemia
Vandewoestyne ML,Pede VC,Lambein KY,Dhaenens MF,Offner FC,Praet MM,Philippé JJ,Kipps TJ,Deforce DL
MA5-14520 was used in immunohistochemistry to evaluate the laser microdissection technique for assessing the clonal relationship in chronic lymphocytic leukemia/small lymphocytic lymphoma
Sun May 01 00:00:00 EDT 2011
Quantitative assessment of hepatic function during liver regeneration in a standardized rat model.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
de Graaf W,Bennink RJ,Heger M,Maas A,de Bruin K,van Gulik TM
MA5-14520 was used in immunohistochemistry to compare different methods for assessing hepatic function during liver regeneration in a rat partial hepatectomy model
Tue Feb 01 00:00:00 EST 2011
Gastrointestinal stromal tumours in children and young adults: a clinicopathologic series with long-term follow-up from the database of the Cooperative Weichteilsarkom Studiengruppe (CWS).
European journal of cancer (Oxford, England : 1990)
Benesch M,Leuschner I,Wardelmann E,Thielen M,Schmid I,Kontny U,Ebetsberger G,Frey E,Graf N,Schneider DT,Kremens B,Amann G,Urban C,Schlemmer M,Quehenberger F,Klingebiel T,Dantonello T,Koscielniak E
MA5-14520 was used in immunohistochemistry to investigate gastrointestinal stromal tumours in patients with long-term follow-up
Fri Jul 01 00:00:00 EDT 2011
Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models.
The Journal of pathology
Navis AC,Hamans BC,Claes A,Heerschap A,Jeuken JW,Wesseling P,Leenders WP
MA5-14520 was used in immunohistochemistry to investigate the role of VEGF and PDGF pathway in glioma development
Fri Apr 01 00:00:00 EDT 2011
Trastuzumab-DM1 is highly effective in preclinical models of HER2-positive gastric cancer.
Cancer letters
Barok M,Tanner M,Köninki K,Isola J
MA5-14520 was used in immunohistochemistry to investigate the efficacy of Trastuzumab-DM1 for the treatment of gastric cancer expressing HER2
Thu Jul 28 00:00:00 EDT 2011
Inhibition of angiogenic and non-angiogenic targets by sorafenib in renal cell carcinoma (RCC) in a RCC xenograft model.
British journal of cancer
Yuen JS,Sim MY,Siml HG,Chong TW,Lau WK,Cheng CW,Huynh H
MA5-14520 was used in immunohistochemistry to study the molecular targets of sorafenib in a xenograft model of renal cell carcinoma
Tue Mar 15 00:00:00 EDT 2011
Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo.
Oncogene
Nogueira L,Ruiz-Ontañon P,Vazquez-Barquero A,Lafarga M,Berciano MT,Aldaz B,Grande L,Casafont I,Segura V,Robles EF,Suarez D,Garcia LF,Martinez-Climent JA,Fernandez-Luna JL
MA5-14520 was used in immunohistochemistry to investigate the role of NF-kappaB signal in the survival and development of glioblastoma-initiating cells
Thu Aug 11 00:00:00 EDT 2011
Resistance or sensitivity of Wilms' tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target.
Oncogene
Pode-Shakked N,Harari-Steinberg O,Haberman-Ziv Y,Rom-Gross E,Bahar S,Omer D,Metsuyanim S,Buzhor E,Jacob-Hirsch J,Goldstein RS,Mark-Danieli M,Dekel B
MA5-14520 was used in immunocytochemistry to investigate the therapeutic value of FZD7 in Wilms tumor
Thu Apr 07 00:00:00 EDT 2011
Development of skin-humanized mouse models of pachyonychia congenita.
The Journal of investigative dermatology
García M,Larcher F,Hickerson RP,Baselga E,Leachman SA,Kaspar RL,Del Rio M
MA5-14520 was used in immunohistochemistry to develop and evaluate a mouse model for pachyonychia congenita
Sun May 01 00:00:00 EDT 2011
Endothelium-coated tumor clusters are associated with poor prognosis and micrometastasis of hepatocellular carcinoma after resection.
Cancer
Ding T,Xu J,Zhang Y,Guo RP,Wu WC,Zhang SD,Qian CN,Zheng L
MA5-14520 was used in immunohistochemistry to investigate the relationship between endothelium-coated tumor clusters and severity of liver cancer patients
Tue Nov 01 00:00:00 EDT 2011
The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Sampson ER,Martin BA,Morris AE,Xie C,Schwarz EM,O'Keefe RJ,Rosier RN
MA5-14520 was used in immunohistochemistry to study the ability of a selective Met inhibitor to attenuate osteosarcoma growth
Wed Jun 01 00:00:00 EDT 2011
Optic nerve gliomas: role of Ki-67 staining of tumour and margins in predicting long-term outcome.
The British journal of ophthalmology
Yeung SN,White VA,Nimmo M,Rootman J
MA5-14520 was used in immunohistochemistry to investigate the distribution of Ki-67 in optic nerve gliomas
Mon Aug 01 00:00:00 EDT 2011
High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice.
Journal of molecular medicine (Berlin, Germany)
Ognibene M,Barbieri O,Vanni C,Mastracci L,Astigiano S,Emionite L,Salani B,Fedele M,Resaz R,Tenca C,Fais F,Sabatini F,De Santanna A,Altruda F,Varesio L,Hirsch E,Eva A
MA5-14520 was used in immunohistochemistry to investigate the role of Dbl in the development of B cell lymphoma in mice
Sun May 01 00:00:00 EDT 2011
Elf3 plays a role in regulating bronchiolar epithelial repair kinetics following Clara cell-specific injury.
Laboratory investigation; a journal of technical methods and pathology
Oliver JR,Kushwah R,Wu J,Pan J,Cutz E,Yeger H,Waddell TK,Hu J
MA5-14520 was used in immunohistochemistry to study the role of Elf3 in the repair of airway epithelium following injury
Sat Oct 01 00:00:00 EDT 2011
Cyclooxygenase-2 supports tumor proliferation in vestibular schwannomas.
Neurosurgery
Hong B,Krusche CA,Schwabe K,Friedrich S,Klein R,Krauss JK,Nakamura M
MA5-14520 was used in immunohistochemistry to study the role of cyclooxygenase-2 in tumor proliferation in vestibular Schwannomas
Fri Apr 01 00:00:00 EDT 2011
Restrictions that control herpes simplex virus type 1 infection in mouse brain ex vivo.
The Journal of general virology
Cohen M,Braun E,Tsalenchuck Y,Panet A,Steiner I
MA5-14520 was used in immunohistochemistry to investigate tissue factors controlling HSV-1 infection in mouse brain slice culture
Sat Oct 01 00:00:00 EDT 2011
Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation.
Carcinogenesis
Hur K,Niwa T,Toyoda T,Tsukamoto T,Tatematsu M,Yang HK,Ushijima T
MA5-14520 was used in immunohistochemistry to investigate the role of persistent inflammation and cell proliferation in aberrant DNA methylation
Sat Jan 01 00:00:00 EST 2011
Influence of heparan sulfate chains in proteoglycan at the dermal-epidermal junction on epidermal homeostasis.
Experimental dermatology
Iriyama S,Hiruma T,Tsunenaga M,Amano S
MA5-14520 was used in immunohistochemistry to investigate the functional properties of heparan sulfate chains at the dermal-epidermal junction
Sat Oct 01 00:00:00 EDT 2011
Infrared radiation does not enhance the frequency of ultraviolet radiation-induced skin tumors, but their growth behaviour in mice.
Experimental dermatology
Jantschitsch C,Weichenthal M,Maeda A,Proksch E,Schwarz T,Schwarz A
MA5-14520 was used in immunohistochemistry to investigate the effect of infrared radiation on skin tumor induction and growth
Fri Apr 01 00:00:00 EDT 2011
CDKN1B/p27 expression in peripheral T cell lymphoma not otherwise specified.
Journal of clinical pathology
Gazzola A,Sista MT,Agostinelli C,Righi S,Sapienza MR,Mannu C,Rossi M,Bacci F,Sabattini E,Went P,Zinzani PL,Pileri SA,Piccaluga PP
MA5-14520 was used in immunohistochemistry to study whether peripheral T-cell lymphoma involves aberrations of CDKN1B/p27
Sat Jan 01 00:00:00 EST 2011
Analysis of the IgVH genes in T cell-mediated and antibody-mediated rejection of the kidney graft.
Journal of clinical pathology
Bellan C,Amato T,Carmellini M,Onorati M,D'Amuri A,Leoncini L,del Vecchio MT
MA5-14520 was used in immunohistochemistry to investigate the role of IgVH genes in host-graft rejection in renal transplants
Sat Jan 01 00:00:00 EST 2011
Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury.
Journal of neuroscience research
Lepore AC,O'Donnell J,Bonner JF,Paul C,Miller ME,Rauck B,Kushner RA,Rothstein JD,Fischer I,Maragakis NJ
MA5-14520 was used in immunohistochemistry to investigate the changes of astrocyte glutamate transporter GLT1 promoter activity after traumatic spinal cord injury
Fri Jul 01 00:00:00 EDT 2011
The relationship among PDX1, CDX2, and mucin profiles in gastric carcinomas; correlations with clinicopathologic parameters.
Journal of cancer research and clinical oncology
Oz Puyan F,Can N,Ozyilmaz F,Usta U,Sut N,Tastekin E,Altaner S
MA5-14520 was used in immunohistochemistry to study the association of PDX1 expression with various clinicopathologic parameters in gastric carcinomas
Thu Dec 01 00:00:00 EST 2011
Kidney spheroids recapitulate tubular organoids leading to enhanced tubulogenic potency of human kidney-derived cells.
Tissue engineering. Part A
Buzhor E,Harari-Steinberg O,Omer D,Metsuyanim S,Jacob-Hirsch J,Noiman T,Dotan Z,Goldstein RS,Dekel B
MA5-14520 was used in immunocytochemistry to study the strategy to maintain and control human renal cell growth and differentiation
Thu Sep 01 00:00:00 EDT 2011
Topographical analysis of telomere length and correlation with genomic instability in whole mount prostatectomies.
The Prostate
Joshua AM,Shen E,Yoshimoto M,Marrano P,Zielenska M,Evans AJ,Van der Kwast T,Squire JA
MA5-14520 was used in immunohistochemistry to investigate the association between telomere length and prostatic carcinogenesis
Sun May 15 00:00:00 EDT 2011
Molecular phenotypes of matched in situ and invasive components of breast carcinomas.
Human pathology
Martins D,Sousa B,Lopes N,Gomes M,Veronese L,Albergaria A,Paredes J,Schmitt F
MA5-14520 was used in immunohistochemistry to compare the tissue microarray immunoprofiles of in situ and invasive breast carcinoma components within the same sample
Sat Oct 01 00:00:00 EDT 2011
Usefulness of p16ink4a, ProEX C, and Ki-67 for the diagnosis of glandular dysplasia and adenocarcinoma of the cervix uteri.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
Negri G,Bellisano G,Carico E,Faa G,Kasal A,Antoniazzi S,Egarter-Vigl E,Piccin A,Dalla Palma P,Vittadello F
MA5-14520 was used in immunohistochemistry to evaluate p16ink4a, ProEX C, and Ki-67 as biomarkers for glandular dysplasia and adenocarcinoma of the cervix uteri
Fri Jul 01 00:00:00 EDT 2011
Cytogenetic analysis of a malignant triton tumour by comparative genomic hybridization (CGH) and review of the literature.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Koutsimpelas D,Brieger J,Heinrich U,Torzewski M,Sommer C,Mann WJ
MA5-14520 was used in immunohistochemistry to conduct comparative genomic hybridization analysis of malignant triton tumour
Thu Sep 01 00:00:00 EDT 2011
X-irradiation reduces the proliferation of astrocytes by cell cycle arrest.
Neuroscience letters
Wang Q,Xu Y,Xie MJ,Yu ZY,Qin YY,Wang W,Zhu Z
MA5-14520 was used in immunocytochemistry to study the mechanism by which X-ray irradiation attenuates the proliferation of astrocytes
Fri Jul 01 00:00:00 EDT 2011
Tumour eosinophilia combined with an immunohistochemistry panel is useful in the differentiation of type B3 thymoma from thymic carcinoma.
International journal of experimental pathology
Khoury T,Chandrasekhar R,Wilding G,Tan D,Cheney RT
MA5-14520 was used in immunohistochemistry to investigate an immunohistochemistry method to distinguish type B3 thymoma from thymic carcinoma
Fri Apr 01 00:00:00 EDT 2011
Ki-67 and minichromosome maintenance-7 (MCM7) expression in canine pituitary corticotroph adenomas.
Domestic animal endocrinology
Ishino H,Hara Y,Takekoshi S,Teshima T,Teramoto A,Osamura RY,Tagawa M
MA5-14520 was used in immunohistochemistry to study the expression of Ki-67 and MCM7 in canine pituitary corticotroph adenomas
Tue Nov 01 00:00:00 EDT 2011
Investigation of galectin-3 and heparanase in endometrioid and serous carcinomas of the endometrium and correlation with known predictors of survival.
Archives of gynecology and obstetrics
Ege CB,Akbulut M,Zekioğlu O,Ozdemir N
MA5-14520 was used in immunohistochemistry to investigate the effect of galectin-3 and heparanase on the pathogenesis of endometrial carcinomas
Tue Nov 01 00:00:00 EDT 2011
Ectopic endometrial tissue in mesonephric duct remnants in bitches.
Reproduction in domestic animals = Zuchthygiene
Bartel C,Berghold P,Walter I
MA5-14520 was used in immunohistochemistry to study canine mesonephric remnants by immunohistochemistry
Thu Dec 01 00:00:00 EST 2011
Lymphoepithelioma-like carcinoma of the ovary.
International journal of surgical pathology
Ambrosio MR,Rocca BJ,Onorati M,Mourmouras V,Mastrogiulio MG,Crispino S,Liberatore C,Santopietro R
MA5-14520 was used in immunohistochemistry to report on a case of lymphoepithelioma-like carcinoma of the ovary
Mon Aug 01 00:00:00 EDT 2011
Osteosarcoma arising in a long-standing uterine leiomyoma: a case report and literature review.
International journal of surgical pathology
Wang RC,Wen MC,Wang J,Ho SC,Jan YJ
MA5-14520 was used in immunohistochemistry to report on a case of osteosarcoma occurring in a long-standing uterine leiomyoma
Tue Feb 01 00:00:00 EST 2011
Tumor-in-tumor of the thyroid with basaloid differentiation: a lesion with a solid cell nest neoplastic component?
International journal of surgical pathology
Eloy C,Vinagre J,Cameselle-Teijeiro J,Paiva ME,Soares P,Sobrinho-Simões M
MA5-14520 was used in immunohistochemistry to report on a case of tumor-in-tumor of the thyroid with basaloid differentiation
Fri Apr 01 00:00:00 EDT 2011
Increased diagnostic accuracy of atypical glandular cells in cervical liquid-based cytology using cell blocks.
Cytopathology : official journal of the British Society for Clinical Cytology
Risse EK,Holierhoek JP,Meijer-Marres EM,Ouwerkerk-Noordam E,Boon ME
MA5-14520 was used in blocking or activating experiment to investigate the cell block experiment for the accurate diagnoses of atypical glandular cells
Mon Aug 01 00:00:00 EDT 2011
Recurrence of benign meningiomas: predictive value of proliferative index, BCL2, p53, hormonal receptors and HER2 expression.
British journal of neurosurgery
Abdelzaher E,El-Gendi SM,Yehya A,Gowil AG
MA5-14520 was used in immunohistochemistry to identify biomarkers that predict the recurrence of benign meningiomas
Thu Dec 01 00:00:00 EST 2011
Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis.
Nature communications
Li S,Thangapazham RL,Wang JA,Rajesh S,Kao TC,Sperling L,Moss J,Darling TN
MA5-14520 was used in immunohistochemistry to study the role of tuberous sclerosis complex in hair follicle formation and tissue regeneration
Mon Aug 01 00:00:00 EDT 2011
Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.
PloS one
Lepore AC,O'Donnell J,Kim AS,Williams T,Tuteja A,Rao MS,Kelley LL,Campanelli JT,Maragakis NJ
MA5-14520 was used in immunohistochemistry to study the transplantation of human glial-restricted progenitors into the cervical spinal cord in a murine model of amyotrophic lateral sclerosis
Mon Feb 13 00:00:00 EST 2012
Enhancement of in vitro human tubulogenesis by endothelial cell-derived factors: implications for in vivo tubular regeneration after injury.
American journal of physiology. Renal physiology
Miya M,Maeshima A,Mishima K,Sakurai N,Ikeuchi H,Kuroiwa T,Hiromura K,Yokoo H,Nojima Y
MA5-14520 was used in immunohistochemistry to study the effect of endothelial cell-derived proteins on human tubulogenesis and the significance for post-injury regeneration
Mon Aug 01 00:00:00 EDT 2011
Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged.
ISRN oncology
Langenkamp E,Vom Hagen FM,Zwiers PJ,Moorlag HE,Schouten JP,Hammes HP,Gouw AS,Molema G
MA5-14520 was used in immunohistochemistry to study the angiogenesis during the progression of tumor growth
Thu Aug 23 00:00:00 EDT 2012
Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation.
BMC cancer
Ager EI,Wen SW,Chan J,Chong WW,Neo JH,Christophi C
MA5-14520 was used in immunohistochemistry to test if targeting the classical and alternative arms of the renin angiotensin system inhibits colorectal cancer liver metastases
Sun Jun 26 00:00:00 EDT 2011
Heat shock attenuates VEGF expression in three-dimensional myoblast sheets deteriorating therapeutic efficacy in heart failure.
Medical science monitor : international medical journal of experimental and clinical research
Augustin M,Ali Asim Mahar M,Lakkisto P,Tikkanen I,Vento A,Patila T,Harjula A
MA5-14520 was used in immunohistochemistry - paraffin section to test if heat shock pre-treatment affects the angiogenic properties of myoblast sheets in vivo and in vitro
Thu Dec 01 00:00:00 EST 2011
Expression of fascin protein and mRNA in the KB carcinoma cell line following treatment with doxorubicin.
Journal of cancer research and therapeutics
Alaeddini M,Fouladdel S,Etemad-Moghadam S,Azizi E
MA5-14520 was used in immunocytochemistry to study the effect of doxorubicin on fascin protein and mRNA expression in the KB carcinoma cell line
Tue Mar 20 00:00:00 EDT 2012
A comparative immunohistochemical analysis of COX-2, p53, and Ki-67 expression in keratocystic odontogenic tumors.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
Mendes RA,Carvalho JF,van der Waal I
MA5-14520 was used in immunohistochemistry to investigate the expression of cyclooxygenase-2, p53 and Ki-67 in keratocystic odontogenic tumors
Tue Mar 01 00:00:00 EST 2011
Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice.
Arthritis and rheumatism
Hsu HC,Yang P,Wu Q,Wang JH,Job G,Guentert T,Li J,Stockard CR,Le TV,Chaplin DD,Grizzle WE,Mountz JD
MA5-14520 was used in immunohistochemistry to determine if loss of activation-induced cytidine deaminase catalytic activity can suppress hyper-reactive germinal centre responses.
Fri Jul 01 00:00:00 EDT 2011
Therapeutic antibody targeting of individual Notch receptors.
Nature
Wu Y,Cain-Hom C,Choy L,Hagenbeek TJ,de Leon GP,Chen Y,Finkle D,Venook R,Wu X,Ridgway J,Schahin-Reed D,Dow GJ,Shelton A,Stawicki S,Watts RJ,Zhang J,Choy R,Howard P,Kadyk L,Yan M,Zha J,Callahan CA,Hymowitz SG,Siebel CW
MA5-14520 was used in immunohistochemistry to study therapeutic antibody targeting of individual Notch receptors
Thu Apr 15 00:00:00 EDT 2010
Thyroid transcription factor-1 influences the early phase of compensatory lung growth in adult mice.
American journal of respiratory and critical care medicine
Takahashi Y,Izumi Y,Kohno M,Kimura T,Kawamura M,Okada Y,Nomori H,Ikeda E
MA5-14520 was used in immunohistochemistry to investigate the role of thyroid transcription factor-1 in lung development
Tue Jun 15 00:00:00 EDT 2010
The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.
The Journal of experimental medicine
Pechloff K,Holch J,Ferch U,Schweneker M,Brunner K,Kremer M,Sparwasser T,Quintanilla-Martinez L,Zimber-Strobl U,Streubel B,Gewies A,Peschel C,Ruland J
MA5-14520 was used in immunohistochemistry to investigate the role of the fusion ITK-SYK kinase in oncogenesis
Mon May 10 00:00:00 EDT 2010
PF-03732010: a fully human monoclonal antibody against P-cadherin with antitumor and antimetastatic activity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Zhang CC,Yan Z,Zhang Q,Kuszpit K,Zasadny K,Qiu M,Painter CL,Wong A,Kraynov E,Arango ME,Mehta PP,Popoff I,Casperson GF,Los G,Bender S,Anderes K,Christensen JG,VanArsdale T
MA5-14520 was used in immunohistochemistry to study the biological properties of an anti-P-cadherin human monoclonal antibody in cell assays and in multiple tumor models
Mon Nov 01 00:00:00 EDT 2010
PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase.
Clinical cancer research : an official journal of the American Association for Cancer Research
Bartholomeusz C,Gonzalez-Angulo AM,Kazansky A,Krishnamurthy S,Liu P,Yuan LX,Yamasaki F,Liu S,Hayashi N,Zhang D,Esteva FJ,Hortobagyi GN,Ueno NT
MA5-14520 was used in immunohistochemistry to study the mechanism by which PEA-15 inhibits tumorigenesis in a xenograft model of triple-negative breast cancer
Mon Mar 15 00:00:00 EDT 2010
Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth.
Cancer research
Mellick AS,Plummer PN,Nolan DJ,Gao D,Bambino K,Hahn M,Catena R,Turner V,McDonnell K,Benezra R,Brink R,Swarbrick A,Mittal V
MA5-14520 was used in immunohistochemistry to develop a system to selectively target endothelial progenitor cells as a novel strategy to inhibit tumor angiogenesis and growth
Wed Sep 15 00:00:00 EDT 2010
Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.
Cancer research
Efferson CL,Winkelmann CT,Ware C,Sullivan T,Giampaoli S,Tammam J,Patel S,Mesiti G,Reilly JF,Gibson RE,Buser C,Yeatman T,Coppola D,Winter C,Clark EA,Draetta GF,Strack PR,Majumder PK
MA5-14520 was used in immunohistochemistry to study the effect of gamma-secretase inhibition of the Notch pathway on AKT/mTor signaling and glucose uptake in a murine ERBB2 breast cancer model
Mon Mar 15 00:00:00 EDT 2010
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.
Proceedings of the National Academy of Sciences of the United States of America
Murray BW,Guo C,Piraino J,Westwick JK,Zhang C,Lamerdin J,Dagostino E,Knighton D,Loi CM,Zager M,Kraynov E,Popoff I,Christensen JG,Martinez R,Kephart SE,Marakovits J,Karlicek S,Bergqvist S,Smeal T
MA5-14520 was used in immunohistochemistry to study anti-tumor activity and mechanism of a novel small molecule PAK4 inhibitor in vitro and against a number of human cancer xenograft models
Tue May 18 00:00:00 EDT 2010
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
Journal of the National Cancer Institute
Hendrix A,Maynard D,Pauwels P,Braems G,Denys H,Van den Broecke R,Lambert J,Van Belle S,Cocquyt V,Gespach C,Bracke M,Seabra MC,Gahl WA,De Wever O,Westbroek W
MA5-14520 was used in immunohistochemistry to investigate the role of secretory small GTPase Rab27B in breast cancer proliferation and metastasis
Wed Jun 16 00:00:00 EDT 2010
111In-bevacizumab imaging of renal cell cancer and evaluation of neoadjuvant treatment with the vascular endothelial growth factor receptor inhibitor sorafenib.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Desar IM,Stillebroer AB,Oosterwijk E,Leenders WP,van Herpen CM,van der Graaf WT,Boerman OC,Mulders PF,Oyen WJ
MA5-14520 was used in immunohistochemistry to study the use of (111)Ln bavacizumab to evaluate the response to treatment with aVEGF receptor inhibitor in renal cell cancer.
Mon Nov 01 00:00:00 EDT 2010
VHL and PTEN loss coordinate to promote mouse liver vascular lesions.
Angiogenesis
Chen S,Sanford CA,Sun J,Choi V,Van Dyke T,Samulski RJ,Rathmell WK
MA5-14520 was used in immunohistochemistry to investigate the role of PTEN/VHL deletion in the development of liver vascular lesions
Mon Mar 01 00:00:00 EST 2010
Indirubin-3'-monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivo.
Arteriosclerosis, thrombosis, and vascular biology
Schwaiberger AV,Heiss EH,Cabaravdic M,Oberan T,Zaujec J,Schachner D,Uhrin P,Atanasov AG,Breuss JM,Binder BR,Dirsch VM
MA5-14520 was used in immunohistochemistry to investigate the effect of indirubin-3-monoxime on vascular smooth muscle cell proliferation and neointima formation
Wed Dec 01 00:00:00 EST 2010
The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development.
Science signaling
Maruyama T,Mirando AJ,Deng CX,Hsu W
MA5-14520 was used in immunohistochemistry to investigate the effect of WNT and FGF signaling on mesenchymal stem cell differentiation
Tue May 25 00:00:00 EDT 2010
Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa.
British journal of cancer
de Bruijn MT,Raats DA,Hoogwater FJ,van Houdt WJ,Cameron K,Medema JP,Borel Rinkes IH,Kranenburg O
MA5-14520 was used in immunohistochemistry to investigate the effect of KRAS on the cellular response to chemotherapy and its mechanism
Tue Apr 13 00:00:00 EDT 2010
Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E.
Oncogene
Andrieu C,Taieb D,Baylot V,Ettinger S,Soubeyran P,De-Thonel A,Nelson C,Garrido C,So A,Fazli L,Bladou F,Gleave M,Iovanna JL,Rocchi P
MA5-14520 was used in immunohistochemistry to study anti-apoptotic pathways during prostate cancer progression
Thu Apr 01 00:00:00 EDT 2010
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.
International journal of cancer
Harikumar KB,Kunnumakkara AB,Sethi G,Diagaradjane P,Anand P,Pandey MK,Gelovani J,Krishnan S,Guha S,Aggarwal BB
MA5-14520 was used in immunohistochemistry to study the ability of resveratrol to enhance the antitumor activity of gemcitabine against pancreatic cancer cell lines and a xenograpft model of human pancreatic cancer
Thu Jul 15 00:00:00 EDT 2010
Extraribosomal function of metallopanstimulin-1: reducing paxillin in head and neck squamous cell carcinoma and inhibiting tumor growth.
International journal of cancer
Dai Y,Pierson SE,Dudney WC,Stack BC
MA5-14520 was used in immunohistochemistry to investigate the effect of metallopanstimulin-1 on tumor growth and gene expression
Mon Feb 01 00:00:00 EST 2010
Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bianchi P,Ciani E,Guidi S,Trazzi S,Felice D,Grossi G,Fernandez M,Giuliani A,Calzà L,Bartesaghi R
MA5-14520 was used in immunohistochemistry to study whether early pharmacotherapy corrects neurogenesis and cognitive function in a mouse model of Downs syndrome.
Wed Jun 30 00:00:00 EDT 2010
Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gao Y,Vasilyev DV,Goncalves MB,Howell FV,Hobbs C,Reisenberg M,Shen R,Zhang MY,Strassle BW,Lu P,Mark L,Piesla MJ,Deng K,Kouranova EV,Ring RH,Whiteside GT,Bates B,Walsh FS,Williams G,Pangalos MN,Samad TA,Doherty P
MA5-14520 was used in immunohistochemistry to investigate the effect of DAGLalpha on retrograde synaptic plasticity and adult neurogenesis
Wed Feb 10 00:00:00 EST 2010
Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ables JL,Decarolis NA,Johnson MA,Rivera PD,Gao Z,Cooper DC,Radtke F,Hsieh J,Eisch AJ
MA5-14520 was used in immunohistochemistry to study the role of Notch1 in maintaining a reservoir of adult hippocampal stem cells
Wed Aug 04 00:00:00 EDT 2010
Antiangiogenic effect of licochalcone A.
Biochemical pharmacology
Kim YH,Shin EK,Kim DH,Lee HH,Park JH,Kim JK
MA5-14520 was used in immunohistochemistry to study whether licochalcone A is able to inhibit angiogenesis
Fri Oct 15 00:00:00 EDT 2010
A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.
Molecular cancer therapeutics
Harikumar KB,Kunnumakkara AB,Ochi N,Tong Z,Deorukhkar A,Sung B,Kelland L,Jamieson S,Sutherland R,Raynham T,Charles M,Bagherzadeh A,Foxton C,Boakes A,Farooq M,Maru D,Diagaradjane P,Matsuo Y,Sinnett-Smith J,Gelovani J,Krishnan S,Aggarwal BB,Rozengurt E,Ireson CR,Guha S
MA5-14520 was used in immunohistochemistry to study the inhibition of pancreatic cancer growth by a novel small molecule protein kinase D inhibitor
Sat May 01 00:00:00 EDT 2010
The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Nguyen Dinh Cat A,Griol-Charhbili V,Loufrani L,Labat C,Benjamin L,Farman N,Lacolley P,Henrion D,Jaisser F
MA5-14520 was used in immunohistochemistry to investigate the effect of endothelial mineralocorticoid receptor on vasoconstrictor tone and blood pressure
Thu Jul 01 00:00:00 EDT 2010
S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer.
The American journal of pathology
Wang XH,Zhang LH,Zhong XY,Xing XF,Liu YQ,Niu ZJ,Peng Y,Du H,Zhang GG,Hu Y,Liu N,Zhu YB,Ge SH,Zhao W,Lu AP,Li JY,Ji JF
MA5-14520 was used in immunohistochemistry to investigate the prognostic significance of S100A6 overexpression in gastric cancer
Sun Aug 01 00:00:00 EDT 2010
Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment.
The American journal of pathology
de Neergaard M,Kim J,Villadsen R,Fridriksdottir AJ,Rank F,Timmermans-Wielenga V,Langerød A,Børresen-Dale AL,Petersen OW,Rønnov-Jessen L
MA5-14520 was used in immunohistochemistry to investigate the role of epithelial-stromal interaction-1 in human tumors
Mon Mar 01 00:00:00 EST 2010
Eph receptor tyrosine kinases regulate astrocyte cytoskeletal rearrangement and focal adhesion formation.
Journal of neurochemistry
Puschmann TB,Turnley AM
MA5-14520 was used in immunocytochemistry to study the role of EphA4 in regulating astrocyte cytoskeletal responses
Sat May 01 00:00:00 EDT 2010
Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals.
Journal of immunology (Baltimore, Md. : 1950)
Gordon SN,Cervasi B,Odorizzi P,Silverman R,Aberra F,Ginsberg G,Estes JD,Paiardini M,Frank I,Silvestri G
MA5-14520 was used in immunohistochemistry to investigate the role of intestinal CD4+ T cell homeostasis in HIV-infected individuals
Mon Nov 01 00:00:00 EDT 2010
Heparanase expression of glioma in human and animal models.
Journal of neurosurgery
Hong X,Nelson KK,deCarvalho AC,Kalkanis SN
MA5-14520 was used in immunohistochemistry to characterize the expression of mammalian heparanase
Sun Aug 01 00:00:00 EDT 2010
TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytes.
Journal of dermatological science
Räsänen K,Vaheri A
MA5-14520 was used in immunohistochemistry to study the role of Cox-2 in the TGF-beta1 mediated epithelial-mesenchymal transition response
Sat May 01 00:00:00 EDT 2010
Immuno-histochemical evaluation of solar lentigines: The association of KGF/KGFR and other factors with lesion development.
Journal of dermatological science
Lin CB,Hu Y,Rossetti D,Chen N,David C,Slominski A,Seiberg M
MA5-14520 was used in immunohistochemistry to study the role of KGF/KGF receptor and other pigmentary genes in the development of lesions in solar lentigines
Sun Aug 01 00:00:00 EDT 2010
A class discovery and class prediction approach to histopathological classification of mammographic screen detected columnar cell lesions of the breast.
Pathology
Pathmanathan N,Salisbury EL,Provan PJ,Bilous AM,Byth K,Milliken JS,Clarke CL,Balleine RL
MA5-14520 was used in immunohistochemistry to evaluate a novel method for the classification of breast columnar cell lesions
Fri Jan 01 00:00:00 EST 2010
Chemokine expression in renal ischemia/reperfusion injury is most profound during the reparative phase.
International immunology
Stroo I,Stokman G,Teske GJ,Raven A,Butter LM,Florquin S,Leemans JC
MA5-14520 was used in immunohistochemistry to examine the proliferation of tubular epithelial cells after renal ischemia/reperfusion injury
Tue Jun 01 00:00:00 EDT 2010
Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark.
Molecular and cellular biology
Revenko AS,Kalashnikova EV,Gemo AT,Zou JX,Chen HW
MA5-14520 was used in immunohistochemistry to study the mechanism of chromatin loading of the E2F-MLL complex by cancer-associated coregulator ANCCA
Mon Nov 01 00:00:00 EDT 2010
The role of keratinocyte growth factor in melanogenesis: a possible mechanism for the initiation of solar lentigines.
Experimental dermatology
Chen N,Hu Y,Li WH,Eisinger M,Seiberg M,Lin CB
MA5-14520 was used in immunohistochemistry to investigate the role of keratinocyte growth factor in melanogenesis and solar lentigines
Fri Oct 01 00:00:00 EDT 2010
Diagnostic value of p16INK4A, Ki-67, and human papillomavirus L1 capsid protein immunochemical staining on cell blocks from residual liquid-based gynecologic cytology specimens.
Cancer cytopathology
Yu L,Wang L,Zhong J,Chen S
MA5-14520 was used in immunocytochemistry to evaluate a cell block preparation technique for cytologic diagnosis of residual liquid-based gynecologic specimens
Thu Feb 25 00:00:00 EST 2010
Proliferation and motility of HaCaT keratinocyte derivatives is enhanced by fibroblast nemosis.
Experimental cell research
Räsänen K,Vaheri A
MA5-14520 was used in immunohistochemistry to study the effect of fibroblast nemosis on the proliferation and motility of HaCaT keratinocyte derivatives and the significance for tumor progression
Thu Jun 10 00:00:00 EDT 2010
Adipose tissue progenitor cells directly interact with endothelial cells to induce vascular network formation.
Tissue engineering. Part A
Merfeld-Clauss S,Gollahalli N,March KL,Traktuev DO
MA5-14520 was used in immunohistochemistry to study the mechanisms by which the interaction of adipose tissue progenitor cells with endothelial cells promotes vasculogenesis
Wed Sep 01 00:00:00 EDT 2010
Desmoplastic small round cell tumor of the submandibular gland--a rare but distinctive primary salivary gland neoplasm.
Human pathology
Yin WH,Guo SP,Yang HY,Chan JK
MA5-14520 was used in immunohistochemistry to report on a case of desmoplastic small round cell tumor of the submandibular gland
Mon Mar 01 00:00:00 EST 2010
The pathogenic role of Epstein-Barr virus (EBV) in sclerosing polycystic adenosis.
Pathology, research and practice
Swelam WM
MA5-14520 was used in immunohistochemistry to study the role of EBV infection in the pathogenesis of sclerosing polycystic adenosis
Sun Aug 15 00:00:00 EDT 2010
Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors.
Developmental biology
Laine H,Sulg M,Kirjavainen A,Pirvola U
MA5-14520 was used in immunohistochemistry to study the role of cyclin D1 in inner ear sensory epithelial cell cycle regulation
Fri Jan 01 00:00:00 EST 2010
What would be left behind if subtotal thyroidectomy were preferred instead of total thyroidectomy?
American journal of surgery
Tekin K,Yilmaz S,Yalçin N,Coban S,Aydin C,Kabay B,Erdem E,Ozbaş S,Ozden A
MA5-14520 was used in immunohistochemistry to study the cellular proliferative activity of remnant thyroid tissues after subtotal thyroidectomy
Tue Jun 01 00:00:00 EDT 2010
A comparison of Ki-67 antigen presentation in acute generalized exanthematous pustulosis and pustular psoriasis.
Archives of dermatological research
Chang SL,Hu S,Hung SI,Huang YL,Hsiao WC,Chung WH
MA5-14520 was used in immunohistochemistry to compare Ki-67 immunostaining in acute generalized exanthematous pustulosis and pustular psoriasis
Wed Sep 01 00:00:00 EDT 2010
Evaluation of clinico-pathological criteria and the Ki67 index as prognostic indicators in canine insulinoma.
Veterinary journal (London, England : 1997)
Buishand FO,Kik M,Kirpensteijn J
MA5-14520 was used in immunohistochemistry to investigate the prognostic significance of Ki67 in insulinoma
Thu Jul 01 00:00:00 EDT 2010
Expression of Ki-67, PCNA, and p27kip1 in canine pituitary corticotroph adenomas.
Domestic animal endocrinology
van Rijn SJ,Grinwis GC,Penning LC,Meij BP
MA5-14520 was used in immunohistochemistry to investigate the level of specific proliferative proteins in pituitary corticotroph adenomas
Sat May 01 00:00:00 EDT 2010
Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: potential for prostate cancer management.
Anticancer research
Ghosh R,Graham H,Rivas P,Tan XJ,Crosby K,Bhaskaran S,Schoolfield J,Banu J,Fernandes G,Yeh IT,Kumar AP
MA5-14520 was used in immunohistochemistry to study the effect of Phellodendron amurense bark extract on the progression of prostate tumors in a mouse model
Mon Mar 01 00:00:00 EST 2010
Synchronous presentation of GISTs and other primary neoplasms: a single center experience.
In vivo (Athens, Greece)
Arnogiannaki N,Martzoukou I,Kountourakis P,Dimitriadis E,Papathanasaki A,Nastoulis E,Gazalidou M,Fida A,Apostolikas N,Agnantis NJ
MA5-14520 was used in immunohistochemistry to perform immunohistochemical and mutational analysis of clinical cases of gastrointestinal stromal tumors
Wed Apr 14 00:00:00 EDT 2010
Acute ANIT toxicity in male IL-10 knockout and wild-type mice.
Toxicologic pathology
Faiola B,Peterson RA,Kimbrough CL,Jordan HL,Cullen JM
MA5-14520 was used in immunohistochemistry to study acute alpha-napthylisothiocyanate toxicity in male IL-10 knockout and wild-type mice
Sun Aug 01 00:00:00 EDT 2010
Evaluation of the presence of Helicobacter species in the biliary system of Turkish patients with cholelithiasis.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Bostanoğlu E,Karahan ZC,Bostanoğlu A,Savaş B,Erden E,Kiyan M
MA5-14520 was used in immunohistochemistry to evaluate the presence of Helicobacter species in the biliary system of Turkish patients with cholelithiasis
Wed Dec 01 00:00:00 EST 2010
High-precision radiosurgical dose delivery by interlaced microbeam arrays of high-flux low-energy synchrotron X-rays.
PloS one
Serduc R,Bräuer-Krisch E,Siegbahn EA,Bouchet A,Pouyatos B,Carron R,Pannetier N,Renaud L,Berruyer G,Nemoz C,Brochard T,Rémy C,Barbier EL,Bravin A,Le Duc G,Depaulis A,Estève F,Laissue JA
MA5-14520 was used in immunohistochemistry to evaluate interlaced microbeam arrays of high-flux low-energy synchrotron X-rays for radiosurgery
Wed Feb 03 00:00:00 EST 2010
DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration.
PloS one
Osada M,Jardine L,Misir R,Andl T,Millar SE,Pezzano M
MA5-14520 was used in immunocytochemistry to investigate Wnt signaling effects on T cell development
Mon Feb 08 00:00:00 EST 2010
Methylnitrosourea induces neural progenitor cell apoptosis and microcephaly in mouse embryos.
Birth defects research. Part B, Developmental and reproductive toxicology
Komada M,Fujiyama F,Yamada S,Shiota K,Nagao T
MA5-14520 was used in immunohistochemistry to study the pathogenic mechanisms of methylnitrosourea in developing mouse cerebral cortex
Tue Jun 01 00:00:00 EDT 2010
Mutually exclusive expression of DLX2 and DLX5/6 is associated with the metastatic potential of the human breast cancer cell line MDA-MB-231.
BMC cancer
Morini M,Astigiano S,Gitton Y,Emionite L,Mirisola V,Levi G,Barbieri O
MA5-14520 was used in immunohistochemistry to study the association of mutually exclusive expression of DLX2 and DLX5/6 with metastatic potential in a human breast cancer cell line
Thu Nov 25 00:00:00 EST 2010
Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: signaling partners, hierarchy and physiological significance.
PloS one
Cohen I,Maoz M,Turm H,Grisaru-Granovsky S,Maly B,Uziely B,Weiss E,Abramovitch R,Gross E,Barzilay O,Qiu Y,Bar-Shavit R
MA5-14520 was used in immunohistochemistry to study the cellular signalling pathways involved in proteinase-activated receptor-1 (PAR-1) mediated breast cancer invasion.
Tue Jun 15 00:00:00 EDT 2010
Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation.
BMC developmental biology
DeRouen MC,Zhen H,Tan SH,Williams S,Marinkovich MP,Oro AE
MA5-14520 was used in immunocytochemistry to investigate the role of laminin-511 in hair follicle development
Wed Nov 10 00:00:00 EST 2010
Small blue round cell tumor of the interosseous membrane bearing a t(2;22)(q34;q12)/EWS-CREB1 translocation: a case report.
Molecular cytogenetics
Pacheco M,Horsman DE,Hayes MM,Clarkson PW,Huwait H,Nielsen TO
MA5-14520 was used in immunohistochemistry to report on a case of small blue round cell tumor of the interosseous membrane bearing a t(2;22)(q34;q12)/EWS-CREB1 translocation
Fri Jul 02 00:00:00 EDT 2010
Species differences in reactivity of mouse and rat astrocytes in vitro.
Neuro-Signals
Puschmann TB,Dixon KJ,Turnley AM
MA5-14520 was used in immunocytochemistry to study the different reactivities of mouse and rat astrocytes in vitro
Thu Feb 09 00:00:00 EST 2012
Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice.
Gut
Freitag TL,Rietdijk S,Junker Y,Popov Y,Bhan AK,Kelly CP,Terhorst C,Schuppan D
MA5-14520 was used in immunohistochemistry to study the role of gliadin-primed CD4+CD45RBlowCD25- T cells in gluten-induced enteropathy
Tue Dec 01 00:00:00 EST 2009
A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of ethynyl deoxyuridine (EdU).
Nucleic acids research
Limsirichaikul S,Niimi A,Fawcett H,Lehmann A,Yamashita S,Ogi T
MA5-14520 was used in immunocytochemistry to evaluate a novel method for DNA repair analysis
Sun Mar 01 00:00:00 EST 2009
Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes.
Hepatology (Baltimore, Md.)
Vick B,Weber A,Urbanik T,Maass T,Teufel A,Krammer PH,Opferman JT,Schuchmann M,Galle PR,Schulze-Bergkamen H
MA5-14520 was used in immunohistochemistry to study the role of Mcl-1 in liver damage and apoptosis in hepatocytes from knockout mice
Sun Feb 01 00:00:00 EST 2009
Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes.
Acta neuropathologica
Pfister S,Remke M,Castoldi M,Bai AH,Muckenthaler MU,Kulozik A,von Deimling A,Pscherer A,Lichter P,Korshunov A
MA5-14520 was used in immunohistochemistry to report on a case of pediatric embryonal tumor displaying novel genomic amplification targeting the microRNA cluster at 19q13.42
Wed Apr 01 00:00:00 EDT 2009
Role of the microenvironment for radiosensitization by patupilone.
Clinical cancer research : an official journal of the American Association for Cancer Research
Bley CR,Jochum W,Orlowski K,Furmanova P,Vuong V,McSheehy PM,Pruschy M
MA5-14520 was used in immunohistochemistry to study the role of the tumor microenvironment in radiosensitization by the microtubule-stabilizing compound patupilone
Sun Feb 15 00:00:00 EST 2009
Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a Pten-deficient mouse model of prostate cancer.
Cancer research
Zhang W,Zhu J,Efferson CL,Ware C,Tammam J,Angagaw M,Laskey J,Bettano KA,Kasibhatla S,Reilly JF,Sur C,Majumder PK
MA5-14520 was used in immunohistochemistry to investigate the anti-tumor effect of anti-androgen and rapamycin treatment in a murine prostate cancer model
Tue Sep 15 00:00:00 EDT 2009
Coordination of intratumoral immune reaction and human colorectal cancer recurrence.
Cancer research
Camus M,Tosolini M,Mlecnik B,Pagès F,Kirilovsky A,Berger A,Costes A,Bindea G,Charoentong P,Bruneval P,Trajanoski Z,Fridman WH,Galon J
MA5-14520 was used in immunohistochemistry to study the correlation of intratumoral immune markers and human colorectal cancer escape
Sun Mar 15 00:00:00 EDT 2009
Proliferation of immature tumor vessels is a novel marker of clinical progression in prostate cancer.
Cancer research
Gravdal K,Halvorsen OJ,Haukaas SA,Akslen LA
MA5-14520 was used in immunohistochemistry to study proliferation of immature tumor vessels as a novel marker of clinical progression in prostate cancer
Mon Jun 01 00:00:00 EDT 2009
Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide.
Cardiovascular research
Wang P,Xu TY,Guan YF,Su DF,Fan GR,Miao CY
MA5-14520 was used in immunocytochemistry to study the role of perivascular adipose tissue-derived visfatin as a vascular smooth muscle cell growth factor
Sun Feb 01 00:00:00 EST 2009
Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene.
Proceedings of the National Academy of Sciences of the United States of America
Dupressoir A,Vernochet C,Bawa O,Harper F,Pierron G,Opolon P,Heidmann T
MA5-14520 was used in immunohistochemistry to investigate the role of syncytin during placenta development in mice
Tue Jul 21 00:00:00 EDT 2009
Apoptosis-related (survivin, Bcl-2), tumor suppressor gene (p53), proliferation (Ki-67), and non-receptor tyrosine kinase (Src) markers expression and correlation with clinicopathologic variables in 60 thymic neoplasms.
Chest
Khoury T,Arshad A,Bogner P,Ramnath N,Zhang S,Chandrasekhar R,Wilding G,Alrawi S,Tan D
MA5-14520 was used in immunohistochemistry to investigate the changes of specific genes in patients with thymic neoplasms
Wed Jul 01 00:00:00 EDT 2009
Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma.
European journal of cancer (Oxford, England : 1990)
Verhoeff JJ,Stalpers LJ,Claes A,Hovinga KE,Musters GD,Peter Vandertop W,Richel DJ,Leenders WP,van Furth WR
MA5-14520 was used in immunohistochemistry to identify the efficacy of anti-VEGF treatment and irradiation to control brain tumour proliferation in mice.
Sun Nov 01 00:00:00 EDT 2009
Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia.
British journal of pharmacology
Tammam J,Ware C,Efferson C,O'Neil J,Rao S,Qu X,Gorenstein J,Angagaw M,Kim H,Kenific C,Kunii K,Leach KJ,Nikov G,Zhao J,Dai X,Hardwick J,Scott M,Winter C,Bristow L,Elbi C,Reilly JF,Look T,Draetta G,Van der Ploeg L,Kohl NE,Strack PR,Majumder PK
MA5-14520 was used in immunocytochemistry to study the anti-tumor effects of inhibiting Notch signaling with a gamma secretase inhibitor in a mouse T-cell leukaemia model
Sun Nov 01 00:00:00 EDT 2009
Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice.
Oncogene
Goel VK,Ibrahim N,Jiang G,Singhal M,Fee S,Flotte T,Westmoreland S,Haluska FS,Hinds PW,Haluska FG
MA5-14520 was used in immunohistochemistry to examine the role of BRAFV600E mutation in the pathogenesis of melanocytic melanoma
Thu Jun 11 00:00:00 EDT 2009
Gender differences in pulmonary regenerative response to naphthalene-induced bronchiolar epithelial cell injury.
Cell proliferation
Oliver JR,Kushwah R,Wu J,Cutz E,Yeger H,Waddell TK,Hu J
MA5-14520 was used in immunohistochemistry to study gender differences in lung repair responses to naphthalene-induced Clara cell ablation
Thu Oct 01 00:00:00 EDT 2009
Cross-species immunohistochemical investigation of the activation of the liver progenitor cell niche in different types of liver disease.
Liver international : official journal of the International Association for the Study of the Liver
Schotanus BA,van den Ingh TS,Penning LC,Rothuizen J,Roskams TA,Spee B
MA5-14520 was used in immunohistochemistry to investigate the activation of liver progenitor cell niche in various liver diseases
Tue Sep 01 00:00:00 EDT 2009
Vessel density assessed by endoglin expression in breast carcinomas with different expression profiles.
Histopathology
Lopes N,Sousa B,Vieira D,Milanezi F,Schmitt F
MA5-14520 was used in immunohistochemistry to study the microvessel features in subtype of breast carcinomas
Sun Nov 01 00:00:00 EDT 2009
Cypermethrin effects on the adult mice seminal glands.
Ecotoxicology and environmental safety
Rodriguez H,Tamayo C,Inostroza J,Soto C,Bustos-Obregón E,Paniagua R
MA5-14520 was used in immunohistochemistry to investigate the effect of cypermethrin on murine seminal glands
Sun Feb 01 00:00:00 EST 2009
Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence.
Neurobiology of disease
Richardson HN,Chan SH,Crawford EF,Lee YK,Funk CK,Koob GF,Mandyam CD
MA5-14520 was used in immunohistochemistry to study the effects of alcohol consumption on cortical gliogenesis and hippocampal neurogenesis
Thu Oct 01 00:00:00 EDT 2009
Double blind randomized phase II study with radiation+5-fluorouracil+/-celecoxib for resectable rectal cancer.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Debucquoy A,Roels S,Goethals L,Libbrecht L,Van Cutsem E,Geboes K,Penninckx F,D'Hoore A,McBride WH,Haustermans K
MA5-14520 was used in immunohistochemistry to perform a phase II clinical trial of the effects of celecoxib in resectable rectal cancer patients treated with radiation plus 5-fluorouracil
Sun Nov 01 00:00:00 EDT 2009
A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary.
The American journal of surgical pathology
Köbel M,Kalloger SE,Carrick J,Huntsman D,Asad H,Oliva E,Ewanowich CA,Soslow RA,Gilks CB
MA5-14520 was used in immunohistochemistry to examine the diagnostic markers of clear cell and high-grade serous carcinoma of the ovary
Thu Jan 01 00:00:00 EST 2009
Predicting recurrence of nonfunctioning pituitary adenomas.
The Journal of clinical endocrinology and metabolism
Noh TW,Jeong HJ,Lee MK,Kim TS,Kim SH,Lee EJ
MA5-14520 was used in immunohistochemistry to study cellular markers that predict the recurrence of nonfunctioning pituitary adenomas
Sun Nov 01 00:00:00 EDT 2009
Hecate-CGbeta conjugate and gonadotropin suppression shows two distinct mechanisms of action in the treatment of adrenocortical tumors in transgenic mice expressing Simian Virus 40 T antigen under inhibin-alpha promoter.
Endocrine-related cancer
Vuorenoja S,Mohanty BP,Arola J,Huhtaniemi I,Toppari J,Rahman NA
MA5-14520 was used in immunohistochemistry to study the therapeutic potential of a peptide-chorionic gonadotrophin fragement conjugate in adrenocortical tumors
Mon Jun 01 00:00:00 EDT 2009
Amplification of the urokinase-type plasminogen activator receptor (uPAR) gene in ductal pancreatic carcinomas identifies a clinically high-risk group.
The American journal of pathology
Hildenbrand R,Niedergethmann M,Marx A,Belharazem D,Allgayer H,Schleger C,Ströbel P
MA5-14520 was used in immunohistochemistry to examine the role of urokinase-type plasminogen activator receptor in the pathogenesis of ductal pancreatic carcinomas
Mon Jun 01 00:00:00 EDT 2009
FoxP3+ regulatory T cells suppress early stages of granuloma formation but have little impact on sarcoidosis lesions.
The American journal of pathology
Taflin C,Miyara M,Nochy D,Valeyre D,Naccache JM,Altare F,Salek-Peyron P,Badoual C,Bruneval P,Haroche J,Mathian A,Amoura Z,Hill G,Gorochov G
MA5-14520 was used in immunohistochemistry to assess the proliferation levels of Treg cells in blood and in granulomas
Sun Feb 01 00:00:00 EST 2009
In pursuit of leucine-rich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus.
Endocrinology
Sun X,Jackson L,Dey SK,Daikoku T
MA5-14520 was used in immunohistochemistry to characterize the uterine leucine-rich repeat-containing G protein-coupled receptor-5
Sun Nov 01 00:00:00 EDT 2009
Prolactin treatment improves engraftment and function of transplanted pancreatic islets.
Endocrinology
Johansson M,Olerud J,Jansson L,Carlsson PO
MA5-14520 was used in immunohistochemistry to investigate the influence of prolactin on pancreatic transplantation
Wed Apr 01 00:00:00 EDT 2009
Comparison of the histology, gene expression profile, and phenotype of cultured human limbal epithelial cells from different limbal regions.
Investigative ophthalmology & visual science
Utheim TP,Raeder S,Olstad OK,Utheim ØA,de La Paz M,Cheng R,Huynh TT,Messelt E,Roald B,Lyberg T
MA5-14520 was used in immunohistochemistry to compare the celular heterogeneity of epithelial cells derived from various limbal regions
Sun Nov 01 00:00:00 EDT 2009
Effect of yeast-derived beta-glucan in conjunction with bevacizumab for the treatment of human lung adenocarcinoma in subcutaneous and orthotopic xenograft models.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Zhong W,Hansen R,Li B,Cai Y,Salvador C,Moore GD,Yan J
MA5-14520 was used in immunohistochemistry to evaluate a combination therapy for human lung adenocarcinoma in subcutaneous and orthotopic xenograft models
Tue Sep 01 00:00:00 EDT 2009
EphA2 as a promoter of melanoma tumorigenicity.
Cancer biology & therapy
Margaryan NV,Strizzi L,Abbott DE,Seftor EA,Rao MS,Hendrix MJ,Hess AR
MA5-14520 was used in immunohistochemistry to study the role of EphA2 in melanoma tumorigenicity
Sun Feb 01 00:00:00 EST 2009
Combination of methylselenocysteine with tamoxifen inhibits MCF-7 breast cancer xenografts in nude mice through elevated apoptosis and reduced angiogenesis.
Breast cancer research and treatment
Li Z,Carrier L,Belame A,Thiyagarajah A,Salvo VA,Burow ME,Rowan BG
MA5-14520 was used in immunohistochemistry to investigate the effect of methylselenocysteine and tamoxifen on breast cancer cell apoptosis and xenograft angiogenesis
Sun Nov 01 00:00:00 EDT 2009
Synchrotron microbeam radiation therapy for rat brain tumor palliation-influence of the microbeam width at constant valley dose.
Physics in medicine and biology
Serduc R,Bouchet A,Bräuer-Krisch E,Laissue JA,Spiga J,Sarun S,Bravin A,Fonta C,Renaud L,Boutonnat J,Siegbahn EA,Estève F,Le Duc G
MA5-14520 was used in immunohistochemistry to study the effects of beam width during Synchrotron microbeam radiation therapy on the survival of gliosarcoma tumor-bearing rats
Sat Nov 07 00:00:00 EST 2009
Distribution and severity of spontaneous lesions in the neuroepithelium and Bowman's glands in mouse olfactory mucosa: age-related progression.
Cell and tissue research
Kondo K,Watanabe K,Sakamoto T,Suzukawa K,Nibu K,Kaga K,Yamasoba T
MA5-14520 was used in immunohistochemistry to study the age-related changes of spontaneous lesions in the neuroepithelium and Bowman glands in mouse olfactory mucosa
Sun Mar 01 00:00:00 EST 2009
Keratinocyte-derived chemokine induces prostate epithelial hyperplasia and reactive stroma in a novel transgenic mouse model.
The Prostate
Schauer IG,Ressler SJ,Rowley DR
MA5-14520 was used in immunohistochemistry to test if overexpressed IL-8 and keratinocyte-derived chemokine induce prostate epithelial hyperplasia and a reactive phenotype
Sun Mar 01 00:00:00 EST 2009
Energetics and mammary carcinogenesis: effects of moderate-intensity running and energy intake on cellular processes and molecular mechanisms in rats.
Journal of applied physiology (Bethesda, Md. : 1985)
Zhu Z,Jiang W,McGinley JN,Thompson HJ
MA5-14520 was used in western blot to investigate the effect of energy manipulations on mammary tumorigenesis
Sun Mar 01 00:00:00 EST 2009
Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain.
Neuroscience
Yawno T,Hirst JJ,Castillo-Melendez M,Walker DW
MA5-14520 was used in immunohistochemistry to study the role of neurosteroids in the development of the fetal brain in late gestation
Tue Oct 20 00:00:00 EDT 2009
Targeted genomic disruption of H-ras and N-ras has no effect on early renal changes after unilateral ureteral ligation.
World journal of urology
Grande MT,Arévalo M,Núñez A,Cannata-Andía JB,Santos E,López-Novoa JM
MA5-14520 was used in immunohistochemistry to investigate the effect of targeted genomic disruption of H-ras and N-ras on obstructive nephropathy
Tue Dec 01 00:00:00 EST 2009
Increased p53 immunoreactivity in proliferative inflammatory atrophy of prostate is related to focal acute inflammation.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Wang W,Bergh A,Damber JE
MA5-14520 was used in immunohistochemistry to study the role of increased p53 immunoreactivity in proliferative inflammatory atrophy
Sun Mar 01 00:00:00 EST 2009
Immunohistochemical expression of SPARC is correlated with recurrence, survival and malignant potential in meningiomas.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Bozkurt SU,Ayan E,Bolukbasi F,Elmaci I,Pamir N,Sav A
MA5-14520 was used in immunohistochemistry to determine the prognotic significance of SPARC expression in meningioma
Tue Sep 01 00:00:00 EDT 2009
Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice.
Biochemical and biophysical research communications
Shima H,Takubo K,Iwasaki H,Yoshihara H,Gomei Y,Hosokawa K,Arai F,Takahashi T,Suda T
MA5-14520 was used in immunocytochemistry to investigate the role of hypoxia in the maintenance of hematopoietic stem cells
Fri Jan 16 00:00:00 EST 2009
Craniofacial malformation in R-spondin2 knockout mice.
Biochemical and biophysical research communications
Yamada W,Nagao K,Horikoshi K,Fujikura A,Ikeda E,Inagaki Y,Kakitani M,Tomizuka K,Miyazaki H,Suda T,Takubo K
MA5-14520 was used in immunohistochemistry to investigate the abnormalities of craniofacial structure in R-spondin2 knockout mice
Fri Apr 10 00:00:00 EDT 2009
Leukemia inhibitory factor favours neurogenic differentiation of long-term propagated human midbrain precursor cells.
Neuroscience letters
Andersen RK,Widmer HR,Zimmer J,Wahlberg LU,Meyer M
MA5-14520 was used in immunohistochemistry to study the effect of leukemia inhibitory factor on the neurogenic differentiation of ventral mesencaphalic precursor cells cultured for extended periods of time
Fri Oct 30 00:00:00 EDT 2009
Soy consumption and histopathologic markers in breast tissue using tissue microarrays.
Nutrition and cancer
Maskarinec G,Erber E,Verheus M,Hernandez BY,Killeen J,Cashin S,Cline JM
MA5-14520 was used in immunohistochemistry to detect effects of soy consumption on markers of tumor proliferation
Fri Jan 15 00:00:00 EST 2010
Prognostic significance of oncogenic markers in ductal carcinoma in situ of the breast: a clinicopathologic study.
The breast journal
Altintas S,Lambein K,Huizing MT,Braems G,Asjoe FT,Hellemans H,Van Marck E,Weyler J,Praet M,Van den Broecke R,Vermorken JB,Tjalma WA
MA5-14520 was used in immunohistochemistry to evaluate oncogenic markers with prognostic significance in breast ductal carcinoma in situ
Wed Jul 08 00:00:00 EDT 2009
Diagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Horváth E,Mezei T,Pávai Z,Turcu M,Demian S,Tóth E,Chira L,Jung I
MA5-14520 was used in immunohistochemistry to investigate the diagnosis of lymphoid neoplasmas through bone marrow trephine biopsies
Wed Dec 16 00:00:00 EST 2009
Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice.
PloS one
Farioli-Vecchioli S,Saraulli D,Costanzi M,Leonardi L,Cinà I,Micheli L,Nutini M,Longone P,Oh SP,Cestari V,Tirone F
MA5-14520 was used in immunohistochemistry to investigate the effect of PC3/Tis21 on hippocampal development and function in mice
Thu Dec 17 00:00:00 EST 2009
Dicer is required for maintaining adult pancreas.
PloS one
Morita S,Hara A,Kojima I,Horii T,Kimura M,Kitamura T,Ochiya T,Nakanishi K,Matoba R,Matsubara K,Hatada I
MA5-14520 was used in immunohistochemistry to study the role of Dicer in maintaining the adult pancreas
Mon Mar 23 00:00:00 EDT 2009
Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?
Diagnostic pathology
Behzatoğlu K,Durak H,Canberk S,Aydin O,Huq GE,Oznur M,Ozyalvaçli G,Yildiz P
MA5-14520 was used in immunohistochemistry to report on two cases of giant cell tumor-like lesion of the urinary bladder
Thu Dec 31 00:00:00 EST 2009
A 19-year follow-up of a patient with type 3 ectrodactyly-ectodermal dysplasia-clefting syndrome who developed non-Hodgkin lymphoma.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
Balci S,Engiz O,Okten G,Sipahier M,Gursu G,Kandemir B
MA5-14520 was used in immunohistochemistry to perform clinical, radiologic and histopathologic studies of a patient with type 3 ectrodactyly-ectodermal dysplasia-clefting syndrome
Tue Sep 01 00:00:00 EDT 2009
Mammographic density and epithelial histopathologic markers.
BMC cancer
Verheus M,Maskarinec G,Erber E,Steude JS,Killeen J,Hernandez BY,Cline JM
MA5-14520 was used in immunohistochemistry to investigate the association between mammographic density and expression of steroid receptors and proliferation markers in benign breast tissue
Sat Jun 13 00:00:00 EDT 2009
Loss of NADPH quinone oxidoreductase in the prostate and enhanced serum levels of cytokine-induced neutrophil chemoattractant 2alpha in hormone-stimulated noble rats: potential role in prostatic intraepithelial neoplasia development.
Translational oncology
Ghosh R,Schoolfield J,Yeh IT,Smith ML,Hursting SD,Chan DC,Lucia MS,Kumar AP
MA5-14520 was used in immunohistochemistry to study the role of NADPH quinone oxidoreductase and cytokine-induced neutrophil chemoattractant 2alpha in prostate cancer development
Fri May 01 00:00:00 EDT 2009
Ki-67 in screen-detected, low-grade, low-stage prostate cancer, relation to prostate-specific antigen doubling time, Gleason score and prostate-specific antigen relapse after radical prostatectomy.
Scandinavian journal of urology and nephrology
Khatami A,Hugosson J,Wang W,Damber JE
MA5-14520 was used in immunohistochemistry to study the value of Ki-67 in predicting relapse after radical prostatectomy in early prostate cancer
Tue Mar 31 00:00:00 EDT 2009
Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions.
Cell stem cell
Shen Q,Wang Y,Kokovay E,Lin G,Chuang SM,Goderie SK,Roysam B,Temple S
MA5-14520 was used in immunohistochemistry to study whether neural stem cells in the adult subventricular zone are close to blood vessels
Thu Sep 11 00:00:00 EDT 2008
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.
The Journal of clinical investigation
Carracedo A,Ma L,Teruya-Feldstein J,Rojo F,Salmena L,Alimonti A,Egia A,Sasaki AT,Thomas G,Kozma SC,Papa A,Nardella C,Cantley LC,Baselga J,Pandolfi PP
MA5-14520 was used in immunohistochemistry to study the mechanism by which mTORC1 inhibition leads to MAPK pathway activation in human cancer
Mon Sep 01 00:00:00 EDT 2008
Pulmonary arterial remodeling induced by a Th2 immune response.
The Journal of experimental medicine
Daley E,Emson C,Guignabert C,de Waal Malefyt R,Louten J,Kurup VP,Hogaboam C,Taraseviciene-Stewart L,Voelkel NF,Rabinovitch M,Grunig E,Grunig G
MA5-14520 was used in immunohistochemistry to examine the role of Th2 immune response in the pathogenesis of pulmonary arterial remodeling
Mon Feb 18 00:00:00 EST 2008
Selective portal vein embolization and ligation trigger different regenerative responses in the rat liver.
Hepatology (Baltimore, Md.)
Furrer K,Tian Y,Pfammatter T,Jochum W,El-Badry AM,Graf R,Clavien PA
MA5-14520 was used in immunohistochemistry to compare the different effects of portal vein embolization portal vein ligation on the induction of a regenerative response of the remnant liver
Thu May 01 00:00:00 EDT 2008
Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Verma A,Guha S,Diagaradjane P,Kunnumakkara AB,Sanguino AM,Lopez-Berestein G,Sood AK,Aggarwal BB,Krishnan S,Gelovani JG,Mehta K
MA5-14520 was used in immunohistochemistry to study the therapeutic potential of tissue transglutaminase inhibition in pancreatic cancer
Tue Apr 15 00:00:00 EDT 2008
Combining agents that target the tumor microenvironment improves the efficacy of anticancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Blansfield JA,Caragacianu D,Alexander HR,Tangrea MA,Morita SY,Lorang D,Schafer P,Muller G,Stirling D,Royal RE,Libutti SK
MA5-14520 was used in immunohistochemistry to study the therapeutic potential of combining agents that target the tumor microenvironment
Tue Jan 01 00:00:00 EST 2008
Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer.
Cancer research
Tong Z,Kunnumakkara AB,Wang H,Matsuo Y,Diagaradjane P,Harikumar KB,Ramachandran V,Sung B,Chakraborty A,Bresalier RS,Logsdon C,Aggarwal BB,Krishnan S,Guha S
MA5-14520 was used in immunohistochemistry to study the role of neutrophil gelatinase-associated lipocalin in suppressing invasion and angiogenesis in pancreatic cancer
Fri Aug 01 00:00:00 EDT 2008
Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target.
Cancer research
Sawada K,Mitra AK,Radjabi AR,Bhaskar V,Kistner EO,Tretiakova M,Jagadeeswaran S,Montag A,Becker A,Kenny HA,Peter ME,Ramakrishnan V,Yamada SD,Lengyel E
MA5-14520 was used in immunohistochemistry to study the mechanism by which E-cadherin loss promotes ovarian cancer metastasis
Tue Apr 01 00:00:00 EDT 2008
Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts.
Cancer research
Nocito A,Dahm F,Jochum W,Jang JH,Georgiev P,Bader M,Graf R,Clavien PA
MA5-14520 was used in immunohistochemistry to study the regulation of macrophage-mediated angiogenesis by serotonin in a mouse model of colon cancer
Tue Jul 01 00:00:00 EDT 2008
Effect of n-3 polyunsaturated fatty acids on Barrett's epithelium in the human lower esophagus.
The American journal of clinical nutrition
Mehta SP,Boddy AP,Cook J,Sams V,Lund EK,Johnson IT,Rhodes M
MA5-14520 was used in immunohistochemistry to study the effects the n-3 fatty acid eicosapentaenoic acid on a number of biological endpoints in Barrett's esophagus
Tue Apr 01 00:00:00 EDT 2008
Can clinically relevant prognostic subsets of breast cancer patients with four or more involved axillary lymph nodes be identified through immunohistochemical biomarkers? A tissue microarray feasibility study.
Breast cancer research : BCR
Crabb SJ,Bajdik CD,Leung S,Speers CH,Kennecke H,Huntsman DG,Gelmon KA
MA5-14520 was used in immunohistochemistry to identify prognostic biomarkers for breast cancer involving 4 or more auxilliary lymph nodes
Wed Jun 11 00:00:00 EDT 2008
Diagnostic and prognostic markers for gastrointestinal stromal tumors in Norway.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Steigen SE,Bjerkehagen B,Haugland HK,Nordrum IS,Løberg EM,Isaksen V,Eide TJ,Nielsen TO
MA5-14520 was used in immunohistochemistry to confirm several diagnostic markers for gastrointestinal stromal tumors in Norway
Tue Jan 01 00:00:00 EST 2008
Human ASH1 expression in prostate cancer with neuroendocrine differentiation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Rapa I,Ceppi P,Bollito E,Rosas R,Cappia S,Bacillo E,Porpiglia F,Berruti A,Papotti M,Volante M
MA5-14520 was used in immunohistochemistry to study the expression of human ASH1 in prostate cancer with neuroendocrine differentiation
Sun Jun 01 00:00:00 EDT 2008
Phenotypic and genotypic characterization of orthotopic human glioma models and its relevance for the study of anti-glioma therapy.
Brain pathology (Zurich, Switzerland)
Claes A,Schuuring J,Boots-Sprenger S,Hendriks-Cornelissen S,Dekkers M,van der Kogel AJ,Leenders WP,Wesseling P,Jeuken JW
MA5-14520 was used in immunohistochemistry to evaluate murine models of human glioma
Tue Jul 01 00:00:00 EDT 2008
Magnetic resonance imaging-based detection of glial brain tumors in mice after antiangiogenic treatment.
International journal of cancer
Claes A,Gambarota G,Hamans B,van Tellingen O,Wesseling P,Maass C,Heerschap A,Leenders W
MA5-14520 was used in immunohistochemistry to detect glial brain tumors after antigangiogenic treatment by magnetic resonance imaging
Thu May 01 00:00:00 EDT 2008
Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis.
Development (Cambridge, England)
Iulianella A,Sharma M,Durnin M,Vanden Heuvel GB,Trainor PA
MA5-14520 was used in immunohistochemistry to examine the role of Cux2 during spinal cord neurogenesis
Fri Feb 01 00:00:00 EST 2008
Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling.
American journal of physiology. Lung cellular and molecular physiology
Nozik-Grayck E,Suliman HB,Majka S,Albietz J,Van Rheen Z,Roush K,Stenmark KR
MA5-14520 was used in immunohistochemistry to examine the involvement of extracellular superoxide dismutase in chronic hypoxia-induced pulmonary hypertension
Mon Sep 01 00:00:00 EDT 2008
Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy.
Molecular cancer therapeutics
Zhang C,Lundgren K,Yan Z,Arango ME,Price S,Huber A,Higgins J,Troche G,Skaptason J,Koudriakova T,Nonomiya J,Yang M,O'Connor P,Bender S,Los G,Lewis C,Jessen B
MA5-14520 was used in immunohistochemistry to study the pharmacology of a novel a pan-Cdk inhibitor with antitumor activity
Tue Apr 01 00:00:00 EDT 2008
Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma.
Endocrine-related cancer
Hammoud Z,Tan B,Badve S,Bigsby RM
MA5-14520 was used in immunohistochemistry to use a genetically defined murine lung adenocarcinoma model to study the effects of estrogen on tumor progression
Sun Jun 01 00:00:00 EDT 2008
Effect of leukemia inhibitory factor on long-term propagation of precursor cells derived from rat forebrain subventricular zone and ventral mesencephalon.
Experimental neurology
Andersen RK,Zimmer J,Wahlberg LU,Meyer M
MA5-14520 was used in immunohistochemistry to investigate the effect of leukemia inhibitory factor on the propagation of neuronal precursor cells
Thu May 01 00:00:00 EDT 2008
Dearterialization of the liver causes intrahepatic cholestasis due to reduced bile transporter expression.
Transplantation
Hoekstra H,Tian Y,Jochum W,Stieger B,Graf R,Porte RJ,Clavien PA
MA5-14520 was used in immunohistochemistry to study the role of bile acid transporter expression in liver injury after hepatic artery thrombosis
Sun Apr 27 00:00:00 EDT 2008
Inhibition of beta-catenin signaling causes defects in postnatal cartilage development.
Journal of cell science
Chen M,Zhu M,Awad H,Li TF,Sheu TJ,Boyce BF,Chen D,O'Keefe RJ
MA5-14520 was used in immunohistochemistry to study the role of beta-catenin in postnatal skeletal growth and development
Thu May 01 00:00:00 EDT 2008
Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation.
Molecular and cellular biology
Georges R,Nemer G,Morin M,Lefebvre C,Nemer M
MA5-14520 was used in immunohistochemistry to investigate the role of Tbx5 isoforms in cell growth and differentiation
Sun Jun 01 00:00:00 EDT 2008
Foxg1 haploinsufficiency reduces the population of cortical intermediate progenitor cells: effect of increased p21 expression.
Cerebral cortex (New York, N.Y. : 1991)
Siegenthaler JA,Tremper-Wells BA,Miller MW
MA5-14520 was used in immunohistochemistry to study the effects of Foxg1 haploinsufficiency on the population of cortical intermediate progenitor cells
Fri Aug 01 00:00:00 EDT 2008
Mechanisms associated with dose-dependent inhibition of rat mammary carcinogenesis by dry bean (Phaseolus vulgaris, L.).
The Journal of nutrition
Thompson MD,Thompson HJ,Brick MA,McGinley JN,Jiang W,Zhu Z,Wolfe P
MA5-14520 was used in immunohistochemistry to investigate the mechanisms for the effect of dry bean on rat mammary carcinogenesis
Sat Nov 01 00:00:00 EDT 2008
Activated Akt as an indicator of prognosis in gastric cancer.
Virchows Archiv : an international journal of pathology
Cinti C,Vindigni C,Zamparelli A,La Sala D,Epistolato MC,Marrelli D,Cevenini G,Tosi P
MA5-14520 was used in immunohistochemistry to examine the prognostic significance of activated AKT in gastric cancer
Sat Nov 01 00:00:00 EDT 2008
Bone marrow-derived cells expressing Iba1 are constitutively present as resident tissue macrophages in the mouse cochlea.
Journal of neuroscience research
Okano T,Nakagawa T,Kita T,Kada S,Yoshimoto M,Nakahata T,Ito J
MA5-14520 was used in immunohistochemistry to investigate the expression of Iba1 in bone marrow-derived cells in the mouse cochlea
Sun Jun 01 00:00:00 EDT 2008
Expression of NANOG, but not POU5F1, points to the stem cell potential of primitive germ cells in neonatal pig testis.
Reproduction (Cambridge, England)
Goel S,Fujihara M,Minami N,Yamada M,Imai H
MA5-14520 was used in immunohistochemistry to investigate the relationship between NANOG expression and pluripotency of primitive germ cells in neonatal pig testis
Sun Jun 01 00:00:00 EDT 2008
Coordinated expression of activated mitogen-activated protein kinases in salivary gland adenoid cystic carcinoma.
Human pathology
Handra-Luca A,Mauguen A,Ménard P,Fouret P
MA5-14520 was used in immunohistochemistry to investigate the expression of phosphorylated forms of mitogen-activated protein kinases in salivary gland adenoid cystic carcinoma
Sat Nov 01 00:00:00 EDT 2008
Combination therapy with antiangiogenic treatment and photodynamic therapy for the nude mouse bearing U87 glioblastoma.
Photochemistry and photobiology
Jiang F,Zhang X,Kalkanis SN,Zhang Z,Yang H,Katakowski M,Hong X,Zheng X,Zhu Z,Chopp M
MA5-14520 was used in immunohistochemistry to study the efficacy of combination therapy with antiangiogenic treatment and photodynamic therapy in glioblastoma
Thu Mar 27 00:00:00 EDT 2008
Imaging proliferation to monitor early response of lymphoma to cytotoxic treatment.
Molecular imaging and biology
Graf N,Herrmann K,den Hollander J,Fend F,Schuster T,Wester HJ,Senekowitsch-Schmidtke R,zum Büschenfelde CM,Peschel C,Schwaiger M,Dechow T,Buck AK
MA5-14520 was used in immunohistochemistry to examine the application of thymidine analogue 3'-deoxy-3'-[18F]fluorothymidine in positron emission tomography imaging of nucleoside metabolism
Thu Dec 11 00:00:00 EST 2008
Regeneration with proliferation of the endothelium of cultured human donor corneas with extended postmortem time.
Cornea
Slettedal JK,Lyberg T,Røger M,Beraki K,Ramstad H,Nicolaissen B
MA5-14520 was used in immunohistochemistry to investigate the survival time of the corneal endothelium postmortem
Fri Feb 01 00:00:00 EST 2008
HDAC4 inhibits cell-cycle progression and protects neurons from cell death.
Developmental neurobiology
Majdzadeh N,Wang L,Morrison BE,Bassel-Duby R,Olson EN,D'Mello SR
MA5-14520 was used in immunohistochemistry to investigate the effect of HDAC4 on cell-cycle progression and cell survival
Tue Jul 01 00:00:00 EDT 2008
An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: relationship between fibrosis and angiogenesis.
International journal of experimental pathology
Vanheule E,Geerts AM,Van Huysse J,Schelfhout D,Praet M,Van Vlierberghe H,De Vos M,Colle I
MA5-14520 was used in immunohistochemistry to investigate the relationship between angiogenesis in liver and cirrhogenesis
Mon Dec 01 00:00:00 EST 2008
Serdin1/Lrrc10 is dispensable for mouse development.
Genesis (New York, N.Y. : 2000)
Manuylov NL,Manuylova E,Avdoshina V,Tevosian S
MA5-14520 was used in immunohistochemistry to study the function of Serdin1/Lrrc10 in mouse cardiac development
Mon Sep 01 00:00:00 EDT 2008
Immunohistochemical and ultrastructural characterization of brain tumors in S100beta-v-erbB transgenic rats.
Neuropathology : official journal of the Japanese Society of Neuropathology
Yokoo H,Tanaka Y,Nobusawa S,Nakazato Y,Ohgaki H
MA5-14520 was used in immunohistochemistry to investigate the characteristic of brain tumors in S100beta-v-erbB transgenic rats
Mon Dec 01 00:00:00 EST 2008
Applications of laser scanning cytometry in immunohistochemistry and routine histopathology.
Toxicologic pathology
Peterson RA,Krull DL,Butler L
MA5-14520 was used in immunohistochemistry to evaluate laser scanning cytometry for routine histopathological analysis
Tue Jan 01 00:00:00 EST 2008
Chronic microcystin exposure induces hepatocyte proliferation with increased expression of mitotic and cyclin-associated genes in P53-deficient mice.
Toxicologic pathology
Clark SP,Ryan TP,Searfoss GH,Davis MA,Hooser SB
MA5-14520 was used in immunohistochemistry to study the effect of chronic exposure to microcystin on hepatocyte proliferation in p53-deficient mice
Fri Feb 01 00:00:00 EST 2008
Plasmoblastic lymphoma associated with human immunodeficiency virus.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Horváth E,Krenács L,Bagdi E,Pávai Z,Macarie I,Nagy EE,Demian S
MA5-14520 was used in immunohistochemistry to investigate the association of plasmoblastic lymphoma with human immunodeficiency virus
Thu Dec 11 00:00:00 EST 2008
Down-regulation of Notch signaling during corneal epithelial proliferation.
Molecular vision
Djalilian AR,Namavari A,Ito A,Balali S,Afshar A,Lavker RM,Yue BY
MA5-14520 was used in immunocytochemistry to study Notch pathway expression and activation in the adult corneal epithelium during proliferation
Thu Jun 05 00:00:00 EDT 2008
The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis.
The Journal of biological chemistry
Palazuelos J,Davoust N,Julien B,Hatterer E,Aguado T,Mechoulam R,Benito C,Romero J,Silva A,Guzmán M,Nataf S,Galve-Roperh I
MA5-14520 was used in immunohistochemistry to investigate the role of CB2 cannabinoid receptor on the pathogenesis of multiple sclerosis
Fri May 09 00:00:00 EDT 2008
Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development.
BMC developmental biology
Pantalacci S,Prochazka J,Martin A,Rothova M,Lambert A,Bernard L,Charles C,Viriot L,Peterkova R,Laudet V
MA5-14520 was used in immunohistochemistry to investigate the process of rugae development in mouse
Tue Dec 16 00:00:00 EST 2008
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors.
Nature medicine
Soucek L,Lawlor ER,Soto D,Shchors K,Swigart LB,Evan GI
MA5-14520 was used in immunohistochemistry to study the role of mast cells in Myc-induced pancreatic islet tumors
Mon Oct 01 00:00:00 EDT 2007
p63 Is essential for the proliferative potential of stem cells in stratified epithelia.
Cell
Senoo M,Pinto F,Crum CP,McKeon F
MA5-14520 was used in immunocytochemistry to study the role of p63 in the proliferative activity of stratified epithelia stem cells
Fri May 04 00:00:00 EDT 2007
Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity.
Blood
Smit LA,Hallaert DY,Spijker R,de Goeij B,Jaspers A,Kater AP,van Oers MH,van Noesel CJ,Eldering E
MA5-14520 was used in immunohistochemistry to investigate the role of Noxa expression in the pathogenesis of chronic lymphocytic leukemia
Thu Feb 15 00:00:00 EST 2007
Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647.
Clinical cancer research : an official journal of the American Association for Cancer Research
Gendreau SB,Ventura R,Keast P,Laird AD,Yakes FM,Zhang W,Bentzien F,Cancilla B,Lutman J,Chu F,Jackman L,Shi Y,Yu P,Wang J,Aftab DT,Jaeger CT,Meyer SM,De Costa A,Engell K,Chen J,Martini JF,Joly AH
MA5-14520 was used in immunohistochemistry to investigate the inhibitory effect of EXEL-7647 on the activity of wild-type and mutant EGFR
Fri Jun 15 00:00:00 EDT 2007
Akt/cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron amurense bark extract.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kumar AP,Bhaskaran S,Ganapathy M,Crosby K,Davis MD,Kochunov P,Schoolfield J,Yeh IT,Troyer DA,Ghosh R
MA5-14520 was used in immunohistochemistry to study the role of the Akt/cAMP-responsive element binding protein/cyclin D1 network in the inhibition of prostate cancer by Nexrutine in a mouse model
Tue May 01 00:00:00 EDT 2007
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
Cancer research
Kunnumakkara AB,Guha S,Krishnan S,Diagaradjane P,Gelovani J,Aggarwal BB
MA5-14520 was used in immunohistochemistry to study the mechanism by which curcumin potentiates the antitumor activity of gemcitabine in a model of pancreatic cancer
Sun Apr 15 00:00:00 EDT 2007
The properties of a mammary gland cancer stem cell.
Proceedings of the National Academy of Sciences of the United States of America
Zucchi I,Sanzone S,Astigiano S,Pelucchi P,Scotti M,Valsecchi V,Barbieri O,Bertoli G,Albertini A,Reinbold RA,Dulbecco R
MA5-14520 was used in immunohistochemistry to study the properties of a single mammary gland cancer stem cell
Tue Jun 19 00:00:00 EDT 2007
Generation and expansion of multipotent mesenchymal progenitor cells from cultured human pancreatic islets.
Cell death and differentiation
Gallo R,Gambelli F,Gava B,Sasdelli F,Tellone V,Masini M,Marchetti P,Dotta F,Sorrentino V
MA5-14520 was used in immunocytochemistry to examine the capability of cultured human pancreatic islets to yield multipotent mesenchymal progenitor cells
Thu Nov 01 00:00:00 EDT 2007
Improved vascular engraftment and function of autotransplanted pancreatic islets as a result of partial pancreatectomy in the mouse and rat.
Diabetologia
Johansson M,Jansson L,Carlsson PO
MA5-14520 was used in immunohistochemistry to examine the effect of surgical tissue trauma on the function of autotransplanted pancreatic islets
Fri Jun 01 00:00:00 EDT 2007
The anticancer prodrugs of butyric acid AN-7 and AN-9, possess antiangiogenic properties.
Cancer letters
Blank-Porat D,Gruss-Fischer T,Tarasenko N,Malik Z,Nudelman A,Rephaeli A
MA5-14520 was used in immunohistochemistry to study the anti-angiogenic properties of the anticancer prodrugs of butyric acid AN-7 and AN-9
Thu Oct 18 00:00:00 EDT 2007
Snail silencing effectively suppresses tumour growth and invasiveness.
Oncogene
Olmeda D,Jordá M,Peinado H,Fabra A,Cano A
MA5-14520 was used in immunohistochemistry to investigate the suppressive effect of Snail silencing on tumour growth and invasiveness
Thu Mar 22 00:00:00 EDT 2007
Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection.
The Journal of infectious diseases
Estes JD,Wietgrefe S,Schacker T,Southern P,Beilman G,Reilly C,Milush JM,Lifson JD,Sodora DL,Carlis JV,Haase AT
MA5-14520 was used in immunocytochemistry and immunohistochemistry to study the role of TGF-beta1-positive regulatory T cells in SIV-induced lymphatic tissue fibrosis
Thu Feb 15 00:00:00 EST 2007
The contribution of bifunctional SkipDewax pretreatment solution, rabbit monoclonal antibodies, and polymer detection systems in immunohistochemistry.
Archives of pathology & laboratory medicine
Wong SC,Chan JK,Lo ES,Chan AK,Wong MC,Chan CM,Lam MY,Chan AT
MA5-14520 was used in immunohistochemistry to evaluate novel immunohistochemistry reagents and techniques
Sun Jul 01 00:00:00 EDT 2007
Objective risk definition for endometrial lesion spectrum: a diagnostic algorithm.
Gynecologic oncology
Yilmaz I,Baloglu H,Haholu A,Berber U,Yildirim S,Ergur AR
MA5-14520 was used in immunohistochemistry to evaluate a prognostic algorithm for endometrial lesion spectrum
Tue May 01 00:00:00 EDT 2007
The efficacy and safety of topically applied indigo naturalis ointment in patients with plaque-type psoriasis.
Dermatology (Basel, Switzerland)
Lin YK,Wong WR,Chang YC,Chang CJ,Tsay PK,Chang SC,Pang JH
MA5-14520 was used in immunohistochemistry to study the potential therapeutic effects of topical indigo naturalis in plaque-type psoriasis
Wed May 16 00:00:00 EDT 2007
Role of alpha1beta1-integrin in arterial stiffness and angiotensin-induced arterial wall hypertrophy in mice.
American journal of physiology. Heart and circulatory physiology
Louis H,Kakou A,Regnault V,Labat C,Bressenot A,Gao-Li J,Gardner H,Thornton SN,Challande P,Li Z,Lacolley P
MA5-14520 was used in immunohistochemistry to investigate the effect of alpha(1)beta(1)-integrin on p38 MAPK and FAK phosphorylation and its role in the vascular abnormalities
Mon Oct 01 00:00:00 EDT 2007
Epidermal hyperplasia and papillomatosis in mice with a keratinocyte-restricted deletion of csk.
Carcinogenesis
Honda K,Sakaguchi T,Sakai K,Schmedt C,Ramirez A,Jorcano JL,Tarakhovsky A,Kamisoyama H,Sakai T
MA5-14520 was used in immunohistochemistry to study the role of csk in epidermal hyperplasia and papillomatosis
Mon Oct 01 00:00:00 EDT 2007
Ferumoxtran-10 enhancement in orthotopic xenograft models of human brain tumors: an indirect marker of tumor proliferation?
Journal of neuro-oncology
Kremer S,Pinel S,Védrine PO,Bressenot A,Robert P,Bracard S,Plénat F
MA5-14520 was used in immunohistochemistry to examine the utility of a contrasting agent ferumoxtran-10 in tumor diagnosis
Fri Jun 01 00:00:00 EDT 2007
Microvascular proliferation in congenital vascular malformations of skin and soft tissue.
Journal of clinical pathology
Meijer-Jorna LB,van der Loos CM,de Boer OJ,van der Horst CM,van der Wal AC
MA5-14520 was used in immunohistochemistry to study microvascular proliferation in surgically treated congenital vascular malformations
Sun Jul 01 00:00:00 EDT 2007
Involvement of apoptotic cell death and cell cycle perturbation in retinoic acid-induced cleft palate in mice.
Toxicology and applied pharmacology
Okano J,Suzuki S,Shiota K
MA5-14520 was used in immunohistochemistry to study the role of apoptotic cell death and cell cycle perturbation in retinoic acid-induced cleft palate in mice
Tue May 15 00:00:00 EDT 2007
Anaplastic thyroid carcinoma: expression profile of targets for therapy offers new insights for disease treatment.
Annals of surgical oncology
Wiseman SM,Masoudi H,Niblock P,Turbin D,Rajput A,Hay J,Bugis S,Filipenko D,Huntsman D,Gilks B
MA5-14520 was used in immunohistochemistry to search therapical targets for the treatment of anaplastic thyroid carcinoma
Thu Feb 01 00:00:00 EST 2007
Cellular responses to disruption of the permeability barrier in a three-dimensional organotypic epidermal model.
Experimental cell research
Ajani G,Sato N,Mack JA,Maytin EV
MA5-14520 was used in immunohistochemistry to examine the role of permeability barrier breach in epidermal hyperplasia
Wed Aug 15 00:00:00 EDT 2007
Increased expression of CCAAT/enhancer-binding protein beta in proliferative inflammatory atrophy of the prostate: relation with the expression of COX-2, the androgen receptor, and presence of focal chronic inflammation.
The Prostate
Wang W,Bergh A,Damber JE
MA5-14520 was used in immunohistochemistry to study the mechanisms driving increased expression of C/EBPbeta in proliferative inflammatory atrophy of the prostate
Wed Aug 01 00:00:00 EDT 2007
Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells.
The European journal of neuroscience
Barraud P,He X,Zhao C,Ibanez C,Raha-Chowdhury R,Caldwell MA,Franklin RJ
MA5-14520 was used in immunocytochemistry to study the effects of bFGF and EGF on mouse neonatal olfactory mucosa cells
Sat Dec 01 00:00:00 EST 2007
The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors.
Human pathology
Li Y,Tabatabai ZL,Lee TL,Hatakeyama S,Ohyama C,Chan WY,Looijenga LH,Lau YF
MA5-14520 was used in immunohistochemistry to investigate the role of the Y-encoded TSPY protein in the pathogenesis of testicular germ cell tumors
Mon Oct 01 00:00:00 EDT 2007
Using behavioral measurement to assess tumor progression and functional outcome after antiangiogenic treatment in mouse glioma models.
Behavioural brain research
Yang H,Chopp M,Zhang X,Jiang F,Zhang Z,Kalkanis S,Schallert T
MA5-14520 was used in immunohistochemistry to study the use of behavioral measurement to assess tumor progression and functional outcome after antiangiogenic treatment in mouse glioma models
Wed Aug 22 00:00:00 EDT 2007
Lymphoma-like lesion of the uterine cervix: report of 12 cases of a rare entity.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
Ma J,Shi QL,Zhou XJ,Meng K,Chen JY,Huang WB
MA5-14520 was used in immunohistochemistry to investigate the clinicopathologic features of 12 clinical cases of lymphoma-like lesions of the uterine cervix
Sun Apr 01 00:00:00 EDT 2007
Expression of glucose transporter protein-1 (Glut-1) in ocular surface squamous neoplasia.
Cornea
Gurses I,Doganay S,Mizrak B
MA5-14520 was used in immunohistochemistry to study GLUT-1 glucose transporter expression in ocular surface squamous neoplasia
Wed Aug 01 00:00:00 EDT 2007
Nested variant of transitional cell carcinoma with osseous metaplasia of the urinary bladder: a case report and review of published reports.
International journal of urology : official journal of the Japanese Urological Association
Neşe N,Kandiloğlu AR,Atesçi YZ
MA5-14520 was used in immunohistochemistry to report on a case of a nested variant of transitional cell carcinoma with osseous metaplasia of the urinary bladder
Sun Apr 01 00:00:00 EDT 2007
Post-acute response of 9L gliosarcoma to Photofrin-mediated PDT in athymic nude mice.
Lasers in medical science
Zhang X,Jiang F,Kalkanis SN,Zhang Z,Hong X,Yang H,Chopp M
MA5-14520 was used in immunohistochemistry to study the post-acute response of 9L gliosarcoma to Photofrin-mediated photodynamic therapy in athymic nude mice
Thu Nov 01 00:00:00 EDT 2007
Prognostic significance of cell proliferation and apoptosis-regulating proteins in Epstein-Barr virus positive and negative pediatric Hodgkin lymphoma.
Lymphatic research and biology
Aktaş S,Kargi A,Olgun N,Diniz G,Erbay A,Vergin C
MA5-14520 was used in immunohistochemistry to evaluate prognostic markers for Epstein-Barr virus positive and negative pediatric Hodgkin lymphoma
Mon Mar 03 00:00:00 EST 2008
The intermediate filament nestin is highly expressed in normal human podocytes and podocytes in glomerular disease.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Perry J,Ho M,Viero S,Zheng K,Jacobs R,Thorner PS
MA5-14520 was used in immunocytochemistry to study the expression of nestin in human podocytes in health and in glomerular disease
Wed Dec 12 00:00:00 EST 2007
Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis.
The Journal of biological chemistry
Aguado T,Carracedo A,Julien B,Velasco G,Milman G,Mechoulam R,Alvarez L,Guzmán M,Galve-Roperh I
MA5-14520 was used in immunocytochemistry to investigate the effect of cannabinoids on glioma stem-like cell differentiation and gliomagenesis
Fri Mar 02 00:00:00 EST 2007
A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence.
PLoS genetics
Li G,Vega R,Nelms K,Gekakis N,Goodnow C,McNamara P,Wu H,Hong NA,Glynne R
MA5-14520 was used in immunohistochemistry to study the role of the Alström syndrome protein alms1 in kidney ciliogenesis and cellular quiescence
Fri Jan 05 00:00:00 EST 2007
The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis.
The Journal of biological chemistry
Aguado T,Romero E,Monory K,Palazuelos J,Sendtner M,Marsicano G,Lutz B,Guzmán M,Galve-Roperh I
MA5-14520 was used in immunohistochemistry to investigate the role of CB1 cannabinoid receptor in neural progenitor proliferation and neurogenesis
Fri Aug 17 00:00:00 EDT 2007
SIRNA-directed in vivo silencing of androgen receptor inhibits the growth of castration-resistant prostate carcinomas.
PloS one
Compagno D,Merle C,Morin A,Gilbert C,Mathieu JR,Bozec A,Mauduit C,Benahmed M,Cabon F
MA5-14520 was used in immunohistochemistry to study the role of the androgen receptor in inhibiting the growth of castration-resistant prostate carcinomas
Wed Oct 10 00:00:00 EDT 2007
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.
Cancer cell
Ringshausen I,O'Shea CC,Finch AJ,Swigart LB,Evan GI
MA5-14520 was used in immunohistochemistry to investigate the role of Mdm2 in the regulation of p53 activity in vivo
Fri Dec 01 00:00:00 EST 2006
Bile salt toxicity aggravates cold ischemic injury of bile ducts after liver transplantation in Mdr2+/- mice.
Hepatology (Baltimore, Md.)
Hoekstra H,Porte RJ,Tian Y,Jochum W,Stieger B,Moritz W,Slooff MJ,Graf R,Clavien PA
MA5-14520 was used in immunohistochemistry to study the effect of bile salt toxicity on cold ischemic bile duct injury after liver transplantation in multidrug resistance 2 (+/-) mice
Mon May 01 00:00:00 EDT 2006
Ionizing radiation antagonizes tumor hypoxia induced by antiangiogenic treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research
Riesterer O,Honer M,Jochum W,Oehler C,Ametamey S,Pruschy M
MA5-14520 was used in immunohistochemistry to study the role of ionizing radiation in antagonizing tumor hypoxia induced by antiangiogenic treatment
Thu Jun 01 00:00:00 EDT 2006
Selective inhibition of ErbB2-overexpressing breast cancer in vivo by a novel TAT-based ErbB2-targeting signal transducers and activators of transcription 3-blocking peptide.
Cancer research
Tan M,Lan KH,Yao J,Lu CH,Sun M,Neal CL,Lu J,Yu D
MA5-14520 was used in immunohistochemistry to develop a new peptide delivery system for the targeted therapy of breast cancer overexpressing ErbB2
Sat Apr 01 00:00:00 EST 2006
Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord.
Glia
Kitada M,Rowitch DH
MA5-14520 was used in immunohistochemistry to study transcription factor co-expression patterns and heterogeneity of oligodendroglial subpopulations in adult spinal cord
Sat Jul 01 00:00:00 EDT 2006
Heparanase promotes growth, angiogenesis and survival of primary breast tumors.
International journal of cancer
Cohen I,Pappo O,Elkin M,San T,Bar-Shavit R,Hazan R,Peretz T,Vlodavsky I,Abramovitch R
MA5-14520 was used in western blot to investigate the role of heparanase in breast tumors
Sat Apr 01 00:00:00 EST 2006
Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivo.
American journal of physiology. Lung cellular and molecular physiology
Asikainen TM,Waleh NS,Schneider BK,Clyman RI,White CW
MA5-14520 was used in immunohistochemistry to study the enhancement of angiogenic effectors by HIF-1 in preterm primate lung in vivo
Sun Oct 01 00:00:00 EDT 2006
Effects of retrorsine on mouse hepatocyte proliferation after liver injury.
World journal of gastroenterology
Zhou XF,Wang Q,Chu JX,Liu AL
MA5-14520 was used in immunohistochemistry to study the effect of retrorsine on the proliferation of mouse hepatocyte
Tue Mar 07 00:00:00 EST 2006
Immunohistochemical separation of follicular variant of papillary thyroid carcinoma from follicular adenoma.
Endocrine pathology
Nakamura N,Erickson LA,Jin L,Kajita S,Zhang H,Qian X,Rumilla K,Lloyd RV
MA5-14520 was used in immunohistochemistry to investigate the differences between follicular adenoma and follicular variant of papillary thyroid carcinoma
Thu Mar 29 00:00:00 EDT 2007
A three-dimensional model of differentiation of immortalized human bronchial epithelial cells.
Differentiation; research in biological diversity
Vaughan MB,Ramirez RD,Wright WE,Minna JD,Shay JW
MA5-14520 was used in immunohistochemistry to examine the differentiation potential of immortalized human bronchial epithelial cells
Sat Apr 01 00:00:00 EST 2006
Inflammation and atrophy precede prostatic neoplasia in a PhIP-induced rat model.
Neoplasia (New York, N.Y.)
Borowsky AD,Dingley KH,Ubick E,Turteltaub KW,Cardiff RD,Devere-White R
MA5-14520 was used in immunohistochemistry to validate PhIP-induced rat prostatic neoplasia as a model of human prostate cancer progression
Fri Sep 01 00:00:00 EDT 2006
The kd/kd mouse is a model of collapsing glomerulopathy.
Journal of the American Society of Nephrology : JASN
Barisoni L,Madaio MP,Eraso M,Gasser DL,Nelson PJ
MA5-14520 was used in immunohistochemistry to investigate the possible usage of kd/kd mouse as a research tool for collapsing glomerulopathy
Sat Oct 01 00:00:00 EDT 2005
Antitumor efficacy of capecitabine and celecoxib in irradiated and lead-shielded, contralateral human BxPC-3 pancreatic cancer xenografts: clinical implications of abscopal effects.
Clinical cancer research : an official journal of the American Association for Cancer Research
Blanquicett C,Saif MW,Buchsbaum DJ,Eloubeidi M,Vickers SM,Chhieng DC,Carpenter MD,Sellers JC,Russo S,Diasio RB,Johnson MR
MA5-14520 was used in immunohistochemistry to investigate the abscopal effect of X-ray therapy on BxPC-3 xenografts in nude mice
Thu Dec 15 00:00:00 EST 2005
Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Renyi-Vamos F,Tovari J,Fillinger J,Timar J,Paku S,Kenessey I,Ostoros G,Agocs L,Soltesz I,Dome B
MA5-14520 was used in immunohistochemistry to study the correlation of lymphangiogenesis with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer
Sat Oct 15 00:00:00 EDT 2005
Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer.
Cancer research
Guha S,Eibl G,Kisfalvi K,Fan RS,Burdick M,Reber H,Hines OJ,Strieter R,Rozengurt E
MA5-14520 was used in immunohistochemistry to study the effect of a broad-spectrum G protein-coupled receptor antagonist on growth and angiogenesis in pancreatic cancer
Fri Apr 01 00:00:00 EST 2005
A germ line mutation that delays prostate cancer progression and prolongs survival in a murine prostate cancer model.
Oncogene
Majeed N,Blouin MJ,Kaplan-Lefko PJ,Barry-Shaw J,Greenberg NM,Gaudreau P,Bismar TA,Pollak M
MA5-14520 was used in immunohistochemistry to investigate the role of growth hormone-insulin-like growth factor-I pathway in prostate carcinogenesis and progression
Thu Jul 07 00:00:00 EDT 2005
The role of Axin2 in calvarial morphogenesis and craniosynostosis.
Development (Cambridge, England)
Yu HM,Jerchow B,Sheu TJ,Liu B,Costantini F,Puzas JE,Birchmeier W,Hsu W
MA5-14520 was used in immunohistochemistry to study the role of Axin2 in calvarial morphogenesis and craniosynostosis
Fri Apr 01 00:00:00 EST 2005
Transforming growth factor beta 1 promotes cell cycle exit through the cyclin-dependent kinase inhibitor p21 in the developing cerebral cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Siegenthaler JA,Miller MW
MA5-14520 was used in immunocytochemistry and immunohistochemistry to study the mechanism by which TGF-beta1 promotes cell cycle exit in the developing cerebral cortex
Wed Sep 21 00:00:00 EDT 2005
Characterization and localization of side population cells in mouse skin.
Stem cells (Dayton, Ohio)
Yano S,Ito Y,Fujimoto M,Hamazaki TS,Tamaki K,Okochi H
MA5-14520 was used in immunohistochemistry to study the role and localization of side population cells in mouse skin
Fri Sep 16 00:00:00 EDT 2005
Ethanol disrupts cell cycle regulation in developing rat cortex interaction with transforming growth factor beta1.
Journal of neurochemistry
Siegenthaler JA,Miller MW
MA5-14520 was used in immunohistochemistry to study the effect of ethanol on normal cell proliferation and TGFbeta1-regulated cell proliferation in the developing cortex
Tue Nov 01 00:00:00 EST 2005
p63, cytokeratin 5, and P-cadherin: three molecular markers to distinguish basal phenotype in breast carcinomas.
Virchows Archiv : an international journal of pathology
Matos I,Dufloth R,Alvarenga M,Zeferino LC,Schmitt F
MA5-14520 was used in immunohistochemistry to study the diagnostic markers of basal breast carcinomas
Sat Oct 01 00:00:00 EDT 2005
Resin tissue microarrays: a universal format for immunohistochemistry.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Howat WJ,Warford A,Mitchell JN,Clarke KF,Conquer JS,McCafferty J
MA5-14520 was used in western blot to establish a tissue array platform for immunohistochemistry
Sat Oct 01 00:00:00 EDT 2005
Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic model.
The Journal of biological chemistry
Mack JA,Li L,Sato N,Hascall VC,Maytin EV
MA5-14520 was used in immunohistochemistry to investigate the role of Hoxb13 in epidermal differentiation
Fri Aug 19 00:00:00 EDT 2005
