Invitrogen

IL23R Polyclonal Antibody

View all (24) IL23R antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-72940

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-1.0 µg/mL
-

Immunohistochemistry (IHC)

5-10 µg/mL
-

Flow Cytometry (Flow)

1:10-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide located at amino acids 439-455 of human IL-23R (NP_653302).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2718794

Target Information

IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: IBD17; IL 23R; IL-23 receptor; Interleukin-23 receptor

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Gene Aliases: IL-23R; IL23R

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UniProt ID: (Human) Q5VWK5, (Mouse) Q8K4B4

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Entrez Gene ID: (Human) 149233, (Mouse) 209590

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Function(s)
interleukin-12 receptor binding protein binding interleukin-23 binding interleukin-23 receptor activity transmembrane signal receptor
Process(es)
positive regulation of T cell mediated cytotoxicity positive regulation of defense response to virus by host positive regulation of T-helper 1 type immune response inflammatory response positive regulation of activation of JAK2 kinase activity response to lipopolysaccharide negative regulation of interleukin-10 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of natural killer cell proliferation response to interferon-gamma interleukin-23-mediated signaling pathway positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat4 protein positive regulation of tyrosine phosphorylation of Stat5 protein positive regulation of memory T cell differentiation positive regulation of osteoclast differentiation defense response to Gram-negative bacterium positive regulation of NK T cell activation positive regulation of T-helper 17 type immune response positive regulation of T-helper 17 cell lineage commitment immune system process leukocyte mediated immunity JAK-STAT cascade cytokine-mediated signaling pathway innate immune response
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