Product References
The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.
PLoS biology
Merchak AR,Cahill HJ,Brown LC,Brown RM,Rivet-Noor C,Beiter RM,Slogar ER,Olgun DG,Gaultier A
13-7042-85 was used in Enzyme-linked immunosorbent assay to demonstrate a newly emerging role for AHR in mediating the interdependence between T lymphocytes and the microbiota, while simultaneously identifying new potential molecular targets for the treatment of MS and other autoimmune diseases.
Wed Feb 01 00:00:00 EST 2023
Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response.
ImmunoHorizons
Eddie AM,Chen KW,Schenkel LB,Swinger KK,Molina JR,Kunii K,Raybuck AL,Keilhack H,Gibson-Corley KN,Niepel M,Peebles RS,Boothby MR,Cho SH
13-7042-85 was used in Enzyme-linked immunosorbent assay to conclude that PARP14 catalytic activity can contribute to pathogenesis in allergic or atopic processes and propose that other biological endpoints dependent on ADP-ribosylation by PARP14 can be targeted using selective inhibition.
Mon Jul 11 00:00:00 EDT 2022
Tumor suppressor p53 regulates intestinal type 2 immunity.
Nature communications
Chang CY,Wang J,Zhao Y,Liu J,Yang X,Yue X,Wang H,Zhou F,Inclan-Rico JM,Ponessa JJ,Xie P,Zhang L,Siracusa MC,Feng Z,Hu W
13-7042-85 was used in ELISA to demonstrate that p53 plays a pivotal role in intestinal type 2 immunity during parasitic infection.
Mon Jun 07 00:00:00 EDT 2021
NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
PLoS pathogens
Kastelberg B,Tubau-Juni N,Ayubi T,Leung A,Leber A,Hontecillas R,Bassaganya-Riera J,Kale SD
Published figure using IL-4 monoclonal antibody (Product # 13-7042-81) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2020
DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.
Journal of cellular and molecular medicine
Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G
Published figure using IL-4 monoclonal antibody (Product # 13-7042-81) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
The Journal of experimental medicine
Carpier JM,Zucchetti AE,Bataille L,Dogniaux S,Shafaq-Zadah M,Bardin S,Lucchino M,Maurin M,Joannas LD,Magalhaes JG,Johannes L,Galli T,Goud B,Hivroz C
14-5931 was used in ELISA to show the role of MKP5 in restraining p38 MAPK-mediated neutrophil oxidant production, thereby preventing LPS-induced vascular injury in mice.
Mon Apr 02 00:00:00 EDT 2018
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.
Acta pharmacologica Sinica
Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW
Published figure using IL-4 monoclonal antibody (Product # 13-7042-81) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Der f 31, a novel allergen from Dermatophagoides farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells.
Scientific reports
Wang H,Lin J,Zeng L,Ouyang C,Ran P,Yang P,Liu Z
Published figure using IL-4 monoclonal antibody (Product # 13-7042-81) in ELISA
Thu Aug 17 00:00:00 EDT 2017
Non-glycosidic compounds can stimulate both human and mouse iNKT cells.
European journal of immunology
Jukes JP,Gileadi U,Ghadbane H,Yu TF,Shepherd D,Cox LR,Besra GS,Cerundolo V
13-7042 was used in an ELISA assay to investigate novel non-glycosidic ThrCer-based analogs that have improved potency in iNKT-cell activation compared with that of α-GalCer, and are clinically relevant iNKT-cell agonists.
Sun May 01 00:00:00 EDT 2016
Altered Glycosylation Patterns Increase Immunogenicity of a Subunit Hepatitis C Virus Vaccine, Inducing Neutralizing Antibodies Which Confer Protection in Mice.
Journal of virology
Li D,von Schaewen M,Wang X,Tao W,Zhang Y,Li L,Heller B,Hrebikova G,Deng Q,Ploss A,Zhong J,Huang Z
13-7042 was used in an ELISpot assay to identify a promising broadly protective HCV vaccine candidate that should be considered for further preclinical and clinical development.
Thu Dec 01 00:00:00 EST 2016
Mucosal Langerhans Cells Promote Differentiation of Th17 Cells in a Murine Model of Periodontitis but Are Not Required for Porphyromonas gingivalis-Driven Alveolar Bone Destruction.
Journal of immunology (Baltimore, Md. : 1950)
Bittner-Eddy PD,Fischer LA,Kaplan DH,Thieu K,Costalonga M
13-7042 was used in an ELISpot assay to indicate that both Langerhans cells and Th17 cells are redundant in contributing to alveolar bone destruction in a murine model of periodontitis.
Mon Aug 15 00:00:00 EDT 2016
A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.
PLoS genetics
Kassem S,Gaud G,Bernard I,Benamar M,Dejean AS,Liblau R,Fournié GJ,Colacios C,Malissen B,Saoudi A
13-7042 was used in Flow cytometry/Cell sorting to highlight the importance of Vav1 adaptor functions in inflammatory cytokine production by effector T cells and susceptibility to neuroinflammation.
Fri Jul 01 00:00:00 EDT 2016
Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis.
The Journal of allergy and clinical immunology
Bartnikas LM,Gurish MF,Burton OT,Leisten S,Janssen E,Oettgen HC,Beaupré J,Lewis CN,Austen KF,Schulte S,Hornick JL,Geha RS,Oyoshi MK
13-7042 was used in an ELISA assay to explore whether epicutaneous sensitization with food antigen predisposes to IgE-mediated anaphylaxis on oral allergen challenge.
Fri Feb 01 00:00:00 EST 2013
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
Nature immunology
Motomura Y,Kitamura H,Hijikata A,Matsunaga Y,Matsumoto K,Inoue H,Atarashi K,Hori S,Watarai H,Zhu J,Taniguchi M,Kubo M
13-7042 was used in an ELISA assay to indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in Th1 cells, and IL-10 in Th1, Th2, Treg and NKT cells.
Sun May 01 00:00:00 EDT 2011
Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization.
Journal of immunology (Baltimore, Md. : 1950)
Weber KS,Hildner K,Murphy KM,Allen PM
13-7042 was used in an ELISpot assay to study the regulation of unique Th cell subset calcium signals and their correlation to biological functions, showing that Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization.
Wed Sep 01 00:00:00 EDT 2010
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
Nature immunology
Perrigoue JG,Saenz SA,Siracusa MC,Allenspach EJ,Taylor BC,Giacomin PR,Nair MG,Du Y,Zaph C,van Rooijen N,Comeau MR,Pearce EJ,Laufer TM,Artis D
13-7042 was used in an ELISA assay to suggest that major histocompatibility complex class II-dependent interactions between basophils and CD4+ T cells promote T helper type 2 cytokine responses and immunity to helminth infection.
Wed Jul 01 00:00:00 EDT 2009
Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis.
Glia
Bai L,Lennon DP,Eaton V,Maier K,Caplan AI,Miller SD,Miller RH
13-7042 was used in an ELISpot assay to suggest that bone marrow-derived mesenchymal stem cells represent a viable option for therapeutic approaches to multiple sclerosis.
Sat Aug 15 00:00:00 EDT 2009
Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization.
Vaccine
Seavey MM,Mosmann TR
13-7042 was used in an ELISpot assay to investigate the effect of estradiol during intravaginal immunisation, showing that estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming.
Tue Apr 14 00:00:00 EDT 2009
Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.
Virology
Steel CD,Hahto SM,Ciavarra RP
13-7042 was used in an ELISpot assay to study the adaptive primary antiviral immune response in the CNS and the effect of dendritic cells upon this in vivo.
Sat Apr 25 00:00:00 EDT 2009
Characterization of T-cell immunogenicity of two PE/PPE proteins of Mycobacterium tuberculosis.
Journal of medical microbiology
Chaitra MG,Shaila MS,Nayak R
13-7042 was used in Functional assays to demonstrate the immunogenicity of two PE/PPE proteins in BALB/c mice.
Mon Sep 01 00:00:00 EDT 2008
An immune response directed to proteinase and adhesin functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss.
Journal of immunology (Baltimore, Md. : 1950)
O'Brien-Simpson NM,Pathirana RD,Paolini RA,Chen YY,Veith PD,Tam V,Ally N,Pike RN,Reynolds EC
13-7042-85 was used in Enzyme-linked immunosorbent spot to suggest that when the RgpA-Kgp complex, or functional binding motif or active site peptides are used as a vaccine, they induce a Th2 response that blocks function of the RgpA-Kgp complex and protects against periodontal bone loss.
Thu Sep 15 00:00:00 EDT 2005
