Product References
Regulation of adipose tissue inflammation and systemic metabolism in murine obesity by polymer implants loaded with lentiviral vectors encoding human interleukin-4.
Biotechnology and bioengineering
Youngblood R,Flesher CG,Delproposto J,Baker NA,Neeley CK,Li F,Lumeng CN,Shea LD,O'Rourke RW
M450 was used in Immunohistochemistry to demonstrate that polymer biomaterials implanted into adipose tissue have the potential to modulate local tissue and systemic inflammation and metabolism.
Tue Dec 01 00:00:00 EST 2020
Dependence of Glomerulonephritis Induction on Novel Intraglomerular Alternatively Activated Bone Marrow-Derived Macrophages and Mac-1 and PD-L1 in Lupus-Prone NZM2328 Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sung SJ,Ge Y,Dai C,Wang H,Fu SM,Sharma R,Hahn YS,Yu J,Le TH,Okusa MD,Bolton WK,Lawler JR
M450 was used in Magnetic cell separation to identify glomerulus-infiltrating leukocyte populations in NZM2328 lupus-prone mice with spontaneous chronic glomerulonephritis and anti-glomerular basement membrane-induced nephritis.
Sat Apr 01 00:00:00 EDT 2017
Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.
The Journal of experimental medicine
Tesio M,Tang Y,Müdder K,Saini M,von Paleske L,Macintyre E,Pasparakis M,Waisman A,Trumpp A
M450 was used in Flow cytometry/Cell sorting to elucidate the molecular mechanisms regulating haematopoietic stem cell dormancy.
Mon Apr 06 00:00:00 EDT 2015
Primary murine CD4+ T cells fail to acquire the ability to produce effector cytokines when active Ras is present during Th1/Th2 differentiation.
PloS one
Janardhan SV,Marks R,Gajewski TF
M450 was used in Western Blotting to demonstrate that constitutive Ras signaling inhibits the ability of CD4+ T-cells to properly differentiate into Th1/Th2 effector cytokine-producing cells.
Wed Dec 30 00:00:00 EST 2015
Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization.
The Journal of experimental medicine
Tesio M,Oser GM,Baccelli I,Blanco-Bose W,Wu H,Göthert JR,Kogan SC,Trumpp A
M450 was used in Magnetic cell separation to investigate the effect of PTEN deletion in bone marrow, showing that it leads to G-CSF-mediated hematopoietic stem cell mobilisation.
Mon Oct 21 00:00:00 EDT 2013
Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility.
PloS one
Chang CJ,Kuo HC,Chang JS,Lee JK,Tsai FJ,Khor CC,Chang LC,Chen SP,Ko TM,Liu YM,Chen YJ,Hong YM,Jang GY,Hibberd ML,Kuijpers T,Burgner D,Levin M,Burns JC,Davila S,Chen YT,Chen CH,Wu JY,Lee YC
M450 was used in Flow cytometry/Cell sorting to suggest that peripheral B cells play a pathogenic role during the acute stage of Kawasaki disease.
Tue Apr 15 00:00:00 EDT 2014
TH17, TH22 and Treg cells are enriched in the healthy human cecum.
PloS one
Wolff MJ,Leung JM,Davenport M,Poles MA,Cho I,Loke P
M450 was used in flow cytometry to determine the localization of CD4 positive T cells subsets in the healthy intestine
Fri Dec 07 00:00:00 EST 2012
Assessment of circulating tumor cells (CTCs) in prostate cancer patients with low-volume tumors.
Pathology international
Ali A,Furusato B,Ts'o PO,Lum ZP,Elsamanoudi S,Mohamed A,Srivastava S,Moul JW,Brassell SA,Sesterhenn IA,McLeod DG
M450 was used in Flow cytometry/Cell sorting to assess the incidence of circulating tumor cells (CTCs) in prostate cancer patients with low-volume tumors (less than 0.5 cc) after radical prostatectomy (RP).
Fri Oct 01 00:00:00 EDT 2010
Epstein-Barr virus and cytomegalovirus are differentially associated with numbers of cytokine-producing cells and early atopy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Nilsson C,Larsson Sigfrinius AK,Montgomery SM,Sverremark-Ekström E,Linde A,Lilja G,Blomberg MT
M450 was used in ELISA to investigate the relationship between the cytokine profile in PBMC and Epstein-Barr virus serostatus and between the cytokine profile and cytomegalovirus serostatus
Wed Apr 01 00:00:00 EDT 2009
Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides.
Biochemical and biophysical research communications
Curbo S,Gaudin R,Carlsten M,Malmberg KJ,Troye-Blomberg M,Ahlborg N,Karlsson A,Johansson M,Lundberg M
M450 was used in ELISA to study the effect of disulfide bonds on interleukin-4 signaling
Fri Dec 25 00:00:00 EST 2009
Interleukin-13 mucosal production in Helicobacter pylori-related gastric diseases.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Marotti B,Rocco A,De Colibus P,Compare D,de Nucci G,Staibano S,Tatangelo F,Romano M,Nardone G
M450 was used in ELISA to study the mucosal production of interleukin 13 in Helicobacter pylori-related gastric diseases
Tue Apr 01 00:00:00 EDT 2008
Tuning the formation and rupture of single ligand-receptor bonds by hyaluronan-induced repulsion.
Biophysical journal
Robert P,Sengupta K,Puech PH,Bongrand P,Limozin L
M450 was used in Flow cytometry/Cell sorting to open the way for further quantitative studies of the effect of molecular environment and separation distance on ligand-receptor association and dissociation.
Wed Oct 01 00:00:00 EDT 2008
General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines.
Journal of virology
Kueng HJ,Leb VM,Haiderer D,Raposo G,Thery C,Derdak SV,Schmetterer KG,Neunkirchner A,Sillaber C,Seed B,Pickl WF
M450 was used in immunocytochemistry to develop a system for the decoration of enveloped viruses with functionally active cytokines
Wed Aug 01 00:00:00 EDT 2007
The presence of MOMA-2+ macrophages in the outer B cell zone and protection of the splenic micro-architecture from LPS-induced destruction depend on secreted IgM.
European journal of immunology
Fischer MB,Rüger B,Vaculik C,Becherer A,Wadsak W,Yanagida G,Losert UM,Chen J,Carroll MC,Eibl MM
M450 was used in ELISA, Western Blot, Flow Cytometry to address the question whether natural IgM antibody can protect the lymphoid tissue from LPS over-stimulation and investigate the role of C3-producing macrophages in this complex scenario.
Mon Oct 01 00:00:00 EDT 2007
Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood.
European journal of immunology
Bratke K,Kuepper M,Bade B,Virchow JC,Luttmann W
M450 was used in flow cytometry to use flow cytometry to study granzyme A, B, and K expression in human peripheral blood lymphocytes
Thu Sep 01 00:00:00 EDT 2005
Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia.
Respiratory research
Chialda L,Zhang M,Brune K,Pahl A
Published figure using IL-4 monoclonal antibody (Product # M450) in ELISA
Fri Apr 15 00:00:00 EDT 2005
Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.
Journal of immunology (Baltimore, Md. : 1950)
McGeachy MJ,Stephens LA,Anderton SM
M450 was used in ELISA, Western Blot, Flow Cytometry to investigate the natural resolution of autoimmune pathology within the CNS using murine experimental autoimmune encephalomyelitis (EAE).
Thu Sep 01 00:00:00 EDT 2005
Enhanced monocyte Th1 cytokine production in HCV-infected cryoglobulinemic patients.
Journal of hepatology
Loffreda S,Muratori P,Muratori L,Mele L,Bianchi FB,Lenzi M
M450 was used in ELISA to investigate the augmented production of Th1-type cytokines in HCV-infected cryoglobulinemic patients
Sat Feb 01 00:00:00 EST 2003
Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis.
Clinical and experimental immunology
Melgar S,Yeung MM,Bas A,Forsberg G,Suhr O,Oberg A,Hammarstrom S,Danielsson A,Hammarstrom ML
M450 was used in immunohistochemistry to study the involvement of interleukin 10 in active ulcerative colitis
Wed Oct 01 00:00:00 EDT 2003
CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid.
The Journal of rheumatology
Hatachi S,Iwai Y,Kawano S,Morinobu S,Kobayashi M,Koshiba M,Saura R,Kurosaka M,Honjo T,Kumagai S
M450 was used in flow cytometry to investigate the involvement of the PD-1 system in rheumatoid arthritis
Tue Jul 01 00:00:00 EDT 2003
Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells.
Diabetes
Greening JE,Tree TI,Kotowicz KT,van Halteren AG,Roep BO,Klein NJ,Peakman M
M450 was used in ELISA, Western Blot, Misc to examine the ability of ECs expressing HLA class II molecules to process and present the islet autoantigen GAD65 and examined the effects of presentation on transmigration of GAD65-specific T-cells.
Sat Mar 01 00:00:00 EST 2003
Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Dimitrova P,Skapenko A,Herrmann ML,Schleyerbach R,Kalden JR,Schulze-Koops H
M450 was used in blocking/activating experiment to investigate the role of de novo pyrimidine biosynthesis restriction for Th1 cell activation and Th2 cell differentiation
Sun Sep 15 00:00:00 EDT 2002
Influence of atopic heredity on IL-4-, IL-12- and IFN-gamma-producing cells in in vitro activated cord blood mononuclear cells.
Clinical and experimental immunology
Gabrielsson S,Söderlund A,Nilsson C,Lilja G,Nordlund M,Troye-Blomberg M
M450 was used in ELISA to study the effect of fetal environment on the development of atopic disease
Sat Dec 01 00:00:00 EST 2001
Antigen-independent Th2 cell differentiation by stimulation of CD28: regulation via IL-4 gene expression and mitogen-activated protein kinase activation.
Journal of immunology (Baltimore, Md. : 1950)
Skapenko A,Lipsky PE,Kraetsch HG,Kalden JR,Schulze-Koops H
M450 was used in ELISA to investigate the role of interleukin 4 gene expression
Sun Apr 01 00:00:00 EST 2001
Staphylococcal acid phosphatase binds to endothelial cells via charge interaction; a pathogenic role in Wegener's granulomatosis?
Clinical and experimental immunology
Brons RH,Bakker HI,Van Wijk RT,Van Dijk NW,Muller Kobold AC,Limburg PC,Manson WL,Kallenberg CG,Tervaert JW
M450 was used in ELISA, Western Blot, Flow Cytometry to study the ability of staphylococcal acid phosphatase to bind to human umbilical vein endothelial cells (HUVEC) and human glomerular endothelial cells.
Wed Mar 01 00:00:00 EST 2000
An RNA polymerase II complex containing all essential initiation factors binds to the activation domain of PAR leucine zipper transcription factor thyroid embryonic factor.
Molecular and cellular biology
Ossipow V,Fonjallaz P,Schibler U
M450 was used in Western Blotting to study the interaction between an RNA polymerase II complex and thyroid embryonic factor.
Mon Feb 01 00:00:00 EST 1999
Functional expression of transmembrane 4 superfamily molecules on human eosinophils.
International archives of allergy and immunology
Matsumoto K,Bochner BS,Wakiguchi H,Kurashige T
M450 was used in Flow cytometry/Cell sorting to suggest that several TM4SF molecules are functionally expressed on human eosinophils, and therefore might participate in allergic inflammation.
Tue Nov 09 00:00:00 EST 1999
Aberrant expression and reverse signalling of CD70 on malignant B cells.
British journal of haematology
Lens SM,Drillenburg P,den Drijver BF,van Schijndel G,Pals ST,van Lier RA,van Oers MH
M450 was used in Immunohistochemistry, ELISA, Western Blot to study CD70 on B-CLLs, follicle centre lymphomas, large B-cell lymphomas, and mantle cell lymphomas.
Sun Aug 01 00:00:00 EDT 1999
Altered expression of CD11b and CD62L after cross-linking of CD45 isoforms on human eosinophils.
International archives of allergy and immunology
Matsumoto K,Bochner BS,Wakiguchi H,Kurashige T
M450 was used in Flow cytometry/Cell sorting to suggest that CD45 isoforms are functionally expressed on human eosinophils, and are capable of modulating eosinophil function and might participate in allergic inflammation.
Tue Sep 01 00:00:00 EDT 1998
Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression.
The Journal of experimental medicine
Anstey NM,Weinberg JB,Hassanali MY,Mwaikambo ED,Manyenga D,Misukonis MA,Arnelle DR,Hollis D,McDonald MI,Granger DL
M450 was used in ELISA to measure the interleukin-10 and interleukin-4 level in Tanzanian children with malaria
Thu Aug 01 00:00:00 EDT 1996
