Invitrogen

IL-2 Monoclonal Antibody (MQ1-17H12), PE

FIGURE: 1 / 1

IL-2 Antibody (RHCIL204) in Flow

R-PE of anti-human IL-2 mAb antibody stained intracellularly on IL-2 expressing commercially available human intracellular cytokine positive control cells (HiCK-1 cells), purchased from BD Biosciences.

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Product Details

RHCIL204

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

5 µL / 1x10^6 cells

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Published species

Human

Host/Isotype

Rat / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

MQ1-17H12

Immunogen

Human IL-2.

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_10375725

Target Information

Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

The RNA-Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation.

PloS one

La Porta J,Matus-Nicodemos R,Valentín-Acevedo A,Covey LR

RHCIL204 was used in flow cytometry to investigate the role of polypyrimidine tract-binding protein 1 in CD4 T cell activation

Thu Jul 27 00:00:00 EDT 2017

Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus.

Allergy

Bratke K,Klein C,Kuepper M,Lommatzsch M,Virchow JC

RHCIL204 was used in flow cytometry to test if Th1- and Th2-like conditions alter antigen expression and function of plasmacytoid dendritic cells

Tue Mar 01 00:00:00 EST 2011

Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood.

European journal of immunology

Bratke K,Kuepper M,Bade B,Virchow JC,Luttmann W

RHCIL204 was used in flow cytometry to use flow cytometry to study granzyme A, B, and K expression in human peripheral blood lymphocytes

Thu Sep 01 00:00:00 EDT 2005

Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines.

Journal of immunology (Baltimore, Md. : 1950)

Cousins DJ,Lee TH,Staynov DZ

RHCIL204 was used in flow cytometry to report an in vitro differentiation assay in which human naive CD4(+) cells are driven toward either the Th1 or Th2 phenotype and study them.

Sun Sep 01 00:00:00 EDT 2002

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