Product References
Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation.
The Journal of clinical investigation
Song J,Navarro-Garcia JA,Wu J,Saljic A,Abu-Taha I,Li L,Lahiri SK,Keefe JA,Aguilar-Sanchez Y,Moore OM,Yuan Y,Wang X,Kamler M,Mitch WE,Ruiz-Hurtado G,Hu Z,Thomas SS,Dobrev D,Wehrens XH,Li N
Published figure using IL-1 beta monoclonal antibody (Product # 14-7012-81) in Neutralization
Mon Oct 02 00:00:00 EDT 2023
Origin and Function of Stress-Induced IL-6 in Murine Models.
Cell
Qing H,Desrouleaux R,Israni-Winger K,Mineur YS,Fogelman N,Zhang C,Rashed S,Palm NW,Sinha R,Picciotto MR,Perry RJ,Wang A
14-7012-81 was used in ELISA to study the cytokine interleukin-6 (IL-6) and its induction following acute stress in mouse models.
Thu Jul 23 00:00:00 EDT 2020
Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2.
The Journal of experimental medicine
Fachi JL,Sécca C,Rodrigues PB,Mato FCP,Di Luccia B,Felipe JS,Pral LP,Rungue M,Rocha VM,Sato FT,Sampaio U,Clerici MTPS,Rodrigues HG,Câmara NOS,Consonni SR,Vieira AT,Oliveira SC,Mackay CR,Layden BT,Bortoluci KR,Colonna M,Vinolo MAR
Published figure using IL-1 beta monoclonal antibody (Product # 14-7012-81) in Neutralization
Mon Mar 02 00:00:00 EST 2020
Differential Activation of Macrophages Based on Their Environment in Advanced Age.
Chonnam medical journal
Lee DY,Lim JS,Cho KA
Published figure using IL-1 beta monoclonal antibody (Product # 14-7012-81) in ELISA
Wed Jan 01 00:00:00 EST 2020
NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma.
Molecular neurodegeneration
Chen H,Deng Y,Gan X,Li Y,Huang W,Lu L,Wei L,Su L,Luo J,Zou B,Hong Y,Cao Y,Liu Y,Chi W
14-7012-81 was used in Neutralization to indicate that the collaborative effects of NLRP12, NLRP3 and NLRC4 on pyroptosis are responsible for RGCs death and shed novel mechanistic insights into microglial pyroptosis, paving novel therapeutic avenues for the treatment of glaucoma-induced irreversible vision loss through simultaneously targeting of pyroptosis.
Wed Apr 15 00:00:00 EDT 2020
NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma.
Molecular neurodegeneration
Chen H,Deng Y,Gan X,Li Y,Huang W,Lu L,Wei L,Su L,Luo J,Zou B,Hong Y,Cao Y,Liu Y,Chi W
14-7012-81 was used in Neutralization to indicate that the collaborative effects of NLRP12, NLRP3 and NLRC4 on pyroptosis are responsible for RGCs death and shed novel mechanistic insights into microglial pyroptosis, paving novel therapeutic avenues for the treatment of glaucoma-induced irreversible vision loss through simultaneously targeting of pyroptosis.
Wed Apr 15 00:00:00 EDT 2020
Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation.
Scientific reports
Dai D,Yuan J,Wang Y,Xu J,Mao C,Xiao Y
Published figure using IL-1 beta monoclonal antibody (Product # 14-7012-81) in ELISA
Wed May 29 00:00:00 EDT 2019
A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses.
Frontiers in immunology
Min CK,Kim HI,Ha NY,Kim Y,Kwon EK,Yen NTH,Youn JI,Jeon YK,Inn KS,Choi MS,Cho NH
14-7012 was used in Neutralization experiments to show that the induction of the type I IFN/IL-10 axis by O. tsutsugamushi infection might play a significant role in the suppression of T cell responses and contribute to the short longevity of cell-mediated immunity, often observed in scrub typhus patients.
Mon Sep 30 00:00:00 EDT 2019
Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission.
Cell
Rao S,Schieber AMP,O'Connor CP,Leblanc M,Michel D,Ayres JS
14-7012 was used in an ELISA assay to study the mechanism by which Salmonella Typhimurium inhibits anorexia.
Thu Jan 26 00:00:00 EST 2017
Intestinal fungi contribute to development of alcoholic liver disease.
The Journal of clinical investigation
Yang AM,Inamine T,Hochrath K,Chen P,Wang L,Llorente C,Bluemel S,Hartmann P,Xu J,Koyama Y,Kisseleva T,Torralba MG,Moncera K,Beeri K,Chen CS,Freese K,Hellerbrand C,Lee SM,Hoffman HM,Mehal WZ,Garcia-Tsao G,Mutlu EA,Keshavarzian A,Brown GD,Ho SB,Bataller R,Stärkel P,Fouts DE,Schnabl B
14-7012 was used in an ELISA assay to investigate the contribution of intestinal fungi, or mycobiota, to alcoholic liver disease.
Fri Jun 30 00:00:00 EDT 2017
Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion.
Frontiers in immunology
Shi G,Abbott KN,Wu W,Salter RD,Keyel PA
14-7012 was used in an ELISA assay to investigate the possibility that immune activation, specifically inflammasome activation, is regulated by Dnase1L3.
Fri Aug 04 00:00:00 EDT 2023
Orally administered sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice.
Experimental and therapeutic medicine
Ono K,Nimura S,Hideshima Y,Nabeshima K,Nakashima M
14-7012 was used in an ELISA assay to investigate the effects of orally administered sodium 4-phenylbutyrate in mice.
Fri Dec 01 00:00:00 EST 2017
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
PloS one
Selby MJ,Engelhardt JJ,Johnston RJ,Lu LS,Han M,Thudium K,Yao D,Quigley M,Valle J,Wang C,Chen B,Cardarelli PM,Blanset D,Korman AJ
14-7012 was used in Flow cytometry/Cell sorting to exhibit a preclinical strategy for the identification and development of highly effective antitumour combination immunotherapies.
Fri Aug 25 00:00:00 EDT 2017
Cholera Toxin Promotes Th17 Cell Differentiation by Modulating Expression of Polarizing Cytokines and the Antigen-Presenting Potential of Dendritic Cells.
PloS one
Kang JO,Lee JB,Chang J
14-7012 was used in Neutralization experiments to determine how cholera toxin skews the differentiation of CD4 T cells to form IL-17-producing Th17 cells.
Tue Aug 08 00:00:00 EDT 2017
Cyclo(Phe-Pro) produced by the human pathogen Vibrio vulnificus inhibits host innate immune responses through the NF-κB pathway.
Infection and immunity
Kim K,Kim NJ,Kim SY,Kim IH,Kim KS,Lee GR
14-7012 was used in an ELISA assay to investigate the effects of a secondary metabolite produced by the lethal human bacterial pathogen Vibrio vulnificus on the mammalian innate immune system.
Sun Mar 01 00:00:00 EST 2015
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.
Nature communications
Shao L,Zhou HJ,Zhang H,Qin L,Hwa J,Yun Z,Ji W,Min W
Published figure using IL-1 beta monoclonal antibody (Product # 14-7012-81) in ELISA
Tue Nov 24 00:00:00 EST 2015
NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen.
Mucosal immunology
Nordlander S,Pott J,Maloy KJ
14-7012 was used in an ELISA assay to study how early NLRC4 sensing in intestinal epithelial cells regulates colonization by an extracellular bacterial pathogen and limits subsequent intestinal damage.
Tue Jul 01 00:00:00 EDT 2014
Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen.
Mucosal immunology
Song-Zhao GX,Srinivasan N,Pott J,Baban D,Frankel G,Maloy KJ
14-7012 was used in an ELISA assay to investigate how protection from disease is mediated through Nlrp3 activation in nonhematopoietic cells and is initiated very early after infection.
Tue Jul 01 00:00:00 EDT 2014
The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles.
Particle and fibre toxicology
Rabolli V,Badissi AA,Devosse R,Uwambayinema F,Yakoub Y,Palmai-Pallag M,Lebrun A,De Gussem V,Couillin I,Ryffel B,Marbaix E,Lison D,Huaux F
14-7012 was used in Functional assays to assess the implication of alarmins (IL-1α, IL-33 and HMGB1) in the lung response to silica particles.
Sat Dec 13 00:00:00 EST 2014
Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium.
Nature immunology
Robinson N,McComb S,Mulligan R,Dudani R,Krishnan L,Sad S
14-7012 was used in Neutralization experiments to propose that S. Typhimurium induces the production of type I interferon, which drives necroptosis of macrophages and allows them to evade the immune response.
Mon Oct 01 00:00:00 EDT 2012
Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis.
European journal of immunology
Freigang S,Ampenberger F,Spohn G,Heer S,Shamshiev AT,Kisielow J,Hersberger M,Yamamoto M,Bachmann MF,Kopf M
14-7012 was used in an ELISA assay to identify NF-E2-related 2 as an essential positive regulator of inflammasome activation and IL-1-mediated vascular inflammation.
Fri Jul 01 00:00:00 EDT 2011
Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.
The Journal of experimental medicine
González-Navajas JM,Law J,Nguyen KP,Bhargava M,Corr MP,Varki N,Eckmann L,Hoffman HM,Lee J,Raz E
14-7012 was used in Neutralization experiments to investigate the role of IL-1R in antiinflammatory cytokine production.
Mon Dec 20 00:00:00 EST 2010
Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.
The Journal of experimental medicine
González-Navajas JM,Law J,Nguyen KP,Bhargava M,Corr MP,Varki N,Eckmann L,Hoffman HM,Lee J,Raz E
14-7012 was used in Neutralization experiments to investigate the role of IL-1R in antiinflammatory cytokine production.
Mon Dec 20 00:00:00 EST 2010
Tim3 binding to galectin-9 stimulates antimicrobial immunity.
The Journal of experimental medicine
Jayaraman P,Sada-Ovalle I,Beladi S,Anderson AC,Dardalhon V,Hotta C,Kuchroo VK,Behar SM
14-7012 was used in an ELISA assay to explore the role of the Th1 cell surface molecule Tim3 in the regulation of antimicrobial immunity.
Mon Oct 25 00:00:00 EDT 2010
Inflammation recapitulates the ontogeny of lymphoid stromal cells.
Journal of immunology (Baltimore, Md. : 1950)
Peduto L,Dulauroy S,Lochner M,Späth GF,Morales MA,Cumano A,Eberl G
14-7012 was used in Functional assays to show that LS cells are both programmed during ontogeny and reinduced during inflammation.
Fri May 01 00:00:00 EDT 2009
Transfer of tolerance to collagen type V suppresses T-helper-cell-17 lymphocyte-mediated acute lung transplant rejection.
Transplantation
Braun RK,Molitor-Dart M,Wigfield C,Xiang Z,Fain SB,Jankowska-Gan E,Seroogy CM,Burlingham WJ,Wilkes DS,Brand DD,Torrealba J,Love RB
14-7012 was used in Neutralization experiments to test whether Tregs from tolerant rats could suppress Th17-mediated rejection in the syngeneic model of lung transplantation.
Sun Dec 27 00:00:00 EST 2009