Proteintech

GM-CSF Polyclonal Antibody

GM-CSF Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GM-CSF Antibody (17762-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using (Product # 17762-1-AP) (GM-CSF antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

17762-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GM-CSF Fusion Protein Ag12142 (1-144 aa encoded by BC108724)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MWLQSLLLL GTVACSISAP ARSPSPSTQP WEHVNAIQEA RRLLNLSRDT AAEMNETVEV ISEMFDLQEP TCLQTRLELY KQGLRGSLTK LKGPLTMMAS HYKQHCPPTP ETSCATQIIT FESFKENLKD FLLVIPFDCW EPVQE (1-144 aa encoded by BC108724)

Target Information

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CMAHP promotes metastasis by reducing ubiquitination of Snail and inducing angiogenesis via GM-CSF overexpression in gastric cancer.

Oncogene

Huang HW,Chen CY,Huang YH,Yeh CT,Wang CS,Chang CC,Lin KH

Sat Jan 01 00:00:00 EST 2022

Regulation of Th17/Treg Balance by 27-Hydroxycholesterol and 24S-Hydroxycholesterol Correlates with Learning and Memory Ability in Mice.

International journal of molecular sciences

Wang T,Cui S,Hao L,Liu W,Wang L,Ju M,Feng W,Xiao R

Fri Apr 15 00:00:00 EDT 2022

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.

Journal of immunology (Baltimore, Md. : 1950)

Fan TW,Daneshmandi S,Cassel TA,Uddin MB,Sledziona J,Thompson PT,Lin P,Higashi RM,Lane AN

Tue Nov 01 00:00:00 EDT 2022

An Amide Alkaloid Isolated from Ephedra sinica Ameliorates OVA-Induced Allergic Asthma by Inhibiting Mast Cell Activation and Dendritic Cell Maturation.

International journal of molecular sciences

Jia J,Zeng M,Zhu D,Jiao X,Zhang B,Yang R,Feng W,Zheng X

Fri Nov 04 00:00:00 EDT 2022

An Amide Alkaloid Isolated from Ephedra sinica Ameliorates OVA-Induced Allergic Asthma by Inhibiting Mast Cell Activation and Dendritic Cell Maturation.

International journal of molecular sciences

Jia J,Zeng M,Zhu D,Jiao X,Zhang B,Yang R,Feng W,Zheng X

Fri Nov 04 00:00:00 EDT 2022

Moderate tibial loading and treadmill running, but not overloading, protect adult murine bone from destruction by metastasized breast cancer.

Bone

Wang S,Pei S,Wasi M,Parajuli A,Yee A,You L,Wang L

Wed Dec 01 00:00:00 EST 2021

Myeloid-derived suppressor cells promote epithelial ovarian cancer cell stemness by inducing the CSF2/p-STAT3 signalling pathway.

The FEBS journal

Li X,Wang J,Wu W,Gao H,Liu N,Zhan G,Li L,Han L,Guo X

Tue Dec 01 00:00:00 EST 2020

Myeloid-derived suppressor cells promote epithelial ovarian cancer cell stemness by inducing the CSF2/p-STAT3 signalling pathway.

The FEBS journal

Li X,Wang J,Wu W,Gao H,Liu N,Zhan G,Li L,Han L,Guo X

Tue Dec 01 00:00:00 EST 2020

Antitumor Efficacy of Oncolytic Herpes Virus Type 1 Armed with GM-CSF in Murine Uveal Melanoma Xenografts.

Cancer management and research

Liu S,Liu F,Zhao M,Zhang J

Mon Apr 18 00:00:00 EDT 2022

Antitumor Efficacy of Oncolytic Herpes Virus Type 1 Armed with GM-CSF in Murine Uveal Melanoma Xenografts.

Cancer management and research

Liu S,Liu F,Zhao M,Zhang J

Mon Apr 18 00:00:00 EDT 2022

Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma.

The Journal of experimental medicine

Liu J,Jiang W,Zhao K,Wang H,Zhou T,Bai W,Wang X,Zhao T,Huang C,Gao S,Qin T,Yu W,Yang B,Li X,Fu D,Tan W,Yang S,Ren H,Hao J

Mon Mar 04 00:00:00 EST 2019

Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma.

The Journal of experimental medicine

Liu J,Jiang W,Zhao K,Wang H,Zhou T,Bai W,Wang X,Zhao T,Huang C,Gao S,Qin T,Yu W,Yang B,Li X,Fu D,Tan W,Yang S,Ren H,Hao J

Mon Mar 04 00:00:00 EST 2019

RNA Helicase A Is an Important Host Factor Involved in Dengue Virus Replication.

Journal of virology

Wang Y,Chen X,Xie J,Zhou S,Huang Y,Li YP,Li X,Liu C,He J,Zhang P

Fri Feb 15 00:00:00 EST 2019

Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury.

Journal of the American Society of Nephrology : JASN

Xu L,Sharkey D,Cantley LG

Tue Oct 01 00:00:00 EDT 2019

HIF-1α mediates tumor-nerve interactions through the up-regulation of GM-CSF in pancreatic ductal adenocarcinoma.

Cancer letters

Wang H,Jia R,Zhao T,Li X,Lang M,Lan C,Wang H,Li Z,Zhou B,Wu L,Sun Y,Wang X,Ren H,Hao J

Mon Jul 01 00:00:00 EDT 2019

HIF-1α mediates tumor-nerve interactions through the up-regulation of GM-CSF in pancreatic ductal adenocarcinoma.

Cancer letters

Wang H,Jia R,Zhao T,Li X,Lang M,Lan C,Wang H,Li Z,Zhou B,Wu L,Sun Y,Wang X,Ren H,Hao J

Mon Jul 01 00:00:00 EDT 2019

Pre-transplant infusion of donor-derived dendritic cells maintained at the immature stage by sinomenine increases splenic Foxp3⁺ Tregs in recipient rats after renal allotransplantation.

Transplant immunology

Li L,Luo Z,Song Z,Zheng L,Chen T

Fri Dec 01 00:00:00 EST 2017

Pre-transplant infusion of donor-derived dendritic cells maintained at the immature stage by sinomenine increases splenic Foxp3⁺ Tregs in recipient rats after renal allotransplantation.

Transplant immunology

Li L,Luo Z,Song Z,Zheng L,Chen T

Fri Dec 01 00:00:00 EST 2017

Bioinformatics

Protein Aliases: colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; GM-CSF; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; Granulocyte-macrophage colony-stimulating factor; M-GM-CSF; MGC131935; MGC138897; MGC151255; MGC151257; Molgramostin; Sargramostim

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Gene Aliases: CSF2; GMCSF

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UniProt ID: (Human) P04141

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Entrez Gene ID: (Human) 1437

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Function(s)

protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity cytokine activity granulocyte macrophage colony-stimulating factor receptor binding protein binding growth factor activity cytokine

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GM-CSF Polyclonal Antibody

GM-CSF Antibody (17762-1-AP) in IHC (P)

Product Details

17762-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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