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Fc epsilon RI alpha Polyclonal Antibody

Fc epsilon RI alpha Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Fc epsilon RI alpha Antibody (10980-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer using 10980-1-AP (Fc epsilon RI alpha antibody) at dilution of 1:100 (under 10x lens).

Fc epsilon RI alpha Antibody in Western Blot (WB)

Product Image Gallery

Product Details

10980-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Fc epsilon RI alpha Fusion Protein Ag1398 (1-257 aa encoded by BC015195)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAPAMESPT LLCVALLFFA PDGVLAVPQK PKVSLNPPWN RIFKGENVTL TCNGNNFFEV SSTKWFHNGS LSEETNSSLN IVNAKFEDSG EYKCQHQQVN ESEPVYLEVF SDWLLLQASA EVVMEGQPLF LRCHGWRNWD VYKVIYYKDG EALKYWYENH NISITNATVE DSGTYYCTGK VWQLDYESEP LNITVIKAPR EKYWLQFFIP LLVVILFAVD TGLFISTQQQ ATFLLKIKRT RKGFRLLNPH PKPNPKNN (1-257 aa encoded by BC015195)

Target Information

FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Allergic asthma aggravates angiotensin Ⅱ-induced cardiac remodeling in mice.

Translational research : the journal of laboratory and clinical medicine

Geng C,Feng Y,Yang Y,Yang H,Li Z,Tang Y,Wang J,Zhao H

Wed Jun 01 00:00:00 EDT 2022

Elevated IgE promotes cardiac fibrosis by suppressing miR-486a-5p.

Theranostics

Zhao H,Yang H,Geng C,Chen Y,Tang Y,Li Z,Pang J,Shu T,Nie Y,Liu Y,Jia K,Wang J

Wed Jul 28 00:00:00 EDT 2021

Response to Comment on "Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression".

Science (New York, N.Y.)

Taniguchi S,Elhance A,Van Duzer A,Kumar S,Leitenberger J,Oshimori N

Fri Apr 09 00:00:00 EDT 2021

Thymic stromal lymphopoietin epigenetically upregulates Fc receptor γ subunit-related receptors on antigen-presenting cells and induces T_H2/T_H17 polarization through dectin-2.

The Journal of allergy and clinical immunology

Liang Y,Yu B,Chen J,Wu H,Xu Y,Yang B,Lu Q

Tue Oct 01 00:00:00 EDT 2019

Alveolar mast cells shift to an FcεRI-expressing phenotype in mild atopic asthma: a novel feature in allergic asthma pathology.

Allergy

Andersson CK,Tufvesson E,Aronsson D,Bergqvist A,Mori M,Bjermer L,Erjefält JS

Thu Dec 01 00:00:00 EST 2011

Alveolar mast cells shift to an FcεRI-expressing phenotype in mild atopic asthma: a novel feature in allergic asthma pathology.

Allergy

Andersson CK,Tufvesson E,Aronsson D,Bergqvist A,Mori M,Bjermer L,Erjefält JS

Thu Dec 01 00:00:00 EST 2011

Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma.

The Journal of allergy and clinical immunology

Andersson CK,Bergqvist A,Mori M,Mauad T,Bjermer L,Erjefält JS

Fri Apr 01 00:00:00 EDT 2011

Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma.

The Journal of allergy and clinical immunology

Andersson CK,Bergqvist A,Mori M,Mauad T,Bjermer L,Erjefält JS

Fri Apr 01 00:00:00 EDT 2011

Novel site-specific mast cell subpopulations in the human lung.

Thorax

Andersson CK,Mori M,Bjermer L,Löfdahl CG,Erjefält JS

Wed Apr 01 00:00:00 EDT 2009

Novel site-specific mast cell subpopulations in the human lung.

Thorax

Andersson CK,Mori M,Bjermer L,Löfdahl CG,Erjefält JS

Wed Apr 01 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc-epsilon RI-alpha; FcERI; high affinity immunoglobulin epsilon receptor alpha-subunit; High affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RP11-550P17.3

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Gene Aliases: FCE1A; fcepsilonri; FCER1A; FcERI; Fcr-5

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UniProt ID: (Human) P12319, (Mouse) P20489

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Entrez Gene ID: (Human) 2205, (Mouse) 14125

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Function(s)

IgE receptor activity IgE binding protein binding immunoglobulin receptor superfamily

Process(es)

positive regulation of type I hypersensitivity serotonin secretion activation of JUN kinase activity leukotriene biosynthetic process Fc-epsilon receptor signaling pathway positive regulation of mast cell degranulation positive regulation of interleukin-3 biosynthetic process positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of calcium-mediated signaling activation of MAPK activity signal transduction cell surface receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Fc epsilon RI alpha Polyclonal Antibody

Fc epsilon RI alpha Antibody (10980-1-AP) in IHC (P)

Product Details

10980-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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