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NeoBiotechnologies
Desmin (Muscle Cell Marker) Recombinant Mouse Monoclonal Antibody (rDES/8846)
Product Details
1674-MSM11-P1
Species Reactivity
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Conjugate
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Product Specific Information
Positive Control: SJRH30 cells. Human uterus small intestine or leiomyosarcoma.
Cellular Location: Cytoplasm.
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CMD1I; Desmin; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament protein; MFM1; mutant desmin p.K241E; SCPNK
Gene Aliases: CSM1; CSM2; DES; LGMD2R
UniProt ID: (Human) P17661
Entrez Gene ID: (Human) 1674
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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