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Product Details
PA5-57872
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
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RRID
Product Specific Information
Immunogen sequence: VTPGGFDQIN PATNRVLCSY DYRNIEGFVD LSDYQGGFCI LYGGFSRLHL FASEQREEII KSAIDHAGNY IGISLRIRKE PLEFEQYLNL RF
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 92%.
Target Information
DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans. It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles. DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: DnaJ (Hsp40) homolog, subfamily C, member 13; DnaJ domain-containing protein RME-8; DnaJ homolog subfamily C member 13; Required for receptor-mediated endocytosis 8; RME-8
Gene Aliases: DNAJC13; KIAA0678; PARK21; RME8
UniProt ID: (Human) O75165
Entrez Gene ID: (Human) 23317
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